Navigation Links
Food for thought -- regulating energy supply to the brain during fasting
Date:10/5/2008

LA JOLLA, CAIf the current financial climate has taught us anything, it's that a system where over-borrowing goes unchecked eventually ends in disaster. It turns out this rule applies as much to our bodies as it does to economics. Instead of cash, our body deals in energy borrowed from muscle and given to the brain.

Unlike freewheeling financial markets, the lending process in the body is under strict regulation to ensure that more isn't lent than can be afforded. New research by scientists at the Salk Institute for Biological Studies reveals just how this process is implemented.

"We have all seen the sub-prime mortgage crisis," says Marc Montminy, M.D., Ph.D., a professor in the Clayton Foundation Laboratories for Peptide Biology who led the current study. "If you take out a loan, sooner or later you've got to pay your debt, and the same is true in fasting metabolism."

The Salk researchers' findings, which are published ahead of print in the Oct. 5 edition of the journal Nature, may pave the way for novel therapies for sufferers of metabolic diseases in whom such regulation can spiral out of control.

Most tissues in our bodies respond to fasting by switching from their usual high-octane energy sourceglucoseto burning a low-octane, cheaper alternative-fat. For our brains, however, only the high-performance fuel will do. If no food-derived glucose is available, the body must manufacture its own supply to maintain the brain in the manner to which it is accustomed. It does so by taking energy from muscle in the form of protein and converting it to glucose in the liver, a process known as gluconeogenesis. The sugar is then shipped via the bloodstream to the brain to keep it running smoothly.

Gluconeogenesis needs to be turned on rapidly in response to fasting, but shutting it off again is just as crucial. "You don't want gluconeogenesis to be prolonged," says postdoctoral researcher and co-first author Yi Liu,
'/>"/>

Contact: Gina Kirchweger
Kirchweger@salk.edu
858-453-4100 x1340
Salk Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Ancient marine invertebrate diversity less explosive than thought
2. Britains last Neanderthals were more sophisticated than we thought
3. Sierra Nevada rose to current height earlier than thought, say Stanford geologists
4. Shell-breaking crabs lived 20 million years earlier than thought
5. Food for thought
6. Food for thought: delivering the promise of food processing
7. Toll of climate change on world food supply could be worse than thought
8. Baiji Dolphin previously thought extinct spotted in the Yangtze River
9. CSHL team traces extensive networks regulating alternative RNA splicing
10. Glypican-3 gene function in regulating body size helps inform novel cancer treatments
11. 2 genes are important key to regulating immune response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... America (ESA) is very pleased to announce that it ... Science from the University of Wisconsin. , The ... an international, open-access, peer-reviewed journal that publishes papers on ... arthropods -- from the molecular to the ecological -- ... is freely available to individuals and institutions, and it ...
(Date:4/24/2014)... Researchers from North Carolina State University and the University ... new ultrasound device that could help identify arterial plaque ... causing heart attack or stroke. , At issue is ... age. Some types of plaque are deemed "vulnerable," meaning ... artery wall and cause heart attack or stroke. , ...
(Date:4/24/2014)... WASHINGTON, April 24A droplet of clear liquid can bend ... well-known phenomenon, researchers have developed a new process to ... than a penny apiece. , Because they,re so ... of applications, including tools to detect diseases in the ... and microscopes for education in classrooms. , "What ...
Breaking Biology News(10 mins):ESA to publish the Journal of Insect Science 2New ultrasound device may add in detecting risk for heart attack, stroke 2Bake your own droplet lens 2Bake your own droplet lens 3
... especially in intensive production. Piglets commonly become susceptible to ... to losses of 10% or more. The antibiotics used ... have now fallen out of use, mainly due to ... A radical solution has been found by using a ...
... cushy haploid environs to take up residence in a ... but Indiana University Bloomington scientists report in this week's ... plants. , "Plants that reproduce clonally or are ... mitochondrion to the nucleus," said graduate student Yaniv Brandvain, ...
... that help shape our understanding of how tool use ... chimpanzees, at least under some conditions, are capable of ... The work, reported by Jill Pruetz of Iowa State ... will appear online in the journal Current Biology on ...
Cached Biology News:A healthier start to a pig's life 2Mitochondrial genes move to the nucleus -- but it's not for the sex 2Chimpanzees found to use tools to hunt mammalian prey 2
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 DTS ... to its Online Web Portal for Life Science organizations who ... to specify the subject matter of their documents in advance ... will help reduce time-to-delivery of translations, often a critical factor ...
(Date:1/15/2014)... 15, 2014 Freeslate, Inc ., ... announced that Lupin Limited, one of India’s top five ... Protégé PharmD System for high throughput solid form ... focused on a wide range of quality, affordable generic ...
(Date:1/15/2014)... TaiGen Biotechnology Company, Limited ("TaiGen") today announced that they ... Russian pharmaceutical company, to develop and commercialize nemonoxacin (Taigexyn ... , Turkey and other members ... antibiotic for the treatment of bacterial infections including those ...
(Date:1/14/2014)... Carahsoft and CDS Federal Services have scheduled a ... EST (11am PST), “Natural Language Processing: Converting Raw Data ... can turn raw, heterogeneous data into actionable knowledge to ... webinar will last approximately one hour. , Synopsis: Big ...
Breaking Biology Technology:DTS Improves Efficiency for Life Science Document Translations 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2
... expanded access to choice, quality and cost-efficiency for patients ... Fla., June 24 Galichia Heart Hospital and Mobile ... to host MSI-coordinated, highly specialized, urologic surgical teams at ... Galichia,s capabilities as a center of excellence for selected ...
... 24 /PRNewswire-FirstCall/ - AEterna Zentaris Inc. (NASDAQ: ... company focused on endocrine therapy and oncology, announced ... registered direct offering of US$10 million of units ... warrants to certain institutional investors. AEterna Zentaris received ...
... and diagnostics, including new technologies, enhanced biotech and drug developments, ... the center of Cleveland Clinic,s 7th Annual Medical Innovation Summit, ... more than 900 leaders from throughout the healthcare industry to ... and gain actionable insights. , , This year,s ...
Cached Biology Technology:Galichia Heart Hospital Partners with Mobile Surgery International to Develop Wichita-based Center of Excellence with Global Convenience(TM) 2Galichia Heart Hospital Partners with Mobile Surgery International to Develop Wichita-based Center of Excellence with Global Convenience(TM) 3AEterna Zentaris Receives US$10 Million from Institutional Investors 2AEterna Zentaris Receives US$10 Million from Institutional Investors 32009 Medical Innovation Summit at Cleveland Clinic to Highlight the Latest Developments in Cancer Care 22009 Medical Innovation Summit at Cleveland Clinic to Highlight the Latest Developments in Cancer Care 3
12 breakable polypropylene strips of 8 wells each held in a rigid frame. Ideal for antibody assays....
... in vitro diagnostic assays, all EIA/RIA plates ... uniform binding, high optical clarity and low ... part of the Certified Surface Chemistry Programme, ... within QA release specifications. Linkage: This CLS ...
... Stabilizer is an aqueous solution that contains ... stabilizing chemicals in a saline solution, pH ... of 0.02% methylisothiazolone and 0.02% bromonitrodioxane as ... a diluent and stabilizer for biologically active ...
AC input: 230 V...
Biology Products: