Navigation Links
Gladstone scientists reveal that fat synthesizing enzyme is key to healthy skin and hair
Date:2/12/2009

Scientists at the Gladstone Institutes of Cardiovascular Disease (GICD) have found that an enzyme associated with the synthesis of fat in the body is also an element in healthy skin and hair.

The enzyme is acyl CoA:diacylglycerol acyltransferase 1 or DGAT1. Mice that lack DGAT1 have many interesting characteristics. For example, they are lean, resistant to diet-induced obesity, are more sensitive to insulin and leptin, and have abnormalities in mammary gland development and skin.

When Gladstone researchers in the laboratory of Robert V. Farese, Jr. used genetic engineering to delete the enzyme in mice, they found that lack of DGAT1 caused levels of retinoic acid (RA) to be greatly increased in skin and resulted in the loss of hair. Their findings were reported in The Journal of Biological Chemistry.

"For some time, we have been studying the enzymes that make triglycerides," said Robert V. Farese, Jr., senior investigator and senior author on the study. "We found that one of these enzymes is a major regulator of retinoic acid actions in the skin."

RA, which comes from vitamin A (retinol) has been used to treat skin disorders, such as acne and psoriasis, and certain cancers, but it is fairly toxic and must be carefully controlled.

In mice without DGAT1, the skin was very sensitive to retinol. The loss of DGAT1 also caused alopecia, or hair loss. Both of these effects could be prevented by depriving the mice of a source of retinol in their diet. It turns out that DGAT1 can convert retinol to a relatively inert storage form. Without DGAT1, this ability is lost, and any excess retinol in the skin can be converted to RA.

"Our results show that DGAT1 is an important component for controlling retinoic acid levels in the skin of mice," said Michelle Shih, the lead author on the study. "These findings may have implications for the treatment of human skin or hair disorders."


'/>"/>

Contact: Valerie Tucker
vtucker@gladstone.ucsf.edu
415-734-2019
Gladstone Institutes
Source:Eurekalert

Page: 1

Related biology news :

1. Gladstone scientists create Wikipathways to foster research collaboration
2. Gladstone and Izumi Bio in partnership in regenerative medicine and cardiovascular disease
3. Gladstones Shinya Yamanaka wins prestigious Shaw Prize
4. New target for medicine to combat Alzheimers: VIB scientists confirm proteins key role
5. Scientists to sequence DNA of British wheat varieties
6. Singapore-US scientists first to develop revolutionary microchip that uses 30 times less energy
7. Scientists deconstruct cell division
8. Scripps scientists create first crystal structure of an intermediate particle in virus assembly
9. Biotech scientists team with curators to stem decay of worlds art, cultural heritage
10. Federal scientists recognized for contributions to knowledge of bird ecology and habitat
11. Scientists can predict nano drug outcome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) (the "Company") announced the publication ... 3 study of Zerenex (ferric citrate), the Company,s investigational ... hyperphosphatemia in patients with end-stage renal disease (ESRD) on ... with FErric CiTrate in EsrD) was published online today ... Nephrology ( JASN ). , This ...
(Date:7/24/2014)... species of fish, according to a new study ... tested fish anti-predator behaviour. , Three-spined sticklebacks ... when exposed to additional noise, whereas no effects ... author Dr Irene Voellmy of Bristol,s School of ... environments have increased substantially during the last few ...
(Date:7/24/2014)... A sake brewery has its own microbial terroir, meaning ... resemble those found in the product, creating the final ... the journal Applied and Environmental Microbiology . This ... census of a sake brewery. , Many sake ... author David A. Mills of the University of California, ...
Breaking Biology News(10 mins):Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 4The microbes make the sake brewery 2
... Baylor College of Medicine (BCM) and the Puget Sound Blood ... small blood vessels of the heart and brain could cause ... clots. The scientists were surprised to find that the proteins ... five hours before returning to their normal, healthy shape. ...
... are the origins of life on Earth? A new ... building blocks of life could have been created on icy ... Chemists from the University of California, Berkeley, and the University ... of creating complex dipeptides linked pairs of amino acids ...
... discovered that deleting a specific gene in mice prevents them ... finding they believe may be replicated in humans. "When ... fat," said Prof. James McManaman, Ph.D., lead author of the ... the University of Colorado School of Medicine. "It may be ...
Cached Biology News:Stressed proteins can cause blood clots for hours 2Stressed proteins can cause blood clots for hours 3New evidence that comets could have seeded life on Earth 2Researchers discover gene that causes obesity in mice 2
(Date:7/25/2014)... 2014 At the request of the ... 60-day extension for the public comment period (Docket No. ... Model Aircraft established by Congress as part of the ... extension establishes the new deadline for comments as September ... Transportation/FAA notice published in the Federal Register on July ...
(Date:7/24/2014)... 24, 2014 Gain recognition for ... Chain of the biotech industry. Nominations are now ... brought to you by the Bio Supply ... supply chain management professionals for the past 7 ... of the Biotech industry – Manufacturers, Service Providers, ...
(Date:7/24/2014)... sophisticated equipment, trained personnel, and detection dogs to ... attacks. A revolutionary new electronic chip with nano-sized ... much easier. , The groundbreaking nanotechnology-inspired sensor, devised ... ,s School of Chemistry and Center for Nanoscience ... Tracense, picks up the scent of explosives molecules ...
(Date:7/24/2014)... to settle into equilibriuma state of unchanging balance ... of non-equilibrium conditions where new possibilities lie. Non-equilibrium ... such as temperature fluctuations, freezing and melting, or ... body temperature, airplanes to fly, and the Earth ... even though these conditions exist naturally and are ...
Breaking Biology Technology:FAA Grants Comment Extension at the Request of AMA 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 3Nano-sized chip 'sniffs out' explosives far better than trained dogs 2New approach to form non-equilibrium structures 2
... American Stock Exchange(R),(Amex(R)) today listed the common ... symbol RNN., Rexahn Pharmaceuticals is a ... discover, develop and commercialize,innovative treatments for cancer, ... unmet medical needs. Rexahn,s compounds are designed,to ...
... Judges for Nikon Small World, MELVILLE, N.Y., ... received a record number of entries for the ... by over 300,images. The oldest and most respected ... world,s best photomicrographers who create beautiful,imagery while showing ...
... Informed Medical Communications,(IMC), a leading provider of peer-to-peer ... appointment of Bert,Marchio to the position of Executive ... ), Marchio brings to IMC over 20 ... both the public and private sectors, with the ...
Cached Biology Technology:American Stock Exchange Lists the Common Stock of Rexahn Pharmaceuticals, Inc. 2Nikon Instruments Receives Record Number of Entries for Nikon Small World 2Informed Medical Communications Appoints New Chief Financial Officer 2
... Western Blot Recycling Kit is effective ... blots that have been developed with ... isotopes. It is not recommended for ... etc.), as it is not possible ...
Applications: Western blotting ...
Ethylene glycol-bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid, Molecular Biology Grade...
Required to perform reference file generation, flatfield calibration and performance verification processes on the GSD-501...
Biology Products: