Navigation Links
Gaining a better understanding of kidney diseases
Date:9/4/2008

This press release is available in German.

Cystic kidney disease, renal fibrosis, or renal cell carcinoma: Many diseases of the excretory organs are characterized by overproduction or on the contrary absence of characteristic proteins in the renal cells. An international research team under the leadership of scientists from DKFZ and Heidelberg University Hospitals has now developed an animal model to better investigate these conditions.

The researchers introduced a genetic switch into the genome of mice. This switch allows to selectively turn on and off the production of disease-typical proteins in renal tissue. It is activated simply by adding the antibiotic tetracycline to the animal food.

To find out whether it is possible to study the development of kidney diseases in the genetically modified (transgenic) animals, the investigators stimulated the production of c-Myc in the renal tissue of the mice. Numerous tumors have been reported to be associated with elevated levels of this transcription factor. Shortly after activation of the c-Myc gene the animals started developing cysts that led to organ failure. Pathologists also discovered renal cell carcinomas in some of the mice. As a reaction to the overexpression of another signaling molecule, the mice developed renal fibrosis.

Earlier attempts to study disease development using transgenic animals have often failed because the proteins to be studied are overproduced in the murine embryos already. As a result, the animals often develop severe malformations that make meaningful conclusions impossible. "A particular advantage of our model is that we can switch on and off disease-typical renal proteins at any given time," explained Associate Professor (PD) Dr. Robert Ksters of the Institute of Human Genetics of the University of Heidelberg and Professor Dr. Hermann-Josef Grne of the G
'/>"/>

Contact: Dr. Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. How to stop regaining weight? Thats the real question
2. Gaining ground on sickle cell disease
3. New caledonian crows find 2 tools better than 1
4. Restoring sight, advances in fertility treatments and better visibility for pilots at FIO
5. New CPR promises better results by compressing abdomen, not Chest
6. City birds better than rural species in coping with human disruption
7. Doctors learn to control their own brains pain responses to better treat patients
8. Study reveals that immigrant teenagers eat better than Spanish teenagers
9. New membrane strips carbon dioxide from natural gas faster and better
10. New approach builds better proteins inside a computer
11. People who skip meals: are they better off?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... news release is available in German . ... as individuals prompt our fellow humans to behave socially? ... social dilemmas in game theory. Previous studies assumed that ... groups. Nonetheless, scientists from the Max Planck Institute for ... can exert an influence on the cooperative behaviour of ...
(Date:10/30/2014)... North Carolina State University researchers have developed a suite ... between dogs and humans, which has applications in everything ... our pets. , "We,ve developed a platform for computer-mediated ... to new avenues for interpreting dogs, behavioral signals and ... Dr. David Roberts, an assistant professor of computer science ...
(Date:10/29/2014)... oil and gas production are well over recommended levels ... access journal Environmental Health . High levels of ... is the first to be based on community sampling ... be used to supplement official air-quality monitoring programs. , ... not readily flow to the surface. This is because ...
Breaking Biology News(10 mins):Together we are strong -- or insufferable 2Together we are strong -- or insufferable 3Together we are strong -- or insufferable 4New tech aims to improve communication between dogs and humans 2Air quality and unconventional oil and gas sites 2Air quality and unconventional oil and gas sites 3
... not all plants from the same species can be ... only prevent the exchange of genes between well-established species ... but also between varieties of one and the same ... if one wants to understand the origin of biodiversity. ...
... global inventory of farm animals showing many breeds of ... extinction, scientists from the Consultative Group on International Agricultural ... genebanks to conserve the sperm and ovaries of key ... An over-reliance on just a few breeds of ...
... clear nearly a century ago that many genes likely influence ... has followed in defining the myriad genes. Now an international ... a genetic variant associated with human height the first ... in the September 2 advance online edition of Nature Genetics, ...
Cached Biology News:How the plant immune system can drive the formation of new species 2How the plant immune system can drive the formation of new species 3Report: African, Asian, Latin American farm animals face extinction 2Report: African, Asian, Latin American farm animals face extinction 3Report: African, Asian, Latin American farm animals face extinction 4Genome study shines light on genetic link to height 2Genome study shines light on genetic link to height 3
(Date:10/30/2014)... 2014  Ardelyx, Inc. (NASDAQ: ARDX ... gastrointestinal and metabolic diseases, today announced that it ... Thursday, November 6, 2014. Following the announcement, the ... call and webcast at 4:30pm ET to review ... update. The live webcast can be ...
(Date:10/30/2014)... 30, 2014 SoundConnect , ... offers Office 365 end users the key to ... phone system by adding voice enablement and hybrid ... Lync Online, a communication tool that includes presence, ... hosted voice, O365 becomes a comprehensive unified communications ...
(Date:10/30/2014)... (PRWEB) October 30, 2014 Whitehouse Laboratories ... its ICH Stability Testing and Package Test Capacity. Responding ... centers on a dramatic increase in environmental chamber storage ... stability, storage and aging samples to be securely held ... this major capital expenditure has already taken place with ...
(Date:10/30/2014)... A new report, commissioned by BioCrossroads and ... in-depth look at Indiana,s capital ... two different time frames: 1993 to 2002 and 2003 ... opportunities for investment growth.  The Life Science Innovation ... gains in innovation dollars as well as an increase ...
Breaking Biology Technology:Ardelyx to Report Third Quarter 2014 Financial Results on November 6, 2014 2SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 2SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 3Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 2Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 2New report shows Indiana's gains in life sciences innovation capital outpace the nation 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 4New report shows Indiana's gains in life sciences innovation capital outpace the nation 5
... 18 /Xinhua-PRNewswire-FirstCall/ --,China-Biotics, Inc. (OTC Bulletin Board: ... specializing in the manufacture,research, development, marketing and ... applied for listing approval on the Nasdaq ... milestone for China-Biotics, and we are committed,to ...
... 18 Swedish environmental technology,company SEKAB has signed ... its sustainability with LDC Bioenergia, a Brazilian ethanol,and ... group Louis Dreyfus., "The agreement safeguards supplies ... production chain for environmental and social,sustainability," says Anders ...
... a magnet that,s smaller than the head of a pin? ... of MRI technique to do just that. , The technique may ... doctors a new tool for studying the plaques in blood vessels ... In a recent issue of Physical Review Letters, the ...
Cached Biology Technology:China-Biotics, Inc. Files Application for Nasdaq Listing 2SEKAB Agreement: More Verified Ethanol to Europe 2New kind of MRI enables study of magnets for computer memory 2New kind of MRI enables study of magnets for computer memory 3
... harvesting of cells • Blade design minimizes ... the growth surface • Designed for use ... wrapped • Sterilized by gamma radiation and ... a new product number, created to easily ...
... single use spatulas have been designed to ... are for those interested in eliminating the ... Each spatula is individually packaged, RNase/DNase free, ... is a new product number, created to ...
... use with dishes and cell culture clusters. ... product number, created to easily match Cornings ... please order under the old Sigma-Aldrich number ... Comp Dim: blade L 1.9 cm handle ...
... interferons are cytopathic effect inhibition assays, also ... The neutralization assay measures the antibody's ability ... cytokine. Sample types include; tissue culture supernatents; ... assays, one unit is defined as the ...
Biology Products: