Navigation Links
Gaining a better understanding of kidney diseases
Date:9/4/2008

This press release is available in German.

Cystic kidney disease, renal fibrosis, or renal cell carcinoma: Many diseases of the excretory organs are characterized by overproduction or on the contrary absence of characteristic proteins in the renal cells. An international research team under the leadership of scientists from DKFZ and Heidelberg University Hospitals has now developed an animal model to better investigate these conditions.

The researchers introduced a genetic switch into the genome of mice. This switch allows to selectively turn on and off the production of disease-typical proteins in renal tissue. It is activated simply by adding the antibiotic tetracycline to the animal food.

To find out whether it is possible to study the development of kidney diseases in the genetically modified (transgenic) animals, the investigators stimulated the production of c-Myc in the renal tissue of the mice. Numerous tumors have been reported to be associated with elevated levels of this transcription factor. Shortly after activation of the c-Myc gene the animals started developing cysts that led to organ failure. Pathologists also discovered renal cell carcinomas in some of the mice. As a reaction to the overexpression of another signaling molecule, the mice developed renal fibrosis.

Earlier attempts to study disease development using transgenic animals have often failed because the proteins to be studied are overproduced in the murine embryos already. As a result, the animals often develop severe malformations that make meaningful conclusions impossible. "A particular advantage of our model is that we can switch on and off disease-typical renal proteins at any given time," explained Associate Professor (PD) Dr. Robert Ksters of the Institute of Human Genetics of the University of Heidelberg and Professor Dr. Hermann-Josef Grne of the German Cancer Research Center. "Thus, we are able to simulate the natural course of disease development and also of healing processes."


'/>"/>

Contact: Dr. Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Related biology news :

1. How to stop regaining weight? Thats the real question
2. Gaining ground on sickle cell disease
3. New caledonian crows find 2 tools better than 1
4. Restoring sight, advances in fertility treatments and better visibility for pilots at FIO
5. New CPR promises better results by compressing abdomen, not Chest
6. City birds better than rural species in coping with human disruption
7. Doctors learn to control their own brains pain responses to better treat patients
8. Study reveals that immigrant teenagers eat better than Spanish teenagers
9. New membrane strips carbon dioxide from natural gas faster and better
10. New approach builds better proteins inside a computer
11. People who skip meals: are they better off?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... Calif. , April 13, 2017 UBM,s ... York will feature emerging and evolving technology ... Both Innovation Summits will run alongside the expo portion ... speaker sessions, panels and demonstrations focused on trending topics ... largest advanced design and manufacturing event will take place ...
(Date:4/11/2017)... April 11, 2017 No two people ... at the New York University Tandon School of ... have found that partial similarities between prints are ... in mobile phones and other electronic devices can ... The vulnerability lies in the fact that fingerprint-based ...
(Date:4/5/2017)... 5, 2017 Today HYPR Corp. , ... server component of the HYPR platform is officially ... end-to-end security architecture that empowers biometric authentication across Fortune ... already secured over 15 million users across the financial ... connected home product suites and physical access represent a ...
Breaking Biology News(10 mins):
(Date:7/20/2017)... ... 2017 , ... Corista, a leader in integrated pathology solutions, ... 25, during the Association of Pathology Chairs’ Jubilee Meeting in Washington, DC. The ... Director of Pathology Informatics, will present “The Digital Pathology Experience at Johns Hopkins.” ...
(Date:7/18/2017)... ... July 18, 2017 , ... Sourcing custom glass or quartz parts ... has the capabilities to properly execute your job can take many hours of emails, ... a sourcing portal designed to showcase the company’s capabilities and core custom categories, and ...
(Date:7/18/2017)... ... 18, 2017 , ... Recently recognized by CIO Magazine as ... migration of its flagship cloud-based product Planet Life Cycle – a robust work ... system that merges strategic and financial planning with execution. The solution is leveraged ...
(Date:7/17/2017)... ... July 17, 2017 , ... ... a wide range of overlapping clinical features. The advancement of targeted next-generation sequencing ... of NDD research and testing. , However, designing a custom panel for ...
Breaking Biology Technology: