Navigation Links
Gene variant influences chronic kidney disease risk
Date:3/9/2011

A team of researchers from the United States and Europe has identified a single genetic mutation in the CUBN gene that is associated with albuminuria both with and without diabetes. Albuminuria is a condition caused by the leaking of the protein albumin into the urine, which is an indication of kidney disease.

The research team, known as the CKDGen Consortium, examined data from several genome-wide association studies to identify missense variant (I2984V) in the CUBN gene. The association between the CUBN variant and albuminuria was observed in 63,153 individuals with European ancestry and in 6,981 individuals of African American ancestry, and in both the general population and in individuals with diabetes. The findings are published in the March 2011 edition of JASN.

Chronic kidney disease is a serious public health problem in the U.S. and around the world. Characterized by reduced kidney function or kidney damage, the disease affects approximately 10 percent of adults in the U.S. Elevated levels of urinary albumin (albuminuria) are a cardinal manifestation of chronic kidney disease. Higher levels of albuminuria, even within the low normal range, are associated with not only increased risks of end-stage renal disease, requiring kidney transplant or dialysis, but also cardiovascular disease and mortality.

Important risk factors for chronic kidney disease include diabetes and hypertension, although kidney disease clusters in families. The hereditary factors underlying chronic kidney disease have been difficult to determine until recently, when new methods to search for risk genes became available. The CKDGen Consortium applied one of the new methods, called genome-wide association study. In 2008, Johns Hopkins researchers used similar methods to identify common variants for non-diabetic end-stage renal disease, gout and sudden cardiac death.

"The significance of this finding is that even though the field has known abou
'/>"/>

Contact: Tim Parsons
tmparson@jhsph.edu
410-955-7619
Johns Hopkins University Bloomberg School of Public Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gene variants in autism linked to brain development
2. Genetic variants linked to increased risk of common gynecological disease
3. Genome study identifies genetic variant linked to TB susceptibility in Africans
4. New variants found that indicate a predisposition to type 2 diabetes
5. Small genetic variant can predict response to hepatitis C treatment
6. Autism genome project identifies genetic variants that may make people susceptible to disorder
7. Newly discovered gene variants lead to autism and mental retardation
8. Receptor variant influences dopamine response to alcohol
9. Meta-analysis: Radiotherapy variants improve survival in non-metastatic lung cancer
10. Common gene variant may increase risk for a type of cardiac arrhythmia
11. Scientists identify first genetic variant linked to biological aging in humans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... by researchers at the University of Warwick in the ... published in the Journal Early Human Development , ... in hospital after birth and the use of mechanical ... preterm children. , Mathematic abilities are crucial for lifelong ... very preterm children. Earlier studies of children who are ...
(Date:9/2/2014)... breast milk is considered the most ideal source ... played a critical role in the evolution and ... human milk contains a large number of bacterial ... phenomenon comes as no surprise to scientists and ... is considered to be the result of co-evolutionary ...
(Date:9/2/2014)... In the battle between our immune systems and ... bacteria-killing viruses known as phages. In a new study, ... Health, Haiti,s National Public Health Laboratory, and elsewhere, report ... their virulence in order to survive. Importantly, the study ... cholera,s mutational escape from phage predation occurs during human ...
Breaking Biology News(10 mins):Mechanical ventilation a key indicator for pre-term children's math problems 2Are human breast milk microbiome 'neutral'? 2Are human breast milk microbiome 'neutral'? 3War between bacteria and phages benefits humans 2War between bacteria and phages benefits humans 3
... Medicine (BUSM) have brought attention to the potential health impacts ... brown seaweed soup. Seaweed is a known source of dietary ... on the iodine content in Korean seaweed soup. Written ... Thyroid and published online, the authors discuss the adverse ...
... investigation into the underlying causes of sudden cardiac death (SCD) ... the United States researchers have discovered a variation in ... increase in a person,s risk of SCD. The new ... region along the genome containing three genes previously unknown to ...
... useful strategy for helping prevent the development of panic and ... with an intense fear of the nausea, racing heart, dizziness, ... known as "high anxiety sensitivity" reacted with less anxiety ... high levels of physical activity, said researchers at Southern Methodist ...
Cached Biology News:BUSM researchers urge awareness of dietary iodine intake in postpartum Korean-American women 2Johns Hopkins researchers identify new genetic risk factor for sudden cardiac death 2Study: People at risk for panic buffered from stressor by high levels of physical activity 2Study: People at risk for panic buffered from stressor by high levels of physical activity 3
(Date:9/2/2014)... MA (PRWEB) September 02, 2014 ... today the signage of a distribution agreement with ... is now distributing Myriant’s bio-succinic acid in the ... and Ireland, targeting customers in the industrial and ... distribution powerhouse, Azelis offers a far-reaching chemical portfolio ...
(Date:9/2/2014)... SAN DIEGO , Sept. 2, 2014 ... announced that the U.S. Patent and Trademark Office (PTO) ... investigational medication being evaluated for weight loss. NB32 is ... bupropion SR. U.S. Patent No. 8,815,889 claims ... naltrexone and bupropion. The patent expires in 2024. If ...
(Date:9/2/2014)... Sept. 2, 2014 /PRNewswire/ - Oncothyreon Inc. (Nasdaq: ONTY ... and Chief Executive Officer, will present at the Rodman & ... New York on Tuesday, Sept. 9, 2014 ... archived webcast of the presentation will be accessible by visiting ... Events" section. About Oncothyreon ...
(Date:9/2/2014)... , Sept. 2, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ... $2.1 million. The orders consist of three large odour control ... . "These orders are consistent with the ... Peter Bruijns , President and CEO. "After a difficult ... we are now beginning to see sales growth. Our lower ...
Breaking Biology Technology:Myriant and Azelis Sign European Distribution Agreement for Bio-Succinic Acid 2Orexigen Expands NB32 Intellectual Property Portfolio With New U.S. Patent 2Orexigen Expands NB32 Intellectual Property Portfolio With New U.S. Patent 3Orexigen Expands NB32 Intellectual Property Portfolio With New U.S. Patent 4
... DCGN ) announced that on February 2, 2009, ... (the "Panel") stating that the Panel,will transfer the listing ... the Nasdaq Capital Market, effective at the open of ... Capital Market, which is,one of the three market tier ...
... Health,Inc. (Nasdaq: GHDX ) today reported financial results ... 31, 2008. , Total revenue for ... $19.3 million in the fourth quarter of 2007. Product ... in the fourth,quarter of 2008, an increase of 60 percent, ...
... Abt Associates announced that Ricky Takai, Ph.D., has ... brief orientation to the firm, Dr. Takai will become ... 2009. Dr. Takai brings his more than 20 ... evaluation studies in the field of education to the ...
Cached Biology Technology:deCODE Announces Transfer of the Listing of its Common Stock from Nasdaq Global Market to Nasdaq Capital Market 2deCODE Announces Transfer of the Listing of its Common Stock from Nasdaq Global Market to Nasdaq Capital Market 3Genomic Health Announces Fourth Quarter and Year-End 2008 Financial Results and Business Progress, Provides 2009 Financial Guidance 2Genomic Health Announces Fourth Quarter and Year-End 2008 Financial Results and Business Progress, Provides 2009 Financial Guidance 3Genomic Health Announces Fourth Quarter and Year-End 2008 Financial Results and Business Progress, Provides 2009 Financial Guidance 4Genomic Health Announces Fourth Quarter and Year-End 2008 Financial Results and Business Progress, Provides 2009 Financial Guidance 5Genomic Health Announces Fourth Quarter and Year-End 2008 Financial Results and Business Progress, Provides 2009 Financial Guidance 6Genomic Health Announces Fourth Quarter and Year-End 2008 Financial Results and Business Progress, Provides 2009 Financial Guidance 7Genomic Health Announces Fourth Quarter and Year-End 2008 Financial Results and Business Progress, Provides 2009 Financial Guidance 8Genomic Health Announces Fourth Quarter and Year-End 2008 Financial Results and Business Progress, Provides 2009 Financial Guidance 9Dr. Ricky Takai, Expert in Designing and Managing Federal Evaluation Studies in Education, Joins Abt Associates 2
... For nucleofection of optimized cell lines in ... the nucleofection parameters. Nucleofector Kits are only ... Different cell lines can be transfected with ... are given in brackets in percent (Efficiency ...
... Human Pathogenic Viruses The National ... preserves well characterised, authenticated human ... facility, and NCPV is able ... nucleic acids derived from them, ...
B-FABP (FL-132)...
... a highly purified preparation of the catalytic ... which recognizes the identical cleavage site as ... enzymatic activity (1). Novagen&'s enzyme is produced ... the highest activity available, and is qualified ...
Biology Products: