Navigation Links
Genome-wide imaging study identifies new gene associated with Alzheimer's plaques
Date:2/20/2013

INDIANAPOLIS -- A study combining genetic data with brain imaging, designed to identify genes associated with the amyloid plaque deposits found in Alzheimer's disease patients, has not only identified the APOE gene -- long associated with development of Alzheimer's -- but has uncovered an association with a second gene, called BCHE.

A national research team, led by scientists at the Indiana University School of Medicine, reported the results of the study in an article in Molecular Psychiatry posted online Tuesday. The study is believed to be the first genome-wide association study of plaque deposits using a specialized PET scan tracer that binds to amyloid.

The research also is believed to be the first to implicate variations in the BCHE gene in plaque deposits visualized in living individuals who have been diagnosed with Alzheimer's disease or are at-risk for developing the disease. The enzyme coded by the BCHE gene has previously been studied in post-mortem brain tissue and is known to be found in plaques.

"The findings could recharge research efforts studying the molecular pathways contributing to amyloid deposits in the brain as Alzheimer's disease develops and affects learning and memory," said Vijay K. Ramanan, the paper's first author and an M.D./Ph.D. student at the IU School of Medicine.

The BCHE gene finding "brings together two of the major hypotheses about the development of Alzheimer's disease," said Andrew J. Saykin, Psy.D., Raymond C. Beeler Professor of Radiology and Imaging Sciences at IU and principal investigator for the genetics core of the Alzheimer's Disease Neuroimaging Initiative.

Scientists have long pointed to the loss of an important brain neurotransmitter, acetylcholine, which is depleted early in the development of the disease, as a key aspect of the loss of memory related neurons. The BCHE gene is responsible for an enzyme that breaks down acetylcholine in the brain. The othe
'/>"/>

Contact: Eric Schoch
eschoch@iu.edu
317-274-8205
Indiana University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. In the blink of an eye: X-ray imaging on the attosecond timescale
2. Elsevier announces the launch of a new journal: Journal of Forensic Radiology and Imaging
3. UT Arlington bioengineer to use hybrid imaging system to see deep tissue
4. Improved X-ray microscopic imaging
5. New modeling approach transforms imaging technologies
6. Imaging biomarker predicts response to rapid antidepressant
7. Improving the development of new cancer models using an advanced biomedical imaging method
8. Lyncean Technologies Inc. sells Compact Light Source to Munich biomedical-imaging research center
9. Ocean Thin Films Announces Multispectral Imaging Research Grant Program
10. NREL researchers use imaging technologies to solve puzzle of plant architecture
11. 3dMD Transitions Anatomical Research from 3D-Static to 4D-Movement Surface Imaging
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genome-wide imaging study identifies new gene associated with Alzheimer's plaques
(Date:10/15/2014)... Lithuania , Oct. 15, 2014   ... technologies, today announced the availability of the ... VeriLook Surveillance 3.0 provides real-time biometric face identification ... high-resolution digital surveillance cameras. The new version not ... and differentiates people from objects while they are ...
(Date:10/14/2014)... ATHENS, Ohio (Oct. 14, 2014)—It,s been millions of years ... but a team led by Ohio University scientists is ... to model airflow through dinosaur snouts. The research has ... not only breathe but to enhance the sense of ... pretty ,nosy, animals," said Ohio University doctoral student Jason ...
(Date:10/14/2014)... team has discovered a new kind of stem cell that ... lines liver blood vessels, according to a study published today ... of such a cell type contradicts current theory on how ... hold clues to origins of, and future treatment for, liver ... cell into a complex being made up of more than ...
Breaking Biology News(10 mins):VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3Stem cell discovery challenges dogma on how fetus develops; holds insights for liver cancer and reg 2Stem cell discovery challenges dogma on how fetus develops; holds insights for liver cancer and reg 3
... Gremaud has shown that an alloy of the metals magnesium, ... alloy brings us a step closer to the everyday use ... A hydrogen ,tank, using this alloy would have a relative ... In order to find the best alloy Gremaud developed a ...
... but needs to be activated to function properly in the ... primarily in the kidneys, but a new University of Iowa ... lung airway cells. The study also links the vitamin ... of two genes that help fight infection. The study results ...
... COLD SPRING HARBOR, N.Y. (Mon., Nov. 3, 2008) ... kidney, and reproductive tissues requires experimental systems that allow ... tissues in the laboratory. This month,s issue of ... features two articles with detailed instructions for setting up ...
Cached Biology News:Hydrogen tank lighter than battery 2Lung airway cells activate vitamin D and increase immune response 2Lung airway cells activate vitamin D and increase immune response 3Cold Spring Harbor Protocols features organ and cell culture methods 2
(Date:10/22/2014)... SC (PRWEB) October 22, 2014 ... of its cardiovascular pharmacogenetics menu, which enables healthcare ... outcomes. With PCLS’s evidence-based results, healthcare providers ... and optimize their therapy, while minimizing risks for ... the U.S., according to the FDA [1] more ...
(Date:10/22/2014)... NEW YORK , Oct. 22, 2014 ... Diabetes Federation, approximately 400 million people worldwide are living ... 552 million people by 2030.  The global market for ... In 2012 approximately 330,000 people worldwide died from pancreatic ... of death due to cancer in the ...
(Date:10/20/2014)... 2014 Mapp Biopharmaceutical,s valiant effort to ... to fight the Ebola outbreak will make the ... production of pharmaceuticals can be, according to Kalorama ... while some may be taken aback by the ... industry knowledge are well aware of the complex ...
(Date:10/20/2014)... 2014 , A major pan-European ... the delivery of care has revealed changing trends in ... in the provision of healthcare services across the continent. ... United European Gastroenterology (UEG), have been announced today and ... of the burden of GI disorders across ...
Breaking Biology Technology:PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 2PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 3Nuvilex Brief Analyst Report: Thinking Outside the Box by BrokerBank Securities, Inc. 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 2Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 5
... New Mexico-based biotechnology company, has selected the Waisman ... vaccine. , ,Located at the University of ... designed to manufacture clinical-grade biological pharmaceutical products for Phase ... have clinical trials underway before the end of next ...
... value-added move aimed at media-savvy students, the mobile ... Sonic Foundry has introduced new podcasting ... communications product. , ,The latest release of ... media company, calls Mediasite Podcast. The new product ...
... big business (untold billions of dollars every year), they also ... of the fundamental ethical principle of informed consent ... is that conducting a clinical trial carries with it the ... positive or negative or even if the clinical trial is ...
Cached Biology Technology:What patients want: A story of choice, clinical trials & evidence-based medicine 2What patients want: A story of choice, clinical trials & evidence-based medicine 3What patients want: A story of choice, clinical trials & evidence-based medicine 4What patients want: A story of choice, clinical trials & evidence-based medicine 5
Weinreb Linker...
Goat anti-VAV2 Class: Antibody Product Group: Miscellaneous Antibody...
Anti-Human Factor XIII HRPO (Polyclonal) (sheep IgG)...
Rabbit polyclonal to M13 Bacteriophage Coat Proteins ( Abpromise for all tested applications)....
Biology Products: