Navigation Links
Genetic predictors of postpartum depression uncovered by Hopkins researchers
Date:5/21/2013

The epigenetic modifications, which alter the way genes function without changing the underlying DNA sequence, can apparently be detected in the blood of pregnant women during any trimester, potentially providing a simple way to foretell depression in the weeks after giving birth, and an opportunity to intervene before symptoms become debilitating.

The findings of the small study involving 52 pregnant women are described online in the journal Molecular Psychiatry.

"Postpartum depression can be harmful to both mother and child," says study leader Zachary Kaminsky, Ph.D., an assistant professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine. "But we don't have a reliable way to screen for the condition before it causes harm, and a test like this could be that way."

It is not clear what causes postpartum depression, a condition marked by persistent feelings of sadness, hopelessness, exhaustion and anxiety that begins within four weeks of childbirth and can last weeks, several months or up to a year. An estimated 10 to 18 percent of all new mothers develop the condition, and the rate rises to 30 to 35 percent among women with previously diagnosed mood disorders. Scientists long believed the symptoms were related to the large drop-off in the mother's estrogen levels following childbirth, but studies have shown that both depressed and nondepressed women have similar estrogen levels.

By studying mice, the Johns Hopkins researchers suspected that estrogen induced epigenetic changes in cells in the hippocampus, a part of the brain that governs mood. Kaminsky and his team then created a complicated statistical model to find the candidate genes most likely undergoing those epigenetic changes, which could be potential predictors for postpartum depression. That process resulted in the identification of two genes, known as TTC9B and HP1BP3, about which little is known save for their involv
'/>"/>

Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Genetic risk for schizophrenia is connected to reduced IQ
2. European Society of Human Genetics urges caution over use of new genetic sequencing techniques
3. University of Maryland Medical Center launches genetic-testing program for cardiac patients
4. Penn Medicine researchers identify 4 new genetic risk factors for testicular cancer
5. Fred Hutch evolutionary geneticist Harmit Malik selected as an HHMI investigator
6. Genetic and clinical factors best to predict late recurrence in estrogen receptor POS breast cancer
7. Study examines effects of genetic variants for infants with neonatal abstinence syndrome
8. Genetics Society of Americas GENETICS journal highlights for May 2013
9. Europe needs genetically engineered crops, scientists say
10. Epigenetic changes shed light on biological mechanism of autism
11. Genetic circuit allows both individual freedom, collective good
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... to an unexpected extent. The outbreak does not follow ... shows a new disease dynamic in regions, where it ... German National Academy of Sciences Leopoldina, acatech – the ... of the German Academies of Sciences and Humanities have ... In the statement the academies call for the following ...
(Date:10/15/2014)... 15, 2014   Neurotechnology , a provider ... availability of the VeriLook Surveillance 3.0 software ... real-time biometric face identification using live video streams ... The new version not only identifies faces in ... objects while they are moving through the video ...
(Date:10/14/2014)... sequenced the house fly genome for the first time, ... an insect that thrives in pathogen-rich dung piles and ... the journal Genome Biology , will increase understanding ... flies quickly adapt to resist insecticides, which could lead ... domestica) carry and transmit more than 100 human and ...
Breaking Biology News(10 mins):Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3House fly genome reveals expanded immune system 2
... Solutions, a global life sciences technology solutions company ... to announce the latest release of ENLIGHTEN ... ENLIGHTEN system, which provides a proven, highly ... clinical trial management system (CTMS), has effectively supported ...
... University of Tennessee, Knoxville, researchers have found ... an estrogen-like compound in the environment which could ... adversely affect fish, plants and human health. Previously, ... these impacts. Theodore Henry, an adjunct ...
... is pleased to announce the recipients of the 2010 ... Advancement of Biotherapy. The 6 award winners were presented ... in Los Angeles; they are: David Armstrong, MD, DPM, ... MD, MPH; Kosta Mumcuoglu, PhD; and Aletha Tippett, MD, ...
Cached Biology News:MedNet Solutions Announces Significant Enhancements to ENLIGHTEN, Its Flagship EDC / eClinical Solution 2UT researchers link algae to harmful estrogen-like compound in water 2BTER Foundation announces winners of the William S. Baer Award 2BTER Foundation announces winners of the William S. Baer Award 3
(Date:10/22/2014)... 2014 Involution Studios , a ... a new infographic, Understanding Ebola . The ... designed, easy to follow informative tool for anyone wanting ... symptoms and prevention. , "As the news has spread ... Ebola outbreak represents not only a healthcare crisis with ...
(Date:10/22/2014)... According to new market research report ... Integration, Deployment & Support), by Service Model (SaaS, ... Others (Hybrid & Community)) - Global Forecast to ... Cloud Professional Services Market into various sub-segments with ... also identifies the drivers and restraints for this ...
(Date:10/22/2014)... and HONG KONG , ... rare disease therapeutics enterprise, announced today that rare disease ... company as vice president, research. Dr. McKew brings more ... key leadership positions at the National Institutes of Health, ... acquisition by Wyeth). Dr. McKew will lead aTyr,s efforts to ...
(Date:10/20/2014)... 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") ... orders to $5.8 million and provides a good start to Q4.  ... North America and one in the Middle ... at record levels," said Peter Bruijns , President & CEO. ... of Q3 than they have been for any complete year since ...
Breaking Biology Technology:Involution Studios' Ebola Infographic Provides Key Disease Information and Statistics at a Glance 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3
... BC, March 20 /PRNewswire-FirstCall/ - Chromos Molecular,Systems Inc. ... a secured, convertible debenture agreement to borrow $400,000. ... to fund expenses associated with the,preparation of delinquent ... remaining assets of the Company. The principal and,interest, ...
... January 7,2008, Signalife received a deficiency letter from ... advised that Signalife would need to,comply with the ... under AMEX Rules 1003(a)(iii). This notification was,triggered by ... than,$50 million, which previously exempted Signalife from meeting ...
... as Interim President, HOUSTON, March 20 Nova ... marketer of ASTM quality biodiesel, announced,today that it has ... its Interim President. Mr. Zeidman has been a Nova ... Managing Director of the law firm,Greenberg Traurig, LLP since ...
Cached Biology Technology:Chromos enters into loan and lending arrangements 2AMEX Notifies Signalife That It Has Accepted Signalife's Plan of Compliance 2Nova Biosource Fuels Expands Senior Executive Team 2Nova Biosource Fuels Expands Senior Executive Team 3
... Amplification Kit, 100 reactions. Prepare circular ... 4-6 h.Generate microgram quantities of template ... material.Use amplified DNA directly for cycle ... or M13 liquid cultures, colonies, plaques, ...
... Microplate Rack inserts fit ... Rack, and allow you to ... capacity, shake deepwell format plates ... many plates from the shaker ...
BD FastImmune EDTA Solution. Applications: Flow Cytometry Storage Temperature: Refrigerate(2 to 8C)...
Spaced cover glasses to promote effective hybridization...
Biology Products: