Navigation Links
Gaining a better understanding of kidney diseases
Date:9/4/2008

This press release is available in German.

Cystic kidney disease, renal fibrosis, or renal cell carcinoma: Many diseases of the excretory organs are characterized by overproduction or on the contrary absence of characteristic proteins in the renal cells. An international research team under the leadership of scientists from DKFZ and Heidelberg University Hospitals has now developed an animal model to better investigate these conditions.

The researchers introduced a genetic switch into the genome of mice. This switch allows to selectively turn on and off the production of disease-typical proteins in renal tissue. It is activated simply by adding the antibiotic tetracycline to the animal food.

To find out whether it is possible to study the development of kidney diseases in the genetically modified (transgenic) animals, the investigators stimulated the production of c-Myc in the renal tissue of the mice. Numerous tumors have been reported to be associated with elevated levels of this transcription factor. Shortly after activation of the c-Myc gene the animals started developing cysts that led to organ failure. Pathologists also discovered renal cell carcinomas in some of the mice. As a reaction to the overexpression of another signaling molecule, the mice developed renal fibrosis.

Earlier attempts to study disease development using transgenic animals have often failed because the proteins to be studied are overproduced in the murine embryos already. As a result, the animals often develop severe malformations that make meaningful conclusions impossible. "A particular advantage of our model is that we can switch on and off disease-typical renal proteins at any given time," explained Associate Professor (PD) Dr. Robert Ksters of the Institute of Human Genetics of the University of Heidelberg and Professor Dr. Hermann-Josef Grne of the G
'/>"/>

Contact: Dr. Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. How to stop regaining weight? Thats the real question
2. Gaining ground on sickle cell disease
3. New caledonian crows find 2 tools better than 1
4. Restoring sight, advances in fertility treatments and better visibility for pilots at FIO
5. New CPR promises better results by compressing abdomen, not Chest
6. City birds better than rural species in coping with human disruption
7. Doctors learn to control their own brains pain responses to better treat patients
8. Study reveals that immigrant teenagers eat better than Spanish teenagers
9. New membrane strips carbon dioxide from natural gas faster and better
10. New approach builds better proteins inside a computer
11. People who skip meals: are they better off?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/10/2015)... April 10, 2015 Research and ... the "Security Competitive Profiles - NEC" report ... NEC will continue to supply a range ... market, with a company focus on the development of ... Winning opportunities in the Asia-Pacific ...
(Date:4/6/2015)... Conn. , Apr. 6, 2015 NXT-ID, ... "Company"), a biometric authentication company focused on the ... has filed provisional patent 62/143028 for ... COMMUNICATIONS AND ENERGY TRANSFER  NXT-ID introduces a ... payments. This patent surrounds the use of miniature ...
(Date:4/2/2015)... Sweden , April 2, 2015 ... for Q1 2015 attributed to somewhat higher than 125 ... in the year-end report 2014 that revenues for Q1 ... that the company reported for Q4 2014. The operating ... to be negative. The complete interim report will as ...
Breaking Biology News(10 mins):NEC Security Competitive Profile 2015 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4Fingerprint Cards Revises Revenues for Q1 2015 2
... of Adelaide reproductive biologist has achieved a major breakthrough ... of women around the world who have suffered previous ... NHMRC Principal Research Fellow and member of the University,s ... develop a product which improves IVF embryo implantation rates ...
... (Jan. 5, 2011) The number of women who ... 59 percent over the last two decades thanks to ... recent study. The report,s lead researcher, Joy Hawkins, ... at the University of Colorado School of Medicine, said ...
... St. Louis, MO, January 6, 2011 Thanks to the ... statistics like 1 in 4 children are obese and childhood ... With this platform, nutrition education and physical activity in the ... study in the January/February 2011 issue of the Journal ...
Cached Biology News:IVF breakthrough to hit the world market 2Deaths from anesthesia during childbirth plummet 2School-based interventions for obesity 2
(Date:5/5/2015)... , May 5, 2015  23andMe, Inc., the ... the Lupus Research Study in collaboration with ... with systemic lupus erythematosus, more commonly known as lupus, ... of lupus. The effort is also in collaboration with ... Awareness Month in May. Approximately 1.5 million ...
(Date:5/5/2015)... Hayden-McNeil is pleased to announce they ... for smaller courses. This program is specifically designed for ... , “I’m very excited about offering our publishing ... said Jeff McCarthy, Hayden-McNeil president. “By working with more ... to make education both more effective and affordable.” , ...
(Date:5/5/2015)... Psyche Systems Corporation and Luminate Health have ... platform that helps labs comply with new federal HHS ... way patients engage with these results, and improves provider ... a HIPAA-compliant digital platform that gives labs an easy ... lab results, and uniquely connects labs, physicians, and patients ...
(Date:5/5/2015)... May 05, 2015 The Academy of ... of Indiana, led by Indiana Gov. Mike Pence, has ... AMA Foundation will host a Family Fest and aviation ... proceeds will benefit the Wounded Warrior Project. , National ... of Model Aeronautics—the country’s foremost organization for model aviation—to ...
Breaking Biology Technology:23andMe Launches the Lupus Research Study in Collaboration with Pfizer Inc. 223andMe Launches the Lupus Research Study in Collaboration with Pfizer Inc. 3Hayden-McNeil Expands Publishing Program to Service Lower Enrollment Courses 2Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 2Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 3State of Indiana proclaims August 15 as Model Aviation Day 2
... For the second time this year, a tech-based company in ... to the public. Called an initial public offering, this kind ... and investors who are directly involved, but to others who ... Madison-based biotechnology company, has filed papers with the Securities ...
... rates of failure. As a result, many organizations are ... result stifles innovation, growth, and a company's competitive advantage. ... flawed processes of yesterday, and introducing methods that create ... delivery of functional software. , , Evidence , ...
... - Now that two companies he once owned have ... Brian Wiegand's days as a self-described serial entrepreneur might ... NameProtect , a developer of digital brand management services, ... of Wilmington, Del. , ,He will concentrate on growing ...
Cached Biology Technology:Wisconsin IPOs are a harbinger of growing tech economy 2Wisconsin IPOs are a harbinger of growing tech economy 3Agile Revolution: A new era of software delivery 2Agile Revolution: A new era of software delivery 3Agile Revolution: A new era of software delivery 4NameProtect sold, tech entrepreneur to focus on Jellyfish.com 2
...
... kit contains sufficient materials for 1,464 array sample elements. ... each , Blocker BSA in PBS ... Antibody, HRP-conjugated: 10 g , BupH ... 10% Tween-20: 2 x 10 ml ampules , ...
... Clean and Accurate Results Laser Capture ... the sensitivity and accuracy of molecular assays ... types and multi-cellular structures isolated from whole ... to microdissection-developed in 1996 at the National ...
Mouse monoclonal antibody raised against a partial recombinant DHX8. NCBI Entrez Gene ID = DHX8...
Biology Products: