Navigation Links
Got to go? Harvard scientists figure out how you know
Date:2/8/2013

Bethesda, MDIf you have an overactive bladder or incontinence, help could be on the way. A new research report published online in the FASEB Journal, shows that the epithelium, a thin layer of cells which line the surface of the bladder, is able to sense how full the bladder is through the action of a family of proteins called integrins. As the bladder becomes full, the cells in the epithelium stretch and become thinner, which activates the integrins to send that information to nerves and other cells in the bladder. As a result of this new knowledge, researchers may one day be able to design drugs that target this mechanism to treat conditions like incontinence and overactive bladder, both of which are common, serious, problems affecting millions of people.

"I am very hopeful that as we learn more about how the bladder senses fullness and conveys that information to the nerves and the muscles which control our ability to urinate, that this greater understanding and knowledge will lead to new treatments," said Warren G. Hill, Ph.D., a researcher involved in the work from the Department of Medicine at Beth Israel Deaconess Medical Center and Harvard Medical School in Boston, MA. "It is extremely important that we do this as quickly as possible, since there are millions of people who suffer enormously from the anguish of bladder pain, incontinence and constant feelings of needing to go. I am optimistic these new insights into the role of integrins will begin the process of discovering important new drug targets which will dramatically improve the quality of life for many of these people."

To make this discovery, Hill and colleagues tested two groups of mice. The first were genetically modified to not have an important member of the integrin family present in the epithelium. The second group of mice was normal. The mice lacking the integrin protein had normal looking bladders but very little urinary control. The normal mice also had normal looking bladders, but as expected, had bladder control. Researchers then tested the bladders from the integrin knockout mice and found that their bladders were constantly squeezing and very overactive. In addition, they overfilled their bladders and took much longer to urinate than the normal mice. Since most drug treatments for overactive bladder target proteins in the muscle surrounding the bladder, this study shows that it may be possible to design drugs that target sensory proteins in the epithelium.

"No one wants to pee in his or her pants," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal, "but the reality is that bladder problems incontinence, frequency and pain - affect more people than we realize. This report offers hope that new drugs targeting the bladder's epithelium will succeed when current drugs fail."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Harvards Wyss Institute to develop smart suit that improves soldiers physical endurance
2. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
3. Queens scientists seek vaccine for Pseudomonas infection
4. Scientists produce eye structures from human blood-derived stem cells
5. American Society of Plant Biologists honors early career women scientists
6. Brandeis scientists win prestigious prize for circadian rhythms research
7. Scientists discover new method of proton transfer
8. Salk scientists open new window into how cancers override cellular growth controls
9. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
10. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
11. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2016)... -- Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH) (the "Company") ... million principal amount of its 1.414% senior unsecured notes due ... unsecured notes due 2026. The closing of ... to the satisfaction of customary closing conditions.  The notes will ... The Company intends to use the net proceeds from ...
(Date:12/2/2016)... AUSTIN, Texas , Dec. 1, 2016 /PRNewswire/ ... provider, today announced BioLock , an electrocardiogram ... and health monitoring, a key IoT asset. The ... embedded into a vehicle,s steering wheel and mobile ... a simple touch. As vehicle technology ...
(Date:11/29/2016)... , November 29, 2016 Nearly one billion ... Continue Reading ... ... part of an efficient Identity Management. (PRNewsFoto/DERMALOG Identification Systems) ... DERMALOG is Germany's largest Multi-Biometric supplier: The ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... , December 8, 2016 ... expanded its customisable SureSeqâ„¢ NGS panel range with the launch ... fast and cost-effective study of variants in familial hypercholesterolemia (FH). ... variation (CNV) detection on a single small panel and allows ... content. This includes all exons for LDLR , ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... flexible packaging for their exceptionally efficient human mesenchymal stem/stromal cell (hMSC) expansion ... of bioprocess media products engineered to radically streamline culture processes, minimize processing ...
(Date:12/8/2016)...  Soligenix, Inc. (OTCQB: SNGX) (Soligenix or the ... and commercializing products to treat rare diseases where ... the long-term follow-up data from its Phase 2 ... Defense Regulator (IDR), in the treatment of oral ... undergoing chemoradiation therapy (CRT).  The additional 12-month safety ...
(Date:12/8/2016)... , Dec. 8, 2016 Savannah ... remediation technologies and selected NewTechBio,s NT-MAX Lake ... microbial based beneficial bacteria, in conjunction with Hexa ... correct deficiencies with National Pollutant Discharge Elimination System ... has experienced a steady history of elevated pH ...
Breaking Biology Technology: