Navigation Links
Genetic abnormality offers diagnostic hope for children's cancer
Date:3/28/2012

A chromosomal abnormality in children with a deadly form of brain cancer is linked with a poorer chance of survival, clinician scientists at The University of Nottingham have discovered.

The study led by experts at Nottingham's Children's Brain Tumour Research Centre as part of a European collaboration could potentially lead to a new diagnostic test to allow doctors to identify youngsters who are at the highest risk associated with an ependymoma tumour and may need aggressive life-saving treatments.

The research could also help them to decide which children with the tumour have a better prognosis and would benefit from less intensive therapies, reducing their exposure to a range of side effects which can cause permanent disabilities, having a debilitating impact on them for the rest of their lives.

The study, published in the April 1 edition of the journal Clinical Cancer Research, focused on looking at abnormal copies of chromosomes in the cells of ependymoma tumours and aimed to establish whether it was associated with a worse outlook for children suffering from the disease.

The research, led by Professor Richard Grundy and Dr John-Paul Kilday, found that increased copies of a specific region of a chromosome called 1q25 were associated with around 20 per cent of the 147 tumours they tested from European children with ependymoma and that it was associated with a worse outcome in younger children treated with surgery and chemotherapy.

In addition, when combining the results for 1q25 copy gain with how much tumour was removed at the time of surgery, the scientists could accurately place the children into three risk groups high, intermediate and standard.

Dr Kilday said: "This study is the first to assess copy number gain like this in groups of children with ependymoma who have been treated in a similar way and is an important step forward in being able to predict the future for children with these bra
'/>"/>

Contact: Emma Thorne
emma.thorne@nottingham.ac.uk
44-011-595-15793
University of Nottingham
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. U-M Health and Retirement Study adds genetic data to NIH database
2. Researchers unravel genetic mechanism of fatty liver disease in obese children
3. Genetic mutation found in familial chronic diarrhea syndrome
4. New genetic path for scleroderma
5. Genetic research develops tools for studying diseases, improving regenerative treatment
6. First complete full genetic map of promising energy crop
7. Genetic variation in East Asians found to explain resistance to cancer drugs
8. Epigenetics and epidemiology -- hip, hype and science
9. Epigenetic signatures direct the repair potential of reprogrammed cells
10. Genetic survey of endangered Antarctic blue whales shows surprising diversity
11. A foot in the door to genetic information
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2015)... According to a new ... Software, Services), by Applications (Surveillance (Airborne, Maritime, Land), ... (Military & Defense & Commercial) - Global Forecast ... is expected to grow from $7252.0 Million in ... Compound Annual Growth Rate (CAGR) of 6.6%. ...
(Date:5/20/2015)... 2015 Research ... the addition of the  "5-year Opportunity ... Market"  report to their offering.  ,     ... analyses trends in the iris recognition ... sectors, globally. Despite hardware pricing and ...
(Date:5/19/2015)... -- Fingerprint Cards (FPC) has received an order ... FPC1035 from one if its module partners. Deliveries are planned ... and the sensors will be used by smartphone manufacturers in ... hereby amount to 740 MSEK to date. In addition to ... a number of smaller orders not separately communicated amounting to ...
Breaking Biology News(10 mins):Thermal Imaging Market Worth $9,998.9 Million by 2020 2Thermal Imaging Market Worth $9,998.9 Million by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 4Global Iris Recognition Market Report 2015 - 5-Year Opportunity Analysis 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2
... group of leading UK scientists and social scientists led by the ... joined-up thinking on the emerging politics of plants. Green is ... of plants from food to fuel, industrial feedstocks to carbon ... cornerstone of the global economy. But such fame comes ...
... Feb. 24 BIO-key International, Inc. (OTC Bulletin Board: ... biometric identification solutions, today reported results for the fourth ... Company,s results reflected profitability for the fourth quarter and ... strong revenue growth for the quarter and the year. ...
... Damon Runyon Cancer Research Foundation named 13 new ... Award Committee review. The recipients of this ... basic and translational cancer research in the laboratories ... The Fellowship is specifically intended to encourage the ...
Cached Biology News:Plants are political hot potatoes 2BIO-key(R) Reports Profitability for Fourth Quarter and Full Year 2008 2BIO-key(R) Reports Profitability for Fourth Quarter and Full Year 2008 3BIO-key(R) Reports Profitability for Fourth Quarter and Full Year 2008 4BIO-key(R) Reports Profitability for Fourth Quarter and Full Year 2008 5BIO-key(R) Reports Profitability for Fourth Quarter and Full Year 2008 6Damon Runyon Cancer Research Foundation awards prestigious fellowships to 13 top young investigators 2Damon Runyon Cancer Research Foundation awards prestigious fellowships to 13 top young investigators 3Damon Runyon Cancer Research Foundation awards prestigious fellowships to 13 top young investigators 4
(Date:5/22/2015)... , May 22, 2015 ... by Product (1D & 2D Gel Electrophoresis, Agarose & ... MEKC, Reagents, Informatics), by Application & by End User ... Electrophoresis Market is expected to reach around $1.98 Billion ... forecast period 2015 to 2020. Browse ...
(Date:5/21/2015)... 21, 2015 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" or ... that develops and commercializes proprietary technologies and products for ... results for the second fiscal quarter ended March 31, ... continued to advance business with our existing customers and ... President and CEO of SQI. "The delivery of a ...
(Date:5/21/2015)...  Prima Biomed Ltd. (NASDAQ: PBMD ) a ... a leader in the development of immunotherapeutic products for ... CVac data from the Phase II CAN-003 ovarian cancer ... clinically meaningful improvement in Overall Survival ("OS") over standard ... In the group of second remission patients (n=20), the ...
(Date:5/21/2015)... (PRWEB) May 21, 2015 W. ... its manufacturing facility in Worms, Germany has received ... independent subsidiary of the International Pharmaceutical Excipient Council ... facilities that produce its SYLOID® FP brand of ... GMP certification, following the Curtis Bay, Maryland (USA) ...
Breaking Biology Technology:Electrophoresis Market Worth $1.98 Billion by 2020 2Electrophoresis Market Worth $1.98 Billion by 2020 3Electrophoresis Market Worth $1.98 Billion by 2020 4SQI Diagnostics Reports Second Quarter Financial Results 2SQI Diagnostics Reports Second Quarter Financial Results 3SQI Diagnostics Reports Second Quarter Financial Results 4SQI Diagnostics Reports Second Quarter Financial Results 5SQI Diagnostics Reports Second Quarter Financial Results 6SQI Diagnostics Reports Second Quarter Financial Results 7SQI Diagnostics Reports Second Quarter Financial Results 8Correction Continues after Big Move - BrokerBank Securities, Inc. 2Grace European Facility Receives GMP Excipient Certification for SYLOID® FP Silica Gel 2
... Fisher,Scientific Inc. (NYSE: TMO ) today ... a leading third-party logistics provider to the,pharmaceutical ... was previously majority-owned by Arsenal Capital,Partners. With ... Priority,Solutions offers a comprehensive range of services ...
... With a special eye for the,details hidden from casual ... G. Aspinall. Photographs of architectural details from beaches,to buildings ... fore. The,collection includes images from seven different countries., ... the,president of Genzyme Genetics, is also a talented artist ...
... - Biomira Inc. (Nasdaq: BIOM ),(TSX: BRA) ... Chief,Executive Officer, is scheduled to present at the ... EDT on Wednesday, October 10. The presentation ... be accessed at: http://www.corporate-ir.net/ireye/confLobby.zhtml?ticker=BIOM&item_id=1 ,657575 ...
Cached Biology Technology:Thermo Fisher Scientific Acquires Logistics Provider to Strengthen Clinical Trials Management Services 2Thermo Fisher Scientific Acquires Logistics Provider to Strengthen Clinical Trials Management Services 3Thermo Fisher Scientific Acquires Logistics Provider to Strengthen Clinical Trials Management Services 4An Uncommon Eye: Photography Exhibit by Biotechnology Executive at BHCC Gallery 2