Navigation Links
Garvan Institute receives grant to research role of long non-coding RNAs in Parkinson's disease
Date:10/2/2013

The Michael J. Fox Foundation for Parkinson's Research and Shake It Up Australia Foundation are co-funding a 12-month research project by Sydney's Garvan Institute of Medical Research to look at the role of long non-coding RNAs in Parkinson's disease.

Long non-coding RNAs are complex molecules, produced from a DNA blueprint, that appear to play regulatory roles in the body. Unlike conventional genes, they do not make proteins (which carry out specific functions in cells). Instead, they seem to act by dictating how and when other genes are expressed and when some already produced proteins are released into the cell.

Long non-coding RNAs have been shown to influence the development of certain diseases, and recent evidence suggests they may control human development, and be particularly important in brain plasticity and learning.

Garvan's Professor John Mattick and Associate Professor Antony Cooper will be combining their respective expertise in long non-coding RNAs and Parkinson's disease to focus on small regions of the human genome that influence susceptibility to Parkinson's disease.

Recent genome-wide association studies comparing the DNA of thousands of healthy people with the DNA of Parkinson's patients, showed regions that differed slightly.

When Cooper took a close look at one of these differing regions, he found several long non-coding RNAs that correlated strongly with disease. The current grant will allow several such regions to be examined in great detail.

Mattick and Cooper will extract RNA from the post-mortem brains of Parkinson's patients and healthy 'controls' and use a new technique called 'RNA CaptureSeq' (developed by the Mattick lab) to study regions of interest at a depth never before imagined, far less undertaken.

Commenting on the extraordinary complexity of the genome, Professor Mattick said "the deeper we drill down, the more surprises we find, and in this case we hope to u
'/>"/>

Contact: Alison Heather
a.heather@garvan.org.au
61-292-958-128
Garvan Institute of Medical Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. $1.5 million NCI Grant to aid Huntsman Cancer Institute researcher study melanoma, sun damage link
2. BIDMC cardiovascular institute researchers will lead $4 million NIH grant to study micrornas
3. UTSA, Southwest Research Institute to develop low-cost method to treat fracking water
4. UTSA, Southwest Research Institute to develop drug-loaded scaffold for bone grafting
5. La Jolla Institute continues longtime collaboration with Kyowa Hakko Kirin California
6. La Jolla Institute discovers new player critical to unleashing T cells against disease
7. National Institutes of Health to fund research probing proteins linked to cancer, diabetes
8. Roy J. Carver Charitable Trust funds new research focus at Institute for Genomic Biology
9. The DOE Joint Genome Institute expands capabilities via new partnerships
10. St. Jude scientist named Howard Hughes Medical Institute investigator
11. Feinstein Institute collaborates with GSK, UPenn, MIT to research bodys electrical impulses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... --  HOYOS Labs , a leading global authentication infrastructure ... Company will demonstrate multiple biometrics-based technologies under its identity ... on March 23 through 25, 2015, in ... IEEE Biometric Open Protocol Standard; free biometrics-based consumer app, ... system. BOPS was invented by HOYOS Labs and contributed ...
(Date:3/20/2015)... Mar. 20, 2015 Research and Markets ... of the "India Sensors Market Forecast and ... The sensor market is projected to grow ... Consumer electronics, automotive, industrial and healthcare sectors ... the country. In addition, adoption of MEMS technology ...
(Date:3/20/2015)... Markets ( http://www.researchandmarkets.com/research/vkzvcs/iris_biometrics ) has announced the addition ... report to their offering. This report analyzes ... report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... . Annual estimates and forecasts are provided for ...
Breaking Biology News(10 mins):HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5
... head-to-head comparison of "improved cookstoves" (ICs) and traditional mud ... emit more of the worrisome "black carbon," or soot, ... concerns than traditional mud stoves or open-cook fires. The ... a clean cooking technology in the developing world, appears ...
... 2012 A new lecture series at the University of Houston ... making a difference in health and medicine. The first of five ... 25 at the Hilton University of Houston. The theme ... and will focus on diabetes, obesity, heart disease and cancer. Sponsored ...
... Mass. The U.S. National Research Council this week ... in 60 countries who took part in the International ... years to offer a benchmark for environmental conditions and ... of Massachusetts Amherst geosciences researcher and expert in the ...
Cached Biology News:New UH lecture series examines impact of science on health 2NRC authors brief federal agencies on the state of polar regions 2NRC authors brief federal agencies on the state of polar regions 3
(Date:4/17/2015)... Fremont, CA (PRWEB) April 17, 2015 ... http://www.medispend.com ) for its 20 Most Promising Pharma and ... based on MMIS’s MediSpend global compliance software platform for ... companies is selected by a panel of experts and ... promote technology entrepreneurship. “MMIS’s MediSpend Platform has been on ...
(Date:4/17/2015)... April 17, 2015 Global Stem ... GTCbio Stem Cell Summit 2015 April 27 - 29, ... latest developments in all areas of stem cell research ... stem cells and regenerative medicine. , The conference ... as well as translational research in stem cell therapies, ...
(Date:4/16/2015)... OSAKA, Japan , April 16, ... (CiRA) of Kyoto University and Takeda Pharmaceutical Company ... together to develop clinical applications of induced pluripotent ... diabetes mellitus, neurological disorders and cancer immunotherapy. The ... is designed to expedite multiple research projects for ...
(Date:4/16/2015)... April 16, 2015 Proove Biosciences ... Buzz of BIO Contest for the 2015 BIO ... the 2015 BIO International Convention will take place June ... During the Buzz of BIO contest, industry leaders will ... present at the conference. The community voting period began ...
Breaking Biology Technology:MMIS Chosen by CIO Review as Top 20 Most Promising Pharma and Life Science Technology Solution Providers 2015 2Global Stem Cells Group To Join GTCbio Stem Cell and Regenerative Medicine Summit in Boston, April 27-29, 2015 2Global Stem Cells Group To Join GTCbio Stem Cell and Regenerative Medicine Summit in Boston, April 27-29, 2015 3CiRA and Takeda Enter 10-year Collaboration on iPS Cell Research 2CiRA and Takeda Enter 10-year Collaboration on iPS Cell Research 3Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 2Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 3
... 11, 2011 Ardea Biosciences, Inc. (Nasdaq: ... of small-molecule therapeutics for the treatment of serious diseases, ... full-year 2010 financial results. "With approximately $160 ... we are in an excellent financial position," commented Barry ...
... 11, 2011 BioSpecifics Technologies Corp. (Nasdaq: BSTC ... collagenase-based products, today announced its financial results for the fourth ... "2010 was an exciting year for the Company, but ... forward to sales growth of XIAFLEX® in the U.S., as ...
... How fast an intense laser pulse can change the ... Kiel University in the current edition of Nature ... Bauer, Dr. Kai Ronagel and Professor Lutz Kipp from ... colleagues from the University of Kaiserslautern and the University ...
Cached Biology Technology:Ardea Biosciences Reports Recent Accomplishments and Announces Fourth Quarter and Full-Year 2010 Financial Results 2Ardea Biosciences Reports Recent Accomplishments and Announces Fourth Quarter and Full-Year 2010 Financial Results 3Ardea Biosciences Reports Recent Accomplishments and Announces Fourth Quarter and Full-Year 2010 Financial Results 4Ardea Biosciences Reports Recent Accomplishments and Announces Fourth Quarter and Full-Year 2010 Financial Results 5Ardea Biosciences Reports Recent Accomplishments and Announces Fourth Quarter and Full-Year 2010 Financial Results 6BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2010 Financial Results 2BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2010 Financial Results 3BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2010 Financial Results 4BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2010 Financial Results 5BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2010 Financial Results 6BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2010 Financial Results 7