Navigation Links
Gene variant increases breast cancer risk
Date:3/14/2008

This release is available in German.

In roughly five to ten percent of breast cancer cases there is a family history of breast cancer i.e., hereditary and, thus, genetic factors play a role here. Alterations in the genes known as BRCAI and BRCAII are a major cause of familial breast cancer these are responsible for roughly 25 percent of such cases.

In Germany, 75 percent of familial breast cancers are not attributable to mutations in BRCAI and BRCAII. We assume that these cancers are caused in part by rare mutations and in part by unfavorable combinations of risk variants in various genes, which, on their own, have only little effect. Only very few of these have been identified so far we are searching for the other ones, said Associate Professor Dr. Barbara Burwinkel of the DKFZ.

Members of the AKAP protein family are responsible for transmitting important signals in a cell. Scientists have suspected these proteins to be involved in cancer development. A large international study headed by Barbara Burwinkel has now delivered proof that this is true for breast cancer.

In collaboration with the German Consortium for Familial Breast and Ovarian Cancers, the research team studied six gene variants in the AKAP family. Two of these, both located on the AKAP9 gene, have indeed been found to be associated with an increased breast cancer risk. Since the two gene variants are always inherited together, further investigations will have to determine whether one of these or both variants in combination are responsible for the risk effect. This finding was confirmed by a large international study in collaboration with researchers from Germany, the United Kingdom, the U.S.A. and Australia. The study included 9,523 breast cancer patients including 2,795 familial breast cancer cases and almost 14,000 healthy women.

For women carrying the
'/>"/>

Contact: Dr. Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
49-622-142-2843
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. New genetic variants associated with lipid levels, risk for coronary artery disease
2. Scientists associate 6 new genetic variants with heart disease risk factor
3. Genetic variant predicts antipsychotic response for schizophrenia patients by ethnicity
4. Breastfeeding boost IQ in infants with helpful genetic variant
5. New genetic variant associated with prostate cancer in African-Americans
6. Genetic variant linked to odor perception
7. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
8. Washington University increases fleet of Roche Genome Sequencer FLX Systems
9. Varying prevalence among ethnic groups of gene mutation that increases risk of breast cancer
10. New study increases concerns about climate model reliability
11. Waterborne carbon increases threat of environmental mercury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... Huntington Memorial Hospital is the first facility ... miniaturized, wireless monitoring sensor to manage heart failure (HF). ... FDA-approved heart failure monitoring device that has been proven ... to manage heart failure. The CardioMEMS HF ... pulmonary artery (PA) during a non-surgical procedure to directly ...
(Date:4/17/2015)... Increasing adoption in ... to drive biometric systems market in ... According to a recently released TechSci Research ... biometric systems market in Saudi Arabia ... CAGR of over 22% through 2020. The market ...
(Date:4/14/2015)... OXFORD, Conn. , April 14, 2015 ... "Company"), a biometric authentication company focused on the growing ... has been nominated for the 2015 New York Design ... The Design100, New York City Design Awards are ... are based on over 2,500 ratings from the marketplace, ...
Breaking Biology News(10 mins):Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3
... Amsterdam, 2 November, 2010 - An investigation conducted in the ... Relevance to Humans, Animals and Ecosystems, demonstrates for the first ... is widespread. In the course of the Summer ... was sampled by mothers who had given birth at the ...
... School meal programs play a significant role in ... comprehensive school nutrition services that improve children,s nutritional ... updated joint position paper from the Society for ... the School Nutrition Association (SNA). The updated ...
... NEW YORK, Nov. 2, 2010 The Online Publishers Association ... Effectiveness of the OPA Ad Unit," that found that 90 ... 10 seconds of being on a webpage and users who ... were as emotionally engaged with the advertising as with the ...
Cached Biology News:Exposure of humans to cosmetic UV filters is widespread 2Exposure of humans to cosmetic UV filters is widespread 3Comprehensive nutrition services vital to children's health 2Online Publishers Association Unveils Biometric and Eye Tracking Research to Assess the Effectiveness of New OPA Ad Units 2Online Publishers Association Unveils Biometric and Eye Tracking Research to Assess the Effectiveness of New OPA Ad Units 3
(Date:4/22/2015)... , April 22, 2015  Sangamo BioSciences, Inc. (NASDAQ: ... financial results and accomplishments. For the first ... net loss of $5.3 million, or $0.08 per share, ... $0.12 per share, for the same period in 2014. ... cash equivalents, marketable securities and interest receivable of $226.1 ...
(Date:4/22/2015)... --  MPIRICA Health Inc. , a healthcare quality ... financing from the McQuinn Trust, an early stage, ... employer awareness of MPIRICA.com, delivering easily interpreted, outcomes-based ... hospitals. "As a patient in need ... choosing the hospital and surgeon most likely to ...
(Date:4/22/2015)... 2015 Steep Hill, the industry leader ... it has opened an investment round of $5 ...  The common stock investment round will be offered ... intended to encourage funding of small businesses by ... businesses largely relied on friends and family, venture ...
(Date:4/22/2015)... 22, 2015 Over the ... market witnessed tremendous growth primarily due to ... government support with increased nanotechnology R&D expenditure ... Customization: , http://www.marketsandmarkets.com/requestCustomization.asp?id=65048077 , In ... market is segmented on the basis of ...
Breaking Biology Technology:Sangamo BioSciences Reports First Quarter 2015 Financial Results 2Sangamo BioSciences Reports First Quarter 2015 Financial Results 3Sangamo BioSciences Reports First Quarter 2015 Financial Results 4Sangamo BioSciences Reports First Quarter 2015 Financial Results 5Sangamo BioSciences Reports First Quarter 2015 Financial Results 6Sangamo BioSciences Reports First Quarter 2015 Financial Results 7Sangamo BioSciences Reports First Quarter 2015 Financial Results 8MPIRICA Health Inc. Secures $1.6M to Promote FICO-Like Quality Scores for Surgeries 2Steep Hill Launches $5M Limited Stock Offering 2Steep Hill Launches $5M Limited Stock Offering 3Nanotechnology-based Medical Devices Market to Reach Around $8.5 billion by 2019 - Published by MarketsandMarkets 2Nanotechnology-based Medical Devices Market to Reach Around $8.5 billion by 2019 - Published by MarketsandMarkets 3
... ... Addressing Dynamic Needs of Growing World , ... Wilmington, DE (Vocus) July 9, 2010 -- The world’s population ... than 12 years -- with more than 9 billion people expected on earth before ...
... ... be present at the Process Expo 2010 in Chicago from July 18 ... designing and manufacturing of industrial wastewater treatment systems for the food processing ... technology and that FRC is a major well-known and respected DAF (Dissolved ...
... from microelectronics to power lines because of their ballistic ... those electrons in their tracks? Rice physicist Junichiro ... effect -- the interaction between electrically charged particles and ... nanotubes. While doing so, they came to the ...
Cached Biology Technology:United Nations' World Population Day Calls Attention to Key Global Issues 2United Nations' World Population Day Calls Attention to Key Global Issues 3United Nations' World Population Day Calls Attention to Key Global Issues 4United Nations' World Population Day Calls Attention to Key Global Issues 5FRC Systems International State-of-the-art Industrial Wastewater Treatment Systems 2FRC Systems International State-of-the-art Industrial Wastewater Treatment Systems 3Magnets trump metallics 2
Rabbit polyclonal antibody to NCOA2 [Agarose Immobilized]...
... and low background ,This solution greatly enhances ... higher than obtained with conventional methods. ,Two ... and secondary antibodies, which can suppress the ... , Wide versatility ,It is applicable to ...
Mouse Anti-Human Killer Cell Immunoglobulin-like Receptor, Two Domains, Long Cytoplasmic Tail, 2 (KIR2DL2 (KIR2DL3 Monoclonal Antibody Family: Immunoglobulin Sub-Family: not assigned-Immunogl...
pH-dependent fluorescence; Maximum intensity observed in basic solutions....
Biology Products: