Navigation Links
German Research Foundation approves new priority program in the life sciences
Date:4/15/2014

In recent years, it has become clear that the genetic code is far more complex than previously assumed. In addition to the well-known building blocks adenine, cytosine, guanine, and thymine, numerous chemical variations play an important role. Scientists now assume that the newly discovered nucleic acid modifications may form a second layer of information that extends and complements the genetic code. "The new discoveries are rather like umlauts that extend the standard alphabet," explained Professor Mark Helm of the Institute of Pharmaceutical Sciences and Biochemistry - Therapeutic Life Sciences at Johannes Gutenberg University Mainz (JGU). Helm is the coordinator of the priority program "Chemical Biology of Native Nucleic Acid Modifications", which the German Research Foundation (DFG) has now agreed to fund.

This nationwide priority program will start in 2015 and, according to plans, will continue to receive DFG support for six years. "We are lucky enough in Germany to have some of the leading international researchers in all the core areas in this field and we thus intend to explore this subject with the help of a country-wide network," said Helm. Decoding the information in the modified DNA and RNA bases and nucleosides is a hot topic in chemical biology right now.

Before 2009, scientists were convinced that only the four Watson-Crick bases plus a fifth base called 5-methylcytosine code for the genetic information that is key to life. Then three additional DNA modifications were uncovered in quick succession, which are postulated to act as switches that regulate gene functions. The switch can be used to activate or deactivate a gene. "We are looking at a completely new coding mechanism that had previously escaped our attention," Helm pointed out. On the other hand, scientists have long known that RNA, which is responsible for translating the genetic code into proteins, contains more than 150 different modified nucleosides. The purpose of
'/>"/>

Contact: Dr. Mark Helm
mhelm@uni-mainz.de
49-613-139-25731
Johannes Gutenberg Universitaet Mainz
Source:Eurekalert

Page: 1 2

Related biology news :

1. Heidelberg researcher awarded Animal Welfare Prize of the German Research Foundation
2. 2 of the oldest German journals in Zoology go for platinum open access
3. Biometrics Pioneer DERMALOG Awarded German Foreign Trade Prize
4. Professor Dr. Matthias Tschöp elected member of the German National Academy of Sciences
5. The German National Academy of Sciences Leopoldina makes recommendations for the G8 summit
6. Bowman Design Group is first US company awarded German FAMAB Sustainable Company certification
7. Specialised germanium surface as universal protein adapter
8. German Research Foundation to fund globally unique twin study on social inequality
9. Newly discovered letters and translated German ode expand Texas link to infamous Bone Wars
10. When do German children gain weight?
11. German National Academy of Sciences issues a critical statement on the use of bioenergy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... 18, 2014   LaunchKey , the first decentralized ... and Internet of Things era, today announced the close ... round was led by Metamorphic Ventures with participation from ... VegasTechFund, and others.  LaunchKey has raised $4 million to ... its team and bring LaunchKey to market in 2015. ...
(Date:12/17/2014)... 16, 2014 Valencell, a leader in performance ... technology to industry leaders such as Intel, Jabra, Atlas, ... biometric wearable products. These products will be showcased at ... Las Vegas . "Our partners ... and robust – with the clinical data to back ...
(Date:12/11/2014)... 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition ... Region 2015-2019"  report to their offering. ... is advances in technology. With continuous advances in ... to the latest standard that meets the needs ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... , The bottled water, soda pop, or micro brew-beer that ... cities contains a natural chemical imprint related to geographic location. ... imprint in your hair that could be used to track ... believed to be the first concerted effort to describe the ...
... looking for new antibiotics: A new research published in the ... ( http://www.fasebj.org ) explains for the first time how honey ... protein that they add to the honey, called defensin-1, which ... infections and to develop new drugs that could combat antibiotic-resistant ...
... WEST LAFAYETTE, Ind. - Fast-food restaurants can supersize French ... to supersize a type of apple. Peter Hirst, a ... in some Gala apple trees causes some apples to grow ... reported in the current issue of the Journal of ...
Cached Biology News:Beverages leave 'geographic signatures' that can track people's movements 2Honey as an antibiotic: Scientists identify a secret ingredient in honey that kills bacteria 2Apples grow larger when cells don't divide, study shows 2
(Date:12/19/2014)... (PRWEB) December 18, 2014 LayerBio is ... ophthalmology and wound care. The National Eye Institute (NEI) ... LayerBio a Phase I SBIR grant to develop a ... are the most common cause of vision loss in ... blindness worldwide. According to Dr. Ken Mandell, LayerBio’s Founder ...
(Date:12/19/2014)... MA (PRWEB) December 18, 2014 iLab ... announced the appointment of Siri Bryant as the new ... new Director of Core Implementations. These two new leadership ... outstanding customer service by ensuring that iLab continues to ... “In the last four years, iLab has been deployed ...
(Date:12/19/2014)... 18, 2014 With only 2 weeks ... special on Sartorius Biohit products . The product specials ... Picus Electronic Pipette Trade-in Program, and free pipette tips. ... officers around the world. They are ideal for lab ... include:, ,     Full volume range of 0.1 ...
(Date:12/19/2014)... DALLAS , Dec. 18, 2014   ISN ... Health & Safety Performance Indicators publication series. ... hours of activity reported in 2013 within its online ... health and safety key performance indicator (KPI) statistics. ... Hiring Clients, U.S. publication is available in ...
Breaking Biology Technology:LayerBio Awarded NIH Grant to Develop a Drug Delivery Device for Cataract Surgery 2iLab Solutions Announces Two New Leadership Positions to Meet the Needs of Its Growing Customer Base 2Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3
... June 2, 2011 Morphotek®, Inc., a subsidiary of ... multi-center, phase II study of MORAb-004 for the treatment ... potentially first-in-class monoclonal antibody that specifically binds to endosialin/tumor ... its safety and therapeutic activity at two dosages. ...
... Calif., June 2, 2011 Life Technologies Corporation ... performed in cooperation with the University Hospital Muenster, Germany, on ... bacterium at the root of the deadly outbreak in Germany ... strains. The data obtained from the DNA ...
... electrodes have been coated with a drug-loaded polymer in ... a number of neurological symptoms, such as those associated ... In a study published today, 2 June 2011, ... researchers have developed a novel technology to precisely modulate ...
Cached Biology Technology:Morphotek®, Inc. Announces Initiation of MORAb-004 Phase II Study in Melanoma 2Morphotek®, Inc. Announces Initiation of MORAb-004 Phase II Study in Melanoma 3DNA Sequencing Data Reveals New Hybrid E. coli Strain is Cause of German Outbreak 2DNA Sequencing Data Reveals New Hybrid E. coli Strain is Cause of German Outbreak 3DNA Sequencing Data Reveals New Hybrid E. coli Strain is Cause of German Outbreak 4New technology could inspire brain implant for detecting and treating seizures 2
... Kit is based on quantification of the ... and free orthophosphate. The rapid color formation ... on a spectrophotometer (600-660 nm) or on ... kits have been optimized to offer superior ...
... Chemicon Select Tissue Arrays are intended ... individual tissues were fixed in neutral buffered ... identification and diagnosis was performed by certified ... their paraffin blocks and relocated into a ...
... The desk-top XCAT 50 X-Ray System from KUBTEC ... to provide two and three dimensional representation of ... provides volumetric reconstruction of specimen X-ray images, the ... provide high level of detail in standard 2D ...
... BTX, the leader in electroporation products and ... innovative product line for experiment optimization and ... is a breakthrough in Molecular Delivery. The ... procedures that typically limited the number of ...
Biology Products: