Navigation Links
Frontiers news briefs: 27 June
Date:6/28/2013

l division during mitosis. While some tumors maintain a stably aneuploid genome, many cancer cells persistently mis-segregate their chromosomes during mitosis, a phenomenon known as chromosomal instability (CIN). CIN is thought to drive the genomic re-shuffling that enables cells to acquire new phenotypes such as drug resistance and is intimately associated with loss of mitotic fidelity. Emerging data show that CIN and de-regulated cell signaling pathways are closely interrelated suggesting the roles that signaling pathways play in the accuracy of mitosis may be underappreciated. These results imply that the induction of CIN can no longer be thought of as a separate event from the cancer-associated driver mutations found in cell signaling pathways. In the context of tumorigenesis this may turn out to be a double-edged sword that combines de-regulated cell cycle progression with the disruption of mitosis to generate the highly complex genomic rearrangements typical of solid tumors. These results change the way we think about how to intervene therapeutically in cancer patients and provide insights on the molecular targets that may contribute significantly to improve patient prognosis.

Researcher contact:

Prof. Duane A. Compton
Department of Biochemistry
Geisel School of Medicine at Dartmouth, USA
Email: duane.a.compton@dartmouth.edu

URL: http://www.frontiersin.org/Molecular_and_Cellular_Oncology/10.3389/fonc.2013.00164/abstract


'/>"/>

Contact: Gozde Zorlu
gozde.zorlu@frontiersin.org
Frontiers
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Finding new research frontiers in a single cell
2. Frontiers announces launch of new open-access journal, Frontiers in Public Health
3. Frontiers launches new open-access journal in Bioengineering and Biotechnology
4. Frontiers news briefs: May 23
5. Frontiers launches new open-access journal in physics
6. Frontiers news briefs May 30
7. Frontiers news briefs: June 6
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... 14, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market, announces that ... 2015 New York Design Awards under the category  ,Product ... City Design Awards are part of a global multi-disciplinary ... ratings from the marketplace, industry and judging panel. Winners ...
(Date:4/9/2015)... SAN JOSE, Calif. , April 9, 2015 /PRNewswire/ ... of human interface solutions, announced today that it will ... 2015 on Thursday, April 23, 2015, after the close ... call for analysts and investors at 2:00 p.m. PT ... information.    To participate on the live ...
(Date:4/2/2015)... April 2, 2015 At its 2015 ACMG ... City , the American College of Medical Genetics ... directors to its Board.  Members of the ACMG Board ... for forming and advancing its policies and programs. ACMG ... "It,s an eventful time in medical genetics ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3Synaptics to Report Third Quarter Results on April 23 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8
... Ann Liebert, Inc., publishers announces the launch of ... innovative, peer-reviewed journal on this rapidly growing disruptive technology. ... 2013, and quarterly thereafter in 2014. Editor-in-Chief Hod Lipson, ... Lab at the Sibley School of Mechanical and Aerospace ...
... of the endophytic bacterium H. frisingense GSF30T identifies ... with plants Microbes whose habitat is inside other ... have evolved genes that enable them to overcome their host,s ... such microbes may actually benefit their host, for example, by ...
... coral reefs around the world from dying off, deep ... new study from Carnegie,s Katharine Ricke and Ken Caldeira. ... engulfed in inhospitable ocean chemistry conditions by the end ... emissions trajectory. Their work will be published July 3 ...
Cached Biology News:Frontiers news briefs: 27 June 2Frontiers news briefs: 27 June 3Frontiers news briefs: 27 June 4Major changes needed for coral reef survival 2
(Date:4/16/2015)... Cytokinetics, Incorporated (Nasdaq: CYTK) announced today ... on Thursday, April 30, 2015 at 4:00 PM Eastern ... a conference call at 4:30 PM Eastern Time to ... for the future. , The conference call will be ... and in the Investor Relations section of Cytokinetics’ website ...
(Date:4/16/2015)... IL (PRWEB) April 16, 2015 Regis ... the American Association for Cancer Research (AACR) annual meeting. ... Pennsylvania Convention Center, starting Saturday, April 18, in Philadelphia ... holds claim to title of the oldest and largest ... provides fellowships and grants, and partners with survivors to ...
(Date:4/16/2015)... Mass. , April 16, 2015  In recognition of ... collaborated with hemophilia advocacy groups to illuminate more than 15 ... , including Boston,s Zakim Bridge and ... New Orleans, Mercedes-Benz Superdome and ... occur during the evening of April 17, and coincide with ...
(Date:4/16/2015)... April 16, 2015 ... pharmaceutical investment and R&D group, and Lancet, ... research, development and commercialization of new medicines ... the intention to stimulate the innovative development ...      (Logo: http://photos.prnewswire.com/prnh/20150416/739742-a) ,     (Logo: http://photos.prnewswire.com/prnh/20150416/739742-b) , ...
Breaking Biology Technology:Cytokinetics to Announce First Quarter Results on April 30, 2015 2Cytokinetics to Announce First Quarter Results on April 30, 2015 3Regis Technologies Joins American Association for Cancer Research Annual Meeting 2Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 2Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 3Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 4Lancet and ChemRar High Tech Center Have Announced a Partnership in the Development and Production of Novel Drugs in Russia 2
... 21, Inc.,(Nasdaq: NXXI ), a growing developer ... Essentials(TM) and Iceland Health(R) brands,that help consumers manage ... address chronic joint pain, will report,financial results for ... 31, 2007 on Monday, February 11, 2008, after ...
... ViroPharma Incorporated,(Nasdaq: VPHM ) today announced ... officer of ViroPharma, will present at the BIO ... Monday, February 11, 2008. The,conference is being held ... presentation will be webcast live for investors through, ...
... ST. LOUIS, Feb. 5 Monsanto Company,s ... global commercial,business, and Carl Casale, executive vice ... in separate presentations at two,conferences later this ... an update on the company,s,business performance and ...
Cached Biology Technology:Nutrition 21 to Report Second Quarter Fiscal 2008 Financial Results Monday, February 11, 2008 2
Mouse polyclonal antibody to ALS2CR8 - amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8...
...
Mouse monoclonal [CAT-2] to Chloramphenicol Acetyltransferase...
Recommended fro Western blotting application...
Biology Products: