Navigation Links
Food for thought -- regulating energy supply to the brain during fasting
Date:10/5/2008

Ph.D. "Because it uses muscle as a protein source, it will eventually lead to muscle wastage." Adds Montminy, "The question has always been how is the production of glucose turned on, and how is shut off again?"

Previous work by the Montminy lab and others has shown that two key proteins, CRTC2 and FOXO1, are needed to turn on glucose-making genes during fasting. CRTC2 is activated by glucagon, a hormone whose levels go up when we stop eating. FOXO1, on the other hand, is activated when levels of the food-stimulated hormone insulin drop below a certain threshold. CRTC2's and FOXO1's activity needs to be tightly regulated, since producing too much glucose would result in over-borrowing of energy from muscle tissue.

To uncover the mechanism that ensures that this doesn't happen, the Salk researchers created mice containing the gene for luciferase, a light-emitting enzyme usually found in fireflies, engineered in such a way that it was only turned on when CRTC2 was active. Using imaging equipment, they could then detect CRTC2 activity in the livers of live mice simply by measuring how much they glowed.

When the mice were fasted, CRTC2 was rapidly activated, and the livers lit up, but to the scientists' surprise, after six hours the light went out. Experimentally decreasing the levels of CRTC2 or FOXO1 confirmed there was a two-stage fasting-response. Lowering CRTC2 reduced gluconeogenesis only early on, while less FOXO1 only affected late glucose production. As in a relay race, during fasting the baton for glucose production appeared to be passed from CRTC2 in stage one to FOXO1 in stage two.

The crucial switch from CRTC2 to FOXO1 comes in the form of SIRT1, a nutrient sensor that accumulates in the late fasting stage. Yi discovered that SIRT1 has opposite effects on CRTC2 and FOXO1: it sends the former to the recycling bin, while it activates the latter, and thus the baton is safely transferred from CRTC2 to the FOXO1.

Why
'/>"/>

Contact: Gina Kirchweger
Kirchweger@salk.edu
858-453-4100 x1340
Salk Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Ancient marine invertebrate diversity less explosive than thought
2. Britains last Neanderthals were more sophisticated than we thought
3. Sierra Nevada rose to current height earlier than thought, say Stanford geologists
4. Shell-breaking crabs lived 20 million years earlier than thought
5. Food for thought
6. Food for thought: delivering the promise of food processing
7. Toll of climate change on world food supply could be worse than thought
8. Baiji Dolphin previously thought extinct spotted in the Yangtze River
9. CSHL team traces extensive networks regulating alternative RNA splicing
10. Glypican-3 gene function in regulating body size helps inform novel cancer treatments
11. 2 genes are important key to regulating immune response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/12/2015)... Va. , March 12, 2015 IriTech, ... and a member of the Texas Instruments Design Network, ... Naidu has demonstrated its IriShield USB MK2120U device ... scanning facility for pension distribution. The ... assembled to be marketed in India ...
(Date:3/12/2015)... -- Beta Systems today announced Fast ... (IAM) solution for a fixed price and with ... IAM package, customers benefit from the 30 years, ... implementations across different industries. The new fixed-price IAM ... necessary services and consulting. It spans the implementation ...
(Date:3/11/2015)... DUBLIN , Mar. 11, 2015 Research and ... addition of the "Access Control Market by Product, ... to 2020" report to their offering. , ... is expected to reach $10.4 billion by 2020, with ... control market report covers the products types such as ...
Breaking Biology News(10 mins):Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2Global Access Control (Cards & Readers, Biometrics, Controllers, Management Software) Market 2015-2020 - Analysis of the $10 Billion Market 2
... December 1, 2008 Although naturally occurring smallpox was ... obtain smallpox from a laboratory and release it into ... vaccine may be insufficient for universal administration. In a ... The American Journal of Medicine , researchers found that ...
... induce major differentiations in the metabolic make-up of ... November 28 in the open-access journal PLoS ... led by Karsten Suhre, has conducted a genome-wide ... genes involved in the breakdown of fats. The ...
... through DNA but also through the millions of proteins and ... known as "epigenetic marks," act both as a switch and ... turned on or off, and how much message an "on" ... information is known to be passed from parent to offspring ...
Cached Biology News:New study indicates smallpox vaccination effective for decades 2Study identifies genetic variants giving rise to differences in metabolism 2CSHL scientists discover a new way in which epigenetic information is inherited 2CSHL scientists discover a new way in which epigenetic information is inherited 3
(Date:3/25/2015)... BLOOMINGTON, MN (PRWEB) March 25, 2015 ... a breakthrough in nanoparticle technology that will enable ... and many other diseases with a simple breath ... ahead on the U.S. Food and Drug Administration ... 2016 launch of the innovative Nanoparticle Biomarker Tagging ...
(Date:3/25/2015)... /CNW/ - The Gairdner Foundation is pleased to ... recognizing some of the most significant medical discoveries ... the world,s most esteemed medical research prizes, the ... a $100,000 (CDN) prize to each scientist for their work. ... and innovation across the country, inspiring the next ...
(Date:3/25/2015)... 2015 Proove Biosciences , a ... to announce the success of their commercially supported symposium, ... to Optimize the Management of Pain, at the 31st ... Harbor, Maryland on Thursday, March 19th, 2015. ... President Lynn Webster , M.D., former Florida Society ...
(Date:3/25/2015)... 25, 2015 Oxis International, Inc. (OXIS) (OXI.PA) ... commercialization, announced today Oxis CEO Tony Cataldo ... 2015 at 4:15pm EST to update shareholders and other ...     Oxis Chairman and CEO Tony ... been very exciting for Oxis and our shareholders. There ...
Breaking Biology Technology:Ancon Medical Researchers Make Nanotechnology Breakthrough for Disease Screening Technology 2Ancon Medical Researchers Make Nanotechnology Breakthrough for Disease Screening Technology 32015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 22015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 32015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 42015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 52015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 62015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 72015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 8Proove Biosciences Hosts Symposium on Incorporating Genetic Testing to Optimize the Management of Pain 2Oxis Biotech Inc. Announces Corporate Update Conference Call for March 31 2
... 7 Endocare, Inc. (Nasdaq: ENDO ) ... have entered into a settlement agreement stipulating to termination ... Galil Medical pursuant to which Endocare would have acquired ... in Delaware Chancery Court. , , ...
... Covance Inc. today ... company as vice president and chief scientific officer of ... industry experience, including bioanalytical research, translational research, and talent ... development strategy for Covance,s bioanalytical services. , ...
... advanced energy research , , MONTREAL, July 7 ... technology company, today announced that it will jointly form ... Edmonton and the Alberta Energy Research Institute (AERI). , ... demonstration of novel catalytic conversion processes to produce advanced ...
Cached Biology Technology:Endocare and Galil Medical Announce Settlement of Litigation 2Covance Appoints Dr. Steven M. Michael as Vice President and Chief Scientific Officer of Global Bioanalytical Services 2Enerkem Announces World-Class Advanced Energy Research Center in Edmonton, Alberta, Canada 2Enerkem Announces World-Class Advanced Energy Research Center in Edmonton, Alberta, Canada 3
... to siRNA library screening, optimal ... identified and verified for each ... CellReady siRNA Transfection Optimization Kit, ... optimizing transfection conditions in 96 ...
... positioning slides offers multiple drive technologies ... and manual. With this series, users ... systems. These slides also offer anti-cage ... to 10 nanometers, integrated home/ limit ...
Ethylene glycol-bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid, Molecular Biology Grade...
Kit Components: Anti-PARP LumiGLO Chemiluminescent Substrate Immunoblot Blocking Reagent Pyronin Y Reagent Goat Anti-Rabbit IgG, HRP conjugate Double-It Reagent Film Exposure Folders Autor...
Biology Products: