Navigation Links
Gladstone scientists identify critical process in stem cell development
Date:7/5/2012

SAN FRANCISCO, CA--July 5, 2012--Scientists at the Gladstone Institutes have discovered that environmental factors critically influence the growth of a type of stem cell--called an iPS cell--that is derived from adult skin cells. This discovery offers newfound understanding of how these cells form, while also advancing science closer to stem cell-based therapies to combat disease.

Researchers in the laboratory of Gladstone Senior Investigator Shinya Yamanaka, MD, PhD, have for the first time shown that protein factors released by other cells affect the "reprogramming" of adult cells into stem cells known as induced pluripotent stem cells, or iPS cells. The scientistswho collaborated on this research with colleagues from the University of California, San Francisco (UCSF)announce their findings today online in Cell Stem Cell.

In 2007, Dr. Yamanaka discovered a recipe of specific proteins to add to human skin cells as a way to induce them into becoming iPS cellswhich act very much like embryonic stem cells. Many see iPS cell technology as a new platform for drug discovery and the study of disease fundamentalswhile avoiding the ethical issues surrounding research involving embryonic stem cells. But questions remain about the most efficient way to cultivate iPS cells.

"We've reinforced our hypothesis that the cell's environment is vital to the reprogramming process," said Dr. Yamanaka, who did his postdoctoral studies at Gladstone in the 1990s, returning here in 2007 as a senior investigator. "We can now expand our understanding of cell developmentand use iPS cells to model conditions such as Alzheimer's and heart disease."

Normally when researchers convert skin cells into iPS cells, the cells rest on a special layer of materials in a petri dish. The layer includes "feeder" cells that provide nutrients required for the iPS cells to grow and reproduce. In this study, performed at the Roddenberry Center for Stem Cell Biol
'/>"/>

Contact: Anne Holden
anne.holden@gladstone.ucsf.edu
415-734-2534
Gladstone Institutes
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Gladstone scientist Warner C. Greene receives Washington University School of Medicine Alumni Award
2. Wholly water -- students and scientists gather at NTU to discuss water problem
3. Cancer scientists link ‘oncometabolite’ to onset of acute myeloid leukemia
4. Rensselaer scientists unlock some key secrets of photosynthesis
5. Scripps Research Institute Scientists Develop Alternative to Gene Therapy
6. Scientists urge new approaches to plant research
7. Scientists warn Brazils environmental leadership at risk
8. UCSB scientists compile first study of potential for tsunamis in northwestern California
9. Disappearing grasslands: ASU scientists to study dramatic environmental change
10. SFU scientists engage Science in fisheries debate
11. Hulk smash? Maybe not anymore: scientists block excess aggression in mice
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gladstone scientists identify critical process in  stem cell development
(Date:10/22/2014)... BEDFORD, Mass., Oct. 21, 2014 Aware, Inc. (NASDAQ: ... and services, today reported financial results for its third quarter ... quarter of 2014 was $6.0 million, an increase of 40% ... Operating income in the third quarter of 2014 was $4.1 ... 2013. Higher operating income in the current three month period ...
(Date:10/17/2014)... Accurate knowledge regarding Ebola is critical and pertinent for ... hazardous global outbreak and epidemic. The Journal, Disaster ... special issue, Ebola Virus and Public Health, to surround ... in this critical societal moment. , On October ... for Clinicians . The primer was prepared by Dr. ...
(Date:10/16/2014)... Institute of Marine Science have received a 3-year, ... identify the streams and wetlands most vulnerable to ... local governments and citizens conserve these important ecosystems. ... of tidal-marsh observations first gathered by VIMS scientists ... can today,s researchers accurately map the slow but ...
Breaking Biology News(10 mins):Aware, Inc. Reports Third Quarter 2014 Financial Results 2Aware, Inc. Reports Third Quarter 2014 Financial Results 3Aware, Inc. Reports Third Quarter 2014 Financial Results 4Aware, Inc. Reports Third Quarter 2014 Financial Results 5Aware, Inc. Reports Third Quarter 2014 Financial Results 6Aware, Inc. Reports Third Quarter 2014 Financial Results 7EPA grant will help localities conserve headwater wetlands 2EPA grant will help localities conserve headwater wetlands 3
... Ore. A new study finds that utilities aren,t ... are needed to make energy efficiency as attractive as ... issue of Environmental Law , examines key differences ... Scott, an assistant professor at Oregon State University, outlines ...
... personal, portable, and wearable air pollution sensor, developed under ... at the Health Datapalooza in Washington, D.C. The grand ... The challenge was held by the National Institutes ... Health Information Technology (ONC) of the U.S. Department of ...
... associations between cognitive ability and cortical grey matter in old ... childhood. The joint study by the Montreal Neurological Institute ... Edinburgh, UK was published today, June 4 in Molecular ... preserving brain cortical thickness was a determining factor in superior ...
Cached Biology News:Study finds disincentives to energy efficiency can be fixed 2NIH, ONC, and EPA award $100,000 to winner of health and technology challenge 2New study explains cognitive ability differences among the elderly 2
(Date:10/22/2014)... The Americas Inorganic Refrigerants Market report defines and ... analysis and forecast of revenue. , Browse through ... report, to get an idea of the in-depth ... the segmentation in the Americas inorganic refrigerants market, ... , http://www.micromarketmonitor.com/market/americas-inorganic-refrigerants-4191654241.html , Inorganic refrigerants ...
(Date:10/22/2014)... 22, 2014 Currently offering a ... & D Weighing, Rice Lake, and Ohaus, Pipette.com ... . The Sartorius CPA Semi-Micro Balance is ideal ... precise, and user-friendly laboratory balance. , Sartorius is ... their laboratory balances are well known for their ...
(Date:10/22/2014)... Oct. 22, 2014 /PRNewswire/ - iCo Therapeutics ("iCo" or ... next steps for its Oral Amphotericin B program.  ... in vitro work involving samples from ... plans to complete pre clinical studies and regulatory ... 1A clinical trial, utilizing approximately $700,000 of funding ...
(Date:10/20/2014)... Oct. 20, 2014 Mapp Biopharmaceutical,s valiant ... antibody therapeutic to fight the Ebola outbreak will ... time-consuming the production of pharmaceuticals can be, according ... said that while some may be taken aback ... those with industry knowledge are well aware of ...
Breaking Biology Technology:The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 2The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 3Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 3iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 2iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 3Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3
... Calif., Aug. 6 Telik, Inc. (Nasdaq: TELK ) today ... the second quarter ended June 30, 2009, compared with a net loss ... 2008. , , For the quarter ended June 30, ... million in the 2008 second quarter. Operating expenses in the 2009 ...
... , , EMERYVILLE, Calif., ... firm, added John E. Sealander, AIA, ACHA, NCARB, LEED(R) AP, ... Ratcliff ( http://www.ratcliffarch.com ) provides a ... and civic clients throughout the Western United States. , ...
... , , LOS ... $6 million to an 82 year-old Chinese female immigrant who suffered ... alleged that the Defendant, an osteopathic physician and registered pharmacist, prescribed ... alleged that she did not have gout. The doctor claimed ...
Cached Biology Technology:Telik Announces Second Quarter 2009 Financial Results 2Telik Announces Second Quarter 2009 Financial Results 3Telik Announces Second Quarter 2009 Financial Results 4Ratcliff Adds Architect John Sealander to Healthcare Practice Group 2The Law Offices of Brian D. Witzer Wins 6+ Million Dollar Verdict 2