Navigation Links
Funding for animal testing alternative
Date:8/23/2013

A researcher from Plymouth University Peninsula Schools of Medicine and Dentistry has received an award of 94,365 (Sterling) from the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), for a pilot study to develop the lab-based creation of a type of mouse cell which could be used in place of the live animals for research related to infectious and allergic lung conditions.

Macrophages are crucial components of the immune system and play key roles in the body's defence against invading pathogens. Macrophages can be switched to perform different functions by chemical messengers produced by cells and tissues in response to infection. Some are switched to M2 macrophages which play a role in infections and allergic diseases such as asthma.

More needs to be understood about M2 macrophages if they are to play a part in effective therapies for infections. However, the cells acquired from live mice have a limited lifespan and require the repeated use of the animals.

Dr. Gyorgy Fejer will use the award to establish permanently growing, alternatively activated M2 macrophage cell lines in order to reduce the number of animals currently used to provide such cells for study. His work revolves around mouse lung macrophages which can be grown indefinitely and are available in practically unlimited numbers.

Compared with cell harvesting from a live mouse, the difference is striking: approximately 300,000 cells can be obtained from a mouse, whereas Dr. Fejer and his team can obtain 20-30 million cells from a single tissue culture flask.

This means that scientists who research asthma and pulmonary virus and bacterial infections can for the first time have access to almost limitless cells for study, without the need for live mice.

Dr. Fejer's award is one of several presented to scientists across the UK by NC3Rs for smart approaches to reduce animal use in science. It follows the publ
'/>"/>

Contact: Andrew Gould
andrew.gould@plymouth.ac.uk
University of Plymouth
Source:Eurekalert

Page: 1 2

Related biology news :

1. Research!America says budget negotiations heighten urgency to protect research funding
2. Research!America says house funding levels for FY13 could undermine medical progress
3. Mainz University Medical Center attracts funding of Alexander von Humboldt Professorship
4. University of Tennessee professor receives funding for clean coal research
5. House funding bill will delay research progress and place new burdens on NIH
6. Space research institute awards funding to promising medical products
7. University of Minnesota receives $13.1 million in DOE funding for 2 new nationwide centers
8. 2 pioneering plant genomics efforts given a funding boost by National Science Foundation
9. State stem cell research funding agency awards $37.3 million to aid UC Irvine efforts
10. University spin-out company shares in £7.9 million marine energy funding boost
11. £12 million funding to tackle devastating livestock and poultry viruses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... have captured the popular attention of both children and ... -- sold as dehydrated eggs, these tiny brine shrimp ... a tank of salt water. , Physicists, though, ... brine shrimp vertically migrate in large groups in response ... at night and retreating deeper during the day. , ...
(Date:9/30/2014)... water may increase the risk of stillbirth and ... by a Boston University School of Public Health ... Environmental Health , compared 1,091 PCE-exposed pregnancies ... Cape Cod, Ma., where water was contaminated in ... the installation of vinyl-lined asbestos cement pipes. PCE ...
(Date:9/30/2014)... farm runoff in Hawaii is causing tumors in endangered ... study, published Tuesday in the peer-reviewed open-access journal ... up in algae that the turtles eat, promoting the ... internal organs. , Scientists at Duke University, the University ... (NOAA) conducted the study to better understand the causes ...
Breaking Biology News(10 mins):Laser-guided sea monkeys show how zooplankton migrations may affect global ocean currents 2Contaminated water linked to pregnancy complications, BU study finds 2Pollution linked to lethal sea turtle tumors 2Pollution linked to lethal sea turtle tumors 3
... 2012 Chiltern International Limited (Chiltern), a global contract ... James Gunter have joined Chiltern, bringing their expertise in ... strengthen our Global Clinical Development services. ... Cedric Burg has been appointed to the position of ...
... pests by using ultrasonic frequencies are available and marketed ... been demonstrated as being effective in repelling insect pests ... of evidence for the efficacy of such devices, they ... bugs are readily available. However, according to a ...
... reprogramming a 7-year-old girl,s own immune cells to attack ... has achieved a complete response in his patient, who ... The innovative experimental therapy used bioengineered T cells, custom-designed ... leukemia cells. After the treatment, the child,s doctors found ...
Cached Biology News:Chiltern Welcomes Cedric Burg And James Gunter 2Engineered immune cells produce complete response in child with an aggressive pediatric leukemia 2Engineered immune cells produce complete response in child with an aggressive pediatric leukemia 3
(Date:10/1/2014)... The U.S. Department of Labor has awarded ... as part of the Trade Adjustment Assistance Community College ... by the Department of Labor and Department of Education. ... E. Perez and Secretary of Education Arne Duncan announced ... to nearly 270 colleges across the country. , ...
(Date:9/30/2014)... . , The researchers ... semiconductor layer. Quantum dots are small structures that spontaneously emit ... laser pulse is fired at the photonic crystal, its refractive ... in the electromagnetic field around it. This change can speed ... dot. As soon as the refractive index recovers its usual ...
(Date:9/30/2014)... Mass. Using a bio-mimicking analog of one ... grass, an international research team led by Alejandro ... taken a major step in developing long-sought polymer ... electricity for use in electronic devices. , ... Amherst and others at Stanford University and Dresden ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 Shimadzu ... extensometer, an easy-to-use and highly precise tool for ... with considerable elongation. With 1000-mm maximum movement distance, ... percent for a gauge length of 10 mm. ... measurement accuracy above 50-mm stroke and within +/- ...
Breaking Biology Technology:U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 3U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 4Ultrafast remote switching of light emission 2Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3Shimadzu’s New Long-Travel Extensometer Increases Precision for Soft Material Testing 2
... Products offer biologically safer water through point-of-use ... ... NEP ),a medical device company, announced today that it will ... Healthcare,Engineering (ASHE) Conference and Technical Exhibition in National Harbor,Maryland, July 20th-23rd, ...
... RICHMOND, Va., July 14, 2008 Insmed Inc.,(Nasdaq ... for unmet medical needs, today announced that the,Company ... (RBC) to act as,its strategic financial advisor., ... are dedicated,to enhancing shareholder value and will be ...
... PARK, Calif., July 14 Pacific Biosciences,announced today ... Series E private,equity financing round. The proceeds will ... company,s innovative single-molecule, real-time,(SMRT(TM)) DNA sequencing platform., ... and Intel,Capital, Intel Corporation,s global investment organization. Other ...
Cached Biology Technology:Nephros Exhibiting at Maryland Ashe Conference July 20th-23rd 2Nephros Exhibiting at Maryland Ashe Conference July 20th-23rd 3Nephros Exhibiting at Maryland Ashe Conference July 20th-23rd 4Insmed Retains RBC Capital Markets as Strategic Financial Advisor 2Insmed Retains RBC Capital Markets as Strategic Financial Advisor 3Pacific Biosciences Raises $100 Million to Fund Commercial Product Development 2
... cDNA Library Panels were designed for full-length ... of PCRs to identify the desired cDNA ... in a 96-well "Master Plate," where each ... Having identified the positive well(s) by gel ...
... cDNA Library Panels were designed for full-length ... of PCRs to identify the desired cDNA ... in a 96-well "Master Plate," where each ... Having identified the positive well(s) by gel ...
... 435 is an affordable, compact benchtop ... slides, providing a broad array of ... acquires high-resolution images with high-performance laser ... excitation and emission filter changers, and ...
... Contents include: Microarray hybridization chamber ... chamber top, clamp, thumbscrew) Microarray chamber user ... and are intended to be cleaned and ... with Agilents Catalog Oligo Microarray kits and ...
Biology Products: