Navigation Links
GW professor receives grant to study the role of genes in drug addiction
Date:8/29/2012

WASHINGTON (Aug 29, 2012) Norman H. Lee, Ph.D., professor of pharmacology at the George Washington University School of Medicine and Health Sciences (SMHS), received a total of $405,001 in grant funding from the National Institute on Drug Abuse (NIDA) to continue to study the correlation between genetics and susceptibility to drug abuse. The award will fund Lee's continuing research on drug addiction, titled "Conditional Dicer1 Manipulation to Study miRNA Involvement in Oploids Addiction," for the next two years.

Lee will act as co-principal investigator of the grant, using his expertise in genomics to collaborate with Gregory Elmer, Ph.D., behavioral geneticist at the University of Maryland School of Medicine. Their research will focus primarily on morphine addiction in mouse models. In previous research, the researchers placed mice in a self-administration chamber and taught them to press a lever a certain number of times to receive an injection of morphine, which stimulates the reward center of the brain. While one group of mice eventually stopped pressing the lever, another group continued to work harder and pressed the lever many more times in order to receive an injection of morphine. They found that in this group of mice, there was a significant change in the expression of genes involved in the architecture of neurons in the brain, leading this group to abuse the drug.

"We are asking the question, 'What is it about the brain in certain individuals that's changing and leading them to become more susceptible to abusing drugs, despite the adverse consequences?'" said Lee.

The researchers discovered that the changes occurring in the brain are due in large part to an enzyme being turned on, called Dicer. This enzyme then turns on the expression of small RNA molecules, called micro-RNA (miRNA), which are important for gene regulation. The miRNAs in turn dampen or turn off genes, which Lee believes leads the mice to continue to
'/>"/>

Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Professors Antarctica research shows potential king crab invasion
2. UA engineering professor uses aerospace materials to build endless pipeline
3. University of Tennessee professor releases weight management product
4. University of Illinois professor develops tool that helps dietitians deliver info clients need and can understand
5. Salk Professor Terrence Sejnowski receives IEEE Frank Rosenblatt Award
6. Professors essay is 1 of 10 in special issue of Daedalus
7. University of Tennessee professor wins worlds top prize for ecology, environmental science
8. Notre Dame establishes professorships in adult stem cell research
9. University of Tennessee professor receives funding for clean coal research
10. Normal bacterial makeup has huge implications for health, says CU professor
11. Purdue professor to speak before Congress about nanotechnology in brain treatment research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
GW professor receives grant to study the role of genes in drug addiction
(Date:6/25/2015)... -- According to a new market ... Technology, Material (Optical Prism, Piezoelectric, Capacitive & Adhesives), ... & Geography - Global Forecast to 2014 - ... expected to reach $14,500.07 Million by 2020, at ... 76 market Tables and 109 Figures spread through ...
(Date:6/25/2015)... , June 25, 2015  TAKE Solutions Ltd., a ... by the United States Patent and Trademark Office (USPTO) ... process leverages TAKE Solutions, Clinical Accelerators to reduce the ... (when compared to standardization without the accelerators), thus reducing ... At the heart of the patented ...
(Date:6/24/2015)... 24, 2015 This report provides market analysis ... six years. It contains an analysis of the drivers, ... their impact from the short, medium, and long term ... industry, market, and technology trends that currently, prevail in ... concerned authorities to efficiently manage the increasing marine traffic ...
Breaking Biology News(10 mins):Fingerprint Sensors Market Worth $14,500.07 Million by 2020 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 4TAKE Solutions Awarded Patent By USPTO 2Automatic Identification System Market by Class, by Platform, by Application and by Geography - Global Forecasts & Analysis to 2014 - 2020 2
... that are linked with the onset of Barrett,s oesophagus (BE), ... have been identified for the first time. The discovery of ... develop screening tests for people at high risk of developing ... that there may be genetic causes for BE as well ...
... Sunday, September 9, 2012 A new paper published online ... the second most common type of lung cancer may one ... other lung cancer patients. Squamous cell lung cancer ... cancer, ranking second only to lung adenocarcinoma in the number ...
... 7, 2012 The University of Illinois at ... teams joining the NASA Astrobiology Institute (NAI) to study the ... approximately $8 million. Nigel Goldenfeld, Swanlund Professor of ... Institute for Genomic Biology (IGB), will serve as the principal ...
Cached Biology News:Researchers find first evidence for a genetic cause for Barrett's oesophagus 2Researchers find first evidence for a genetic cause for Barrett's oesophagus 3New potential targets discovered for treating squamous cell lung cancers 2New potential targets discovered for treating squamous cell lung cancers 3University of Illinois at Urbana-Champaign awarded 5-year grant from NASA 2University of Illinois at Urbana-Champaign awarded 5-year grant from NASA 3
(Date:6/30/2015)... ... 2015 , ... Students and faculty from Beijing City University ... “Integrative Biotechnology,” an applied biotechnology course team-taught by faculty members from both institutions. ... from both universities and is taught on both continents. , “Our alliance with ...
(Date:6/30/2015)... June 30, 2015  Today, Americord Registry, one of the ... Andrew Horne , a partner at Kirkland & Ellis LLP, ... Logo - http://photos.prnewswire.com/prnh/20150630/226958LOGO   "We are ... Board," says Martin Smithmyer , CEO of Americord. "He ... career that will assist Americord,s growth and vision." ...
(Date:6/30/2015)... ... June 30, 2015 , ... Matrix Marketing Group, LLC , ... hired Gem Swartz to head up its account management department as vice president of ... and Amanda bring senior account management and delivery expertise to the growing Matrix Marketing ...
(Date:6/30/2015)... IL (PRWEB) , ... June 30, 2015 , ... ... effective August 14. She has accepted the position of vice president of instruction ... August 17. , “I greatly appreciated the opportunity to lead SIUE during ...
Breaking Biology Technology:Rivier University and Beijing City University Academic and Cultural Exchanges Begin 2Americord Registry Announces Andrew Horne as Advisory Board Member 2Matrix Marketing Group Expands Client Services Team 2SIUE’s Furst-Bowe Accepts VP of Instruction at CVTC 2SIUE’s Furst-Bowe Accepts VP of Instruction at CVTC 3
... Heritage has recently,overcome patent claims held by a competitor ... and databases that allow families around,the world to match ... the,use of surnames and Y-chromosomes to establish a family ... rendered a formal opinion,stating that the relevant claims are ...
... of advanced neuromodulation products designed to accelerate recovery from central ... largest provider of inpatient rehabilitative healthcare services, will expand the ... NESS L300™ Foot Drop System to 88 rehabilitation hospitals nationwide. ... ...
... OSAKA, Japan, July 30 /PRNewswire/ - Cytochroma and,Mitsubishi ... have signed a license agreement under which Cytochroma ... Asia, including Japan, to develop,and commercialize CTA018, Cytochroma,s ... development in Canada for the treatment of secondary,hyperparathyroidism ...
Cached Biology Technology:DNA Heritage Success in Patent Battle Helps Keep Genealogy DNA Test Prices Low 2 Bioness Announces NESS H200 and L300 Systems to Be Available at 88 HealthSouth Hospitals Nationwide 2 Bioness Announces NESS H200 and L300 Systems to Be Available at 88 HealthSouth Hospitals Nationwide 3Cytochroma and Mitsubishi Tanabe form partnership for chronic kidney disease therapies in U.S. and Asia 2Cytochroma and Mitsubishi Tanabe form partnership for chronic kidney disease therapies in U.S. and Asia 3Cytochroma and Mitsubishi Tanabe form partnership for chronic kidney disease therapies in U.S. and Asia 4
... The CopyControl™ vector can be induced prior ... vectors provide the stability of single-copy BACs ... or other cloning vectors. The kits provide ... reagents, insert size screening system) necessary to ...
... EPICENTREs patented MasterAmp™ 10X PCR ... performance and allows improved sensitivity and ... templates. Using MasterAmp™ PCR Enhancer in ... of DNA melting, increases enzyme?s thermal ...
... Streptavidin-AP Systems provide rapid, precise localization ... in frozen or paraffin-embedded tissue, cytospins ... also facilitate double or triple labeleing ... simultaneously with primary antibodies of different ...
... Biotin Streptavidin-HRP Systems provide rapid, precise ... antigens in frozen or paraffin-embedded tissue, ... systems also facilitate double or triple ... performed simultaneously with primary antibodies of ...
Biology Products: