Navigation Links
Gene transduction inhibits post-epileptic hippocampal synaptic reconstruction
Date:7/25/2013

Synaptic remodeling is one of the most common pathological changes after epileptic seizures. Ectopic synaptic reconstruction in the hippocampus is considered to be closely related with temporal lobe epilepsy. Mossy fiber sprouting may trigger synaptic connections or synaptic remodeling in hippocampal CA3 pyramidal cells, which could lead to the formation of excitatory synaptic circuits, thereby increasing epileptic susceptibility. Exogenous neuropeptide Y has antiepileptic effects; however, the underlying mechanism and optimal administration method for neuropeptide Y are still unresolved. Previous studies have used intracerebroventricular injection of neuropeptide Y into animal models of epilepsy. Dr. Fan Zhang and team from Hebei Medical University published a relevant study in the Neural Regeneration Research (Vol. 8, No. 17, 2013) entitled "Neuropeptide Y gene transfection inhibits post-epileptic hippocampal synaptic reconstruction". These researchers found that after intracerebroventricular injection of neuropeptide Y gene, mossy fiber sprouting in the hippocampal CA3 region of epileptic rats was significantly suppressed, hippocampal synaptophysin (p38) mRNA and protein expression were inhibited, and epileptic seizures were reduced. These findings suggest that a recombinant adeno-associated virus expression vector carrying the neuropeptide Y gene reduces mossy fiber sprouting and inhibits abnormal synaptophysin expression, thereby suppressing post-epileptic synaptic reconstruction.


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert

Page: 1

Related biology news :

1. FASEB SRC announces conference registration open for: Signal Transduction in the Immune System
2. New agent inhibits HCV replication in mouse models -- No resistance seen
3. Molecule found that inhibits estrogen, key risk factor for endometrial and breast cancers
4. Study finds Western diet detrimental to fetal hippocampal tissue transplants
5. BUSM researchers identify genes that influence hippocampal volume
6. Carnegie Mellon neuroscientists discover new phase of synaptic development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/6/2014)... TALLAHASSEE, Fla. -- A groundbreaking paper from a team ... better understanding of how plants could adapt to and ... The research, published in the latest issue of the ... how chromatin (the complex of DNA and proteins) is ... material, so that some genes are turned on and ...
(Date:11/6/2014)... Baltimore, MD, November 6, 2014 - Insilico Medicine, ... in aging and age related diseases announced a ... medicine of cancer, Champions Oncology, Inc (OTC: CSBR). ... genomics for personalized medicine, but Champions Oncology,s TumorGraft ... can validate the chemotherapy regimen experimentally generating vast ...
(Date:11/5/2014)... Rio de Janeiro, Brazil -Individuals show great diversity in ... importantly, males and females greatly differ in their perceptual ... kinds of smell tests. , Sex differences ... social behaviors and may be connected to one,s perception ... and emotions. Thus, women,s olfactory superiority has been suggested ...
Breaking Biology News(10 mins):Maize analysis yields whole new world of genetic science 2Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2The female nose always knows: Do women have more olfactory neurons? 2
... EUREKA Chairmanship 2009/2010! The conference, hosted and conceptually designed ... be held on July 6-7, 2009, at Maritim Hotel ... heart of the city, only a few steps away ... the current and future opportunities and challenges for Europe,s ...
... used by millions worldwide to effectively lower blood cholesterol ... Sclerosis (MS) patients treated with high daily dosages. ... Institute (MNI), McGill University, demonstrates that statin therapy in ... nervous system. The findings, published in The American ...
... to model in mice because their symptoms are complex ... when transferred to a mouse. The lack of animal ... By strategically altering a protein-making molecule, a mouse was ... feeling and cause paralysis of the arms and legs ...
Cached Biology News:One size does not fit all 2A new mouse model provides insight into genetic neurological disorders 2
(Date:11/18/2014)... SAN BRUNO, Calif. , Nov. 18, 2014 ... is a platinum sponsor of the 10th Annual World Stem ... and regenerative medicine stakeholders. The 2014 World Stem Cell Summit ... San Antonio, Texas . ... the discovery and development of lifesaving cures and therapies, convening ...
(Date:11/18/2014)... Athena Signature Series: Turning Cancer ‘Off’ – ... a professor in the Regulatory Biology Laboratory at the Salk ... points to an “off switch” for drug resistance in cancer. ... local research is making a global impact in the fight ... join host Cheryl K. Goodman, CEO of Social Global Mobile ...
(Date:11/18/2014)... Texas (PRWEB) November 18, 2014 ... Polytetrahydrofuran (PTMEG) Industry is professional and in-depth ... gives Polytetrahydrofuran basic information, including its definition, ... also industry outline. This exploration covers the ... and worldwide industry examination covering macroeconomic environment ...
(Date:11/18/2014)... 2014  Great Basin Scientific, Inc. (NASDAQ: GBSN ... will host a conference call and webcast to provide an ... Nov. 20, at 4:30 pm EST time. "We ... Company,s recent IPO and would like to provide our investors ... Ryan Ashton , President and Chief Executive Officer of Great ...
Breaking Biology Technology:Cord Blood Registry Sponsors 2014 World Stem Cell Summit 2Cord Blood Registry Sponsors 2014 World Stem Cell Summit 3PTMEG Market: 2019 Global Polytetrahydrofuran Industry Development Trends & Analysis Now at DeepResearchReports.com 2PTMEG Market: 2019 Global Polytetrahydrofuran Industry Development Trends & Analysis Now at DeepResearchReports.com 3Great Basin Scientific Announces Conference Call to Provide Update on Corporate Progress 2
... Ambulance Established in Monterrey, MONTERREY, Mexico, and ... Sangui BioTech GmbH,executives jointly opened another wound management ... occasion of a three day working visit. Sangui,BioTech ... Renate Pentzien discussed the next steps of the ...
... approach to a more effective sunscreen , Chronic ... developing skin cancer because UV light from the sun can ... grow in an uncontrolled manner. Hope for a new sunscreen ... been provided by a new study in a mouse model ...
... WALTHAM, Mass., Dec. 3 Thermo Fisher,Scientific Inc. (NYSE: ... today,announced that the China Doping Control Center (CDCC) has ... instrumentation and software for,the testing of athletes at the ... by the Chinese government and the International Olympic,Committee (IOC) ...
Cached Biology Technology:Sangui Partnership Enters a New Phase: 2Sangui Partnership Enters a New Phase: 3Sangui Partnership Enters a New Phase: 4JCI table of contents: Dec. 3, 2007 2JCI table of contents: Dec. 3, 2007 3JCI table of contents: Dec. 3, 2007 4JCI table of contents: Dec. 3, 2007 5JCI table of contents: Dec. 3, 2007 6JCI table of contents: Dec. 3, 2007 7JCI table of contents: Dec. 3, 2007 8JCI table of contents: Dec. 3, 2007 9JCI table of contents: Dec. 3, 2007 10JCI table of contents: Dec. 3, 2007 11JCI table of contents: Dec. 3, 2007 12JCI table of contents: Dec. 3, 2007 13Thermo Fisher Scientific Selected by China Doping Control Center to Supply Testing Instrumentation for the 2008 Olympic Games in Beijing 2Thermo Fisher Scientific Selected by China Doping Control Center to Supply Testing Instrumentation for the 2008 Olympic Games in Beijing 3Thermo Fisher Scientific Selected by China Doping Control Center to Supply Testing Instrumentation for the 2008 Olympic Games in Beijing 4
Alexa Fluor 647 anti-mouse Qa-2...
... 100 IS System is ideal for developing ... reagents. This system contains the new, improved, ... Luminex. The user can design specific templates ... system has fully integrated graphing and data ...
Mouse monoclonal [0.T.81] to Lac1 ( Abpromise for all tested applications). Antigen: Recombinant TrpE fusion protein containing full length E. coli Lac1....
... Sweep- based acquision and analysis ... response type applications. Contains powerful ... flexible analysis functions including automated ... plotting. Also includes many electrophysiology ...
Biology Products: