Navigation Links
Garvan Institute receives grant to research role of long non-coding RNAs in Parkinson's disease

The Michael J. Fox Foundation for Parkinson's Research and Shake It Up Australia Foundation are co-funding a 12-month research project by Sydney's Garvan Institute of Medical Research to look at the role of long non-coding RNAs in Parkinson's disease.

Long non-coding RNAs are complex molecules, produced from a DNA blueprint, that appear to play regulatory roles in the body. Unlike conventional genes, they do not make proteins (which carry out specific functions in cells). Instead, they seem to act by dictating how and when other genes are expressed and when some already produced proteins are released into the cell.

Long non-coding RNAs have been shown to influence the development of certain diseases, and recent evidence suggests they may control human development, and be particularly important in brain plasticity and learning.

Garvan's Professor John Mattick and Associate Professor Antony Cooper will be combining their respective expertise in long non-coding RNAs and Parkinson's disease to focus on small regions of the human genome that influence susceptibility to Parkinson's disease.

Recent genome-wide association studies comparing the DNA of thousands of healthy people with the DNA of Parkinson's patients, showed regions that differed slightly.

When Cooper took a close look at one of these differing regions, he found several long non-coding RNAs that correlated strongly with disease. The current grant will allow several such regions to be examined in great detail.

Mattick and Cooper will extract RNA from the post-mortem brains of Parkinson's patients and healthy 'controls' and use a new technique called 'RNA CaptureSeq' (developed by the Mattick lab) to study regions of interest at a depth never before imagined, far less undertaken.

Commenting on the extraordinary complexity of the genome, Professor Mattick said "the deeper we drill down, the more surprises we find, and in this case we hope to uncover correlations between long non-coding RNAs and Parkinson's disease."

"Ultimately, we need much better insight into the mechanisms at work in order to find biomarkers for the disease and create better therapies for the future."

Associate Professor Antony Cooper views the process as a voyage of discovery. "It will be very informative to see what is going on in human brains at this level of magnification in healthy people as well as those who are ill," he said.

"For many years, we have been able to see that genetics plays a role in Parkinson's disease, but in 80-90% of cases the genetic connection has been very complex this project has the real potential to provide some clarity on the genetic contribution to this disease."

"It is very hard to study human brains, as you obviously can't dissect a brain while someone is alive. I am hopeful that this project will give us a new kind of window into the brain, a window opened by new technologies and the insights they allow."

The hope of all parties is that this project could ultimately lead to breakthroughs for screening and early diagnosis of Parkinson's disease as well as new therapies for patients.


Contact: Alison Heather
Garvan Institute of Medical Research

Related biology news :

1. $1.5 million NCI Grant to aid Huntsman Cancer Institute researcher study melanoma, sun damage link
2. BIDMC cardiovascular institute researchers will lead $4 million NIH grant to study micrornas
3. UTSA, Southwest Research Institute to develop low-cost method to treat fracking water
4. UTSA, Southwest Research Institute to develop drug-loaded scaffold for bone grafting
5. La Jolla Institute continues longtime collaboration with Kyowa Hakko Kirin California
6. La Jolla Institute discovers new player critical to unleashing T cells against disease
7. National Institutes of Health to fund research probing proteins linked to cancer, diabetes
8. Roy J. Carver Charitable Trust funds new research focus at Institute for Genomic Biology
9. The DOE Joint Genome Institute expands capabilities via new partnerships
10. St. Jude scientist named Howard Hughes Medical Institute investigator
11. Feinstein Institute collaborates with GSK, UPenn, MIT to research bodys electrical impulses
Post Your Comments:
(Date:6/7/2016)... 2016  Syngrafii Inc. and San Antonio Credit ... includes integrating Syngrafii,s patented LongPen™ eSignature "Wet" solution ... will result in greater convenience for SACU members ... maintaining existing document workflow and compliance requirements. ... Highlights: ...
(Date:6/2/2016)... 2, 2016 The Department of Transport ... the 44 million US Dollar project, for the , ... including Personalization, Enrolment, and IT Infrastructure , to ... production and implementation of Identity Management Solutions. Numerous renowned international ... Decatur was selected for the most compliant ...
(Date:6/2/2016)... June 2, 2016 Perimeter Surveillance ... Unmanned Systems, Physical Infrastructure, Support & Other Service  ... visiongain offers comprehensive analysis of the global ... will generate revenues of $17.98 billion in 2016. ... Inc, a leader in software and hardware technologies for ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... ... on what they believe could be a new and helpful biomarker for malignant ... Click here to read it now. , Biomarkers are components in ...
(Date:6/27/2016)... PHILADELPHIA , June 27, 2016  Liquid ... today announced the funding of a Sponsored Research ... study circulating tumor cells (CTCs) from cancer patients.  ... changes in CTC levels correlate with clinical outcomes ... therapies. These data will then be employed to ...
(Date:6/24/2016)... , ... June 24, 2016 , ... While the majority ... as the Cary 5000 and the 6000i models are higher end machines that use ... height of the spectrophotometer’s light beam from the bottom of the cuvette holder. ...
(Date:6/23/2016)... 23, 2016   Boston Biomedical , an ... designed to target cancer stemness pathways, announced that ... Orphan Drug Designation from the U.S. Food and ... cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin is ... inhibit cancer stemness pathways by targeting STAT3, and ...
Breaking Biology Technology: