Navigation Links
Flipping the 'off' switch on cell growth
Date:2/22/2013

A protein known for turning on genes to help cells survive low-oxygen conditions also slows down the copying of new DNA strands, thus shutting down the growth of new cells, Johns Hopkins researchers report. Their discovery has wide-ranging implications, they say, given the importance of this copying known as DNA replication and new cell growth to many of the body's functions and in such diseases as cancer.

"We've long known that this protein, HIF-1α, can switch hundreds of genes on or off in response to low oxygen conditions," says Gregg Semenza, M.D., Ph.D., a molecular biologist who led the research team and has long studied the role of low-oxygen conditions in cancer, lung disease and heart disorders. "We've now learned that HIF-1α is even more versatile than we thought, as it can work directly to stop new cells from forming." A report on the discovery appears in the Feb. 12 issue of Science Signaling.

With his team, Semenza, who is the C. Michael Armstrong Professor of Medicine at the Johns Hopkins University School of Medicine's Institute for Cell Engineering and Institute for Genomic Medicine, discovered HIF-1α in the 1990s and has studied it ever since, pinpointing a multitude of genes in different types of cells that have their activity ramped up or down by the activated protein. These changes in so-called "gene expression" help cells survive when oxygen-rich blood flow to an area slows or stops temporarily; they also allow tumors to build new blood vessels to feed themselves.

To learn how HIF-1α's own activity is controlled, the team looked for proteins from human cells that would attach to HIF-1α. They found two, MCM3 and MCM7, that limited HIF-1α's activity, and were also part of the DNA replication machinery. Those results were reported in 2011.

In the new research, Semenza and his colleagues further probed HIF-1α's relationship to DNA replication by comparing cells in low
'/>"/>

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Noncoding RNAs offer huge therapeutic and diagnostic potential
2. Get off my lawn: Song sparrows escalate territorial threats - with video
3. Modern growing methods may be culprit of coffee rust fungal outbreak
4. International biodiversity data symposium to mark the kickoff of the EU BON project
5. Tree die-off triggered by hotter temperatures
6. Experimental gene therapy treatment for Duchenne muscular dystrophy offers hope for youngster
7. Changes to DNA on-off switches affect cells ability to repair breaks, respond to chemotherapy
8. Study of human specimen collections in the US offers first look at their huge diversity
9. Dartmouth research offers new control strategies for bipolar bark beetles
10. Celladon Corporation Receives Notice of Allowance from United States Patent and Trademark Office
11. Study offers new insights into the mechanics of muscle fatigue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... that a single group of microorganisms may be responsible ... the oceans, with implications for the global carbon cycle ... essential molecule required by most life on this planet, ... of microorganisms because it is so large and complex. ... maintaining the brain and nervous systems, as well as ...
(Date:9/15/2014)... coral reef ecologists fears that reef biodiversity may not ... we once thought. , In an international study published ... Excellence for Coral Reef Studies (Coral CoE) says we ... within reef ecosystems. , In coral reefs, just as ... keep the ecosystem safe and functioning. , Professor ...
(Date:9/15/2014)... lifeplants and animalsto thrive in the oceans, there ... In certain coastal areas, extreme oxygen-starvation produces "dead ... web structure. As dissolved oxygen levels decline, energy ... microbial community metabolism resulting in impacts on the ... the past 50 years, oxygen minimum zones (OMZs) ...
Breaking Biology News(10 mins):Researchers discover new producer of crucial vitamin 2Specialized species critical for reefs 2Decoding virus-host interactions in the oxygen-starved ocean 2Decoding virus-host interactions in the oxygen-starved ocean 3Decoding virus-host interactions in the oxygen-starved ocean 4Decoding virus-host interactions in the oxygen-starved ocean 5
... Nile virus alarmed Americans when it made its first ... has since spread from coast to coast, sickened more ... the virus spread, medical investigators hastened research to develop ... a newly published paper by researchers at Washington University ...
... of Health in Angola has reported 266 cases of Marburg ... Province, which remains the epicentre of the outbreak, 253 cases, ... 21 April. , Assessment of the outbreak , The international ... on 22 March. The features of Marburg haemorrhagic fever, and ...
... biological network - can get you lost - quick. Tons of ... even more being unknown, tons of database with tons of information... ... a biologically meaningfull way. Applications are being developped to make it ... of them; I didn't have time to try it yet, but ...
Cached Biology News:Promising new West Nile therapy cures disease in mice 2Marburg haemorrhagic fever in Angola update 2Marburg haemorrhagic fever in Angola update 3GeneNotes - A novel information management software for biologists 2
(Date:9/15/2014)... go downhill fast when a patient has sepsis, a ... a patient,s blood -- often too fast for antibiotics ... spleen and developed by a team at Harvard,s Wyss ... way doctors treat sepsis. , "Even with the ... care units at least 30 percent of the time," ...
(Date:9/15/2014)... MORRISVILLE, NC (PRWEB) September 15, 2014 ... newly developed deep imaging OCT system for the optical ... , The EnvisuTM S4410 SDOCT for Contact ... measurements for standard and high complexity contact lens, IOL ... allows imaging of a complete contact lens immersed in ...
(Date:9/15/2014)... DUBLIN , Sept. 15, 2014 Research ... "Whole Exome Sequencing Market by Product, by Services, by Technology, ... their offering. Whole Exome Sequencing (WES) is ... the genome, i.e. the exon. The exome, which is the ... of the total genome and is actually converted into proteins ...
(Date:9/15/2014)... ANNAPOLIS, Maryland , 15. September 2014 /PRNewswire/ ... Week (IPAW) wird vom 12. bis 18. ... der Plasma Protein Therapeutics Association (PPTA) ... Ziele: , Das globale Bewusstsein für ... Den Beitrag von Plasmaspendern beim Retten und Verbessern ...
Breaking Biology Technology:Blood-cleansing biospleen device developed for sepsis therapy 2Blood-cleansing biospleen device developed for sepsis therapy 3Blood-cleansing biospleen device developed for sepsis therapy 4Bioptigen Introduces Deep Imaging OCT System for Contact Lens Metrology 2Global Whole Exome Sequencing (Systems, Kits, Library Preparation, Target Enrichment) Market by Product, by Services, by Technology, by Application - Forecast to 2018 2Global Whole Exome Sequencing (Systems, Kits, Library Preparation, Target Enrichment) Market by Product, by Services, by Technology, by Application - Forecast to 2018 3International Plasma Awareness Week feiert Spender und rückt seltene Krankheiten in den Mittelpunkt 2International Plasma Awareness Week feiert Spender und rückt seltene Krankheiten in den Mittelpunkt 3
... ... based on the Altera Stratix® IV 820 devices. These contain the largest FPGA on ... , ... 16, 2010 -- IRIS Technologies Inc. ( www.iris-technologies.net ) has released two new ...
... , ... Writers Association Recognizes Buckley/Swartz , ... Boston, MA (PRWEB) June 16, 2010 -- The American Medical Writers Association ... recipient of two Will Solimene Awards for Excellence in Medical Communication. She received the ...
... This release is avaiable in French ... range of high-tech products such as computer displays or ... ordered chemical composition as inorganic materials, preventing scientists from ... team of researchers led by McGill,s Dr. Dmitrii Perepichka ...
Cached Biology Technology:IRIS Technologies Inc. Launches Two New Stratix IV FPGA-Based Boards 2IRIS Technologies Inc. Launches Two New Stratix IV FPGA-Based Boards 3Medical Writer Rita Buckley Wins Awards for Excellence in Medical Communication 2Medical Writer Rita Buckley Wins Awards for Excellence in Medical Communication 3Organic nanoelectronics a step closer 2
... to rapidly and reliably amplify unknown genomic ... APAgene provides hassle-free, ready-to use components, at ... are provided in each kit. The Genome ... filling, localized cloning of genomic DNA, isolating ...
Rabbit polyclonal to Quinaldic Acid ( Abpromise for all tested applications). Antigen: Synthetic peptide Quinaldic Acid conjugated to a protein carrier....
Mol wt: average mol wt16,951.27 Da by calculation...
A set of five peptides which can be used to calibrate a Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) or Electrospray Ionization (ESI) mass spectrometer....
Biology Products: