Navigation Links
Got to go? Harvard scientists figure out how you know
Date:2/8/2013

Bethesda, MDIf you have an overactive bladder or incontinence, help could be on the way. A new research report published online in the FASEB Journal, shows that the epithelium, a thin layer of cells which line the surface of the bladder, is able to sense how full the bladder is through the action of a family of proteins called integrins. As the bladder becomes full, the cells in the epithelium stretch and become thinner, which activates the integrins to send that information to nerves and other cells in the bladder. As a result of this new knowledge, researchers may one day be able to design drugs that target this mechanism to treat conditions like incontinence and overactive bladder, both of which are common, serious, problems affecting millions of people.

"I am very hopeful that as we learn more about how the bladder senses fullness and conveys that information to the nerves and the muscles which control our ability to urinate, that this greater understanding and knowledge will lead to new treatments," said Warren G. Hill, Ph.D., a researcher involved in the work from the Department of Medicine at Beth Israel Deaconess Medical Center and Harvard Medical School in Boston, MA. "It is extremely important that we do this as quickly as possible, since there are millions of people who suffer enormously from the anguish of bladder pain, incontinence and constant feelings of needing to go. I am optimistic these new insights into the role of integrins will begin the process of discovering important new drug targets which will dramatically improve the quality of life for many of these people."

To make this discovery, Hill and colleagues tested two groups of mice. The first were genetically modified to not have an important member of the integrin family present in the epithelium. The second group of mice was normal. The mice lacking the integrin protein had normal looking bladders but very little urinary control. The normal mice also had normal looking bladders, but as expected, had bladder control. Researchers then tested the bladders from the integrin knockout mice and found that their bladders were constantly squeezing and very overactive. In addition, they overfilled their bladders and took much longer to urinate than the normal mice. Since most drug treatments for overactive bladder target proteins in the muscle surrounding the bladder, this study shows that it may be possible to design drugs that target sensory proteins in the epithelium.

"No one wants to pee in his or her pants," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal, "but the reality is that bladder problems incontinence, frequency and pain - affect more people than we realize. This report offers hope that new drugs targeting the bladder's epithelium will succeed when current drugs fail."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Harvards Wyss Institute to develop smart suit that improves soldiers physical endurance
2. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
3. Queens scientists seek vaccine for Pseudomonas infection
4. Scientists produce eye structures from human blood-derived stem cells
5. American Society of Plant Biologists honors early career women scientists
6. Brandeis scientists win prestigious prize for circadian rhythms research
7. Scientists discover new method of proton transfer
8. Salk scientists open new window into how cancers override cellular growth controls
9. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
10. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
11. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2016)... , UAE, April 20, 2016 ... be implemented as a compact web-based "all-in-one" system solution ... the biometric fingerprint reader or the door interface with ... of modern access control systems. The minimal dimensions of ... ID readers into the building installations offer considerable freedom ...
(Date:4/14/2016)... , April 14, 2016 ... and Malware Detection, today announced the appointment of ... the new role. Goldwerger,s leadership appointment comes ... the heels of the deployment of its platform at ... behavioral biometric technology, which discerns unique cognitive and physiological ...
(Date:3/31/2016)... -- Genomics firm Nabsys has completed a financial  restructuring under ... M.D., who returned to the company in October 2015. ... including Chief Technology Officer, John Oliver , Ph.D., ... Vice President of Software and Informatics, Michael Kaiser ... Bready served as CEO of Nabsys from 2005-2014 and ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... 24, 2016  Regular discussions on a range of subjects ... the two entities said Poloz. Speaking at a ... , he pointed to the country,s inflation target, which ... "In certain areas ... have common economic goals, why not sit down and address ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... release of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering ... retention in this eBook by providing practical tips, tools, and strategies for clinical ...
(Date:6/23/2016)... Md. , June 23, 2016 A person ... from the crime scene to track the criminal down. ... the U.S. Food and Drug Administration (FDA) uses DNA evidence ... Sound far-fetched? It,s not. The FDA ... sequencing to support investigations of foodborne illnesses. Put as simply ...
(Date:6/23/2016)... NEW YORK , June, 23, 2016  The ... students to envision new ways to harness living systems ... of Modern Art (MoMA) in New York ... more than 130 participating students, showcased projects at MoMA,s ... included Paola Antonelli , MoMA,s senior curator of ...
Breaking Biology Technology: