Navigation Links
Gladstone scientists identify critical process in stem cell development
Date:7/5/2012

SAN FRANCISCO, CA--July 5, 2012--Scientists at the Gladstone Institutes have discovered that environmental factors critically influence the growth of a type of stem cell--called an iPS cell--that is derived from adult skin cells. This discovery offers newfound understanding of how these cells form, while also advancing science closer to stem cell-based therapies to combat disease.

Researchers in the laboratory of Gladstone Senior Investigator Shinya Yamanaka, MD, PhD, have for the first time shown that protein factors released by other cells affect the "reprogramming" of adult cells into stem cells known as induced pluripotent stem cells, or iPS cells. The scientistswho collaborated on this research with colleagues from the University of California, San Francisco (UCSF)announce their findings today online in Cell Stem Cell.

In 2007, Dr. Yamanaka discovered a recipe of specific proteins to add to human skin cells as a way to induce them into becoming iPS cellswhich act very much like embryonic stem cells. Many see iPS cell technology as a new platform for drug discovery and the study of disease fundamentalswhile avoiding the ethical issues surrounding research involving embryonic stem cells. But questions remain about the most efficient way to cultivate iPS cells.

"We've reinforced our hypothesis that the cell's environment is vital to the reprogramming process," said Dr. Yamanaka, who did his postdoctoral studies at Gladstone in the 1990s, returning here in 2007 as a senior investigator. "We can now expand our understanding of cell developmentand use iPS cells to model conditions such as Alzheimer's and heart disease."

Normally when researchers convert skin cells into iPS cells, the cells rest on a special layer of materials in a petri dish. The layer includes "feeder" cells that provide nutrients required for the iPS cells to grow and reproduce. In this study, performed at the Roddenberry Center for Stem Cell Biol
'/>"/>

Contact: Anne Holden
anne.holden@gladstone.ucsf.edu
415-734-2534
Gladstone Institutes
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Gladstone scientist Warner C. Greene receives Washington University School of Medicine Alumni Award
2. Wholly water -- students and scientists gather at NTU to discuss water problem
3. Cancer scientists link ‘oncometabolite’ to onset of acute myeloid leukemia
4. Rensselaer scientists unlock some key secrets of photosynthesis
5. Scripps Research Institute Scientists Develop Alternative to Gene Therapy
6. Scientists urge new approaches to plant research
7. Scientists warn Brazils environmental leadership at risk
8. UCSB scientists compile first study of potential for tsunamis in northwestern California
9. Disappearing grasslands: ASU scientists to study dramatic environmental change
10. SFU scientists engage Science in fisheries debate
11. Hulk smash? Maybe not anymore: scientists block excess aggression in mice
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gladstone scientists identify critical process in  stem cell development
(Date:4/10/2015)... DUBLIN , April 10, 2015 ... the addition of the "Security Competitive Profiles - ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , NEC will continue to ... solutions to the market, with a company focus on ... solution anticipated. Winning opportunities in the ...
(Date:4/2/2015)... BETHESDA, Md. , April 2, 2015 ... Salt Lake City , the American ... election of five new directors to its Board.  Members ... for the ACMG and for forming and advancing its ... the medical genetics profession. "It,s an eventful ...
(Date:3/31/2015)... YORK , March 31, 2015  Elephant Talk ... "Company"), a global provider of Software Defined Network Architecture ... today announced total revenue of approximately $20.4 million for ... a restated $19.5 million for the year ended December ... calendar 2014, the Company had completed its multi-year transition ...
Breaking Biology News(10 mins):NEC Security Competitive Profile 2015 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6
... at the Salk Institute for Biological Studies and Iowa ... play a role in the production of seed oils, ... and biofuels. Scoring a rare scientific hat trick, ... cress plants ( Arabidopsis thaliana ) that regulate the ...
... Milk poured down Britain,s kitchen sinks each year creates a ... shows. Scientists say the 360,000 tonnes of milk wasted ... to 100,000 tonnes of CO2. The study by the University ... by about 20,000 cars annually. The research identifies ...
... This release is also available in Chinese ... team led by Virginia Tech Associate Professor Boris Vinatzer and ... used the latest DNA sequencing technology to trace a devastating ... Pseudomonas syringae pv. actinidiae ( Psa ) has ...
Cached Biology News:Discovery of plant proteins may boost agricultural yields and biofuel production 2Discovery of plant proteins may boost agricultural yields and biofuel production 3Wasted milk is a real drain on our resources, study shows 2Virginia Tech and University of Tuscia lead team to unravel origin of devastating kiwifruit bacterium 2Virginia Tech and University of Tuscia lead team to unravel origin of devastating kiwifruit bacterium 3
(Date:4/17/2015)... 17, 2015 BellBrook Labs announced ... support for the powerful Orthogonal Pooled Screening (OPS) ... Center at the Lankenau Institute for Medical Research ... to measurably improve successful drug discovery outcomes using ... rare, drug-like libraries available nowhere else, coupled to ...
(Date:4/16/2015)... 16, 2015 Capillus, LLC announces ... physician network in Europe and Asia. The Miami-based ... Fernando Bermúdez, former Business Development Director of Svenson ... veteran, Mr. Bermúdez’s professional achievements include increasing the ... while also penetrating the Portuguese marketplace with centers ...
(Date:4/16/2015)... 16, 2015 OncoTAb, Inc., ... (UNC Charlotte) spin-out company, announced today the appointment ... M.D., as Chief Operating Officer (COO). Cooper brings ... in developing clinical diagnostic and biotechnology platforms in ... , Cooper’s extensive career transcends the field of ...
(Date:4/16/2015)... /CNW/ - Bioenterprise Corporation is pleased to announce that it ... Charlottetown , PEI.  Bioenterprise has established a 3-year ... for the commercialization of agricultural technologies and innovations. ... ADAPT.  They have been at the heart of agri-innovation ... Dave Smardon , President & CEO of Bioenterprise ...
Breaking Biology Technology:BellBrook Labs and Lankenau Institute Partner to Accelerate Drug Discovery using Orthogonal Pooled Screening 2Capillus, LLC Extends Laser Hair Therapy Products to Europe and Asia 2OncoTAb Names Dr. David L. Cooper as COO 2Bioenterprise Corporation Expands into the Maritimes 2
... Technical Specifications , Accelerating Your Research with the ... , . , ... The new BD High Throughput Sampler (HTS) provides fully automated and rapid sample ... with sample carryover tolerances of 1% or less. The BD HTS adapts ...
... Girpa, Angers, France , C. ... Introduction , Phenoxy ... to be detected at trace level to ensure a safe drinking water and ... Among the analytical methods developed, LC/UV exhibits ...
... Beck and C. Schmidt, Varian, Inc. , ... Marijuana is one of the most commonly used illegal recreational drugs in ... is tetrahydrocannabinol or THC. Toxicology, forensic, and clinical labs are often asked ... of THC, most frequently the carboxy form. , ...
Cached Biology Technology:Technical Specifications, Accelerating Your Research with the BD FACSCanto, High Throughput Sampler Option 2Technical Specifications, Accelerating Your Research with the BD FACSCanto, High Throughput Sampler Option 3Fast Analysis of Phenoxyacetic and Phenoxypropionic Herbicides in Vegetable Matrix by Negative Ion Electrospray LC/MS/MS 2Fast Analysis of Phenoxyacetic and Phenoxypropionic Herbicides in Vegetable Matrix by Negative Ion Electrospray LC/MS/MS 3Analysis of ()-11-Nor-9-Carboxy-Delta-9-THC in Urine by Negative Ion Electrospray LC/MS/MS 2Analysis of ()-11-Nor-9-Carboxy-Delta-9-THC in Urine by Negative Ion Electrospray LC/MS/MS 3
WIF-1 (N-20)...
Mouse monoclonal [1.T.4] to WAVE 1 ( Abpromise for all tested applications). Antigen: His6 fusion protein corresponding to full-length rat WAVE1. Entrez Gene ID: 8936...
IgG2b, k APC clone A95-1, Isotype Rat IgG2b, kappa, 0.1 mg ....
...
Biology Products: