Navigation Links
Grant to fund development of drug candidates for rheumatoid arthritis, neurodegenerative disorders
Date:1/25/2013

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded approximately $1.2 million from the National Institute of General Medical Sciences of the National Institutes of Health to identify, test and develop a series of drug candidates for a number of diseases, including rheumatoid arthritis, heart disease and several neurodegenerative disorders.

Derek R. Duckett, associate scientific director in TSRI's Translational Research Institute, and Peter S. Hodder, senior director of lead identification at the Translational Research Institute, will act as co-principal investigators for the three-year grant.

The project will focus on an enzyme known as ASK1, which is part of a larger family of mitogen-activated protein kinases (MAP kinases) that help control how cells respond to stress and is involved in mediating cell survival and programmed cell death (apoptosis). Genetic target validation studies have demonstrated that loss of this kinase shows remarkable efficacy in animal models of various diseases.

"While ASK1 is a highly druggable target, no tool compounds are currently available to probe its biology," Duckett pointed out. "This award will help us remedy the situation."

The new grant will allow the Scripps Florida scientists to perform a high-throughput screening campaign of the TSRI compound collection at their state-of-the-art screening facility. "Our team approach will identify the best lead molecules that will help define the roles that ASK1 plays in normal physiological processes as well as in disease states," Duckett said. "Such leads will also serve as good starting material for chemistry optimization efforts for future therapeutics."

"A very exciting prospect of this research effort is that Scripps's drug discovery compound collection will be assayed for novel inhibitors of ASK1 activity," said Hodder. "Past screening efforts with this collection yielded the antecedents o
'/>"/>

Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. USDA grant advancing deadly plant disease, insect research
2. Salk Institute awarded historic $42 million grant from the Helmsley Charitable Trust
3. Childrens Hospital of Philadelphia receives federal grant to improve health care decision-making
4. AgriLife Research gets grant to crack biofuel production waste issue
5. Damon Runyon-Rachleff Innovation Awards granted for pioneering ideas in cancer research
6. Italian immigrants live longer
7. Grant funded to improve mothers nutrition before pregnancy and impact on baby
8. Researchers and company from Luxembourg awarded a grant from Michael J. Fox Foundation
9. University of Illinois receives grant to study ozone resistance in corn
10. Grant furthers Mercyhurst research for human pathogens in Great Lakes
11. MSU uses grant to help students master scientific mumbo jumbo
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Grant to fund development of drug candidates for rheumatoid arthritis, neurodegenerative disorders
(Date:8/19/2014)... . Wind ... large amount of electricity is to be produced with renewable ... be stored during productive periods so that these fluctuations can ... adequate for the purpose. Science and industry are therefore working ... systems that used to be too expensive or unsophisticated to ...
(Date:8/19/2014)... not a monkey. It,s not a lemur. It,s not an ... Philippine tarsier: a tiny, adorable and downright "cool" primate from ... Americans are familiar with," said Rafe Brown, curator-in-charge at the ... and ears; an extremely cute, furry body; a long tail ... fingers and toe tips that look a bit like the ...
(Date:8/19/2014)... retail seafood counters in 10 different states show ... to unexpectedly high levels of mercury, a harmful ... fish of the same species, but from a ... according to new research by University of Hawai,i ... is essential to allow consumers to choose sustainable ...
Breaking Biology News(10 mins):Asian inventions dominate energy storage systems 2Asian inventions dominate energy storage systems 3Philippine tarsier gets boost from Kansas research, and genetic proof of a new variety 2Philippine tarsier gets boost from Kansas research, and genetic proof of a new variety 3Seafood substitutions can expose consumers to unexpectedly high mercury 2Seafood substitutions can expose consumers to unexpectedly high mercury 3
... as 25 percent of hospital nurses go without sleep for ... on the night shift, which is the least effective strategy ... That is one of the results of the first study ... between day and night sleep cycles. The study was based ...
... hydrogen in a sustainable way is a challenge and production ... Xile Hu has discovered that a molybdenum based catalyst is ... the research are published online in Chemical Science ... this discovery has just been filled. Existing in large quantities ...
... Ceelox, Inc. (OTCBB: CELO) announced today that the ... cloud applications using biometrics. Ceelox ID Online® utilizes a ... Internet server-based biometric software application. This enables users to ... i.e. user name and password, compromised or stolen by ...
Cached Biology News:A sleep strategy commonly used by night nurses throws off their circadian clocks 2A sleep strategy commonly used by night nurses throws off their circadian clocks 3Ceelox Provides Biometric Identity Access to Cloud Applications 2Ceelox Provides Biometric Identity Access to Cloud Applications 3
(Date:8/19/2014)... 2014 Research and Markets ... "Spectroscopy Equipment and Accessories - Global ... offering. This report analyzes ... Accessories in US$ Thousands by the following ... Spectrometers, NMR-EPR Spectrometers, Near Infrared (NIR) Spectrometers, ...
(Date:8/19/2014)... , Aug. 19, 2014 /PRNewswire/ - iCo Therapeutics Inc. ... today reported results of its Oral Amphotericin B ... reservoirs.  The study, conducted by ImmuneCarta®, the immune ... vitro effectiveness of Oral Amp B in ... in individuals despite intensive treatment with antiretroviral therapy. ...
(Date:8/18/2014)... 18, 2014 /PRNewswire/ - SQI Diagnostics Inc. (TSX-V: SQD), a ... and products for advanced microarray diagnostics, today announced it ... 22 at 2:00 pm ET.  During ... a brief review of SQI,s recent commercialization progress and ... industry veteran recently appointed to the Board of Directors ...
(Date:8/18/2014)... Global HIV Infection Drug Market and Pipeline Insight is ... HIV infection and the number of deaths due to AIDS ... across the globe. It has been estimated that the death ... 2013, with the rates for children being even much lower. ... rates has been the improved access to antiretroviral drugs and ...
Breaking Biology Technology:Global Spectroscopy Equipment and Accessories - Strategic Business Report 2014 2iCo Therapeutics Announces Positive Oral Amphotericin B Study Results 2iCo Therapeutics Announces Positive Oral Amphotericin B Study Results 3SQI Diagnostics Announces Investor Conference Call with Dr. Allan Pronovost 2SQI Diagnostics Announces Investor Conference Call with Dr. Allan Pronovost 3Global HIV Infection Drug Market Overview 2Global HIV Infection Drug Market Overview 3Global HIV Infection Drug Market Overview 4
... billions of clot-forming platelets every day, but there are ... with certain diseases or during invasive surgery. Now, University ... can induce bone marrow cells called megakaryocytes to quadruple ... a graduate student of pharmacology in Penn,s Perelman School ...
... Tiny chemical particles emitted by diesel exhaust fumes could raise ... have found that ultrafine particles produced when diesel burns are ... blood clots forming in arteries, leading to a heart attack ... measured the impact of diesel exhaust fumes on healthy volunteers ...
... Mass. -- A novel application of carbon nanotubes, developed by ... solar energy for use whenever it,s needed. Storing the ... to electricity or storing the heat itself in a heavily ... chemical material can be stored for long periods of time ...
Cached Biology Technology:Penn researchers show single drug and soft environment can increase platelet production 2Penn researchers show single drug and soft environment can increase platelet production 3Diesel fumes pose risk to heart as well as lungs, study shows 2MIT research update: New way to store sun's heat 2MIT research update: New way to store sun's heat 3