Navigation Links
Grant to fund development of drug candidates for rheumatoid arthritis, neurodegenerative disorders
Date:1/25/2013

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded approximately $1.2 million from the National Institute of General Medical Sciences of the National Institutes of Health to identify, test and develop a series of drug candidates for a number of diseases, including rheumatoid arthritis, heart disease and several neurodegenerative disorders.

Derek R. Duckett, associate scientific director in TSRI's Translational Research Institute, and Peter S. Hodder, senior director of lead identification at the Translational Research Institute, will act as co-principal investigators for the three-year grant.

The project will focus on an enzyme known as ASK1, which is part of a larger family of mitogen-activated protein kinases (MAP kinases) that help control how cells respond to stress and is involved in mediating cell survival and programmed cell death (apoptosis). Genetic target validation studies have demonstrated that loss of this kinase shows remarkable efficacy in animal models of various diseases.

"While ASK1 is a highly druggable target, no tool compounds are currently available to probe its biology," Duckett pointed out. "This award will help us remedy the situation."

The new grant will allow the Scripps Florida scientists to perform a high-throughput screening campaign of the TSRI compound collection at their state-of-the-art screening facility. "Our team approach will identify the best lead molecules that will help define the roles that ASK1 plays in normal physiological processes as well as in disease states," Duckett said. "Such leads will also serve as good starting material for chemistry optimization efforts for future therapeutics."

"A very exciting prospect of this research effort is that Scripps's drug discovery compound collection will be assayed for novel inhibitors of ASK1 activity," said Hodder. "Past screening efforts with this collection yielded the antecedents o
'/>"/>

Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. USDA grant advancing deadly plant disease, insect research
2. Salk Institute awarded historic $42 million grant from the Helmsley Charitable Trust
3. Childrens Hospital of Philadelphia receives federal grant to improve health care decision-making
4. AgriLife Research gets grant to crack biofuel production waste issue
5. Damon Runyon-Rachleff Innovation Awards granted for pioneering ideas in cancer research
6. Italian immigrants live longer
7. Grant funded to improve mothers nutrition before pregnancy and impact on baby
8. Researchers and company from Luxembourg awarded a grant from Michael J. Fox Foundation
9. University of Illinois receives grant to study ozone resistance in corn
10. Grant furthers Mercyhurst research for human pathogens in Great Lakes
11. MSU uses grant to help students master scientific mumbo jumbo
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Grant to fund development of drug candidates for rheumatoid arthritis, neurodegenerative disorders
(Date:10/22/2014)... Oct. 20, 2014 The Nano-Bio Manufacturing Consortium ... Force Research Laboratory (AFRL), has chosen a project proposed ... the University of Arizona College of Medicine – ... AzCIM project,s goal is to assess different sweat collection ... volumes of sweat under a variety of human-body conditions, ...
(Date:10/18/2014)... stress-related psychiatric disorders are associated with increased ... mechanisms underlying this relation are unknown. Understanding ... of targeted preventive strategies and new or ... work is presented at the European College ... international group of researchers from Germany and ...
(Date:10/17/2014)... available in German . ... every day in order to reproduce? And why are there ... of the latest issue of the research journal Molecular ... biologist Steven Ramm from Bielefeld University Bielefeld has compiled this ... unusual for a female to copulate with several males in ...
Breaking Biology News(10 mins):Nano-Bio Manufacturing Consortium Selects Project Proposed by Arizona Center for Integrative Medicine to Optimize Human Performance Monitoring Techniques 2Nano-Bio Manufacturing Consortium Selects Project Proposed by Arizona Center for Integrative Medicine to Optimize Human Performance Monitoring Techniques 3Researchers find why depression and aging linked to increased disease risk 2Sperm wars 2
... of time, knowledge and training in health promotion and ... the top barriers to including effective physical activity counseling ... The University of Texas School of Public Health, part ... Houston (UTHealth). "Individual and organization barriers must be ...
... DNA can trigger tumorigenesis. Researchers from Ludwig-Maximilians-Universitaet (LMU) ... a protein involved in the repair and signaling ... light on the origins of neurodegenerative diseases and ... or environmental toxins can cause double-stranded breaks in ...
... have found that acceptance of the site of a ... economic background. Writing in the International Journal of Environmental ... more often have a positive opinion on the location ... While the actual quantities of nuclear waste around the ...
Cached Biology News:UTHealth study addresses barriers to physical activity counseling 2UTHealth study addresses barriers to physical activity counseling 3Where to put nuclear waste? 2
(Date:10/25/2014)... RESTON, Va. (PRWEB) October 24, 2014 ... (WEDI), the nation’s leading nonprofit authority on ... in healthcare information exchange, announces its appointment of ... Privacy Workgroup. The workgroup leaders include:, ... Optum ,     Erik Pupo, Specialist Leader, Deloitte ...
(Date:10/25/2014)... Addison, TX (PRWEB) October 24, 2014 ... skincare products, announced the winners of its “Reflect Your ... who have not only seen a difference in their ... also experienced a new outlook on life as a ... Youth” contest originated as an effort by Nerium International ...
(Date:10/25/2014)... 2014 A new way to produce ... of current skin grafting technologies, it also speeds up ... method, outlined in the October issue of STEM CELLS ... skin injuries that result from severe burns and chronic ... skin’s regenerative elements. These wounds heal by contraction, with ...
(Date:10/25/2014)... , October 24, 2014 ... clinical-stage pharmaceutical company focused on the development of oral ... Nadav Kidron will present at FireRock Capital,s ... Capital,s Annual Micro-Cap Conference ,Date: Tuesday, October 28, 2014 ... New York City , ...
Breaking Biology Technology:WEDI Appoints Four New Security and Privacy Workgroup Co-chairs 2Nerium International™ Inspires Conversation About the Journey of Aging with “Reflect Your Youth” Contest 2New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 2New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 3Oramed to Present at the FireRock Annual Micro-Cap Conference 2Oramed to Present at the FireRock Annual Micro-Cap Conference 3
... an Educational Webinar "How Organizations Can Make the Transition ... featuring Virtify, Inc. , , CAMBRIDGE, Mass., ... ), the market leader in Enterprise Content Compliance solutions ... ), a provider of Enterprise Compliance and Quality ...
... -- China-Biotics,Inc. (Nasdaq: CHBT ) ("China-Biotics," ... manufacture, research, development, marketing and,distribution of probiotics products ... management will present at the upcoming,China Rising Conference ... on May 18,2009. , ...
... April 30 Amicus Therapeutics (Nasdaq: FOLD ... the regular close of markets on Thursday, May 7, ... live conference call and webcast that afternoon at 5 ... conference call at 5 p.m. EDT by dialing 877-874-1565 ...
Cached Biology Technology:Event Alert: 'SPL R4 Compliance and its Impact on Regulatory Submission Processes' 2Event Alert: 'SPL R4 Compliance and its Impact on Regulatory Submission Processes' 3China-Biotics, Inc. to Present at CCG Investor Relations' China Rising Conference 2China-Biotics, Inc. to Present at CCG Investor Relations' China Rising Conference 3Amicus Therapeutics Announces First Quarter 2009 Financial Results Release Date 2
... Synthetic peptide derived from the internal ... Specificity: Specific for the junctophilin-1 protein. ... brain and skeletal muscle homogenates frozen ... Applications: Western blotting Immunohistochemistry(froz) ImmunofluorescenceStorage: ...
Laminin beta-1/gamma-1 (612C10)...
100 ug affinity purified rabbit anti-JIP-1 polyclonal antibody. Reacts with mouse and rat. Perform well in Western blotting. Other applications have not been tested. Storage Temperature: -20C Shi...
XBP-1 (F-4)...
Biology Products: