Navigation Links
Gladstone scientists reveal that fat synthesizing enzyme is key to healthy skin and hair
Date:2/12/2009

Scientists at the Gladstone Institutes of Cardiovascular Disease (GICD) have found that an enzyme associated with the synthesis of fat in the body is also an element in healthy skin and hair.

The enzyme is acyl CoA:diacylglycerol acyltransferase 1 or DGAT1. Mice that lack DGAT1 have many interesting characteristics. For example, they are lean, resistant to diet-induced obesity, are more sensitive to insulin and leptin, and have abnormalities in mammary gland development and skin.

When Gladstone researchers in the laboratory of Robert V. Farese, Jr. used genetic engineering to delete the enzyme in mice, they found that lack of DGAT1 caused levels of retinoic acid (RA) to be greatly increased in skin and resulted in the loss of hair. Their findings were reported in The Journal of Biological Chemistry.

"For some time, we have been studying the enzymes that make triglycerides," said Robert V. Farese, Jr., senior investigator and senior author on the study. "We found that one of these enzymes is a major regulator of retinoic acid actions in the skin."

RA, which comes from vitamin A (retinol) has been used to treat skin disorders, such as acne and psoriasis, and certain cancers, but it is fairly toxic and must be carefully controlled.

In mice without DGAT1, the skin was very sensitive to retinol. The loss of DGAT1 also caused alopecia, or hair loss. Both of these effects could be prevented by depriving the mice of a source of retinol in their diet. It turns out that DGAT1 can convert retinol to a relatively inert storage form. Without DGAT1, this ability is lost, and any excess retinol in the skin can be converted to RA.

"Our results show that DGAT1 is an important component for controlling retinoic acid levels in the skin of mice," said Michelle Shih, the lead author on the study. "These findings may have implications for the treatment of human skin or hair disorders."


'/>"/>

Contact: Valerie Tucker
vtucker@gladstone.ucsf.edu
415-734-2019
Gladstone Institutes
Source:Eurekalert

Page: 1

Related biology news :

1. Gladstone scientists create Wikipathways to foster research collaboration
2. Gladstone and Izumi Bio in partnership in regenerative medicine and cardiovascular disease
3. Gladstones Shinya Yamanaka wins prestigious Shaw Prize
4. New target for medicine to combat Alzheimers: VIB scientists confirm proteins key role
5. Scientists to sequence DNA of British wheat varieties
6. Singapore-US scientists first to develop revolutionary microchip that uses 30 times less energy
7. Scientists deconstruct cell division
8. Scripps scientists create first crystal structure of an intermediate particle in virus assembly
9. Biotech scientists team with curators to stem decay of worlds art, cultural heritage
10. Federal scientists recognized for contributions to knowledge of bird ecology and habitat
11. Scientists can predict nano drug outcome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2014)... new study, published today in Nature Climate Change , ... alone will reach, if not exceed, the global targets for ... study,s authors say we should all think carefully about the ... healthier diets across the world is just one of a ... dangerous climate change and ensure there is enough food for ...
(Date:8/31/2014)... in French . ... in the prestigious Nature Neuroscience journal by, Sylvain ... the Douglas Mental Health University Institute and McGill University, opens ... dynamic mechanisms controlling memory as well of the role of ... the subiculum. , In 2009, they developed a unique ...
(Date:8/29/2014)... 2014) Scientists at the Barshop Institute for Longevity ... at the UT Health Science Center at San Antonio, ... of the longest-lived rodent, the naked mole rat. ... of naked mole rats protects and alters the activity ... obsolete proteins. , The factor also protects proteasome function ...
Breaking Biology News(10 mins):Changing global diets is vital to reducing climate change 2Changing global diets is vital to reducing climate change 3Changing global diets is vital to reducing climate change 4Memory and Alzheimer's: Towards a better comprehension of the dynamic mechanisms 2Factor in naked mole rat's cells enhances protein integrity 2
... preterm infants may not be fully protected against invasitve ... The findings are reported in the November issue of ... The study, conducted by researchers from Newcastle University, began ... The survey found that preterm infants at increased risk ...
... Four researchers at the U.S. Department of ... have been awarded a total of 65 million ... Gene/P ("Intrepid") supercomputer. The researchers will conduct advanced ... be almost impossible and impractical in the natural ...
... VA Age-related hearing loss (ARHL), one of the four ... low serum levels of folic acid, according to new research ... Head and Neck Surgery . Hearing loss is ... million Americans between the ages of 60 and 74 dealing ...
Cached Biology News:Argonne scientists awarded supercomputing time to enable scientific breakthroughs 2Argonne scientists awarded supercomputing time to enable scientific breakthroughs 3Argonne scientists awarded supercomputing time to enable scientific breakthroughs 4
(Date:8/29/2014)... August 29, 2014 According to a new ... the global orthobiologics market was valued at USD 3,754.6 million ... USD 5,519.9million in 2019at a CAGR of 5.9% from 2013 ... years and above is afflicted by bone and joint disorders, ... year 2020. This has and will continue to increase the ...
(Date:8/29/2014)... Livermore, California (PRWEB) August 29, 2014 ... Department of Energy's 2014 Hydrogen Production R&D ... photoelectrochemically -- by splitting water using sunlight. , ... Laboratory (NREL) and the University of Nevada, Las ... its work developing models of photoelectrochemical solar-hydrogen production ...
(Date:8/28/2014)... SPIE Fellow Glenn Boreman, Professor and ... and Director of the Center for Optoelectronics and Optical ... and co-founder and Chairman of the Board of Plasmonics, ... Vice President of SPIE, the international society for optics ... recent election results at the Annual General Meeting of ...
(Date:8/28/2014)... new research platform uses a laser to ... undergoing stress and heating, an approach likely ... microelectronics and batteries., This new technique, called ... heating and the surface stress of microscale ... discussed the merits of surface-stress influence on ...
Breaking Biology Technology:Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 2Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 3Livermore Team Awarded for Hydrogen Production Research 2Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3
... an organizational meeting last week to name its leadership. ... Wisconsin institutions. , ,Tom Hefty, former co-chairman of the ... of directors. He is now with law firm Reinhart, ... dean of the UW-Madison College of Engineering , ...
... information officers made the Computerworld magazine's top-100 list this year. ... Manufacturing Co. , in Racine. Modine specializes in thermal management ... London and a carbon-dioxide-cooled Jeep, and has been active in ... CIO of ShopKo Stores Inc. , in Green Bay. ...
... Wis. The invention of three Medical College ... patients' brains. Kyron Clinical Imaging Inc. received FDA clearance ... the Milwaukee Journal-Sentinel reported . , ,Kyron's software would ... MRI, scanner. A sample image released by the company ...
Cached Biology Technology:
BOND ELUT MATRIX-C18, 25 mg ...
(3-[125I]iodotyrosyl26)Galanin, porcine, 370 kBq, 10 uCi. Category: IODINE LIGANDS....
Terrific Broth, 1 kg. Mixture of casein peptone, yeast extract, K2HPO4, and KH2PO4.Used at 47 g/l for E. coli growth with higher cell densities. Category: Nucleotides & Enzymes & Biochemicals, Ultrap...
Homo sapiens postsynaptic protein CRIPT Antigen: Recombinant Protein...
Biology Products: