Navigation Links
Genome study suggests new strategies for understanding and treating pulmonary fibrosis
Date:4/19/2013

A new genome-wide association study of more than 6,000 people has identified seven new genetic regions associated with pulmonary fibrosis. In findings published online in Nature Genetics on April 14, 2013, researchers at National Jewish Health, the University of Colorado and several other institutions found a number of genes associated with host defense, cell-cell adhesion and DNA repair, which provide clues to possible mechanisms underlying this currently untreatable disease.

"This research gives us several new targets for investigation of pulmonary fibrosis ," said David Schwartz, MD, senior author on the paper, Professor of Medicine at National Jewish Health and Chair of Medicine the University of Colorado School of Medicine. "We believe that there are several relatively common genetic risk factors, which combine with repeated lung injury to cause this devastating lung disease."

Pulmonary fibrosis is a potentially deadly scarring of lung tissue. Although there are a number of known contributors to its development, most cases have no known cause. Without an approved medical therapy, patients with the most common form, idiopathic pulmonary fibrosis, survive an average of only two to three years after diagnosis.

"Pulmonary fibrosis has resisted our attempts to find a clearly beneficial treatment," said co-author Kevin K. Brown, MD, Vice Chair of Medicine at National Jewish Health. "This study gives us new insights into how the disease develops. By better understanding this, we can better focus future therapies."

Researchers from more than 20 institutions, led by National Jewish Health and the University of Colorado, confirmed three previously reported genetic risk factors and identified seven new ones, which together account for about one-third of the disease risk.

The team's findings confirmed the risk associated with specific changes in MUC5B, a gene that produces a protein in mucus. Researchers believe
'/>"/>

Contact: William Allstetter
allstetterw@njhealth.org
303-398-1002
National Jewish Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. Coelacanth genome surfaces
2. Genome sequencing of the living coelacanth sheds light on the evolution of land vertebrate
3. Einstein joins the New York Genome Center as 12th institutional founding member
4. Scientists decode genome of painted turtle, revealing clues to extraordinary adaptations
5. Getting under the shell of the turtle genome
6. Peach genome offers insights into breeding strategies for biofuels crops
7. DOE Joint Genome Institute 8th Annual Meeting on March 26-28, 2013
8. ACMG releases report on incidental findings in clinical exome and genome sequencing
9. After the Genome tackles tough questions about medicine, miracles and morality
10. U of T scientists map genome that causes Dutch Elm Disease
11. Eurofins MWG Operon and Queen Mary, University Of London commence genome sequencing analysis of Ash
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... What do seedless watermelon, salmon, and strawberries all have ... have two sets of chromosomes and are diploid, these ... more sets of chromosomesseedless watermelon and salmon have 3 ... 10! While this might seem surprising, in fact ... was first discovered over a century ago, but only ...
(Date:9/30/2014)... Calif. The National Institutes of Health (NIH) ... today to develop an electrode array system that ... brain works through unprecedented resolution and scale. , ... to support President Obama,s BRAIN (Brain Research ... research effort to revolutionize our understanding of the ...
(Date:9/30/2014)... scientists and engineers, led by Clemson University associate ... million grant from the U.S. Department of Energy,s ... a direct positive impact on South Carolina in ... radioactive contaminants. , "Understanding the scientific and engineering ... aspects of nuclear technologies is imperative if South ...
Breaking Biology News(10 mins):Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 3Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 4NIH taps lab to develop sophisticated electrode array system to monitor brain act 2NIH taps lab to develop sophisticated electrode array system to monitor brain act 3Researchers get $5.25 million to advance nuclear technologies in South Carolina 2
... cell biologists there are few better-known proteins than nestin, whose ... "stem cell," such as a neural stem cell. As helpful ... which purpose nestin serves in a cell. In a ... of Nature Neuroscience , Salk Institute of Biological Studies ...
... of California, San Diego School of Medicine provides ... defects associated with a rare childhood neurological disease ... be defective in LND are known to be ... and Parknson,s diseases, suggesting common causes of cognitive ...
... ARBOR, Mich.---DNA, that marvelous, twisty molecule of life, has an ... University of California, Irvine reveals. On rare occasions, its ... into a different shape. "We show that the simple ... of the time---and that this alternative form is functional," said ...
Cached Biology News:Salk researchers discover that stem cell marker regulates synapse formation 2Salk researchers discover that stem cell marker regulates synapse formation 3Genetic clues to compulsive, self-injurious behavior in rare childhood disorder 2Genetic clues to compulsive, self-injurious behavior in rare childhood disorder 3DNA caught rock 'n rollin' 2
(Date:10/1/2014)... This report analyzes the worldwide markets for ... following Product Segments: Proteases, Polymerases, Carbohydrases, and ... analyzed are Pharmaceuticals & Diagnostics, Research/Biotechnology, and ... comprehensive analytics for the US, Canada, Japan, ... Annual estimates and forecasts are provided for ...
(Date:9/30/2014)... . , Electrical ... a new kind of building block for digital integrated ... be based on three-dimensional arrangements of nanometer-scale magnets instead ... semiconductor industry CMOS fabrication of silicon chips ... the University of Notre Dame are exploring "magnetic computing" ...
(Date:9/30/2014)... September 30, 2014 Shimadzu Scientific ... an easy-to-use and highly precise tool for measuring ... considerable elongation. With 1000-mm maximum movement distance, the ... for a gauge length of 10 mm. In ... accuracy above 50-mm stroke and within +/- 100 ...
(Date:9/30/2014)... San Jose, California (PRWEB) September 30, 2014 ... generally measure the level of each type of cholesterol ... essential since the presence of excessive cholesterol levels in ... is a precursor condition to heart attack and other ... of fatality worldwide, therefore testing for cholesterol levels on ...
Breaking Biology Technology:Global Specialty Enzymes Industry 2Global Specialty Enzymes Industry 3Global Specialty Enzymes Industry 4Global Specialty Enzymes Industry 5Global Specialty Enzymes Industry 6Global Specialty Enzymes Industry 7Global Specialty Enzymes Industry 8Global Specialty Enzymes Industry 9Global Specialty Enzymes Industry 10Global Specialty Enzymes Industry 11Global Specialty Enzymes Industry 12Global Specialty Enzymes Industry 13Global Specialty Enzymes Industry 14Global Specialty Enzymes Industry 15Global Specialty Enzymes Industry 16Global Specialty Enzymes Industry 17Global Specialty Enzymes Industry 18Global Specialty Enzymes Industry 19Global Specialty Enzymes Industry 20Global Specialty Enzymes Industry 21Global Specialty Enzymes Industry 22Global Specialty Enzymes Industry 23Global Specialty Enzymes Industry 24Global Specialty Enzymes Industry 25Global Specialty Enzymes Industry 26A new dimension for integrated circuits: 3-D nanomagnetic logic 2A new dimension for integrated circuits: 3-D nanomagnetic logic 3Shimadzu’s New Long-Travel Extensometer Increases Precision for Soft Material Testing 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 3Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 4
... Corn Growers Association reminds U.S. Bt corn growers that the development of ... their planning process. , ... St. Louis, MO (PRWEB) February 20, ... Association (NCGA) reminds U.S. Bt corn growers that the development of ...
... Feb. 20 Mach One Corporation (Pink Sheets: MNCN), ... for positive, long term benefit to the agricultural and ... the acquisition of Modular Process Constructors LLC (MPC).Mach One ... $500,000 of Series B convertible preferred stock at a ...
... February 20 Authentic Natural and Organic,Cosmetic* products ... the NaTrue,Label: the first 100 products have already ... The NaTrue-Label provides orientation for ... criteria for Natural and Organic,Cosmetics. It is international, ...
Cached Biology Technology:Corn Growers Reminded to Follow Refuge Requirements as Spring Planting Nears 2Corn Growers Reminded to Follow Refuge Requirements as Spring Planting Nears 3Mach One Closes on Acquisition of Biopharmaceutical Design & Engineering Firm 2NaTrue-Label: The First 100 Products are Certified 2
...
...
... and supplies, for 10 chips, provides ... perform standard-sensitivity RNA analysis (nanogram levels) ... automated electrophoresis system. Supplied are 1,250 ... StdSens stain, 20 microliters RNA ladder, ...
... vectors are designed for enhanced translation of cloned ... rabbit reticulocyte lysate. The maps for pCITE-2b(+) and ... following exceptions: pCITE-2b(+) is a 3793 bp plasmid; ... and Xcm I sites. Subtract 7 bp from ...
Biology Products: