Navigation Links
Gene variant increases breast cancer risk
Date:3/14/2008

This release is available in German.

In roughly five to ten percent of breast cancer cases there is a family history of breast cancer i.e., hereditary and, thus, genetic factors play a role here. Alterations in the genes known as BRCAI and BRCAII are a major cause of familial breast cancer these are responsible for roughly 25 percent of such cases.

In Germany, 75 percent of familial breast cancers are not attributable to mutations in BRCAI and BRCAII. We assume that these cancers are caused in part by rare mutations and in part by unfavorable combinations of risk variants in various genes, which, on their own, have only little effect. Only very few of these have been identified so far we are searching for the other ones, said Associate Professor Dr. Barbara Burwinkel of the DKFZ.

Members of the AKAP protein family are responsible for transmitting important signals in a cell. Scientists have suspected these proteins to be involved in cancer development. A large international study headed by Barbara Burwinkel has now delivered proof that this is true for breast cancer.

In collaboration with the German Consortium for Familial Breast and Ovarian Cancers, the research team studied six gene variants in the AKAP family. Two of these, both located on the AKAP9 gene, have indeed been found to be associated with an increased breast cancer risk. Since the two gene variants are always inherited together, further investigations will have to determine whether one of these or both variants in combination are responsible for the risk effect. This finding was confirmed by a large international study in collaboration with researchers from Germany, the United Kingdom, the U.S.A. and Australia. The study included 9,523 breast cancer patients including 2,795 familial breast cancer cases and almost 14,000 healthy women.

For women carrying the
'/>"/>

Contact: Dr. Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
49-622-142-2843
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. New genetic variants associated with lipid levels, risk for coronary artery disease
2. Scientists associate 6 new genetic variants with heart disease risk factor
3. Genetic variant predicts antipsychotic response for schizophrenia patients by ethnicity
4. Breastfeeding boost IQ in infants with helpful genetic variant
5. New genetic variant associated with prostate cancer in African-Americans
6. Genetic variant linked to odor perception
7. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
8. Washington University increases fleet of Roche Genome Sequencer FLX Systems
9. Varying prevalence among ethnic groups of gene mutation that increases risk of breast cancer
10. New study increases concerns about climate model reliability
11. Waterborne carbon increases threat of environmental mercury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... , Nov. 18, 2014  The Secure Identity ... Association today jointly announce the formation of The ... of its Identity and Biometric Entry and ... Framework received official support from BORDERPOL, the international ... improve and provide expertise regarding border security, traveler ...
(Date:11/12/2014)... Fla. , Nov. 12, 2014 Crossmatch™, ... today that its U.are.U ® fingerprint readers have ... chain in Central Mexico . The ... 2014 to eliminate payroll issues caused by employees clocking ... installing the U.are.U fingerprint readers, Montparnasse relied on paper ...
(Date:11/7/2014)... November 6, 2014 Leading Biometric companies ... mobile security revolutionizing online transactions.  Companies in focus today are: ... (NYSE: BABA ), Google Inc. (NASDAQ: ... Inc. (NASDAQ: EBAY ) and MasterCard Inc. (NYSE: ... and NXTDW), a biometric authentication company focused on the growing ...
Breaking Biology News(10 mins):Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6
... it is all about watching the kid nearest to you ... the mathematics department at Uppsala University, together with biologists at ... traveling in small shoals. Some of the most mesmerizing ... motion of fish schools and shoals. In the ocean, ...
... , Lake ApopkaFlorida,s third largestwas once a haven for ... toxic broth of chemicals and ranks among America,s more ... his colleagues from the Biodesign Institute at Arizona State ... Gainesville, are testing a new device, designed to measure ...
... MADevelopmental biologist Eric H. Davidson, a longtime affiliate of ... prestigious 2011 International Prize for Biology from The Japan ... be honored for his work on gene regulation in ... Academy in Tokyo on November 28 in the presence ...
Cached Biology News:Fish follow the rules to school 2Troubled waters: New device brings flexibility, precision to contamination measurement 2Troubled waters: New device brings flexibility, precision to contamination measurement 3Troubled waters: New device brings flexibility, precision to contamination measurement 4Marine Biological Laboratory Course Director Eric Davidson awarded International Prize for Biology 2
(Date:11/21/2014)... , Nov. 20, 2014 Polaris Group ... dosed in its Phase 1 trial of ADI-PEG ... the treatment of malignant pleural mesothelioma (MPM) and ... conducting clinical trials on ADI-PEG 20, both as ... the treatment of several other indications, including breast ...
(Date:11/18/2014)... 17, 2014 RPS Diagnostics (RPS®) ... – today announces its third annual partnership of ... Get Smart About Antibiotics Week from November 17-23. ... national campaign designed to highlight the coordinated efforts ... non-profit and for-profit partners to provide education about ...
(Date:11/18/2014)... 18, 2014 American Process Inc. ... formed a partnership with researchers at Georgia Institute ... Technology, and the USDA’s Forest Products Laboratory to ... nanocellulose. Nanocellulose is a rapidly emerging high performance ... project is to replace heavy steel structures within ...
(Date:11/18/2014)... PARK, Calif. , Nov. 18, 2014 /PRNewswire/ ... biotechnology company in the emerging field of regenerative ... program, AST-OPC1 (oligodendrocyte progenitor cells) for complete cervical ... one of ten "Top Advanced Therapies Projects to ... are delighted to receive this significant industry honor, ...
Breaking Biology Technology:Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI-PEG 20 plus Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma And Non-Squamous Non-Small Cell Lung Carcinoma 2RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 2RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 3American Process Inc. Announces Partnership to Develop Ultra-Strong, Lightweight Automotive Components Using Nanotechnology from Nature 2American Process Inc. Announces Partnership to Develop Ultra-Strong, Lightweight Automotive Components Using Nanotechnology from Nature 3Asterias Biotherapeutics Named as a "Top Advanced Therapies Projects to Watch" and Will Present at the Therapeutic Area Partnerships Conference 2Asterias Biotherapeutics Named as a "Top Advanced Therapies Projects to Watch" and Will Present at the Therapeutic Area Partnerships Conference 3
... if on cue, fluffy snow fell over Pittsburgh as I returned ... are upon us and gift giving cannot be far away. This ... the giving. Here are a few of my favorites. , , ... DEMOmobile in September and shipping this week, the Mirra Personal Server ...
... Having customers, employees, vendors and partners feel good about ... Laurie Benson, CEO and co-founder of Inacom Information ... solutions reseller. , ,Benson and Inacom were recently recognized ... , for the second year in a row. According ...
... WAUKESHA, Wis. - According to the American Cancer Society, ... kind of cancer in their lifetime. In an effort ... against cancer, GE Medical Systems has developed innovative medical ... diagnose and treat this deadly disease. , ,The ...
Cached Biology Technology:Holiday Tech Gizmo's to Give and Get 2Inacoms Benson Receives Top Industry Recognition 2Inacoms Benson Receives Top Industry Recognition 3GE Medicals Technologies Aid Battle Against Cancer 2GE Medicals Technologies Aid Battle Against Cancer 3
Alexa Fluor 647 anti-mouse Qa-2...
... 100 IS System is ideal for developing ... reagents. This system contains the new, improved, ... Luminex. The user can design specific templates ... system has fully integrated graphing and data ...
Mouse monoclonal [0.T.81] to Lac1 ( Abpromise for all tested applications). Antigen: Recombinant TrpE fusion protein containing full length E. coli Lac1....
... Sweep- based acquision and analysis ... response type applications. Contains powerful ... flexible analysis functions including automated ... plotting. Also includes many electrophysiology ...
Biology Products: