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Frontiers news briefs: 27 June
Date:6/28/2013

l division during mitosis. While some tumors maintain a stably aneuploid genome, many cancer cells persistently mis-segregate their chromosomes during mitosis, a phenomenon known as chromosomal instability (CIN). CIN is thought to drive the genomic re-shuffling that enables cells to acquire new phenotypes such as drug resistance and is intimately associated with loss of mitotic fidelity. Emerging data show that CIN and de-regulated cell signaling pathways are closely interrelated suggesting the roles that signaling pathways play in the accuracy of mitosis may be underappreciated. These results imply that the induction of CIN can no longer be thought of as a separate event from the cancer-associated driver mutations found in cell signaling pathways. In the context of tumorigenesis this may turn out to be a double-edged sword that combines de-regulated cell cycle progression with the disruption of mitosis to generate the highly complex genomic rearrangements typical of solid tumors. These results change the way we think about how to intervene therapeutically in cancer patients and provide insights on the molecular targets that may contribute significantly to improve patient prognosis.

Researcher contact:

Prof. Duane A. Compton
Department of Biochemistry
Geisel School of Medicine at Dartmouth, USA
Email: duane.a.compton@dartmouth.edu

URL: http://www.frontiersin.org/Molecular_and_Cellular_Oncology/10.3389/fonc.2013.00164/abstract


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Contact: Gozde Zorlu
gozde.zorlu@frontiersin.org
Frontiers
Source:Eurekalert

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