Navigation Links
Gap junction protein vital to successful pregnancy, researchers find
Date:9/10/2008

Researchers studying a critical stage of pregnancy implantation of the embryo in the uterus have found a protein that is vital to the growth of new blood vessels that sustain the embryo. Without this protein, which is produced in higher quantities in the presence of estrogen, the embryo is unlikely to survive.

This is the first study to detail the mechanism by which the steroid hormone estrogen spurs cell differentiation and blood-vessel growth in the uterus during pregnancy, the researchers report.

The findings, from researchers at the University of Illinois, Emory University, Baylor College of Medicine and New York University, appear in the journal Development.

Connexin 43 (Cx43) belongs to a family of proteins that form junctions between cells that regulate the flow of ions and small signaling molecules from cell to cell. At the time of embryo implantation, this gap junction protein is essential to the rapid growth of new blood vessels needed to support the development of the embryo and allow it to implant in the uterine wall, the researchers discovered.

The researchers chose to study Cx43 after analyzing genes that are activated in the presence of estrogen in uterine cells. They found that Cx43 was prominent among the genes whose expression was increased in cells after exposure to estrogen.

University of Illinois veterinary biosciences doctoral student Mary Laws studied the role of Cx43 in pregnant mice and in human endometrial cells. By deleting the Cx43 gene in the uterus immediately after pregnancy in mice, a technique developed by researchers at Baylor, Laws was able to reliably prevent implantation of the embryo in the uterus.

In human endometrial cells (provided by co-author Robert Taylor of Emory University), Cx43 enhanced the differentiation of cells that make up the stromal tissue of the uterus. These cells produce factors that promote the growth of new blood vessels.

One
'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2

Related biology news :

1. NIH awards Argonne $800,000 to develop tool to measure distances within proteins
2. Iowa State University researcher shows proteins have controlled motions
3. Chips are down as Manchester makes protein scanning breakthrough
4. Candy-coating keeps proteins sweet
5. NYU scientists identify critical protein complex in formation of cell cilia
6. Improved technique determines structure in membrane proteins
7. MSUs discovery of plant protein holds promise for biofuel production
8. Study reveals surprising details of the evolution of protein translation
9. Water is designer fluid that helps proteins change shape, scientists say
10. Immune system protein accurate predictor of survival in pediatric septic shock
11. Various species genes evolve to minimize protein production errors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gap junction protein vital to successful pregnancy, researchers find
(Date:12/22/2014)... Holiday Season may be the brightest ever for the ... long anticipated floodgates for consumer biometrics may finally be ... tablets, and wearable mobile devices that incorporate biometrics will ... nearly 4.8 billion biometric devices by 2020.   ...
(Date:12/19/2014)... Calif. , Dec. 18, 2014  23andMe, Inc., the leading ... that pinpoints fine-scale differences in genetic ancestry of individuals from ... Since immigrants first arrived more than four hundred years ago, ... a meeting place for peoples from different continents. This study ...
(Date:12/17/2014)... 2014 The Defense Logistics Agency is insourcing its ... counterfeit microcircuits from entering into its supply chain. ... anti-counterfeit initiative dubbed DNA marking. The capability will validate ... throughout the supply chain. The new quality control measures ...
Breaking Biology News(10 mins):First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 223andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3
... The National Science Foundation has awarded Iowa State ... million grant to establish the NSF Engineering Research ... The award is part of the National ... Program. The third-generation Engineering Research Centers are designed ...
... utilize small, short-lived animals (insects, worms, mice) under ... parasites, superabundant food in the laboratory. Oddly ... such animals in their harsh, stressful natural environments. ... actually age much more slowly in captive luxury ...
... Bats, ability to echolocate may have evolved more than once, ... of London scientists. Species of bat with the ability ... tree of life - some are more related to their ... of whether echolocation in bats has evolved more than once, ...
Cached Biology News:Iowa State wins $18.5M grant to create NSF Center for Biorenewable Chemicals 2Iowa State wins $18.5M grant to create NSF Center for Biorenewable Chemicals 3Iowa State wins $18.5M grant to create NSF Center for Biorenewable Chemicals 4Old before their time? Aging in flies under natural vs. laboratory conditions 2Molecular evolution is echoed in bat ears 2
(Date:1/22/2015)... , a precision medicine software company that has developed a ... genomic, imaging and other biomedical data in research and clinical ... CEO of Aspera, an IBM Company, to its board as ... "We are pleased to welcome Michelle to ...
(Date:12/25/2014)... December 25, 2014 The report “Service ... Product Type & Provider Type - Global Advancements, Worldwide ... with an in-depth analysis and forecasting of revenues. ... through 221 pages and in-depth TOC on “Service Quality ...
(Date:12/24/2014)... , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, Inc. (NASDAQ: ... areas, announced the closing of an underwritten public offering of ... to an aggregate 3,500,000 shares of common stock, at an ... The warrants have a per share exercise price of $5.00, ...
(Date:12/24/2014)... Solutions , Inc. (NASDAQ: BLFS ), a leading ... storage and cryopreservation freeze media and ... or the "Company"), today announced that it will hold its ... "Annual Meeting"). Because the expected date for the ...
Breaking Biology Technology:GenoSpace Expands Board with Appointment of Michelle Munson 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3BioLife Solutions Sets Date for Annual Meeting of Stockholders 2
... global climate change and population growth call for sweeping changes ... a group of prestigious scientists, including an expert in plant ... team, led by Nina Federoff, science and technology adviser to ... "critical need to get beyond popular biases against the use ...
... , -- Leading ... to Offer Innovative Resource for all Ages and Stages of the ... For the more than 1.5 million Americans living with ... is far less frequent on key topics that impact the quality ...
... ... will learn how Microsoft® products, such as SharePoint and Office 2007, can be configured to ... to provide a cost-effective FDA regulated Quality System. , ... Bedford, MA (PRWEB) February 11, 2010 -- Business Intelligence Solutions ...
Cached Biology Technology:Dramatic changes in agriculture needed as world warms and grows, researchers say 2Davis Phinney Foundation Launches 'Every Victory Counts' Program to Inform and Empower People to Live Well With Parkinson's 2Davis Phinney Foundation Launches 'Every Victory Counts' Program to Inform and Empower People to Live Well With Parkinson's 3Davis Phinney Foundation Launches 'Every Victory Counts' Program to Inform and Empower People to Live Well With Parkinson's 4Davis Phinney Foundation Launches 'Every Victory Counts' Program to Inform and Empower People to Live Well With Parkinson's 5Lunch and Learn Workshop for New Jersey-based FDA-Regulated Companies 2
Plasmid expressing the LacZ reporter gene....
Plasmid expressing Zeocin resistance gene....
... These 2800mL wide mouth PYREX Fernbach-style ... the center of the flask bottom to ... These triple baffled flasks have a Delong-style ... stainless steel closures. For plastic closures see ...
... The kit provides a simple and efficient ... normal c lture using annexin V magnetic ... phospholipid binding protein with high affinity for ... provides a simple and efficient means for ...
Biology Products: