Navigation Links
Food contaminants worsen metabolic problems in obese mice
Date:6/27/2013

In order to get a better understanding of these effects, researchers from the Inserm cardiovascular, metabolism, diabetology and nutrition unit (U1060 Laboratoire de recherche en cardiovasculaire, mtabolisme, diabtologie et nutrition Inserm/Inra/Universit Lyon 1) introduced a "cocktail" of contaminants mixed with low doses of dioxin, PCB, bisphenol A and phtalates into the feeding of mice that had already been rendered obese by a high-fat diet.

The results show that metabolic changes occur in these mice, but that the effects differ depending on the gender. Females appeared to be more affected. Their obesity-induced glucose intolerance worsened and their estrogen pathway was altered.

These works have been published in the review Faseb Journal.

Obesity is a major public health problem because it is a risk factor in the development of metabolic complications (diabetes, cardiovascular diseases, etc.). It is a multi-factorial disorder. In addition to genetic predispositions and a life style that combines overeating with lack of exercise, there is a great volume of proof to suggest that contaminants, particularly in the food we eat, are responsible for the obesity epidemic and the resulting metabolic changes.

Researchers have put forward the hypothesis that contaminants in food could worsen certain metabolic problems already caused by eating an over-rich or a high-fat diet.

In this study, the researchers fed mice a high-fat diet (already a health risk), to which low doses of contaminants had been added. They were given this diet throughout their lives. Their mother had been nourished with this diet prior to their birth and during the gestation and lactation periods. Therefore, they suffered chronic exposure to this diet.

Two environmentally persistent contaminants (dioxin and PCB) and two non-persistent contaminants (phtalate and bisphenol A) were added to the high-fat (obesogenic) diet of the mice. The doses g
'/>"/>

Contact: Brigitte Le Magueresse Battistoni
brigitte.lemagueresse@inserm.fr
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Fetal neuromaturation associated with mothers exposure to ddt and other environmental contaminants
2. Notre Dame research reveals migrating Great Lakes salmon carry contaminants upstream
3. Ah, that new car smell: NASA technology protects spacecraft from outgassed molecular contaminants
4. New UC Santa Barbara-based project to study contaminants in urban water environment
5. Gum disease found to worsen infection in animal model of AIDS
6. Symptoms of Prader-Willi syndrome associated with interference in circadian, metabolic genes
7. Metabolic model of E. coli reveals how bacterial growth responds to temperature change
8. Formula-feeding linked to metabolic stress and increased risk of later disease
9. Grape intake may protect against metabolic syndrome-related organ damage
10. Metabolic fingerprinting: Using proteomics to identify proteins in gymnosperm pollination drops
11. FASEB SRC announces conference: Glucose transport -- Gateway for Metabolic Systems Biology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/24/2015)... Aug. 24, 2015  Based on its recent analysis of ... the 2015 African Biometrics Company of the Year Award. DERMALOG ... commercial success in Africa . It has ... it has implemented one of the largest biometric mass applications ... as the Central Bank of Nigeria ...
(Date:8/18/2015)... PRINCETON, N.J. , Aug. 18, 2015 ... be a key contributor to the Submission ... hosted by IRISS, a non-profit forum. Dedicated to ... IRISS provides a neutral platform for industry, ... to share information and work towards a ...
(Date:8/12/2015)... NEW YORK , Aug. 12, 2015 /PRNewswire/ ... how hackers can attack Android phones to steal ... identifies the increasing availability of fingerprint scanners on ... of utmost concern. To secure biometrics on mobile ... platform to augment these convenient authentication systems with ...
Breaking Biology News(10 mins):Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 2Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 3Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 4Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 5Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 6Navitas, a Key Contributor in IRISS Forum Webinar 2Navitas, a Key Contributor in IRISS Forum Webinar 3HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 3
... , Johns Hopkins researchers have created a synthetic protein that, ... within the body where cancer, arthritis and other serious medical ... a new type of diagnostic imaging technology and may someday ... the body where signs of disease have been found. In ...
... A study published in the most recent issue ... ( JAMA ) presented encouraging news regarding physicians, ... disease (CAD) using noninvasive CT scanning technology. Data from ... Tomographic Angiography (DeFACTO) study were presented on August 26 ...
... robots, Northern Illinois University Professor David Gunkel says science fiction ... intelligence have run the gamut from the loyal Robot in ... A Space Odyssey" and the endearing C-3PO and R2-D2 of ... the stuff of fiction, the issues they raised have never ...
Cached Biology News:Collagen-seeking synthetic protein could lead doctors to tumor locations 2Collagen-seeking synthetic protein could lead doctors to tumor locations 3New study evaluates noninvasive technology to determine heart disease 2Morality for robots? 2Morality for robots? 3
(Date:9/1/2015)... ... September 01, 2015 , ... AxioMx Inc. , a ... Institutes of Health (NIH) has awarded the company a Phase I Small Business ... Institute of Diabetes and Digestive and Kidney Diseases. AxioMx will use this award ...
(Date:9/1/2015)... ... September 01, 2015 , ... Knowledgent , the data and analytics ... advanced analytics utilizing data lakes in the healthcare industry. , As the Internet of ... of data over the last few years as more entities become technology enabled through ...
(Date:9/1/2015)... , ... September 01, 2015 , ... ... from University of California Los Angeles, Boston University School of Medicine, Frederick National ... in PLOS One, the world’s first multidisciplinary Open Access journal. , Christopher ...
(Date:8/31/2015)... GUELPH, ON , Aug. 31, 2015 /PRNewswire/ - BIOREM ... new orders totalling $5.7 million. The orders are for air emission ... "Of particular note is a large order for a ... our equipment will be replacing a competitor,s system that failed ... see in our engineered solutions," said Derek S. Webb ...
Breaking Biology Technology:AxioMx Announces Receipt of SBIR Grant for DNA-Protein Complex Antigen Development 2AxioMx Announces Receipt of SBIR Grant for DNA-Protein Complex Antigen Development 3New White Paper Explores Data Lake Opportunities in the Healthcare Industry 2Synedgen’s Director for Pharmaceutical Manufacturing Publishes New Research 2Synedgen’s Director for Pharmaceutical Manufacturing Publishes New Research 3
... Barbara Randolph-Anderson 1 , John E. Boynton 1 , ... Robert Eskes 3 , Nicholas W. Gillham 1 , Anita ... Jan Suttie 2 , and William C. Heiser 4 . ... Biology Group, Box 91000,Duke University, Durham, North Carolina 27708-1000; 2 CIBAGEIGY,Agricultural Biotechnology, ...
... A. Kimberley McAllister, Nina Tang, Lawrence C. Katz, and Donald C. , ... of Neurobiology, Box 3209, Duke University Medical Center, , ... , Introduction , ... interest , remains a rate-limiting step for molecular investigations ...
... Contributed by James V. Anderson and Charles L. ... , Introduction ... Proteins, also known as GRP78; , Glucose ... HSP70 family. 1 BiPs are associated with the transport and ...
Cached Biology Technology:Sub-Micron Gold Particles Are Superior to Larger Particles for Efficient Biolistic Transformation of Organelles and Some Cells 2Sub-Micron Gold Particles Are Superior to Larger Particles for Efficient Biolistic Transformation of Organelles and Some Cells 3Sub-Micron Gold Particles Are Superior to Larger Particles for Efficient Biolistic Transformation of Organelles and Some Cells 4Sub-Micron Gold Particles Are Superior to Larger Particles for Efficient Biolistic Transformation of Organelles and Some Cells 5Sub-Micron Gold Particles Are Superior to Larger Particles for Efficient Biolistic Transformation of Organelles and Some Cells 6Sub-Micron Gold Particles Are Superior to Larger Particles for Efficient Biolistic Transformation of Organelles and Some Cells 7Sub-Micron Gold Particles Are Superior to Larger Particles for Efficient Biolistic Transformation of Organelles and Some Cells 8Sub-Micron Gold Particles Are Superior to Larger Particles for Efficient Biolistic Transformation of Organelles and Some Cells 9Sub-Micron Gold Particles Are Superior to Larger Particles for Efficient Biolistic Transformation of Organelles and Some Cells 10Sub-Micron Gold Particles Are Superior to Larger Particles for Efficient Biolistic Transformation of Organelles and Some Cells 11Sub-Micron Gold Particles Are Superior to Larger Particles for Efficient Biolistic Transformation of Organelles and Some Cells 12Sub-Micron Gold Particles Are Superior to Larger Particles for Efficient Biolistic Transformation of Organelles and Some Cells 13Biolistic Transfection of Organotypic Brain Slices 2Biolistic Transfection of Organotypic Brain Slices 3Biolistic Transfection of Organotypic Brain Slices 4Biolistic Transfection of Organotypic Brain Slices 5Biolistic Transfection of Organotypic Brain Slices 6Biolistic Transfection of Organotypic Brain Slices 7Biolistic Transfection of Organotypic Brain Slices 8Biolistic Transfection of Organotypic Brain Slices 9Biolistic Transfection of Organotypic Brain Slices 10A Rapid Method for the Purification of Analytical Grade Proteins From Plants Using Preparative SDS-PAGE and Preparative IEF 2A Rapid Method for the Purification of Analytical Grade Proteins From Plants Using Preparative SDS-PAGE and Preparative IEF 3A Rapid Method for the Purification of Analytical Grade Proteins From Plants Using Preparative SDS-PAGE and Preparative IEF 4A Rapid Method for the Purification of Analytical Grade Proteins From Plants Using Preparative SDS-PAGE and Preparative IEF 5
... label transfer is fast emerging as a ... and confirmation. Until now, only amino groups ... label transfer reagents such as our Sulfo-SBED. ... Mts-Atf-LC-Biotin, are exciting additions to the protein ...
...
... is a compact benchtop and stackable ... controller with a large display screen ... speed. Air circulation inside to evenly ... can be easily calibrated from the ...
...
Biology Products: