Navigation Links
GW professor receives grant to study the role of genes in drug addiction
Date:8/29/2012

WASHINGTON (Aug 29, 2012) Norman H. Lee, Ph.D., professor of pharmacology at the George Washington University School of Medicine and Health Sciences (SMHS), received a total of $405,001 in grant funding from the National Institute on Drug Abuse (NIDA) to continue to study the correlation between genetics and susceptibility to drug abuse. The award will fund Lee's continuing research on drug addiction, titled "Conditional Dicer1 Manipulation to Study miRNA Involvement in Oploids Addiction," for the next two years.

Lee will act as co-principal investigator of the grant, using his expertise in genomics to collaborate with Gregory Elmer, Ph.D., behavioral geneticist at the University of Maryland School of Medicine. Their research will focus primarily on morphine addiction in mouse models. In previous research, the researchers placed mice in a self-administration chamber and taught them to press a lever a certain number of times to receive an injection of morphine, which stimulates the reward center of the brain. While one group of mice eventually stopped pressing the lever, another group continued to work harder and pressed the lever many more times in order to receive an injection of morphine. They found that in this group of mice, there was a significant change in the expression of genes involved in the architecture of neurons in the brain, leading this group to abuse the drug.

"We are asking the question, 'What is it about the brain in certain individuals that's changing and leading them to become more susceptible to abusing drugs, despite the adverse consequences?'" said Lee.

The researchers discovered that the changes occurring in the brain are due in large part to an enzyme being turned on, called Dicer. This enzyme then turns on the expression of small RNA molecules, called micro-RNA (miRNA), which are important for gene regulation. The miRNAs in turn dampen or turn off genes, which Lee believes leads the mice to continue to
'/>"/>

Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Professors Antarctica research shows potential king crab invasion
2. UA engineering professor uses aerospace materials to build endless pipeline
3. University of Tennessee professor releases weight management product
4. University of Illinois professor develops tool that helps dietitians deliver info clients need and can understand
5. Salk Professor Terrence Sejnowski receives IEEE Frank Rosenblatt Award
6. Professors essay is 1 of 10 in special issue of Daedalus
7. University of Tennessee professor wins worlds top prize for ecology, environmental science
8. Notre Dame establishes professorships in adult stem cell research
9. University of Tennessee professor receives funding for clean coal research
10. Normal bacterial makeup has huge implications for health, says CU professor
11. Purdue professor to speak before Congress about nanotechnology in brain treatment research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
GW professor receives grant to study the role of genes in drug addiction
(Date:7/31/2014)... from shale rock has increased by more than ... not fully understand the industry,s effects on nature ... journal Frontiers in Ecology and the Environment ... outpace scientific examination, a team of eight conservation ... University, concluded that determining the environmental impact of ...
(Date:7/31/2014)... New research, supported by the National Science Foundation ... permafrost uniformly accelerates atmospheric warming, indicating instead that ... they emit into the atmosphere. , The ... Nature , focuses on thermokarst lakes, which occur ... fill with melted fresh water, converting what was ...
(Date:7/31/2014)... biomass burning burning forests to create agricultural ... agriculture and wildfires figures into both climate ... release of a new study by Stanford University ... the degree of that contribution had never been ... paper published July 30 in the Journal ...
Breaking Biology News(10 mins):'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 2'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 3Certain Arctic lakes store more greenhouse gases than they release 2Stanford professor finds that wildfires and other burns play bigger role in climate change 2Stanford professor finds that wildfires and other burns play bigger role in climate change 3Stanford professor finds that wildfires and other burns play bigger role in climate change 4
... the world, this week,s edition of Chemical & Engineering ... on the jobs situation for chemists -- whose work directly ... chemical industry in the United States alone a $674 billion ... American Chemical Society, the world,s largest scientific society. ...
... life scientists have identified a gene that slows the aging ... activated a gene called PGC-1, which increases the activity of ... growth and tell cells when to live and die. ... in different cells and tissues of the fly and asked ...
... tree outside Oak Ridge National Laboratory researcher Pratul Agarwal,s ... may ultimately lead to drugs with fewer side effects, ... breeze causes leaves, branches and ultimately the tree to ... of chemical processes that have a ripple effect necessary ...
Cached Biology News:UCLA biologists slow the aging process in fruit flies 2UCLA biologists slow the aging process in fruit flies 3ORNL fundamental discovery casts enzymes in new light 2
(Date:7/31/2014)... 2014 CollabRx, Inc. (NASDAQ: CLRX), a ... in oncology, today announced that it will hold an ... the Company's financial results for the first quarter of ... business in the current fiscal year. , The dial-in ... August 14, 2014, at 5 p.m. EDT (2 p.m. ...
(Date:7/31/2014)... Francisco, Calif. (PRWEB) July 31, 2014 ... newly diagnosed patients with an overview of the disease ... management of drug side effects, as well as updates ... “We’re grateful to Dr. Sandy Srinivas for organizing this ... survivor of kidney cancer. “Sandy and her colleagues have ...
(Date:7/31/2014)... 2014 “Rapid technological advances will ... U.S., increasing unemployment, depressing American consumer spending and ... a Catch 22—we need automated manufacturing if we ... jobs,” says economist and corporate relocation expert Dr. ... 10 Pro-Business States for 2014, co-published with the ...
(Date:7/31/2014)... Boston, MA (PRWEB) July 31, 2014 ... ) finds itself flush with innovative adult stem cell ... patents and has three additional patent applications ... Office. , The patented inventions address two of the ... and regenerative medicine. Adult stem cells are difficult ...
Breaking Biology Technology:CollabRx, Inc. Schedules First Quarter Fiscal Year 2015 Financial Conference Call and Business Update 2ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 2ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 3ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 4The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 2The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 3
... Leading US Spine Centers Committed to the IEP,s ... 24 Magnifi Group, considered by,many industry observers ... within the medical device and pharmaceutical industries,announced here ... annual,meeting, its intent to organize and develop real-time ...
... Efforts to ... MENTOR, Ohio, Oct. 24 STERIS Corporation,(NYSE: STE ... its,VaproSure(TM) Room Sterilizer from several U.S. hospitals. The VaproSure,Room Sterilizer ... kind for the healthcare market. Since being introduced in,June of ...
... Cell Therapeutics,Inc. (CTI) (Nasdaq and MTAX: ... annual AACR-NCI-EORTC Symposium show its bis-platinate drug,candidates, ... currently,marketed platinum agents carboplatin, cisplatin and oxaliplatin. ... late 2008. "Bis-platinates represent a promising ...
Cached Biology Technology:Magnifi Group Demonstrates Industry's First Interactive Educational Program (IEP) for Spine Fellows 2Hospitals Adopt STERIS Advanced Room Sterilization Technology in the Fight Against 'Superbugs' 2Hospitals Adopt STERIS Advanced Room Sterilization Technology in the Fight Against 'Superbugs' 3Hospitals Adopt STERIS Advanced Room Sterilization Technology in the Fight Against 'Superbugs' 4Hospitals Adopt STERIS Advanced Room Sterilization Technology in the Fight Against 'Superbugs' 5Hospitals Adopt STERIS Advanced Room Sterilization Technology in the Fight Against 'Superbugs' 6First New Class of Platinum-Based Chemotherapy Drug Candidates in 30 Years Demonstrate Ability to Kill Tumors Resistant to Currently Marketed Platinum Drugs 2First New Class of Platinum-Based Chemotherapy Drug Candidates in 30 Years Demonstrate Ability to Kill Tumors Resistant to Currently Marketed Platinum Drugs 3
MOUSE ANTI POLY (ADP-RIBOSE) Immunogen: Purified poly (ADP-ribose) polymer, 10-50 unit chain length...
... et.al. (1997) • Contains short ... biochemistry & molecular biology, arranged ... Entries give details of biochemical ... which they are involved and ...
The Protein Kinase Factsbooks (2 Volume Set)...
All serum is collected from U.S.D.A. fryers and broilers. Pricing: $15/unit for 1 - 10 units; $12/unit for 11 - 50 units...
Biology Products: