Navigation Links
Genome-wide association studies mislead on cardiac arrhythmia risk gene
Date:3/20/2014

Although genome-wide association studies have linked DNA variants in the gene SCN10A with increased risk for cardiac arrhythmia, efforts to determine the gene's direct influence on the heart's electrical activity have been unproductive. Now, scientists from the University of Chicago have discovered that these SCN10A variants regulate the function of a different gene, SCN5A, which appears to be the primary gene responsible for cardiac arrhythmia risk. The SCN10A gene itself plays only a minimal role in the heart, according to the study, published in the Journal of Clinical Investigation on March 18.

"Significant effort has been invested into understanding the function of SCN10A in cardiac rhythm control, with underwhelming results," said study co-leader Ivan Moskowitz MD, PhD, associate professor of pediatrics, pathology and human genetics at the University of Chicago. "It turns out that the genetic variation within SCN10A that confers arrhythmia risk actually functions on a different gene. This study highlights the fact that DNA variation associated with disease can have regulatory impact on functional targets located a considerable distance away."

Mutations within the SCN10A gene are linked with increased risk of Brugada Syndrome, which causes cardiac arrhythmias and is a leading cause of death amongst youth in some parts of the world. Genome-wide association studieslarge scale experiments that look for genetic variants across the human genome with statistical associations to certain traits or diseaseswere used to identify these variants, but follow-up studies have been unable to determine their function.

Curious about previous ambiguous results, Moskowitz and his colleagues looked for other genes with links to SCN10A. First, they discovered that the region of SCN10A that conferred arrhythmia risk physically contacted a neighboring geneSCN5Awhich is well-known to have an important role in cardiac arrhythmias and sudden card
'/>"/>

Contact: Kevin Jiang
kevin.jiang@uchospitals.edu
773-795-5227
University of Chicago Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Genome-wide imaging study identifies new gene associated with Alzheimers plaques
2. 23andMe identifies 5 significant genetic associations for hypothyroidism
3. Amarantus BioSciences to Present at the National Investment Banking Associations (NIBA)122nd Conference in New York City
4. American Association for the Advancement of Science - Pacific Division convenes in Boise June 24-27
5. New research association started: Magnesium implants shall facilitate bone fracture healing
6. Pioneering researcher receives Heart Association Lifetime Achievement Award
7. Researchers sequence swine genome, discover associations that may advance animal and human health
8. Kansas State University scientists named American Association for the Advancement of Science fellows
9. UMass Medical School faculty elected to the American Association for the Advancement of Science
10. Association of Environmental Engineering and Science Professors name Environmental Engineering Science as its official journal
11. NREL employees honored by industry associations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Markets ( http://www.researchandmarkets.com/research/9zq33j/global_chemical ) has announced the ... report to their offering. ... in this market is the increasing demand for medical ... of patient data for quick and correct diagnosis during ...
(Date:12/11/2014)... Markets , http://photos.prnewswire.com/prnh/20130307/600769 ... addition of the "Biometrics Market in India 2015-2019" ... major trend emerging in this market is the adoption ... than one characteristic of an individual for verification and ...
(Date:12/10/2014)... , Dec. 9, 2014  Valencell, a leader in ... seeing a staggering demand from its licensees for highly ... revealed, is not solely coming from fitness and health ... "A wearable is only as useful as ...
Breaking Biology News(10 mins):Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2
... Accounts of the tsunami that killed over a quarter of ... December, 2004, slowly disappear from the media, but the event ... are directly involved. In the aftermath of the disaster, academics ... of casualties could have been reduced and, more important, how ...
... to reduce the risk of stomach ulcers in people taking ... miscarriage, according to a study by researchers at the National ... Institutes of Health and other research institutions. , The study ... Medicine. , The drug, misoprostol, has been used to reduce ...
... –?from a search of 58,000 compounds –?that appear to ... of the three molecules protects the protein called "tau," ... with Alzheimer's. The finding is promising news for the ... co-director of the Neuroscience Research Institute at the University ...
Cached Biology News:Stem Cells to Solve the Blood Shortage Problem? 2Sleeping Sickness Epidemic Spreading in Uganda 2Sleeping Sickness Epidemic Spreading in Uganda 3Sleeping Sickness Epidemic Spreading in Uganda 4Scientists discover that three molecules may be developed into new Alzheimer's drugs 2Scientists discover that three molecules may be developed into new Alzheimer's drugs 3
(Date:1/22/2015)... 22, 2015 Protocol Networks brings independent ... team of brand-neutral, independent consultants, Protocol Networks has recently ... that over the years, his company has attracted several ... of Plainfield, as well as others. With the success ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Dr. Greg Leyer ... 12th annual Scripps Natural Supplements Pre-Conference seminar on probiotics in ... is an annual continuing education conference for health care professionals. ... included the topic of probiotics in health. Dr. Leyer spoke ...
(Date:1/22/2015)... Nueva Jersey , 22 de enero de 2015  El ... abre hoy su llamada a nominaciones para 2015. Este ... ha hecho, o tiene el potencial para hacer, contribuciones ... nominaciones se aceptarán hasta el 15 de marzo de ...
(Date:1/22/2015)... 22, 2015  Derma Sciences, Inc. (Nasdaq: ... advanced wound care, announces that AMNIOEXCEL® and AMNIOMATRIX®, ... added to the Premier, Inc. Regenerative Skin Grafting ... the AMNIOEXCEL® and AMNIOMATRIX® product lines, which continue ...
Breaking Biology Technology:Protocol Networks Brings Independent Technology Consulting to the Constitution State 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5
... City, Mo. - The rate of entrepreneurial activity ... year-to-year shifts in gender, demographic, geographic and ethnic make-up ... according to a national assessment of entrepreneurial activity by ... Kauffman Index of Entrepreneurial Activity also reported a decline ...
... Memorial Day holiday is a paradox. It honors those who ... flags at gravestones and taps in the air, it is ... summer season and with sparkling weather framing joyous graduates, family ... the holiday holds its own festive note as well. I ...
... note: This is the 11th in a series of articles ... , , Madison, Wis. - You've ... equity funds, perhaps through investors. If you still need additional ... point, there are basic financial principles to consider. , ...
Cached Biology Technology:Kauffman study shows consistent entrepreneurial growth 2Who is minding the Innovation Gap? 2Who is minding the Innovation Gap? 3Who is minding the Innovation Gap? 4Who is minding the Innovation Gap? 5Who is minding the Innovation Gap? 6Who is minding the Innovation Gap? 7Who is minding the Innovation Gap? 8Early Stage: Step 11 - Other forms of finance 2Early Stage: Step 11 - Other forms of finance 3Early Stage: Step 11 - Other forms of finance 4
Anti-Mouse C-10, Biotin (Polyclonal) (rabbit IgG)...
Goat polyclonal to SART3 ( Abpromise for all tested applications). Antigen: Synthetic peptide: MSNADFAKLFLRK, corresponding to C terminal amino acids 951-963 of Human SART3 Entrez Gene ID: 9...
... Antibody is used to detect the appearance ... of infected cells as early as 8-24 ... the FastPlax Titer Kit, which allows determination ... The FastPlax Antibody can also ...
Alexa Fluor 647 anti-mouse IL-12 (Interleukin-12) / IL-23 (Interleukin-23) p40 25 ug...
Biology Products: