Navigation Links
Food contaminants worsen metabolic problems in obese mice
Date:6/27/2013

In order to get a better understanding of these effects, researchers from the Inserm cardiovascular, metabolism, diabetology and nutrition unit (U1060 Laboratoire de recherche en cardiovasculaire, mtabolisme, diabtologie et nutrition Inserm/Inra/Universit Lyon 1) introduced a "cocktail" of contaminants mixed with low doses of dioxin, PCB, bisphenol A and phtalates into the feeding of mice that had already been rendered obese by a high-fat diet.

The results show that metabolic changes occur in these mice, but that the effects differ depending on the gender. Females appeared to be more affected. Their obesity-induced glucose intolerance worsened and their estrogen pathway was altered.

These works have been published in the review Faseb Journal.

Obesity is a major public health problem because it is a risk factor in the development of metabolic complications (diabetes, cardiovascular diseases, etc.). It is a multi-factorial disorder. In addition to genetic predispositions and a life style that combines overeating with lack of exercise, there is a great volume of proof to suggest that contaminants, particularly in the food we eat, are responsible for the obesity epidemic and the resulting metabolic changes.

Researchers have put forward the hypothesis that contaminants in food could worsen certain metabolic problems already caused by eating an over-rich or a high-fat diet.

In this study, the researchers fed mice a high-fat diet (already a health risk), to which low doses of contaminants had been added. They were given this diet throughout their lives. Their mother had been nourished with this diet prior to their birth and during the gestation and lactation periods. Therefore, they suffered chronic exposure to this diet.

Two environmentally persistent contaminants (dioxin and PCB) and two non-persistent contaminants (phtalate and bisphenol A) were added to the high-fat (obesogenic) diet of the mice. The doses g
'/>"/>

Contact: Brigitte Le Magueresse Battistoni
brigitte.lemagueresse@inserm.fr
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Fetal neuromaturation associated with mothers exposure to ddt and other environmental contaminants
2. Notre Dame research reveals migrating Great Lakes salmon carry contaminants upstream
3. Ah, that new car smell: NASA technology protects spacecraft from outgassed molecular contaminants
4. New UC Santa Barbara-based project to study contaminants in urban water environment
5. Gum disease found to worsen infection in animal model of AIDS
6. Symptoms of Prader-Willi syndrome associated with interference in circadian, metabolic genes
7. Metabolic model of E. coli reveals how bacterial growth responds to temperature change
8. Formula-feeding linked to metabolic stress and increased risk of later disease
9. Grape intake may protect against metabolic syndrome-related organ damage
10. Metabolic fingerprinting: Using proteomics to identify proteins in gymnosperm pollination drops
11. FASEB SRC announces conference: Glucose transport -- Gateway for Metabolic Systems Biology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2015)... , April 13, 2015 ... TechSci Research, "Global Biometrics Market Forecast & Opportunities, 2020", ... a CAGR of around 14% till 2020. The ... for large scale implementation and review of biometric ... launch of new products with greater efficiency, are ...
(Date:4/9/2015)... April 9, 2015 Synaptics Inc. (NASDAQ: SYNA ... today that it will report financial results for the ... 2015, after the close of market. The company will ... at 2:00 p.m. PT (5:00 p.m. ET), during which ... participate on the live call, analysts and investors should ...
(Date:4/2/2015)... 2, 2015 In the ... far outperforms the strongest competitors, showing outstanding performance ... the system is capable of a throughput of ... up to be ten times faster than most ... performance.      (Photo: http://photos.prnewswire.com/prnh/20150402/738673-a ...
Breaking Biology News(10 mins):Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2Synaptics to Report Third Quarter Results on April 23 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3
... New research from The University of Western Ontario leads ... the Arctic Circle during the Pleistocene Epoch (approx. 150,000 ... three years later than modern day African elephants due ... nursing pattern could have contributed to the prehistoric elephant,s ...
... 21, 2010 Reportlinker.com announces that a new market ... Indian Biometric Market http://www.reportlinker.com/p0351944/Indian-Biometric-Market.html ... fastest emerging technology in the Indian Securities & Identification ... many conventional methods of Identity & Security checks like, ...
... Miscanthus x giganteus is the forerunner in the ... researchers believe "putting all their eggs in one basket" could ... recently reported the first natural occurrence in several decades of ... M. x giganteus is the only variety available, ...
Cached Biology News:Being good moms couldn't save the woolly mammoth 2New Miscanthus hybrid discovery in Japan could open doors for biofuel industry 2New Miscanthus hybrid discovery in Japan could open doors for biofuel industry 3
(Date:4/23/2015)... CA (PRWEB) April 23, 2015 ... leader in Personalized Medicine, is excited to announce ... Response profile . This profile assesses 62 genetic ... provide dosing information for commonly prescribed non-opioid pain ... (brand name Neurontin), alprazolam (brand name Xanax) and ...
(Date:4/23/2015)... , April 23, 2015  Propanc Health ... healthcare company, focuses on the development of cancer ... The company lead product includes PRP, a patented ... and chymotrypsinogen, as well as the enzyme amylase ... also developing a combination of anti-cancer agents working ...
(Date:4/23/2015)... 2015 ReliantHeart's HeartAssist5® Ventricular Assist Device ... through the device) in real time, and this data ... leading provider of Machine to Machine (M2M) communications for ... via VADLink.com can be monitored by a ... in flow below a minimum threshold, the patient can ...
(Date:4/22/2015)... , April 23, 2015  The Heinz Family ... th Heinz Awards, which will present unrestricted ... Americans for their creativity and determination in finding ... This year,s recipients include a prolific ... modern-day life and personal relationships; two former Marines ...
Breaking Biology Technology:Proove Biosciences Launches World’s First Test to Predict Responders to Commonly Prescribed Non-Opioid Pain Medications 2Proove Biosciences Launches World’s First Test to Predict Responders to Commonly Prescribed Non-Opioid Pain Medications 3Early Stage BioTech offers Plenty of Risk; Propanc Health Group Analyst Brief Issued by BrokerBank Securities, Inc. 2From a Scientist Who Develops Human Microlivers to a New Yorker Cartoonist Who Masterfully Depicts the Humor and Heartbreak of Everyday Life: The 20th Heinz Awards Honors Six Changemakers 2From a Scientist Who Develops Human Microlivers to a New Yorker Cartoonist Who Masterfully Depicts the Humor and Heartbreak of Everyday Life: The 20th Heinz Awards Honors Six Changemakers 3From a Scientist Who Develops Human Microlivers to a New Yorker Cartoonist Who Masterfully Depicts the Humor and Heartbreak of Everyday Life: The 20th Heinz Awards Honors Six Changemakers 4From a Scientist Who Develops Human Microlivers to a New Yorker Cartoonist Who Masterfully Depicts the Humor and Heartbreak of Everyday Life: The 20th Heinz Awards Honors Six Changemakers 5From a Scientist Who Develops Human Microlivers to a New Yorker Cartoonist Who Masterfully Depicts the Humor and Heartbreak of Everyday Life: The 20th Heinz Awards Honors Six Changemakers 6
... Omeros Corporation (NASDAQ: OMER ), ... and commercializing products targeting inflammation, coagulopathies and disorders ... Gregory A. Demopulos, M.D., chairman and chief executive ... and Renshaw 13th Annual Healthcare Conference taking place ...
... , Gains US Patent Protection for Proprietary AAV Intellectual ... leader in the field of human gene therapy, today ... agreement with the US National Institutes of Health (NIH) ... therapy vectors for liver and brain indications. This agreement ...
... This September, during Prostate Cancer Awareness Month , ... method that may change the face of prostate ... and one Boston hospital, analyzed by the National Cancer Institute, ... Dr. David Samadi, Vice Chairman, Department of Urology, and ...
Cached Biology Technology:Amsterdam Molecular Therapeutics Licenses Additional Novel Gene Therapy Vectors from National Institutes of Health 2Amsterdam Molecular Therapeutics Licenses Additional Novel Gene Therapy Vectors from National Institutes of Health 3More Precise Prostate Cancer Screening on Horizon 2More Precise Prostate Cancer Screening on Horizon 3
G-protein coupled purinergic receptor P2Y8...
This application changes sensitive keywords in an FCS file to remove patient information. It was contributed by Dr. David Miller....
Recognizes rat Taste Receptor 2 (TR2). The immunogen shows no significant sequence homology with TR1, gustducin or other pheromone receptors....
Rat monoclonal [HK5.3] to B7 RP1 (Biotin) ( Abpromise for all tested applications). entrezGeneID: 23308 SwissProtID: O75144...
Biology Products: