Navigation Links
Flipping the 'off' switch on cell growth
Date:2/22/2013

A protein known for turning on genes to help cells survive low-oxygen conditions also slows down the copying of new DNA strands, thus shutting down the growth of new cells, Johns Hopkins researchers report. Their discovery has wide-ranging implications, they say, given the importance of this copying known as DNA replication and new cell growth to many of the body's functions and in such diseases as cancer.

"We've long known that this protein, HIF-1α, can switch hundreds of genes on or off in response to low oxygen conditions," says Gregg Semenza, M.D., Ph.D., a molecular biologist who led the research team and has long studied the role of low-oxygen conditions in cancer, lung disease and heart disorders. "We've now learned that HIF-1α is even more versatile than we thought, as it can work directly to stop new cells from forming." A report on the discovery appears in the Feb. 12 issue of Science Signaling.

With his team, Semenza, who is the C. Michael Armstrong Professor of Medicine at the Johns Hopkins University School of Medicine's Institute for Cell Engineering and Institute for Genomic Medicine, discovered HIF-1α in the 1990s and has studied it ever since, pinpointing a multitude of genes in different types of cells that have their activity ramped up or down by the activated protein. These changes in so-called "gene expression" help cells survive when oxygen-rich blood flow to an area slows or stops temporarily; they also allow tumors to build new blood vessels to feed themselves.

To learn how HIF-1α's own activity is controlled, the team looked for proteins from human cells that would attach to HIF-1α. They found two, MCM3 and MCM7, that limited HIF-1α's activity, and were also part of the DNA replication machinery. Those results were reported in 2011.

In the new research, Semenza and his colleagues further probed HIF-1α's relationship to DNA replication by comparing cells in low
'/>"/>

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Noncoding RNAs offer huge therapeutic and diagnostic potential
2. Get off my lawn: Song sparrows escalate territorial threats - with video
3. Modern growing methods may be culprit of coffee rust fungal outbreak
4. International biodiversity data symposium to mark the kickoff of the EU BON project
5. Tree die-off triggered by hotter temperatures
6. Experimental gene therapy treatment for Duchenne muscular dystrophy offers hope for youngster
7. Changes to DNA on-off switches affect cells ability to repair breaks, respond to chemotherapy
8. Study of human specimen collections in the US offers first look at their huge diversity
9. Dartmouth research offers new control strategies for bipolar bark beetles
10. Celladon Corporation Receives Notice of Allowance from United States Patent and Trademark Office
11. Study offers new insights into the mechanics of muscle fatigue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... , Oct. 29, 2014  Securus ... criminal justice technology solutions for public safety, ... it has deployed exciting enhancements to its ... analytics to provide actionable intelligence and focused ... continues to drive technological innovation through identifying ...
(Date:10/29/2014)... is open for the Society of ... SIR 2015 is the one place where ... related health care professionals can come together ... and technologies being presented, discussed and tested. ... minimally invasive, image-guided medicine, SIR 2015 will ...
(Date:10/29/2014)... ceremony held in New York City on September 19, ... American Cancer Society Professor of Genome Sciences and Medicine ... Honorary Doctor of Philosophy of Tel Aviv University, was ... Science. , In addition to her honorary degree from ... the TAU School of Medicine, and for the past ...
Breaking Biology News(10 mins):Securus Technologies Adds Advanced Features to Its Industry-Leading Investigative Analytics Product 2SIR 2015: Interventional radiology shapes tomorrow's medicine 2Geneticist and humanitarian: Prof. Mary-Claire King receives Lasker Award 2
... and Technology (NIST) spent 75 days on the job ... dwelling" of the release, distribution and fate of particles ... DNA molecule. Particles ranging in size from 100 nanometers ... and electric stoves, hair dryers, power tools and candles ...
... Philadelphia, PA, -- MicroRNAs (miRNAs) that regulate processes including ... disease. They can be collected from routinely collected ... a number of factors can interfere with the accuracy ... today in the Journal of Molecular Diagnostics , ...
... for females to avoid unwanted male attention: choosing more attractive ... of the Royal Society B, the study is the ... attractive than themselves to reduce harassment from males. Carried ... focuses on the Trinidadian guppy, a species of small freshwater ...
Cached Biology News:Elusive ultrafine indoor air contaminants yield to NIST analysis 2New protocols improve detection of microRNAs for diagnosis 2New protocols improve detection of microRNAs for diagnosis 3Females choose sexier friends to avoid harassment 2
(Date:10/30/2014)... 2014 SoundConnect , an ... Office 365 end users the key to turning ... system by adding voice enablement and hybrid audio ... Online, a communication tool that includes presence, instant ... voice, O365 becomes a comprehensive unified communications solution. ...
(Date:10/30/2014)... Whitehouse Laboratories has formally announced a ... and Package Test Capacity. Responding to growing demands from ... increase in environmental chamber storage space that will enable ... samples to be securely held on site at Whitehouse ... has already taken place with the recent completion of ...
(Date:10/30/2014)... -- A new report, commissioned by BioCrossroads and conducted ... look at Indiana,s capital market ... different time frames: 1993 to 2002 and 2003 to ... for investment growth.  The Life Science Innovation Capital ... in innovation dollars as well as an increase in ...
(Date:10/27/2014)... 2014 Ryan Carfley , Managing Partner ... sit down with Bryan Hamilton, the publisher of the Triangle ... talent in the Research Triangle region of North Carolina. , ... at the roundtable include the role of social media ... work/life balance and the unique role that Millennials play in ...
Breaking Biology Technology:SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 2SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 3Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 2Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 2New report shows Indiana's gains in life sciences innovation capital outpace the nation 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 4New report shows Indiana's gains in life sciences innovation capital outpace the nation 5Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 2Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 3
... , , ... software for the analysis of RNA, DNA, proteins, and cells with the ... , , , , ... tool for RNA,DNA proteins and cells., , , ...
... , , ... , , , This Application ... apoptotic cell samples. Performance of two assays,for apoptosis detection is demonstrated ... cytometer. Histogram quality,of the low number of fluorescent cells counted with ...
... , , ... , , , ... become an essential tool in any,laboratory working on cell-based studies. ... also the determination of growth factor,and cytokine activity. Even more ...
Cached Biology Technology:2100 expert software , Powerful software for the analysis of RNA, DNA, proteins, and cells with the Agilent 2100 bioanalyzer 2Apoptosis detection by annexin V and,active caspase-3 with the Agilent 2100,bioanalyzer 2Apoptosis detection by annexin V and,active caspase-3 with the Agilent 2100,bioanalyzer 3Apoptosis detection by annexin V and,active caspase-3 with the Agilent 2100,bioanalyzer 4Apoptosis detection by annexin V and,active caspase-3 with the Agilent 2100,bioanalyzer 5Apoptosis detection by annexin V and,active caspase-3 with the Agilent 2100,bioanalyzer 6Apoptosis detection by annexin V and,active caspase-3 with the Agilent 2100,bioanalyzer 7Apoptosis detection by annexin V and,active caspase-3 with the Agilent 2100,bioanalyzer 8Apoptosis detection by annexin V and,active caspase-3 with the Agilent 2100,bioanalyzer 9Cell Proliferation and Viability Measurement 2Cell Proliferation and Viability Measurement 3Cell Proliferation and Viability Measurement 4
Homo sapiens olfactomedin 1, transcript variant 3...
... Reticulocyte Lysate contains the cellular components necessary ... initiation, elongation and termination factors) but has ... Lysate is used primarily for the isolation ... source of endogenous globin mRNA. Untreated Lysate ...
...
S. O'Hare & C.K. Atterwill • In vitro toxicity techniques for regular lab use. Ex vivo techniques are also covered with the aim of reducing and refining the use of animals in the future....
Biology Products: