Navigation Links
Genome-wide imaging study identifies new gene associated with Alzheimer's plaques
Date:2/20/2013

r major Alzheimer's hypothesis holds that the development of the amyloid plaques is the primary cause of the disease's debilitating symptoms. As it turns out, the enzyme for which the BCHE gene codes is also found in significant quantities in those plaques.

"This study is connecting two of the biggest Alzheimer's dots," said Dr. Saykin, director of the Indiana Alzheimer Disease Center and the IU Center for Neuroimaging at the IU Health Neuroscience Center.

"The finding that BCHE gene variant predicts the extent of plaque deposit in PET scans among people at risk for Alzheimer's disease is likely to reinvigorate research into drugs that could modify the disease by affecting the BCHE enzyme or its metabolic pathway," he said. Some existing drugs inhibit this enzyme, but it is unclear whether this influences plaque deposits.

Overall, the results appear to offer scientists new potential targets for drugs to slow, reverse or even prevent the disease. Alzheimer's disease affects an estimated 5.4 million Americans and has proven resistant to treatments that do more than temporarily slow the worsening of symptoms.

Amyloid plaque deposits build up abnormally in the brains of Alzheimer's patients and are believed to play an important role in the memory loss and other problems that plague patients.

The study makes use of an imaging agent, florbetapir, now approved for use by the U.S. Food and Drug Administration, that allows physicians to see the level of plaque buildup in a patient's brain, something that previously could be determined only with an autopsy.

In a genome-wide association study, researchers evaluate alternate versions of many genes to determine whether particular genetic variants are associated with a particular trait -- in this case, the amounts of amyloid plaque deposits that the PET scans revealed in the brains of study participants.

Using the imaging agent that enables detection of the plaques in
'/>"/>

Contact: Eric Schoch
eschoch@iu.edu
317-274-8205
Indiana University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. In the blink of an eye: X-ray imaging on the attosecond timescale
2. Elsevier announces the launch of a new journal: Journal of Forensic Radiology and Imaging
3. UT Arlington bioengineer to use hybrid imaging system to see deep tissue
4. Improved X-ray microscopic imaging
5. New modeling approach transforms imaging technologies
6. Imaging biomarker predicts response to rapid antidepressant
7. Improving the development of new cancer models using an advanced biomedical imaging method
8. Lyncean Technologies Inc. sells Compact Light Source to Munich biomedical-imaging research center
9. Ocean Thin Films Announces Multispectral Imaging Research Grant Program
10. NREL researchers use imaging technologies to solve puzzle of plant architecture
11. 3dMD Transitions Anatomical Research from 3D-Static to 4D-Movement Surface Imaging
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genome-wide imaging study identifies new gene associated with Alzheimer's plaques
(Date:11/21/2014)... , November 18, 2014 According ... Market by Systems (Video, RFID, Access Control, Intrusion Detection, ... Hotels, Banks, Government), Component Service Geography - Global Forecasts ... Market is projected to be around $25 Billion in ... 2020, growing at a CAGR of 8.69%. ...
(Date:11/21/2014)... , Nov. 19, 2014  Earlier this year ... York College, and one of the most prolific inventors ... that are transmitted from Smartphones to third party agencies. ... and has one of the earliest known patents in ... usage in the military, child care, elder care and ...
(Date:11/21/2014)... Strict laws against distracted driving and the ... American and European automotive sector towards gesture recognition technologies. ... that are intuitive and able to retrieve information with ... New analysis from Frost & Sullivan,s Strategic ... Europe and North America ...
Breaking Biology News(10 mins):Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4
... almost every plant species on the Iberian Peninsula had ... and Taraxacum lacianense , two dandelions from ... This finding confirms Spain,s privileged position as a hotbed ... now in Spain. It depends on the complexity of ...
... - William T. Talman, MD, President of the Federation ... Barack Obama for his continuing support for science and ... on research," Talman stated. In a letter to ... critical investmenteven during a time of unprecedented budgetary constraintswill ...
... More than a third of coral reef fish species ... climate change on coral reefs, a new scientific study has ... from individual locations, while they continue to persist elsewhere across ... international team of marine scientists has found that a third ...
Cached Biology News:2 new plants discovered in Spain 2Extinction predictor 'will help protect coral reefs' 2Extinction predictor 'will help protect coral reefs' 3
(Date:11/28/2014)... /PRNewswire/ - iCo Therapeutics ("iCo" or "the Company") ... for the nine months ended September 30, 2014.  ... dollars and presented under International Financial Reporting Standards ... it has wound down its Phase 2 diabetic ... will continue to investigate  other potential use indications ...
(Date:11/28/2014)... 2014 The American Association of ... School of Nursing with a very prestigious award ... The 2014 Innovations in Professional Nursing Education Award ... and supports them as they re-envision traditional models ... AACN’s annual meeting in Washington, D.C. to Meredith ...
(Date:11/28/2014)... The report provides qualitative insights on key ... of the market, in order to provide information about ... and market sizes for each sub-segment of the market ... It also includes analysis of the company profiles of ... financial performances, product portfolios, and developments of each company. ...
(Date:11/27/2014)... The Europe Thermal Protective Clothing ... provide crucial revenue forecasts. It estimates the market ... a CAGR of 7.5%, from 2013 to 2018. ... Thermal Protective Clothing market report for a glimpse ... by various tables and figures. , http://www.micromarketmonitor.com/market/europe-thermal-protective-clothing-5957050557.html ...
Breaking Biology Technology:iCo Therapeutics Announces Third Quarter 2014 Financial Results and Corporate Update 2iCo Therapeutics Announces Third Quarter 2014 Financial Results and Corporate Update 3iCo Therapeutics Announces Third Quarter 2014 Financial Results and Corporate Update 4American Association of Colleges of Nursing honors Fairfield University’s School of Nursing for Re-envisioning Nursing Education 2Glycomics Market by Application, Product & End-Users is estimated to reach $928.11 Million by 2019 - New Research Report by MarketsandMarkets 2Glycomics Market by Application, Product & End-Users is estimated to reach $928.11 Million by 2019 - New Research Report by MarketsandMarkets 3Glycomics Market by Application, Product & End-Users is estimated to reach $928.11 Million by 2019 - New Research Report by MarketsandMarkets 4Glycomics Market by Application, Product & End-Users is estimated to reach $928.11 Million by 2019 - New Research Report by MarketsandMarkets 5The Europe Thermal Protective Clothing market is estimated to grow up to $577.9 million by 2018 - Report by MicroMarket Monitor 2The Europe Thermal Protective Clothing market is estimated to grow up to $577.9 million by 2018 - Report by MicroMarket Monitor 3
... venture capitalist in San Francisco or Boston, and youre on the ... Wisconsin. Everything looks right: The management team is in place, the ... ,But then a lawyer steps into the room, clears her ... lien law. Better not write that check, she says, until you ...
... state government information technology consolidation projects bound to be ... for the State of Wisconsin, has indicated the problems ... for large state projects. He has plenty of support ... are cost overruns, implementation delays, and outright failures really ...
... Madison, Wis. - GenTel BioSciences, Inc., ... $1.2 million Phase II SBIR grant from the National ... less painful diagnosis of respiratory allergies. , ,An estimated ... allergies, and current diagnostic tests are uncomfortable, especially for ...
Cached Biology Technology:Why repealing the shareholder wage lien law makes sense 2Why repealing the shareholder wage lien law makes sense 3State IT failures are not inevitable 2State IT failures are not inevitable 3State IT failures are not inevitable 4State IT failures are not inevitable 5GenTel gets federal grant to develop allergy test 2GenTel gets federal grant to develop allergy test 3
...
Buckets for tube holder inserts...
45° Fixed Angle Rotor for use in the IEC Centra CL2, Centra CL3/CL3R, HN-SII, and the Centra-MP4/MP4R....
... a microprocessor controlled, high speed filter ... exceptionally smooth operation make the Lambda ... fluorescence microscopy, ratio imaging, spectrophotometry, visual ... and accurate aperture positioning. The Lambda ...
Biology Products: