Navigation Links
Gene variant increases breast cancer risk
Date:3/14/2008

This release is available in German.

In roughly five to ten percent of breast cancer cases there is a family history of breast cancer i.e., hereditary and, thus, genetic factors play a role here. Alterations in the genes known as BRCAI and BRCAII are a major cause of familial breast cancer these are responsible for roughly 25 percent of such cases.

In Germany, 75 percent of familial breast cancers are not attributable to mutations in BRCAI and BRCAII. We assume that these cancers are caused in part by rare mutations and in part by unfavorable combinations of risk variants in various genes, which, on their own, have only little effect. Only very few of these have been identified so far we are searching for the other ones, said Associate Professor Dr. Barbara Burwinkel of the DKFZ.

Members of the AKAP protein family are responsible for transmitting important signals in a cell. Scientists have suspected these proteins to be involved in cancer development. A large international study headed by Barbara Burwinkel has now delivered proof that this is true for breast cancer.

In collaboration with the German Consortium for Familial Breast and Ovarian Cancers, the research team studied six gene variants in the AKAP family. Two of these, both located on the AKAP9 gene, have indeed been found to be associated with an increased breast cancer risk. Since the two gene variants are always inherited together, further investigations will have to determine whether one of these or both variants in combination are responsible for the risk effect. This finding was confirmed by a large international study in collaboration with researchers from Germany, the United Kingdom, the U.S.A. and Australia. The study included 9,523 breast cancer patients including 2,795 familial breast cancer cases and almost 14,000 healthy women.

For women carrying the
'/>"/>

Contact: Dr. Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
49-622-142-2843
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. New genetic variants associated with lipid levels, risk for coronary artery disease
2. Scientists associate 6 new genetic variants with heart disease risk factor
3. Genetic variant predicts antipsychotic response for schizophrenia patients by ethnicity
4. Breastfeeding boost IQ in infants with helpful genetic variant
5. New genetic variant associated with prostate cancer in African-Americans
6. Genetic variant linked to odor perception
7. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
8. Washington University increases fleet of Roche Genome Sequencer FLX Systems
9. Varying prevalence among ethnic groups of gene mutation that increases risk of breast cancer
10. New study increases concerns about climate model reliability
11. Waterborne carbon increases threat of environmental mercury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... -- The routine use of a molecular testing ... of performing the correct initial surgery for patients ... the University of Pittsburgh Cancer Institute (UPCI), partner ... UPMC/UPCI Multidisciplinary Thyroid Center and other diagnostic testing ... correct initial surgery by 30 percent, according to ...
(Date:7/25/2014)... 2014 Biometrics industry expands and ... digital technology for online & commerce payments while seeking ... GOOG ), LifeLock Inc. (NYSE: ... Apple Inc. (NASDAQ: AAPL ) and Fortinet ... a biometric authentication company focused on the growing m-commerce ...
(Date:7/24/2014)... leads to conflict among people around the world, a ... Health & Ecosystems: Analysis of Linkages (HEAL) Program Director ... tackle global biodiversity decline. , The harvest of wild ... and provides protein for more than a billion of ... that today,s unprecedented loss of wildlife, is bringing with ...
Breaking Biology News(10 mins):Test increases odds of correct surgery for thyroid cancer patients 2Test increases odds of correct surgery for thyroid cancer patients 3Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 2Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 3Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 4Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 5Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 6New study draws links between wildlife loss and social conflicts 2
... CORVALLIS, Ore. Researchers at Oregon State University for the ... overfishing and nitrate pollution can help destroy coral reefs ... bring with it unwanted pathogens, choke off oxygen and disrupt ... big enough to essentially smother corals. They can get out ...
... who take the time to read food labels are ... from a recently released study authored by Steven T. ... of Agriculture,s Department of Agricultural and Resource Economics, in ... Compostela in Spain, the University of Arkansas and the ...
... press release is available in Spanish . ... Development, NEIKER-Tecnalia, and the National Institute of Agricultural Research in ... of ,black dead arm, (BDA) on grapevine leaves are, in ... and BDA are diseases that affect the trunk of ...
Cached Biology News:The 'slippery slope to slime': Overgrown algae causing coral reef declines 2NEIKER and INRA discover that BDA symptoms in grapevine leaves are a sign of esca 2
(Date:7/25/2014)... , July 25, 2014 /PRNewswire-iReach/ -- Xybion ... consulting for global corporations operating in highly regulated ... its first annual Global User Group Conference, Xybion ... Philadelphia, Pennsylvania at the ... http://photos.prnewswire.com/prnh/20140724/130263 This year,s ...
(Date:7/24/2014)... Gain recognition for leadership and ... the biotech industry. Nominations are now being accepted ... you by the Bio Supply Management Alliance ... management professionals for the past 7 years. , ... Biotech industry – Manufacturers, Service Providers, Material Suppliers, ...
(Date:7/24/2014)... A research team led by group leader Yung-Eun ... technology to synthesize sulfur-doped and nitrogen-doped graphenes which ... secondary batteries and fuel cells. Yung-Eun Sung is ... Nanoparticle Research at Institute for Basic Science* (IBS) ... , This achievement has great significance with regards ...
(Date:7/24/2014)... July 24, 2014 Research and Markets ... Genomics and Proteomics Analytical Instruments Market 2014-2018" report ... Genomics is the study of the ... of the structure and functions of proteomes or sets ... and technology. Genomics involves the mapping of genes and ...
Breaking Biology Technology:Xybion Announces It Will Host International User Conference in Philadelphia 2Xybion Announces It Will Host International User Conference in Philadelphia 3Call for Submission: BSMA’s Supply Chain Management Innovation Awards 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 3Global Genomics and Proteomics Analytical Instruments Market 2014-2018: Key Vendors are Agilent, Bio-Rad , F. Hoffmann, La Roche, Illumina, PerkinElmer and Thermo Fisher Scientific 2
... 4, 2011   Creabilis SA, ... in dermatology, inflammation and pain, announces today that Dr David ... Roblin has gained extensive experience in the pharmaceutical industry in ... seen him deliver several drugs to the market. He has ...
... a molecule famous for storing the genetic blueprints for ... In a new paper,* researchers at the National Institute ... strands of DNA can be used to purify the ... wall carbon nanotubes are needed to make "quantum wires" ...
... 3, 2011 Dr. David Samadi, Vice Chairman, Department ... Surgery at The Mount Sinai Medical Center, welcomed 130 ... robotic prostatectomy procedure. National Youth Leadership ... be part of their ten-day residential program for exceptional ...
Cached Biology Technology:Creabilis Appoints Dr David Roblin as Chief Medical Officer 2Creabilis Appoints Dr David Roblin as Chief Medical Officer 3Armchair science: DNA strands that select nanotubes are first step to a practical 'quantum wire' 2Live Robotic Prostate Surgery Performed for Nation's Youth 2Live Robotic Prostate Surgery Performed for Nation's Youth 3
Rabbit polyclonal to ErbB 2 (phospho Y1248) ( Abpromise for all tested applications). entrezGeneID: 2064 SwissProtID: P04626...
The Microseal 384 plate positioner ensures precise positioning of Microseal 384-well plates in the x-, y-, and z-dimensions, for accurate automated liquid handling....
... This thin foil heat sealing material ... pressure from a screw down heated ... is a useful method for sample ... over the existing seal. Ideal for ...
... DS-U2 camera controller is the successor to the ... interface any of the cameras in the Nikon ... a USB2.0 interface. The DS-U2 transmits information at ... by equipping both hub and mass storage USB ...
Biology Products: