Navigation Links
Folate prevents alcohol-induced congenital heart defects in mice
Date:5/24/2010

.2 mg/kg). A third control group ate a normal folate-supplemented diet (3.3 mg/kg) determined to maintain the general health of the pregnant mice, but not to rescue embryos from birth defects.

During the first week of pregnancy, the mice in all three groups were then administered injections of alcohol simulating a single binge drinking event in humans.

Following this alcohol exposure, Doppler ultrasound confirmed that 87 percent of the embryos of pregnant mice in the third group those not receiving folate supplementation beyond what was present in their normal diets had developed heart valve defects. The affected embryos were also smaller in size and their heart muscle walls appeared thinner.

Between days 15 and 16 of pregnancy in the mice equal to 56 days of gestation in humans -- ultrasound also showed that the high-folate diet protected heart valve development against lasting defects and restored heart function and embryonic size to near-normal levels. The moderate-folate diet provided only partial protection; in this group 58 percent of the mouse embryos developed heart valves that functioned abnormally, with a back flow of blood.

The researchers suggest that folate fortification may be most effective at preventing heart birth defects when administered at significantly higher levels than the doses currently recommended to prevent pregnancy complications -- both in normal women (0.4 milligrams recommended daily) and even in women who have delivered an infant with a spinal birth defect (4 milligrams daily). Although higher folate levels did not cause adverse side effects in the pregnant mice, Dr. Linask notes, the safety and effectiveness of higher doses must be proven with human trials.

The heart is the first organ to form and function during embryonic development of vertebrates. The USF researchers suggest that folate supplementation thwarts alcohol's damaging effect on an important early signaling pathway
'/>"/>

Contact: Anne DeLotto Baier
abaier@health.usf.edu
813-974-3300
University of South Florida Health
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Attention-deficit/hyperactivity problems associated with low folate levels in pregnant women
2. SNPs affect folate metabolism in study of Puerto-Rican adults
3. Vitamin B-12 function may be diminished by excessive folate
4. Folate mystery finally solved
5. Yale researchers may have uncovered the mechanism by which progesterone prevents preterm birth
6. Tumor suppressor p53 prevents cancer progression in cells with missegregated chromosomes
7. New mechanism explains how the body prevents formation of blood vessels
8. Novel antibody prevents infection by hepatitis C virus
9. Drug prevents seizure progression in model of epilepsy
10. Sexual harassment from males prevents female bonding, says study
11. Targeted drug therapy prevents exercise-induced arrhythmias
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... Bethesda, MD FASEB MARC (Maximizing Access to ... recipients for the Genetics Society of America,s 27th ... October 3, 2014 in Pacific Grove, California. ... entry of students, post doctorates and scientists from ... science community and to encourage the participation of ...
(Date:8/28/2014)... A unique method for delivering compounds that ... HIV and AIDS may be possible, thanks ... Agricultural Sciences., A semi-soft vaginal suppository made ... loaded with the antiviral drug Tenofovir provides ... against the spread of sexually transmitted infections ...
(Date:8/28/2014)... 28, 2014 Dyslexia, the most commonly diagnosed ... neurological reading disability that occurs when the regions ... function normally. , The use of non-invasive functional ... is disrupted in dyslexia. However, most prior work ... brain regions, leaving a gap in our understanding ...
Breaking Biology News(10 mins):Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 2Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 3Dyslexic readers have disrupted network connections in the brain 2
... 45,000 corneal transplant eye surgeries are performed in the ... effort to standardize this complex procedure, two video articles ... JoVE, the Journal of Visualized Experiments . These ... and the United States. By utilizing the JoVE,s ...
... as ,green phones, for communication with other bugs. A ... insects are also able to leave ,voicemail, messages in ... effects on soil fungi. Researchers from the Netherlands Institute ... unique messaging service in the ragwort plant. The influential ...
... non-protein-coding RNAs start off as long strands of ... a special kind of machinery, the "Microprocessor" complex, to ... miRNAs bind to messenger RNA (mRNAs) molecules, inhibiting their ... hundreds of different proteins. But the Microprocessor complex ...
Cached Biology News:Pre-surgical steps for eye surgery are standardized through JoVE's video publication 2Voicemail discovered in nature 2Living microprocessor tunes in to feedback 2
(Date:8/28/2014)... “This kit has an improved extraction efficiency and provides ... ppb,” said Mark Tess, PhD, Mycotoxin Product Manager for Charm ... and USDA-GIPSA inspection agencies that have a need to detect ... in a matter of minutes with nothing but our equipment ... and grain before accepting it, but they no longer have ...
(Date:8/28/2014)... The ability for organizations to attract top ... individuals to perform at the highest of levels, are ... to compete in this post–recession era. The pharmaceutical ... the sector increasingly focuses on the importance of employee-fit ... real results on the organization's development and the innovation ...
(Date:8/28/2014)... MENLO PARK, Calif. , Aug. 28, 2014 ... company focused on developing novel mid- to late-stage ... raised $7.0 million in its first round of ... AshHill Biomedical Investments and Hercules Bioventures with participation ... biotech entrepreneur and pharmaceutical executive, Dr. Larry ...
(Date:8/28/2014)... 2014 Earlier this month, a ... partnership with the U.S. Air Force on the performance ... indicated that this type of fuel made from mustard ... be important to America’s Eco friendly future. In fact, ... mandate to become independent of foreign oil over the ...
Breaking Biology Technology:Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3Armetheon Completes $7.0 Million Series A Financing 2Armetheon Completes $7.0 Million Series A Financing 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 4Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 5
... 16 ARUP Laboratories, a national,clinical and anatomic pathology ... development, announced today that,company co-founder Carl R. Kjeldsberg, MD, ... of June 2009. Kjeldsberg has held the position,since 1993 ... chairman of,the Board., Effective, July 1, 2009, Edward ...
... MEDX ) announced today data from a ... higher doses of MDX-060, an investigational,anti-CD30 antibody, and ... patients with relapsed or refractory CD30-,positive lymphomas. Results ... the,Annual Meeting of the American Association for Cancer ...
... of Hollings Expanded Building, CHARLESTON, S.C., April 16 ... has dedicated the Edwin and Barbara,Pearlstine Healing Garden. The ... $1 million gift from Edwin S. Pearlstine, Jr., in ... who died of cancer in,1997., "Edwin and Barbara ...
Cached Biology Technology:ARUP Laboratories CEO and Co-Founder Announces Retirement 2Medarex Reports Phase 1/2 Clinical Data of MDX-060 in Lymphoma at American Association for Cancer Research Meeting 2Medarex Reports Phase 1/2 Clinical Data of MDX-060 in Lymphoma at American Association for Cancer Research Meeting 3MUSC's Hollings Cancer Center Dedicates Edwin and Barbara Pearlstine Healing Garden Endowed with $1 Million Gift from Edwin S. Pearlstine, Jr. 2
... Mouse anti-Yersinia pestis F1 antigen, Monoclonal ... ELISA: Use at an ... an assay dependent dilution. WB: Use ... molecular weight: 18 kDa. Not tested ...
Anti-Phospho-JKK/SEK1/MKK4 pAb Description: 100 g rabbit polyclonal antibody. Reacts with human/mouse/rat. Tested in WB. Research Focus: signal transduction Storage: -20C Shipping Tem...
... A - Fixation medium Reagent B - ... for fixing cells in suspension with Reagent ... Reagent B. This procedure gives antibodies access ... scatter characteristics of the cells intact. Specific ...
... formulated for covering tissue sections and cell preparations immunohistochemically stained ... , ... Application: Vision Mount ... that require an aqueous mounting medium, or those that do ...
Biology Products: