Navigation Links
Gladstone scientists reveal that fat synthesizing enzyme is key to healthy skin and hair
Date:2/12/2009

Scientists at the Gladstone Institutes of Cardiovascular Disease (GICD) have found that an enzyme associated with the synthesis of fat in the body is also an element in healthy skin and hair.

The enzyme is acyl CoA:diacylglycerol acyltransferase 1 or DGAT1. Mice that lack DGAT1 have many interesting characteristics. For example, they are lean, resistant to diet-induced obesity, are more sensitive to insulin and leptin, and have abnormalities in mammary gland development and skin.

When Gladstone researchers in the laboratory of Robert V. Farese, Jr. used genetic engineering to delete the enzyme in mice, they found that lack of DGAT1 caused levels of retinoic acid (RA) to be greatly increased in skin and resulted in the loss of hair. Their findings were reported in The Journal of Biological Chemistry.

"For some time, we have been studying the enzymes that make triglycerides," said Robert V. Farese, Jr., senior investigator and senior author on the study. "We found that one of these enzymes is a major regulator of retinoic acid actions in the skin."

RA, which comes from vitamin A (retinol) has been used to treat skin disorders, such as acne and psoriasis, and certain cancers, but it is fairly toxic and must be carefully controlled.

In mice without DGAT1, the skin was very sensitive to retinol. The loss of DGAT1 also caused alopecia, or hair loss. Both of these effects could be prevented by depriving the mice of a source of retinol in their diet. It turns out that DGAT1 can convert retinol to a relatively inert storage form. Without DGAT1, this ability is lost, and any excess retinol in the skin can be converted to RA.

"Our results show that DGAT1 is an important component for controlling retinoic acid levels in the skin of mice," said Michelle Shih, the lead author on the study. "These findings may have implications for the treatment of human skin or hair disorders."


'/>"/>

Contact: Valerie Tucker
vtucker@gladstone.ucsf.edu
415-734-2019
Gladstone Institutes
Source:Eurekalert

Page: 1

Related biology news :

1. Gladstone scientists create Wikipathways to foster research collaboration
2. Gladstone and Izumi Bio in partnership in regenerative medicine and cardiovascular disease
3. Gladstones Shinya Yamanaka wins prestigious Shaw Prize
4. New target for medicine to combat Alzheimers: VIB scientists confirm proteins key role
5. Scientists to sequence DNA of British wheat varieties
6. Singapore-US scientists first to develop revolutionary microchip that uses 30 times less energy
7. Scientists deconstruct cell division
8. Scripps scientists create first crystal structure of an intermediate particle in virus assembly
9. Biotech scientists team with curators to stem decay of worlds art, cultural heritage
10. Federal scientists recognized for contributions to knowledge of bird ecology and habitat
11. Scientists can predict nano drug outcome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... The Parenteral Drug Association (PDA) today confirmed that seven officials ... least seven more will participate in the upcoming 2014 PDA ... Washington D.C. , Dec. 2-4. ... the regulatory agencies in the United States ... to help advance the use of metrics in the regulatory ...
(Date:11/15/2014)... , Nov. 13, 2014  While we may still be ... McCoy used in "Star Trek" to gain instant access to ... to work with smartphones and tablets for monitoring and measuring ... healthcare world. This may seem a tad Orwellian to some, ... adopt some of these technological opportunities into their healthcare regime. ...
(Date:11/11/2014)... CHICAGO , Nov. 11, 2014  Forensicon, Inc., ... eDiscovery firm, is pleased to announce the promotion of ... to Director of Digital Forensics. In Schiff,s new role ... out the team of digital forensics examiners and provide ... Photo - http://photos.prnewswire.com/prnh/20141110/157719 ...
Breaking Biology News(10 mins):FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2
... The Smithsonian Tropical Research Institute will host the workshop ... August, 2008. , The event is sponsored by ... Committee of the Smithsonian National Board, and the Smithsonian ... scientists claim that up to half of all species ...
... Dickey Center for International Understanding, through its Institute ... million by the National Science Foundation through its ... The five-year grant supports the development ... sciences and engineering with a focus on rapid ...
... PASADENA, Calif.-- Individuals with synesthesia perceive the world in ... their senses are ,cross-activated, some synesthetes perceive numbers or ... as possessing personalities, even ,as they function normally in ... Technology have discovered a type of ,synesthesia in which ...
Cached Biology News:Dartmouth awarded NSF grant for new polar sciences, engineering grad program 2Dartmouth awarded NSF grant for new polar sciences, engineering grad program 3Caltech neurobiologists discover individuals who 'hear' movement 2Caltech neurobiologists discover individuals who 'hear' movement 3
(Date:12/19/2014)... CAMBRIDGE, MA (PRWEB) December 18, 2014 ... adults in the United States suffer from one or ... arthritis, asthma, or cancer. Medication can address some of ... to daily activities that many sufferers face. While implanted ... surgery and stimulate the whole nerve, which can induce ...
(Date:12/19/2014)... The empty capsules market is ... population and technological innovations in the empty capsules ... catalysing the growth of the empty capsules market. ... , Scope of Report , The report will ... entrants/smaller firms to gauge the pulse of the ...
(Date:12/19/2014)... -- Egenix, Inc. is pleased to announce that Lionel ... to succeed Donald Fresne ; Mr. Fresne has also ... member of the Board.  In recognition of the many contributions ... almost twenty years, the Board designated Mr. Fresne as Chairman ... a Search Committee to find a suitable replacement with Biotech ...
(Date:12/17/2014)... 2014 The Activated Carbon Manufacturing ... is why IBISWorld updated its original industry research report. ... from an intensified focus on environmental policy. Over the ... standards for power plants and a range of other ... Industry Analyst Sarah Kahn, “a range of downstream industrial ...
Breaking Biology Technology:Draper Wins GSK Funding for Smaller, Smarter Implantable Devices 2Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 2Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 3Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 4Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 2Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 3
... entered in favor of Guidant and its ... 2008 Boston,Scientific Corporation (NYSE: BSX ... Sarah Evans Barker, Indianapolis, dismissed proceedings,filed by ... of Guidant,s former directors and officers. Boston ...
... -- China,Technology Development Group Corporation (Nasdaq: CTDC; ... and renewable energy products and solutions,focusing on ... that the,Company attended the inauguration ceremony of ... Module manufacturing line in Changzhou, China,which is ...
... Pharmaceutical Companies Select Drug Model ... VIEW, Calif., April 2, 2008 ,Pharsight Corporation (Nasdaq: ... consulting, and regulatory services for optimizing clinical drug,development, ... have become customers for its Drug Model Explorer ...
Cached Biology Technology:District Judge Dismisses Shareholder Suit Related to Boston Scientific 2District Judge Dismisses Shareholder Suit Related to Boston Scientific 3CTDC Attends the Inauguration Ceremony of Thin Film A-Si Manufacturing Line in Changzhou, China 2CTDC Attends the Inauguration Ceremony of Thin Film A-Si Manufacturing Line in Changzhou, China 3Pharsight Signs Two New DMX(R) License Customers 2Pharsight Signs Two New DMX(R) License Customers 3