Navigation Links
Gene links to anorexia found by Children's Hospital of Philadelphia researchers
Date:11/19/2010

Scientists at The Children's Hospital of Philadelphia have identified both common and rare gene variants associated with the eating disorder anorexia nervosa. In the largest genetic study of this psychiatric disorder, the researchers found intriguing clues to genes they are subjecting to further investigation, including genes active in neuronal signaling and in shaping interconnections among brain cells.

Anorexia nervosa (AN) affects an estimated 9 in 1000 women in the United States. Patients have food refusal, weight loss, an irrational fear of weight gain even when emaciated, and distorted self-image of body weight and shape.

Women are affected 10 times more frequently than men, with the disorder nearly always beginning during adolescence. AN has the highest mortality rate of all psychiatric disorders, and successful treatment is challenging.

Twin studies and other family studies have suggested that AN is strongly heritable. "However, despite various genetic studies that identified a handful of candidate genes associated with AN, the genetic architecture underlying susceptibility to AN has been largely unknown," said study leader Hakon Hakonarson, M.D., Ph.D., director of the Center for Applied Genomics at The Children's Hospital of Philadelphia. The research appeared online in Molecular Psychiatry on Nov. 16.

"This is the first genome-wide association study on a large anorexia cohort, as well as the first study of copy number variations in the disorder," said Hakonarson. Genome-wide association studies (GWAS) search for single-nucleotide polymorphisms, or SNPscommon gene variants that typically act as pointers to a gene region with a small effect on raising disease risk. The study team also performed a parallel search for copy number variations (CNVs), rarer variants that usually have a stronger impact on disease risk.

The sample size was the largest used in an AN gene studyDNA came from 1,003 AN patien
'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Research links damaged organs to change in biochemical wave patterns
2. Budding research links climate change and earlier flowering plants
3. Study links normal function of protein, not its build up inside cells, to death of neurons
4. UCI-Scripps study links cellular motors to memory
5. Sociological study links state tax credit programs to higher birth weight
6. Study links African ancestry to high-risk breast cancer
7. TGen-led studies identify genetic links to kidney disease, kidney failure
8. Scientist links increase in greenhouse gases to changes in ocean currents
9. New research links decline of endangered California delta smelt to nutrient pollution
10. UC Davis study links obesity with lowest earnings
11. Study links 1976 swine flu shot to stronger immune response to 21st century pandemic flu
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene links to anorexia found by Children's Hospital of Philadelphia researchers
(Date:7/31/2014)... people make a rational choice to be liberal or ... it a matter of genetics?, Two political scientists from ... University say that neither conscious decision-making nor parental upbringing ... lean right. , A growing body of evidence shows ... core of political differences, the researchers say in the ...
(Date:7/31/2014)... conflagration known as the Rim Fire was in full ... trees, when it entered the backcountry of Yosemite National ... But inside the park, the battle began to turn, ... and drought can combine to fuel large, severe fires. ... eventually encountered lands where fire had been used as ...
(Date:7/31/2014)... July 31, 2014 Biometrics industry ... innovative smart technologies; companies turn towards digital currency: NXT-ID, ... ), Amazon.com Inc. (NASDAQ: AMZN ), Facebook ... GOOG ) and Microsoft Corporation (NASDAQ: MSFT) ... on the growing m-commerce market, announces a video featuring ...
Breaking Biology News(10 mins):Scientists find growing consensus: Political attitudes derive from body and mind 2The Rim Fire 1 year later: A natural experiment in fire ecology and management 2The Rim Fire 1 year later: A natural experiment in fire ecology and management 3The Rim Fire 1 year later: A natural experiment in fire ecology and management 4The Rim Fire 1 year later: A natural experiment in fire ecology and management 5Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 2Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 3Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 4Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 5Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 6
... suggests that the addition of ultraviolet light to the ... double the removal of potentially infectious microorganisms from a ... say the findings suggest that incorporating the germicidal properties ... reducing allergens and pathogens from carpets, as well. ...
... Parkinson,s disease, cancer and biofuels production are just a ... in his long career of technological innovation and scientific ... Scientist of the Year for his many significant contributions ... his colleagues, Smith is currently the director of proteomics ...
... not grow on trees, but energy could grow in ... the first extensive geographic yield and economic analysis of ... Demand for biofuels is increasing as Americans seek ... of fluctuating energy prices. Corn ethanol is the main ...
Cached Biology News:UV light nearly doubles vacuum's effectiveness in reducing carpet microbes 2UV light nearly doubles vacuum's effectiveness in reducing carpet microbes 3PNNL's Richard Smith named 2010 Scientist of the Year 2Grasses have potential as alternate ethanol crop, Illinois study finds 2Grasses have potential as alternate ethanol crop, Illinois study finds 3Grasses have potential as alternate ethanol crop, Illinois study finds 4
(Date:7/31/2014)... (1912-1954), is famous for a number of breakthroughs, which ... he published a paper, which laid the foundation of ... computer algorithm. He next played a pivotal role in ... the German military codes, enabling the Allies to defeat ... late 1940,s he turned his attention to artificial intelligence ...
(Date:7/31/2014)... 2014 The SNIS Foundation recognized its ... fund a translational research project.  The first award ... was presented at the Society of NeuroInterventional Surgery ... Colorado Springs, CO. ... neurovascular conditions, SNIS formed the SNIS Foundation, in ...
(Date:7/31/2014)... July 31, 2014 North Shore Towers, a ... partnered with GI Energy, one of the nation’s leading combined ... million upgrade of its 43-year-old CHP system. The original CHP ... an effort to extend the life of the plant, GI ... associated electrical and heat recovery equipment, while maintaining continuous operation ...
(Date:7/31/2014)... Senomyx , Inc. (NASDAQ: SNMX ... technologies to discover, develop, and commercialize novel flavor ... industries, today reported financial results for the second ... with $33.6 million in cash and highly liquid ... Senomyx achieved another important milestone with the regulatory ...
Breaking Biology Technology:A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 2A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 3SNIS Foundation Bestows First Grant Award For Cutting-Edge NeuroInterventional Research 2SNIS Foundation Bestows First Grant Award For Cutting-Edge NeuroInterventional Research 3North Shore Towers Partners with GI Energy to Install Turnkey Natural Gas-Fired Combined Heat and Power Plant 2SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 2SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 3SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 4SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 5SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 6SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 7SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 8SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 9SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 10SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 11SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 12SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 13SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 14SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 15SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 16
... Mich., Sept. 9 Three companies were recently awarded a ... Michigan Pre-Seed Capital Fund, a collaborative effort of Michigan,s SmartZones ... Concepts, FreeStride and RealBio will use the funding to further ... "Helping companies reach commercialization of their technologies is a ...
... Ohio and DENVER, Colorado, September 9 ,Simbionix USA Corporation, ... professionals, today announced the appointment of Mr.,Paul Jensen as ... , Mr. Jensen is an ... products and services for a variety of,professional markets including ...
... BALTIMORE, Sept. 9 Champions Biotechnology, Inc. ... of advanced preclinical platforms and tumor specific data to enhance the ... Annual Healthcare Conference taking place September 9 - 11, 2009, at ... Dr. David Sidransky, will present on Thursday, September 10, 2009, 2:50pm ...
Cached Biology Technology:Michigan Pre-Seed Capital Fund Awards Three Micro Loans 2Simbionix USA Corporation Announces the Appointment of Mr. Paul Jensen as General Manager for its Growing eLearning and Content Business 2Champions Biotechnology to Present at Rodman & Renshaw's Eleventh Annual Healthcare Conference 2Champions Biotechnology to Present at Rodman & Renshaw's Eleventh Annual Healthcare Conference 3
Bovine Pulmonary Artery Smooth Muscle Cells (BPASMC) (>500,000 cells)...
... monoclonal [E12] to MAP1 Light Chain MAP1A ... physical interactions between microtubules and components of the ... heavy chain subunit and multiple light chain subunits. ... of the light chain subunits and can associate ...
Image Acquisition and documentation system for fluorescent and non-fluorescent gels, membranes, blots, film, plates and assays...
PC based system for advanced chemifluorescent, chemiluminescent, fluorescent and colorimetric, microarray and microscope imaging and analysis....
Biology Products: