Navigation Links
Genetic breakthrough offers promise in tackling kidney tumors
Date:1/10/2008

A new study has shown promising results in fighting a severe genetic disorder which can create tumours throughout the body.

Advances in genetic knowledge have transformed our understanding of disease in recent years. We now know which genes are linked to a wide variety of conditions. However, so far, very few cures and treatments have developed as a result of this knowledge.

Now a UK study led by researchers at Cardiff University suggests that a chemical first found on Easter Island could treat the genetic disorder tuberous sclerosis.

Tuberous sclerosis is an inherited disease affecting children and adults which causes tumours to grow in many of the organs of the body. Its consequences can include autism and epilepsy through its effects on the brain. A team from the Institute of Medical Genetics at Cardiff Universitys School of Medicine was the first to identify the genes linked with the disease TSC1 and TSC2.

The Institute is now leading a UK-wide study on a new treatment involving the drug Sirolimus. This was first identified from a soil sample taken from Easter Island and has been shown in the past to control the activity of a protein, mTOR, which is normally controlled by the TSC1 and TSC2 genes. If the genes fail, mTOR is too active leading to tuberous sclerosis.

The UK study tested the effects of Sirolimus on kidney tumours in patients with tuberous sclerosis and a related condition, LAM, a lung and kidney disease affecting young women. The study is at the half-way stage but after one year of treatment the diameters of the tumours have shrunk by an average of 26 per cent. A parallel study in the United States has also reported similar results.

Professor Julian Sampson, director of the Institute of Medical Genetics, said: This is a small-scale study and we will be treating patients for a further year before it is completed. However, what we have seen so far is very promising and already justifies progression to a larger study in many more patients. The findings offer new hope for what is a very serious and distressing genetic disease.


'/>"/>

Contact: Stephen Rouse
stephenrouse@hotmail.co.uk
44-292-087-5596
Cardiff University
Source:Eurekalert

Related biology news :

1. Genetic variant predicts antipsychotic response for schizophrenia patients by ethnicity
2. Recurrent genetic deletion linked to autism
3. Study examines genetic defects linked to body abnormalities in patients with childhood cancer
4. New clinical trial results show how personalized medicine will alter treatment of genetic disorders
5. Cognitive, genetic clues identified in imaging study of alcohol addiction
6. Plant geneticists find veritas in vino
7. UT-Houstons Northrup and colleagues uncover genetic link to spina bifida
8. Study of bear hair will reveal genetic diversity of Yellowstones grizzlies
9. A research of the UGR shows the genetic predisposition to develop alcohol abuse
10. USC researchers explore genetic causes for male infertility
11. Study finds first-ever genetic animal model of autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/12/2020)... ... , ... Mosio recently announced its newly updated text message-based ... all sizes. With a focus on tracking symptoms and monitoring outbreaks as well ... helps public health departments automate communications and provide more personalized care and resources ...
(Date:8/5/2020)... (PRWEB) , ... August 05, 2020 , ... Regenative Labs ... two new innovations, CoreText™ and ProText™, making them the first Wharton’s jelly allografts to ... using a syringe. The company’s solutions are the first Wharton’s jelly allograft product to ...
(Date:7/31/2020)... ... 2020 , ... Justin Zamirowski to lead upcoming launches of ... on Type 2 diabetes and associated comorbidities. , Justin brings over 20 years ... As Chief Commercial Officer, Justin will lead Better Therapeutics’ efforts in ...
Breaking Biology News(10 mins):
(Date:8/15/2020)... ... August 13, 2020 , ... ... Inc. 5000 list, the most prestigious ranking of the nation’s fastest-growing private companies. ... American economy’s most dynamic segment—its independent small businesses. Intuit, Zappos, Under Armour, Microsoft, ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... Anomet Products has ... different materials for use with CRM, neurostimulation, vascular, and related devices. , ... specific design requirements, performance, and cost criteria; especially where solid wire is limited. ...
(Date:7/22/2020)... ... 2020 , ... Join experts from Reed Tech , Gary Saner, Sr. ... one hour live webinar on Thursday, August 13, 2020 at 11am EDT ... medical devices. Specifically, for medical devices, the NMPA has departments dealing with medical device ...
Breaking Biology Technology: