Navigation Links
First in the world - Singapore scientists discover genes responsible for cornea blindness
Date:1/16/2013

atening conditions. Eye doctors can in the future through genetic analysis better manage such patients, preventing regression of their conditions.

Prof Aung Tin, Deputy Director, Singapore Eye Research Institute (SERI) and a senior consultant ophthalmologist and Head of Glaucoma Service at Singapore National Eye Centre and a co-author of the paper, said, "This was a tremendous achievement, involving many centres from several countries around the world. Singapore played a major role in this work, especially SERI's population based studies of 10,000 Chinese, Malay and Indian people."

Assoc Prof Eranga Vithana, Associate Director, Basic and Experimental Sciences, SERI and a co-author of the paper, said, "This paper identified 6 novel genetic variants that confer increased risk of keratoconus, a condition for which genes were not very forthcoming prior to this study. It once again underlined the inevitability of large scale collaborative studies to unravel genes for common complex diseases and also the advantage of having well characterized large cohorts."

Assistant Professor Khor Chiea Chuen, Principal Investigator, Division of Human Genetics, Genome Institute of Singapore-an institute of the Agency for Science, Technology and Research (A*STAR) and the paper's co-lead author, said, "Yet again, this paper underscores the power of modern genetic approaches studied in very large sample sizes in revealing the hereditable basis of normal human traits, and how the extremes of which may give rise to common diseases."

Prof Ng Huck Hui, Executive Director of the Genome Institute of Singapore said, "I am very pleased that the Genome Institute of Singapore is a part of an international effort to dissect the genetics of eye conditions such as keratoconus and glaucoma. Genomics remains a very powerful tool to identify the link between genetic variations and phenotypes. This study that focuses on central corneal thickness illustrates the value
'/>"/>

Contact: Winnie Lim
limcp2@gis.a-star.edu.sg
656-808-8013
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. F1000Research, the first Open Science publisher, launches following a successful beta testing phase
2. DNA prefers to dive head first into nanopores
3. First fossil bird with teeth specialized for tough diet
4. The first genome sequence of Chinese plum provides important resource for fruit improvement
5. OpGen announces sequence assembly and finishing of first reference genome of domestic goat
6. The first goat genome sets a good example for facilitating de novo assembly of large genomes
7. First freshwater mosasaur discovered
8. First evidence of fish sensing geomagnetic fields from a Czech Christmas market
9. Africas Homo sapiens were the first techies
10. Surgical Theater, LLC sells first Surgical Rehearsal Platform to UH Case Medical Center
11. First evidence of ocean acidification affecting live marine creatures in the Southern Ocean
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... available in German . ... organisms is considered the oldest form of communication. Acting ... for example, the sexual attraction between males and females. ... to coordinate reproductive behavior in males and females. Scientists ... the Algarve in Faro, Portugal, and at the Max ...
(Date:8/29/2014)... Boulder, Colo., USA - The rise of the Tibetan ... on Earth -- is important for both its profound ... In this study published in GSA Bulletin , ... -- "clumped" isotope thermometry -- using modern and fossil ... Zhada basin in southwestern Tibet. , Views range ...
(Date:8/28/2014)... study reports that an expansion of marine protected areas ... ecological functions. According to investigators from the Wildlife ... fish have focused on saving the largest numbers of ... provide key and difficult-to-replace ecological functions. , ... by fish species that also are food for millions ...
Breaking Biology News(10 mins):Ready for mating at the right time 2Ready for mating at the right time 3Snails tell of the rise and fall of the Tibetan Plateau 2Snails tell of the rise and fall of the Tibetan Plateau 3Snails tell of the rise and fall of the Tibetan Plateau 4Snails tell of the rise and fall of the Tibetan Plateau 5Snails tell of the rise and fall of the Tibetan Plateau 6Snails tell of the rise and fall of the Tibetan Plateau 7Study finds marine protected areas inadequate for protecting fish and ocean ecology 2
... to a collection of test tubes in her Iowa State ... they were holding very weak coffee. That meant microorganisms ... converting sugars into hydrocarbons, said Jarboe, an Iowa State assistant ... the sugars in those test tubes were produced by the ...
... Heavy and prolonged snowfall can bring about unexpected conditions ... in the Arctic, according to experts. A new international ... helps plants to grow bigger, heavy and prolonged snow can, ... of killer fungal strains. The research results, published in ...
... studies in this special issue document the substantial and growing ... the burden of a chikungunya outbreak in India. Luiz ... country,s worsening trend; from 1999-2009, where cases rose at 6.2% ... Carmen Perez and co-workers, reporting on dengue vector control ...
Cached Biology News:Iowa State hybrid lab combines technologies to make biorenewable fuels and products 2Iowa State hybrid lab combines technologies to make biorenewable fuels and products 3Arctic snow harbors deadly assassin 2World Health Organization releases latest Dengue Bulletin 2World Health Organization releases latest Dengue Bulletin 3World Health Organization releases latest Dengue Bulletin 4World Health Organization releases latest Dengue Bulletin 5World Health Organization releases latest Dengue Bulletin 6World Health Organization releases latest Dengue Bulletin 7World Health Organization releases latest Dengue Bulletin 8
(Date:8/28/2014)... Spin-charge converters are important devices in spintronics, an ... charge of electrons but also on their spin ... transformation of electric into magnetic signals and vice ... Sinova from the Institute of Physics at Johannes ... the UK, Prague, and Japan, has for the ...
(Date:8/28/2014)... 28, 2014 The ability for organizations ... that will allow individuals to perform at the highest ... for employers looking to compete in this post–recession era. ... this trend, as the sector increasingly focuses on the ... which will have real results on the organization's development ...
(Date:8/28/2014)... Aug. 28, 2014   SunTrust Robinson Humphrey ... veterans to its equity research team in biotechnology ... expansion in equity research demonstrates our commitment to ... to enhance their investment decision making," said ... "We continue to make significant investments in differentiated ...
(Date:8/28/2014)... 28, 2014  Armetheon, Inc. ( www.armetheon.com ), ... to late-stage cardiovascular drug candidates, today announced that ... round of financing. The Series A round was ... with participation from investors that included Atheneos Capital ... Larry Hsu , the founder of Impax ...
Breaking Biology Technology:A new, tunable device for spintronics 2A new, tunable device for spintronics 3Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3Armetheon Completes $7.0 Million Series A Financing 2Armetheon Completes $7.0 Million Series A Financing 3
... 2012 Codexis, Inc. (Nasdaq: CDXS ), ... of biofuels, bio-based chemicals, and pharmaceutical intermediates, today announced ... presenting at the Jefferies Global Clean Technology Conference, to ... 23, 2012 at 1:45 p.m. ET. A live webcast ...
... Pharmaceuticals, Inc. (Nasdaq: AVNR ) today announced that ... Conference. , Citi 2012 Global Health Care Conference ... February 29, 2012 , 9:00 a.m. ET ... presentation will be available at http://ir.avanir.com . ...
... Feb. 21, 2012 /PRNewswire-Asia/ -- Simcere Pharmaceutical Group (NYSE: ... in the development, manufacturing, and marketing of branded generic ... will report its unaudited financial results for the fourth ... Wednesday, March 7, 2012, before the market opens in ...
Cached Biology Technology:Simcere Pharmaceutical Group to Announce Fourth Quarter and Fiscal Year 2011 Financial Results on Wednesday, March 7, 2012 2
... performance for all vacuum requirements. A 3 ... to suit all applications. The large, sideview ... proper oil levels at a glance. The ... work with all Thermo Savant SpeedVac concentrating ...
... used to assess the effect of drugs on ... and rats using one unit in a safe ... are placed on textured drums to avoid slipping. ... platforms below, its test results are recorded. • ...
... 8-iso-13,14-dihydro-15-keto Prostaglandin F2α (8-iso-13,14-dihydro-15-keto PGF2α) ... 8-isoprostane (8-iso PGF2α), in rabbits, monkeys ... PG-like product of non-specific lipid peroxidation. ... infused 8-isoprostane is converted primarily to ...
... 3C protease from human rhinovirus (HRV 3C) ... brand line of restriction grade proteases. The ... 6XHis-fusion protein, which recognizes the same cleavage ... small, 22 KDa size of the protease, ...
Biology Products: