Navigation Links
Gene therapy reprograms scar tissue in damaged hearts into healthy heart muscle
Date:1/4/2013

NEW YORK (Jan. 4, 2013) -- A cocktail of three specific genes can reprogram cells in the scars caused by heart attacks into functioning muscle cells, and the addition of a gene that stimulates the growth of blood vessels enhances that effect, said researchers from Weill Cornell Medical College, Baylor College of Medicine and Stony Brook University Medical Center in a report that appears online in the Journal of the American Heart Association.

"The idea of reprogramming scar tissue in the heart into functioning heart muscle was exciting," said Dr. Todd K. Rosengart, chair of the Michael E. DeBakey Department of Surgery at BCM and the report's corresponding author. "The theory is that if you have a big heart attack, your doctor can just inject these three genes into the scar tissue during surgery and change it back into heart muscle. However, in these animal studies, we found that even the effect is enhanced when combined with the VEGF gene."

"This experiment is a proof of principle," said Dr. Ronald G. Crystal, chairman and professor of genetic medicine at Weill Cornell Medical College and a pioneer in gene therapy, who played an important role in the research. "Now we need to go further to understand the activity of these genes and determine if they are effective in even larger hearts."

During a heart attack, blood supply is cut off to the heart, resulting in the death of heart muscle. The damage leaves behind a scar and a much weakened heart. Eventually, most people who have had serious heart attacks will develop heart failure.

Changing the scar into heart muscle would strengthen the heart. To accomplish this, during surgery, Rosengart and his colleagues transferred three forms of the vascular endothelial growth factor (VEGF) gene that enhances blood vessel growth or an inactive material (both attached to a gene vector) into the hearts of rats. Three weeks later, the rats received either Gata4, Mef 2c and Tbx5 (the
'/>"/>

Contact: Lauren Woods
Law2014@med.cornell.edu
646-317-7401
Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New whole plant therapy shows promise as an effective and economical treatment for malaria
2. Transplanted genetically-modified adipose cells offer potential therapy for liver diseases
3. Serendipity points to new potential target and therapy for melanoma
4. MicroRNAs present exciting opportunities for cancer therapy and diagnosis
5. Alzheimers disease: Cutting off immune response promises new approach to therapy
6. Potential gene therapy approach to sickle cell disease highlighted at ASH
7. Predictors of cancer disease progression improve patient selection for metastasis-directed therapy
8. Leukemia patients remain in remission more than 2 years after engineered T cell therapy
9. Another muscular dystrophy mystery solved; MU scientists inch closer to a therapy for patients
10. New technique to deliver stem cell therapy may help damaged eyes regain their sight
11. Research shows immune system response is detrimental to novel brain cancer therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Research and Markets ( http://www.researchandmarkets.com/research/4trb7t/biometrics_a ) has announced ... Overview" report to their offering. , ... an individual is who she/he is claiming to be, and ... person,s unique physical characteristics, such as fingerprint, hand or palm ...
(Date:1/22/2015)... Jan. 13, 2015 /PRNewswire/ - Today, FindBiometrics, the leading source of ... of its new website design. "When we launched ... says Peter O,Neill , founder and CEO of FindBiometrics. ... needs involvement from the key players on a very broad ...
(Date:1/22/2015)... Hall E -   EyeLock Inc. , a market leader ... its EyeLock ID technology integrated in a 3D printed automobile ... Ridge National Laboratory (ORNL) at the 2015 North ... is being used to validate the driver and authorize the ...
Breaking Biology News(10 mins):Biometrics - A Global Market Overview 2Biometrics - A Global Market Overview 3Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3
... In the first field trial of plants genetically tweaked ... plants handily beat out their wild-type counterparts. The results ... alternative for cleaning up polluted soil. , The new ... Science and Technology, show that three transgenic lines of ...
... Hotspots Revisited identifies 34 regions worldwide where 75 percent ... survive within habitat covering just 2.3 percent of the ... the five largest U.S. states). This habitat originally covered ... in size to Russia and Australia combined. The new ...
... novel bio-bar-code amplification (BCA) technology, researchers analyzing fluid from ... protein linked in recent studies to Alzheimer's disease. , ... : , - Gold nanoparticles and bio-bar codes ... Codes for the Ultrasensitive Detection of Proteins ,- ...
Cached Biology News:Transgenic plants remove more selenium from polluted soil than wild plants, new tests show 2Transgenic plants remove more selenium from polluted soil than wild plants, new tests show 3Transgenic plants remove more selenium from polluted soil than wild plants, new tests show 4Biodiversity hotspots identify conservation priorities 2Biodiversity hotspots identify conservation priorities 3Biodiversity hotspots identify conservation priorities 4Biodiversity hotspots identify conservation priorities 5Nanoscale Diagnostic Sets Sights on Alzheimer's 2Nanoscale Diagnostic Sets Sights on Alzheimer's 3
(Date:3/5/2015)... TORONTO , March 5, 2015 /PRNewswire/ ... company developing new therapeutics and molecular diagnostics that target ... William G. Rice , Ph.D., Chairman, President and Chief ... ROTH Conference on Tuesday, March 10 th at ... Laguna Niguel, CA. Dr. Rice will ...
(Date:3/5/2015)... DIEGO , March 5, 2015  In response ... in Miami, FL on February ... are both of strong financial health and their SUDOSCAN® ... clinical research has indicated. Furthermore, Impeto prefers to have the ... There are more than 40 articles written by ...
(Date:3/5/2015)... March 05, 2015 RMI ... and chronic orthopedic conditions such as meniscal tears, ... elbow, and joint pain due to degenerative conditions ... during orthopedic surgeries to promote better post-surgical outcomes. ... in nearly pain-free bone marrow harvesting with two ...
(Date:3/4/2015)... -- The UPMC Center for Health Security today announced ... Leaders in Biosecurity Initiative (ELBI). As part of our ... biosecurity, UPMC has selected 28 US and international emerging ... including biological science, medicine, policy, the military, think tanks ... vision and support of the Defense Threat Reduction Agency ...
Breaking Biology Technology:Aptose Biosciences to Present at the 27th Annual ROTH Conference 2Aptose Biosciences to Present at the 27th Annual ROTH Conference 3Impeto Medical Responds to Published Allegations by LD Technology LLC ("LD") 2Riordan-McKenna Institute of Regenerative Orthopedics and Stem Cell Therapy Announces Open House in Southlake, Texas on Friday, March 6th from 5:30 pm to 7:30 pm. 2Riordan-McKenna Institute of Regenerative Orthopedics and Stem Cell Therapy Announces Open House in Southlake, Texas on Friday, March 6th from 5:30 pm to 7:30 pm. 3Riordan-McKenna Institute of Regenerative Orthopedics and Stem Cell Therapy Announces Open House in Southlake, Texas on Friday, March 6th from 5:30 pm to 7:30 pm. 4Riordan-McKenna Institute of Regenerative Orthopedics and Stem Cell Therapy Announces Open House in Southlake, Texas on Friday, March 6th from 5:30 pm to 7:30 pm. 5UPMC Center for Health Security Announces 2015 Emerging Leaders in Biosecurity 2UPMC Center for Health Security Announces 2015 Emerging Leaders in Biosecurity 3
... BERKELEY, Calif., March 28 Aerovance Inc. today,announced ... financing. Oxford,Finance Corporation led the syndicate, which includes ... $10 million from the financing line,at closing. The ... of,corporate milestones., "This financing reflects continued interest ...
... Joins Investor Syndicate, VIENNA, Austria, March ... novel antibodies and antibody fragments,based on its ... it,has acquired future royalty obligations to New ... Modular Antibody Technology was originally developed by ...
... HAMBURG, Germany and OXFORD, England, March 28 /PRNewswire-FirstCall/,-- ... financial,results according to IFRS for the year ended ... year were driven by strong progress in the,Company,s ... of Neuro3d, the sale of Evotec Technologies (ET), ...
Cached Biology Technology:Antibody Engineering Company F-Star Buys Back Royalty Obligations 2Evotec Announces Financial Results for 2007 2Evotec Announces Financial Results for 2007 3Evotec Announces Financial Results for 2007 4Evotec Announces Financial Results for 2007 5Evotec Announces Financial Results for 2007 6Evotec Announces Financial Results for 2007 7Evotec Announces Financial Results for 2007 8
... is a high-quality four-place microplate shaker with ... speed is adjustable from 100 to 1350 ... a small orbit ensure effective shaking for ... quick and easy to set for 0 ...
... Ascent FL is equipped ... luminometric measurement technologies that ... of advanced features of ... Ascent. Fluoroskan Ascent FL ...
Rabbit polyclonal to STUB1 ( Abpromise for all tested applications). entrezGeneID: 10273 SwissProtID: Q9UNE7...
... stainless steel rack holders ... mechanism that permits selection ... angles, and "snap-in" product ... rack holder will accomodate ...
Biology Products: