Navigation Links
Focus on glaucoma origins continues path toward potential cure
Date:1/17/2012

Glaucoma is the second leading cause of blindness. Nearly 4 million Americans have the disorder, which affects 70 million worldwide. There is no cure and no early symptoms. Once vision is lost, it's permanent.

New findings at Georgia Tech, published in January during Glaucoma Awareness Month, explore one of the many molecular origins of glaucoma and advance research dedicated to fighting the disease.

Glaucoma is typically triggered when fluid is unable to circulate freely through the eye's trabecular meshwork (TM) tissue. Intraocular pressure rises and damages the retina and optic nerve, which causes vision loss. In certain cases of glaucoma, this blockage results from a build-up of the protein myocilin. Georgia Tech Chemistry and Biochemistry Assistant Professor Raquel Lieberman focused on examining the structural properties of these myocilin deposits.

"We were surprised to discover that both genetically defected as well as normal, or wild-type (WT), myocilin are readily triggered to produce very stable fibrous residue containing a pathogenic material called amyloid," said Lieberman, whose work was published in the most recent Journal of Molecular Biology.

Amyloid formation, in which a protein is converted from its normal form into fibers, is recognized as a major contributor to numerous non-ocular disorders, including Alzheimer's, certain forms of diabetes and Mad Cow disease (in cattle). Scientists are currently studying ways to destroy amyloid fibrils as an option for treating these diseases. Further research, based on Lieberman's findings, could potentially result in drugs that prevent or stop myocilin amyloid formation or destroy existing fibrils in glaucoma patients.

Until this point, amyloids linked to glaucoma had been restricted to the retinal area. In those cases, amyloids kill retina cells, leading to vision loss, but don't affect intraocular pressure.

"The amyloid-containing myocili
'/>"/>

Contact: Jason Maderer
maderer@gatech.edu
404-385-2966
Georgia Institute of Technology
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Lung cancer conference to focus on new diagnostic techniques, potential treatments
2. Predictive health symposium will focus on human microbiome
3. Conservationists call for increased focus on coastal ecosystems
4. New book from NJIT professor focuses on art, science and evolution
5. Focus on fats
6. First NIH-funded personalized drug development center in US will focus on muscle disease
7. Fate of lakes focus of international meeting in Sunapee, N.H.
8. Journal focuses on Savannah River National Labratory, Chernobyl Laboratory collaboration
9. Researchers develop optimal algorithm for determining focus error in eyes and cameras
10. International pharmacogenomics conference to focus on better drug treatment based on genetics
11. October 2011 conference focuses on the role of gender in cardiovascular disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Focus on glaucoma origins continues path toward potential cure
(Date:6/25/2015)... 2015  Imagine a tool specifically designed to help ... life. That,s exactly what USANA,s True Health Assessment ... portable health program provides a personalized approached to measuring ... your lifestyle and nutrition. At the ... night, USANA,s THA was honored with the Industry Innovation ...
(Date:6/24/2015)... June 24, 2015 This report provides market ... next six years. It contains an analysis of the ... with their impact from the short, medium, and long ... the industry, market, and technology trends that currently, prevail ... of concerned authorities to efficiently manage the increasing marine ...
(Date:6/24/2015)... Switzerland , June 24, 2015 ... partnership with emerging biometric password solution one face ... one face in, entering ... a ground-breaking and affordable multifactor-authentication biometric answer to ... recognition technology, provided in partnership with KeyLemon, one ...
Breaking Biology News(10 mins):@USANAinc's Personalized Nutrition Program Wins Industry Innovation Award 2Automatic Identification System Market by Class, by Platform, by Application and by Geography - Global Forecasts & Analysis to 2014 - 2020 2KeyLemon Announces Partnership With Biometric Password Solution onefacein 2
... scientists are working together to meet the challenges of climate ... Biology on 28th June will demonstrate innovative techniques and insights ... crop yields and diminishing fish stocks. , In seven ... world,s four most important crops has fallen short of demand, ...
... advance toward treating disease with minute capsules containing not ... for making the drug. In an article in ACS, ... and nano-sized capsules that contain the genetically coded instructions, ... synthesis that can be switched on with an external ...
... international team led by human genetic researchers at the ... identified the latest gene associated with typical late-onset Lewy ... Canadian Mennonite family of Dutch-German-Russian ancestry. Twelve ... participated in the study had previously been diagnosed with ...
Cached Biology News:Parkinson's disease gene identified with help of Mennonite family: UBC-VCH research 2Parkinson's disease gene identified with help of Mennonite family: UBC-VCH research 3
(Date:7/28/2015)... 28, 2015 BioStructures, LLC, a privately ... a milestone of 4,000 implantations of Signafuse® Bioactive ... in early 2014 as a bone void filler ... procedures.  This is a distinguished status among recently ... of new synthetic products have received clearance with ...
(Date:7/28/2015)... July 28, 2015 /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ: ... it has granted to German life sciences entrepreneurs ... and commercialization of biotechnology (collectively, the "Optionee"), an ... allogenic tumor vaccine technology (the "Technology"), including AEZS-120, ... which is ready to enter a Phase 1 ...
(Date:7/28/2015)... Israel , July 28, 2015 /PRNewswire/ ... regenerative medicine company utilizing its proprietary plant-based rhCollagen ... Shomrat Shurtz has been appointed Senior Director of ...      (Photo: http://photos.prnewswire.com/prnh/20150728/246955 ) , ... experience in marketing, regulatory and business strategy. Prior ...
(Date:7/27/2015)... 27, 2015  Amgen (NASDAQ: AMGN ) today ... results on Thursday, July 30, 2015, after the close ... followed by a conference call with the investment community ... Amgen will be Robert A. Bradway , chairman ... senior management team. Live audio of the ...
Breaking Biology Technology:Revolutionary Bone Graft Exceeds Expectations 2Aeterna Zentaris Grants Option to Develop and Commercialize Oral Allogenic Cancer Vaccine Technology 2Aeterna Zentaris Grants Option to Develop and Commercialize Oral Allogenic Cancer Vaccine Technology 3CollPlant Names Shomrat Shurtz Senior Director of Business Development 2Amgen Announces Webcast of 2015 Second Quarter Financial Results 2
... to meet increasing global demand for health ... economics and market access support, ... appointment of Adam Barak as Vice President., Mr. Barak ... of global pricing and reimbursement strategies,for drugs, medical devices, and ...
... - Laureate To Manufacture Tolera,s Monoclonal Antibody ... 28 Laureate Pharma, Inc., a,full-service biopharmaceutical ... it has entered into a cGMP contract ... company that,develops and offers targeted therapies and ...
... globally renowned scientists , ... Gardner, Mass. (PRWEB) October ... internationally renowned specialists to its newly formed scientific advisory board., , ... created to formalize NEP,s network of thought leaders in peptide chemistry. ...
Cached Biology Technology:Boston Healthcare Appoints Adam Barak as Vice President Enhancing Its International Pricing and Reimbursement Capability 2Laureate Pharma Announces Agreement with Tolera Therapeutics, Inc. 2New England Peptide Forms Scientific Advisory Board 2New England Peptide Forms Scientific Advisory Board 3New England Peptide Forms Scientific Advisory Board 4
... Source rat adult and fetal ... $550.00, * T75 plated cells ... * This product requires Celprogen ... M55007-08 and extracellular matrix, * ...
... is a K-12 strain ideally suited as ... high transformation efficiency, blue/white screening capability (with ... result in high yields of excellent quality ... is potentially useful as a stringent host ...
... Purification with an Affinity Chitin-binding Tag) utilizes ... splicing elements (termed inteins) to purify recombinant ... (Figures 1 and 2). This system distinguishes ... its ability to separate a recombinant protein ...
... imaging system from Molecular Devices ... system for automated acquisition and analysis ... screening. ImageXpressULTRA is powered by ... screening acquisition, image storage and analysis. ...
Biology Products: