Navigation Links
Gene therapy reprograms scar tissue in damaged hearts into healthy heart muscle
Date:1/4/2013

NEW YORK (Jan. 4, 2013) -- A cocktail of three specific genes can reprogram cells in the scars caused by heart attacks into functioning muscle cells, and the addition of a gene that stimulates the growth of blood vessels enhances that effect, said researchers from Weill Cornell Medical College, Baylor College of Medicine and Stony Brook University Medical Center in a report that appears online in the Journal of the American Heart Association.

"The idea of reprogramming scar tissue in the heart into functioning heart muscle was exciting," said Dr. Todd K. Rosengart, chair of the Michael E. DeBakey Department of Surgery at BCM and the report's corresponding author. "The theory is that if you have a big heart attack, your doctor can just inject these three genes into the scar tissue during surgery and change it back into heart muscle. However, in these animal studies, we found that even the effect is enhanced when combined with the VEGF gene."

"This experiment is a proof of principle," said Dr. Ronald G. Crystal, chairman and professor of genetic medicine at Weill Cornell Medical College and a pioneer in gene therapy, who played an important role in the research. "Now we need to go further to understand the activity of these genes and determine if they are effective in even larger hearts."

During a heart attack, blood supply is cut off to the heart, resulting in the death of heart muscle. The damage leaves behind a scar and a much weakened heart. Eventually, most people who have had serious heart attacks will develop heart failure.

Changing the scar into heart muscle would strengthen the heart. To accomplish this, during surgery, Rosengart and his colleagues transferred three forms of the vascular endothelial growth factor (VEGF) gene that enhances blood vessel growth or an inactive material (both attached to a gene vector) into the hearts of rats. Three weeks later, the rats received either Gata4, Mef 2c and Tbx5 (the
'/>"/>

Contact: Lauren Woods
Law2014@med.cornell.edu
646-317-7401
Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New whole plant therapy shows promise as an effective and economical treatment for malaria
2. Transplanted genetically-modified adipose cells offer potential therapy for liver diseases
3. Serendipity points to new potential target and therapy for melanoma
4. MicroRNAs present exciting opportunities for cancer therapy and diagnosis
5. Alzheimers disease: Cutting off immune response promises new approach to therapy
6. Potential gene therapy approach to sickle cell disease highlighted at ASH
7. Predictors of cancer disease progression improve patient selection for metastasis-directed therapy
8. Leukemia patients remain in remission more than 2 years after engineered T cell therapy
9. Another muscular dystrophy mystery solved; MU scientists inch closer to a therapy for patients
10. New technique to deliver stem cell therapy may help damaged eyes regain their sight
11. Research shows immune system response is detrimental to novel brain cancer therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... of The Proceedings of the National ... 29, raises a number of startling questions about a ... take for granted. At the end of the last ... shifted from hunting animals and gathering fruits and tubers ... straightforward and yet the more scientists learn, the more ...
(Date:4/16/2014)... TALLAHASSEE, Fla. Florida State University researchers have identified ... deterioration of bone density and muscle mass with obesity. ... heavier you were the better your bones would be ... Ilich-Ernst, the Hazel Stiebeling Professor of Nutrition at Florida ...
(Date:4/16/2014)... Kennedy,s disease, spinal and bulbar muscular atrophy (SBMA) is a ... and atrophy. Researchers have long considered it to be essentially ... the spinal cord and brainstem that control muscle movement. , ... 2014 online issue of Neuron , a team of ...
Breaking Biology News(10 mins):Genetic study tackles mystery of slow plant domestications 2Genetic study tackles mystery of slow plant domestications 3Genetic study tackles mystery of slow plant domestications 4Researchers: Obesity can amplify bone and muscle loss 2Mutant protein in muscle linked to neuromuscular disorder 2
... A new study by researchers at NYU School of Medicine ... cells, causing mutations that can lead to melanoma. ... skin to protect it from the ultraviolet rays of the ... cells because they are unable to repair themselves as efficiently. ...
... been hearing about ESA,s most recently launched mission, CryoSat-2. ... in excellent health with scientists very encouraged by the ... Duncan Wingham, Lead Investigator for the CryoSat mission, stated, ... in-orbit specifications, the ground segment software is fine, the ...
... A new study from researchers in Ottawa and Toronto ... cell may be able to help treat sepsis, a deadly ... body. The study, published in the American Journal of ... can triple survival rates in an experimental model of sepsis. ...
Cached Biology News:UVA radiation damages DNA in human melanocyte skin cells and can lead to melanoma 2CryoSat-2 exceeding expectations 2Stem-cell therapy may provide new approach to fight infection 2
(Date:1/15/2014)... Raleigh, NC (PRWEB) January 15, 2014 ... enhancement to its Online Web Portal for Life Science organizations ... ability to specify the subject matter of their documents in ... This will help reduce time-to-delivery of translations, often a critical ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider ... treatment of tinnitus. Patients listen to sound therapy that ... period of weeks to months, their tinnitus volume decreases. , ... Notched Music and Notched White Noise. Now, AudioNotch is pleased ...
(Date:1/14/2014)... 2014 Carahsoft and CDS Federal Services ... 2014 at 2pm EST (11am PST), “Natural Language Processing: ... on how technology can turn raw, heterogeneous data into ... agencies. The online webinar will last approximately one hour. ...
(Date:1/14/2014)... , Jan. 14, 2014 As pet owners drew up their ... of them wrote: "Take better care of my furry companion." Nowadays ... clothes and top-brand carrying cases to take the little canine or ... also feel compelled to buy some pricey toys at the pet ...
Breaking Biology Technology:DTS Improves Efficiency for Life Science Document Translations 2Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2
... ATLANTA, Dec. 11 WellCentive ( http://www.wellcentive.com ),today ... information technology (HIT),solutions designed to efficiently, securely and ... care providers. WellCentive Gateway allows,providers, such as ... variety of,outside HIT systems. WellCentive Connect is ...
... Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM ) today announced that ... passed away on Wednesday. Dr. Waltz had been a director ... the time of his death, Dr. Waltz served on Peregrine,s Audit ... , "The sudden loss of our business colleague ...
... - SCRIP Awards Recognises the Best and Brightest in ... - Glenmark is the Only Indian Company to ... The best and brightest of ... London at the 2008 SCRIP Awards hosted,by the leading UK broadcaster ...
Cached Biology Technology:WellCentive Launches New Health Information Exchange Platforms 2WellCentive Launches New Health Information Exchange Platforms 3Peregrine Pharmaceuticals Mourns Loss of Chairman Thomas A. Waltz 2SCRIP, the Leading Pharmaceutical Magazine in the World Crowns Glenmark as the "Best Pharma Company in the World - SME" and the "Best Company in Emerging Markets" at the SCRIP Awards 2008 in London 2
Request Info...
Mouse Limitin MAb (Clone 183727)...
Normal human serum collected off the clot from healthy normal humans. Each donor unit is negative for anti-HIV 1&2, HIV-Ag, HCV, and HBsAg by FDA required tests...
Recombinant Human HGF...
Biology Products: