Navigation Links
Genetic predictors of postpartum depression uncovered by Hopkins researchers
Date:5/21/2013

ement in hippocampal activity.

Kaminsky says the genes in question may have something to do with the creation of new cells in the hippocampus and the ability of the brain to reorganize and adapt in the face of new environments two elements important in mood. In some ways, he says, estrogen can behave like an antidepressant, so that when inhibited, it adversely affects mood.

The researchers later confirmed their findings in humans by looking for epigenetic changes to thousands of genes in blood samples from 52 pregnant women with mood disorders. Jennifer L. Payne, M.D., director of the Johns Hopkins Women's Mood Disorders Center, collected the blood samples. The women were followed both during and after pregnancy to see who developed postpartum depression.

The researchers noticed that women who developed postpartum depression exhibited stronger epigenetic changes in those genes that are most responsive to estrogen, suggesting that these women are more sensitive to the hormone's effects. Specifically, two genes were most highly correlated with the development of postpartum depression. TTC9B and HP1BP3 predicted with 85 percent certainty which women became ill.

"We were pretty surprised by how well the genes were correlated with postpartum depression," Kaminsky says. "With more research, this could prove to be a powerful tool."

Kaminsky says the next step in research would be to collect blood samples from a larger group of pregnant women and follow them for a longer period of time. He also says it would be useful to examine whether the same epigenetic changes are present in the offspring of women who develop postpartum depression.

Evidence suggests that early identification and treatment of postpartum depression can limit or prevent debilitating effects. Alerting women to the condition's risk factors as well as determining whether they have a previous history of the disorder, other mental illness and unusual stres
'/>"/>

Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Genetic risk for schizophrenia is connected to reduced IQ
2. European Society of Human Genetics urges caution over use of new genetic sequencing techniques
3. University of Maryland Medical Center launches genetic-testing program for cardiac patients
4. Penn Medicine researchers identify 4 new genetic risk factors for testicular cancer
5. Fred Hutch evolutionary geneticist Harmit Malik selected as an HHMI investigator
6. Genetic and clinical factors best to predict late recurrence in estrogen receptor POS breast cancer
7. Study examines effects of genetic variants for infants with neonatal abstinence syndrome
8. Genetics Society of Americas GENETICS journal highlights for May 2013
9. Europe needs genetically engineered crops, scientists say
10. Epigenetic changes shed light on biological mechanism of autism
11. Genetic circuit allows both individual freedom, collective good
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2014)... years, it has become clear that the genetic ... In addition to the well-known building blocks adenine, ... an important role. Scientists now assume that the ... second layer of information that extends and complements ... like umlauts that extend the standard alphabet," explained ...
(Date:4/15/2014)... New research, partially funded by the U.S. Department of ... can improve their diets simply by enjoying white or ... , In a study published online in ... lead author Theresa Nicklas, DrPH, of Baylor College of ... datasets from 2005-2010 and evaluated the association of rice ...
(Date:4/14/2014)... to swallow, but if you,re over 24 years of ... your cognitive motor performance, according to a new Simon ... psychology doctoral student, associate professor Mark Blair, Thompson,s thesis ... doctoral student, deliver the news in a just-published ... of the first social science experiments to rest on ...
Breaking Biology News(10 mins):German Research Foundation approves new priority program in the life sciences 2Eating rice boosts diet quality, reduces body weight and improves markers for health 2Eating rice boosts diet quality, reduces body weight and improves markers for health 3Study says we're over the hill at 24 2
... 4, 2009) A large body of science supports the ... high-quality protein for growth, muscle strength and energy and promote ... shown to reduce the risk of neural tube birth defects ... 2008 issue of Diabetes Care that examined data ...
... in Spanish . , CAREFREE, A.Z. - ... released for the first time at the American Association for ... in Carefree, Arizona. "Hispanics are the fastest-growing minority ... their risk for breast cancer," said Elena Martinez, Ph.D., professor ...
... 2, 2009--Phosphorus is one of the key nutrients that ... in lakes, rivers, and estuaries worldwide. Phosphorus entering ... land receiving long term applications of organic by-products such ... Such soils often become enriched with P, leading ...
Cached Biology News:Statement by the Egg Nutrition Center and American Egg Board on Diabetes Care study on egg consumption 2Statement by the Egg Nutrition Center and American Egg Board on Diabetes Care study on egg consumption 3Hispanic women and breast cancer: An understudied group 2Hispanic women and breast cancer: An understudied group 3Hispanic women and breast cancer: An understudied group 4Understanding phosphorus in soils is vital to proper management 2
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... the airbag in your car to inflate and rotate ... couch. Now a research group of Tel Aviv University,s ... useful. Prof. Yael Hanein, Dr. Slava Krylov and ... make sensors for microelectromechanical systems (MEMS) significantly more sensitive ...
... , SAN FRANCISCO and BERLIN , March 22 Guidewire Group, the world,s leading analyst firm focused ... at IBB Beteiligungsgesellschaft mbH as part of its Innovate!2010 global competition to identify and promote 100 top technology startups ... ... , ...
... portable electronic medical records management, announced today the addition of internationally-renowned biotechnology veteran Dr. Gurinder Shahi , M.D., Ph.D., to its Advisory Board. , ... , ... ... ...
Cached Biology Technology:A more sensitive sensor 2Meet and Engage With Innovate!100 Semi-Finalists in Berlin on March 22 2Meet and Engage With Innovate!100 Semi-Finalists in Berlin on March 22 3Meet and Engage With Innovate!100 Semi-Finalists in Berlin on March 22 4Meet and Engage With Innovate!100 Semi-Finalists in Berlin on March 22 5Meet and Engage With Innovate!100 Semi-Finalists in Berlin on March 22 6MedeFile Adds International Biotech Expert to Advisory Board 2MedeFile Adds International Biotech Expert to Advisory Board 3MedeFile Adds International Biotech Expert to Advisory Board 4MedeFile Adds International Biotech Expert to Advisory Board 5
Mol wt: average mol wt16,951.27 Da by calculation...
A set of five peptides which can be used to calibrate a Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) or Electrospray Ionization (ESI) mass spectrometer....
... number is a new product ... Cornings product number. If showing ... under the old Sigma-Aldrich number ... for assistance. ID clarifier: filling ...
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. ID clarifier: ...
Biology Products: