Navigation Links
Gladstone scientists reveal that fat synthesizing enzyme is key to healthy skin and hair
Date:2/12/2009

Scientists at the Gladstone Institutes of Cardiovascular Disease (GICD) have found that an enzyme associated with the synthesis of fat in the body is also an element in healthy skin and hair.

The enzyme is acyl CoA:diacylglycerol acyltransferase 1 or DGAT1. Mice that lack DGAT1 have many interesting characteristics. For example, they are lean, resistant to diet-induced obesity, are more sensitive to insulin and leptin, and have abnormalities in mammary gland development and skin.

When Gladstone researchers in the laboratory of Robert V. Farese, Jr. used genetic engineering to delete the enzyme in mice, they found that lack of DGAT1 caused levels of retinoic acid (RA) to be greatly increased in skin and resulted in the loss of hair. Their findings were reported in The Journal of Biological Chemistry.

"For some time, we have been studying the enzymes that make triglycerides," said Robert V. Farese, Jr., senior investigator and senior author on the study. "We found that one of these enzymes is a major regulator of retinoic acid actions in the skin."

RA, which comes from vitamin A (retinol) has been used to treat skin disorders, such as acne and psoriasis, and certain cancers, but it is fairly toxic and must be carefully controlled.

In mice without DGAT1, the skin was very sensitive to retinol. The loss of DGAT1 also caused alopecia, or hair loss. Both of these effects could be prevented by depriving the mice of a source of retinol in their diet. It turns out that DGAT1 can convert retinol to a relatively inert storage form. Without DGAT1, this ability is lost, and any excess retinol in the skin can be converted to RA.

"Our results show that DGAT1 is an important component for controlling retinoic acid levels in the skin of mice," said Michelle Shih, the lead author on the study. "These findings may have implications for the treatment of human skin or hair disorders."


'/>"/>

Contact: Valerie Tucker
vtucker@gladstone.ucsf.edu
415-734-2019
Gladstone Institutes
Source:Eurekalert

Page: 1

Related biology news :

1. Gladstone scientists create Wikipathways to foster research collaboration
2. Gladstone and Izumi Bio in partnership in regenerative medicine and cardiovascular disease
3. Gladstones Shinya Yamanaka wins prestigious Shaw Prize
4. New target for medicine to combat Alzheimers: VIB scientists confirm proteins key role
5. Scientists to sequence DNA of British wheat varieties
6. Singapore-US scientists first to develop revolutionary microchip that uses 30 times less energy
7. Scientists deconstruct cell division
8. Scripps scientists create first crystal structure of an intermediate particle in virus assembly
9. Biotech scientists team with curators to stem decay of worlds art, cultural heritage
10. Federal scientists recognized for contributions to knowledge of bird ecology and habitat
11. Scientists can predict nano drug outcome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2016)... 2016 BioCatch ™, the ... announced the appointment of Eyal Goldwerger as ... Goldwerger,s leadership appointment comes at a time of ... deployment of its platform at several of the world,s ... discerns unique cognitive and physiological factors, is a winner ...
(Date:3/23/2016)... , March 23, 2016 ... erhöhter Sicherheit Gesichts- und Stimmerkennung mit Passwörtern ... (NASDAQ: MESG ), ein führender ... das Unternehmen mit SpeechPro zusammenarbeitet, um erstmals ... Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, im Rahmen ...
(Date:3/17/2016)... ABI Research, the leader in transformative ... market will reach more than $30 billion by ... Consumer electronics, particularly smartphones, continue to boost the ... reach two billion shipments by 2021 at a ... Research Analyst at ABI Research. "Surveillance is also ...
Breaking Biology News(10 mins):
(Date:4/28/2016)... MA (PRWEB) , ... April 28, 2016 , ... ... Asymmetrex will deliver a talk on its first-in-class technologies for tissue ... 2016 Meeting on RNAiMicroRNA Biology to Reprogramming & CRISPR-based Genome Engineering ...
(Date:4/27/2016)... ... ... Cambridge Semantics, the leading provider of Smart Data analytic and data management ... The Silicon Review’s “20 Fastest Growing Big Data Companies of 2016.” , “From ... end users facing some of the most complex data challenges in the industry,” said ...
(Date:4/27/2016)... , ... April 27, 2016 , ... ... Touch screen mobile devices with fingerprint recognition for secure access, voice recognition for ... a few ways consumers are interacting with biometrics technology today. But if ...
(Date:4/27/2016)... ... 27, 2016 , ... The Board of Directors of Biohaven ... Tilton as Chief Commercial Officer.  Mr. Tilton joined Biohaven from Alexion Pharmaceuticals, Inc. ... responsible for the commercialization of multiple orphan drug indications. Mr. Tilton has ...
Breaking Biology Technology: