Navigation Links
Food for thought -- regulating energy supply to the brain during fasting
Date:10/5/2008

LA JOLLA, CAIf the current financial climate has taught us anything, it's that a system where over-borrowing goes unchecked eventually ends in disaster. It turns out this rule applies as much to our bodies as it does to economics. Instead of cash, our body deals in energy borrowed from muscle and given to the brain.

Unlike freewheeling financial markets, the lending process in the body is under strict regulation to ensure that more isn't lent than can be afforded. New research by scientists at the Salk Institute for Biological Studies reveals just how this process is implemented.

"We have all seen the sub-prime mortgage crisis," says Marc Montminy, M.D., Ph.D., a professor in the Clayton Foundation Laboratories for Peptide Biology who led the current study. "If you take out a loan, sooner or later you've got to pay your debt, and the same is true in fasting metabolism."

The Salk researchers' findings, which are published ahead of print in the Oct. 5 edition of the journal Nature, may pave the way for novel therapies for sufferers of metabolic diseases in whom such regulation can spiral out of control.

Most tissues in our bodies respond to fasting by switching from their usual high-octane energy sourceglucoseto burning a low-octane, cheaper alternative-fat. For our brains, however, only the high-performance fuel will do. If no food-derived glucose is available, the body must manufacture its own supply to maintain the brain in the manner to which it is accustomed. It does so by taking energy from muscle in the form of protein and converting it to glucose in the liver, a process known as gluconeogenesis. The sugar is then shipped via the bloodstream to the brain to keep it running smoothly.

Gluconeogenesis needs to be turned on rapidly in response to fasting, but shutting it off again is just as crucial. "You don't want gluconeogenesis to be prolonged," says postdoctoral researcher and co-first author Yi Liu,
'/>"/>

Contact: Gina Kirchweger
Kirchweger@salk.edu
858-453-4100 x1340
Salk Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Ancient marine invertebrate diversity less explosive than thought
2. Britains last Neanderthals were more sophisticated than we thought
3. Sierra Nevada rose to current height earlier than thought, say Stanford geologists
4. Shell-breaking crabs lived 20 million years earlier than thought
5. Food for thought
6. Food for thought: delivering the promise of food processing
7. Toll of climate change on world food supply could be worse than thought
8. Baiji Dolphin previously thought extinct spotted in the Yangtze River
9. CSHL team traces extensive networks regulating alternative RNA splicing
10. Glypican-3 gene function in regulating body size helps inform novel cancer treatments
11. 2 genes are important key to regulating immune response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/12/2015)... , March 12, 2015 IriTech, a ... a member of the Texas Instruments Design Network, announced ... has demonstrated its IriShield USB MK2120U device during ... facility for pension distribution. The iris ... to be marketed in India ...
(Date:3/12/2015)... VIEW, Calif. , March 12, 2015 /PRNewswire/ ... with Complimentary Registration here: http://bit.ly/1G7Os0L . SPEAKERS: ... Manager Aravind SeshagiriPhoto - http://photos.prnewswire.com/prnh/20150311/181111 ... in order to compete in several different markets ... market is currently witnessing an uptrend. ...
(Date:3/10/2015)... NEW YORK , March 10, 2015  Continuing ... and the Unexpected, Hammacher Schlemmer introduces The Eye ... user,s identity before granting access to secure websites or ... trusted to verify travelers at international borders, the device ... 240 distinctive pattern points of the iris, converting them ...
Breaking Biology News(10 mins):Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3Biometrics Key to Future Growth in Healthcare, Retail and Financial Markets 2Biometrics Key to Future Growth in Healthcare, Retail and Financial Markets 3Hammacher Schlemmer Introduces The Eye Scanning Password Authenticator 2
... are reporting the first evidence from human research that ... antioxidants and other so-called phytochemicals improve memory. They ... clinical trials to determine whether blueberries really deserve their ... the study appears in ACS, Journal of Agricultural ...
... jury could decide a man,s guilt through mind reading? What ... And what constitutes ,intent, to commit murder? These are just ... issue of WIREs Cognitive Science, the latest interdisciplinary project from ... first two years. In the article "Neurolaw," in ...
... who have identified brain networks damaged in Parkinson,s disease have ... before symptoms appear. And what,s more, parts of the network ... the brain. "We were surprised," said Chris Tang, ... Medical Research in Manhasset, NY, and an author of the ...
Cached Biology News:Mind reading, brain fingerprinting and the law 2Brain abnormalities in Parkinson's patients develop before symptoms occur 2
(Date:3/25/2015)... Chicago, IL (PRWEB) March 25, 2015 ... Australia in the latter part of 2014, ITRA Global ... ITRA Global, the International Tenant Representative Alliance, based in ... dedicated to representing tenants and occupiers of commercial real ... real estate advisory firm in Poland that exclusively advises ...
(Date:3/25/2015)... , March 25, 2015  The Technology Association of ... association dedicated to the promotion and economic advancement of ... Streamline Health as one of its Top 40 Innovative ... will recognize this prestigious group at the 2015 Georgia ... Cobb Galleria Centre. TAG,S Top 40 Awards ...
(Date:3/25/2015)... 2015 FDNA®, the pioneer in ... Face2Gene, allowing geneticists around the globe to ... as mobile devices. Face2Gene® facilitates detection of facial dysmorphic ... comprehensive and up-to-date genetic references. The date of the ... 2015, in Salt Lake City, UT ...
(Date:3/25/2015)... , March 25, 2015   Demy-Colton Life Science ... investor and business development conferences exclusively for the biopharmaceutical ... launching the Biotech CEO Summit. The ... that brings together biotech industry leaders who are united ... innovation while reaping the rewards of biotech,s new golden ...
Breaking Biology Technology:International Organization Expands its Global Reach to Warsaw, Poland 2Streamline Health, Inc. Named a TAG Top 40 Innovative Technology Company 2Streamline Health, Inc. Named a TAG Top 40 Innovative Technology Company 3Streamline Health, Inc. Named a TAG Top 40 Innovative Technology Company 4FDNA Releases a Multi-Platform Version of Face2Gene, a Genetic Search and Reference Solution at ACMG 2015 2Biotech CEO Summit to Bring Key Biotech Leaders Together in Industry Brain Trust 2
... MS, EDMONTON, March 24 /PRNewswire-FirstCall/ - BioMS Medical ... multiple sclerosis (MS), today,announced that Mr. Kevin Giese, President ... the Biotech Industry" Conference in New York., ... Time), WHERE: The Millennium Broadway Hotel & ...
... 24 Finesse Solutions, LLC, a,manufacturer of measurement ... the release of TruFluor(TM), a single use optical,dissolved ... March,26, 2008., The TruFluor(TM) dissolved oxygen and ... disposable sheath, an optical reader,and a transmitter. The ...
... Martek Biosciences,(Nasdaq: MATK ) announced today the availability ... vegetarian form of DHA,omega-3 for brain, eye and heart ... mg per gram of life,sDHA and contains no soy ... applications where,allergens and labeling are concerns., "Our new ...
Cached Biology Technology:BioMS Medical to present at BioCentury Conference 2Finesse Introduces TruFluor(TM) DO, a Single-Use Optical Dissolved Oxygen Sensor and Transmitter 2Martek's life'sDHA(TM) Now Available in Protein-free Powder 2Martek's life'sDHA(TM) Now Available in Protein-free Powder 3
... The Zero Blunt ... for Sequencing is designed ... sequencing of blunt-end PCR ... provides 5-minute TOPO Cloning ...
...
nucleophosmin (nucleolar phosphoprotein B23, numatrin), mRNA...
Acrylamide PAGE 40% Solution, 1 l. Category: Electrophoresis Systems & Standards & Reagents, Electrophoresis Standards and Reagents, Gel Casting Chemicals....
Biology Products: