Navigation Links
Forcing chromosomes into loops may switch off sickle cell disease
Date:8/14/2014

a milder form of the disease. "This observation has been a major driver in the field to understand the molecular basis of the mechanisms that control the biological switch, with the ultimate goal to reverse it," said Blobel.

In previous research, Blobel's team used bioengineering techniques to adapt zinc-finger proteins to latch onto specific DNA sites far apart on a chromosome. The chromatin loop that results transmits regulatory signals for specific genes.

In their current work, the scientists custom-designed zinc fingers to flip the biological switch in blood-forming cells, reactivating the genes expressing fetal hemoglobin at the expense of the genes expressing adult hemoglobin. The researchers achieved these results in cultured blood cells from adult mice and adult humans.

The next step, said Blobel, is to apply this proof-of-concept technique to preclinical models, by testing the approach in animals genetically engineered to have manifestations of SCD similar to that found in human patients. If this strategy corrects the disease in animals, it may set the stage to move to human trials.

In principle, added Blobel, the forced chromatin looping approach could also be applied to other hemoglobin-related disorders, such as certain forms of thalassemia in which elevated fetal hemoglobin levels might be beneficial.


'/>"/>

Contact: Rachel Salis-Silverman
salis@email.chop.edu
267-426-6063
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2

Related biology news :

1. Rewriting the history of volcanic forcing during the past 2,000 years
2. Drought, river fragmentation forcing endangered fish out of water, biologist finds
3. Unique chromosomes preserved in Swedish fossil
4. Epigenetic regulation required to ensure correct number of chromosomes
5. Chromosomes show off their shapes
6. UMMS researchers answer century old question about 3D structure of mitotic chromosomes
7. X chromosomes: Undoing a hairpin doubles gene activity
8. A closer look at chromosomes
9. Western aspen trees commonly carry extra set of chromosomes
10. Study of fruit fly chromosomes improves understanding of evolution and fertility
11. Men can rest easy - sex chromosomes are here to stay
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... admitted Johannes Gutenberg University Mainz (JGU) as a ... continues to maintain a significant nationwide standing in ... acceptance of Johannes Gutenberg University Mainz as a ... in the national and international competition for the ... Rhineland-Palatinate can be proud that Mainz University has ...
(Date:10/15/2014)... will be awarded the 44th Rosenstiel Award for Distinguished ... pioneering research exploring the mechanisms of genomic instability and ... Alt is the second alumnus to win the Rosenstiel ... in 2003. , Alt is the Charles A. Janeway ... Medical School and an investigator at the Howard Hughes ...
(Date:10/14/2014)... 14, 2014)—It,s been millions of years since T. ... led by Ohio University scientists is breathing life back ... through dinosaur snouts. The research has important implications for ... but to enhance the sense of smell and cool ... said Ohio University doctoral student Jason Bourke, lead author ...
Breaking Biology News(10 mins):Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3
... researchers have,automatically grouped fluorescently tagged proteins from,high-resolution ... a new way to,identify disease proteins and ... cluster together inside a cell.,The approach, developed ... to localize proteins inside cells, says,Professor Robert ...
... California, San Diego have invented a process to ... specialized cells being sought as possible,treatments for dozens ... Shu Chien, UCSD bioengineering professors, and Christopher,J. Flaim, ... a paper published in the February issue of ...
... Nanosphere, Inc. today reported unprecedented benefits in the ... Nanosphere's nanoparticle-based technology allows for rapid, highly-sensitive and specific ... the direct detection of a particular gene and the ... technology, reported in the February 2005 (Volume 33, Number ...
Cached Biology News:New, automated tool successfully classifies and relates proteins in unprecedented way 2Priming embryonic stem cells to fulfill their promise 2Priming embryonic stem cells to fulfill their promise 3Novel technology detects human DNA mutations 2
(Date:10/19/2014)... The Asia-Pacific Speech Analytics market report defines and ... and forecast of revenue. This market is estimated to ... by 2019, at a Compound Annual Growth Rate (CAGR) ... the TOC of the Asia-Pacific Speech Analytics market report ... It also provides a glimpse of the segmentation in ...
(Date:10/18/2014)... (PRWEB) October 19, 2014 The ... (Short Acting, Intermediate Acting, Premixed), Modern Human Insulin ... Apidra, Levemir, NovoRapid, Novomix, Tresiba, Others) - Forecast ... major drivers, restraints, challenges, opportunities, current market trends, ... along with the estimates and forecasts of the ...
(Date:10/18/2014)... (PRWEB) October 18, 2014 The Asia-Pacific ... and segments the concerned market in Asia-Pacific with analysis ... $72.6 million in 2013, and is expected to reach ... from 2013 to 2018. , Browse through the TOC ... an idea of the in-depth analysis provided. This also ...
(Date:10/18/2014)... The “Global Diagnostic Electrocardiograph (ECG) ... End-user (Hospitals, Home/Ambulatory, Research Center, Physician Office, Nursing ... Forecast to 2020” provides a detailed overview of ... trends, and strategies impacting the global diagnostic ECG ... the revenue and share analysis. , The global ...
Breaking Biology Technology:The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 2The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 2Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 3Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 5The Asia-Pacific Liquid Crystal on Silicon (LCoS) display market is expected to reach $380.0 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Liquid Crystal on Silicon (LCoS) display market is expected to reach $380.0 million by 2018 - New Report by MicroMarket Monitor 3The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 2The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 3The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 4The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 5
... (Nasdaq: DNDN ) announced today the closing of ... its common stock, which shares were offered for sale to ... 2009, Deutsche Bank Securities Inc., acting as sole manager of ... an additional 1,279,166 shares of common stock at the public ...
... Microtest Laboratories , a leading single ... to its current suite of analytical testing ... of dissolution testing is the perfect ... President and Scientific Founder of Microtest Laboratories ( www.microtestlabs.com ...
... Italy, May 13 The FDA has approved ... Sciences to,begin a phase I clinical study with ... of cancer. PLK-1 is a mitotic kinase required ... is orally bioavailable,highly efficient and well tolerated in ...
Cached Biology Technology:Dendreon Announces Closing of Common Stock Offering 2Dendreon Announces Closing of Common Stock Offering 3Microtest Labs Adds Dissolution Testing to its Suite of Analytical and Stability Testing Services 2Microtest Labs Adds Dissolution Testing to its Suite of Analytical and Stability Testing Services 3Nerviano Medical Sciences Receives Approval From the FDA to Enter Phase I Clinical Trials for Their Polo Like Kinase (PLK) Inhibitor 2
... The ISOQUANT(R) Isoaspartate Detection Kit is intended ... in proteins and peptides, which can result ... or rearrangement of aspartic acid residues during ... not depend on the monitoring of charge ...
Lipofectin Reagent is the reagent of choice for some cell lines; cells of endothelial derivation transfect well with Lipofectin Reagent....
Rabbit polyclonal to EDG2 ( Abpromise for all tested applications). entrezGeneID: 1902 SwissProtID: Q92633...
Gloves are 9.25 long, latex, powder free, smooth and ambidextrous....
Biology Products: