Navigation Links
First genetic factor in prostate cancer prognosis identified
Date:4/9/2013

Patients with prostate cancer and hereditary mutations in the BRCA2 gene have a worse prognosis and lower survival rates than do the rest of the patients with the disease. This is the main conclusion to come out of a study published this week in the Journal of Clinical Oncology, in which David Olmos, Head of the Prostate Cancer and Genitourinary Tumours Clinical Research Unit at the Spanish National Cancer Research Centre (CNIO), has taken part in, along with Elena Castro, a member of the Unit, and British researchers at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust.

According to Olmos: "Whilst the majority of patients with prostate cancer have an excellent prognosis, one of the biggest challenges we face in daily clinical practice is the difficulty of identifying those patients in which the illness can be fatal".

In order to search for genetic markers that offer clues as to the evolution of the illness, the study's authors examined 61 patients with prostate cancer who were also carriers of mutations in the BRCA2 gene (a gene that suppresses tumours and that protects DNA), 18 patients with mutations in BRCA1 (a gene whose function is similar to BRCA2) and 1,940 patients in which the presence of mutations in both genes had been excluded.

THE LARGEST STUDY TO DATE

The magnitude of the study makes it one of the largest studies carried out so far in prostate cancer patients carrying BRCA1 or BRCA2 mutations; these genes are traditionally known for being responsible for familial breast and ovarian cancer syndrome.

Patient analyses showed that BRCA1 and BRCA2 gene mutation carriers were at greater risk for having more advanced prostate cancer at the time of diagnosis, as well as of developing metastasis.

Furthermore, within the subgroup of patients in which the disease had not spread at the time of diagnosis, 23% of carriers of mutations in these genes developed metastasis o
'/>"/>

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Page: 1 2

Related biology news :

1. First tests of old patent medicine remedies from a museum collection
2. Student named universitys first Lawrence scholar, researching at national laboratory
3. The first caffeine-addicted bacteria
4. Ludwig cancer researchers honored among first class of fellows in AACR Academy
5. Discovery of first motor with revolution motion in a virus-killing bacteria advances nanotechnology
6. Antarcticas first whale skeleton found with 9 new deep-sea species
7. Antarcticas first whale skeleton found with nine new deep-sea species
8. Series of studies first to examine acupunctures mechanisms of action
9. Researchers explain a key developmental mechanism for the first time in plants
10. Age at first menstrual cycle, menopause tied to heart disease risk
11. Genetic signs of alcoholism in women studied for the first time
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/10/2014)... appearing on U.S. store shelves in early 2010, and ... The small packets can be tossed into a washing ... or powder. The convenience, though, has come with risks ... at Nationwide Children,s Hospital found that from 2012 through ... children younger than 6 years of age swallowing, inhaling, ...
(Date:11/7/2014)... , November 6, 2014 Leading ... for better mobile security revolutionizing online transactions.  Companies in focus ... Holdings Ltd. (NYSE: BABA ), Google Inc. (NASDAQ: ... ), eBay Inc. (NASDAQ: EBAY ) and MasterCard ... NXTD and NXTDW), a biometric authentication company focused on ...
(Date:11/6/2014)... PITTSBURGH--Speed is an asset for a predator. Except when that ... The tiger beetle, relative to its size, is the fastest ... 120 body lengths per second (at about five miles per ... To take the sprinting gold from the tiger beetle, a ... BUT! The tiger beetle has a problem. At peak speeds, ...
Breaking Biology News(10 mins):Study finds laundry detergent pods, serious poisoning risk for children 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6The tiger beetle: Too fast to see 2
... Amsterdam, The Netherlands: For the first time, researchers have ... or failure of IVF treatment in blood. Dr. Cathy Allen, ... conference of the European Society of Human Reproduction and Embryology ... why IVF works for some patients but not for others. ...
... Denmark have shown that if elderly men were given ... muscle mass increase. Dr. Geoff Goldspink (Royal Free and ... question: Can age-related loss of muscle strength and increased ... growth factor (MGF)?". There is hope that MGF can ...
... WASHINGTON, DC The misleading "health" halo ... starting to dim. Recent announcements by Starbucks ... fructose corn syrup from certain products are being ... experts and respected journalists. These articles have ...
Cached Biology News:Will IVF work for a particular patient? The answer may be found in her blood 2Will IVF work for a particular patient? The answer may be found in her blood 3Recent news reports of sweetener reformulations raise questions about motivations 2
(Date:11/26/2014)... 26, 2014 CUREā„¢ magazine ... on December 5, 2014, in San Francisco prior to ... Heroes event will honor clinicians, caregivers, and advocates who ... neoplasms (MPNs). , Special guest speaker Charles Esten, ... cancer journey at the reception. Over a decade ...
(Date:11/26/2014)... , Nov. 25, 2014 Bio-Techne Corporation ... has appointed Robert Gavin to serve in ... the Protein Platforms Division.  Mr. Gavin will be responsible ... segment, which includes the ProteinSimple business acquired in July ... San Jose, California -based ProteinSimple develops ...
(Date:11/24/2014)... N.J. , Nov. 24, 2014  IGI Laboratories, ... based specialty generic pharmaceutical company, today announced ... (ANDA) to the U.S. Food and Drug Administration (FDA), ... in 2014 to seven, with eighteen submissions now pending ... , President and CEO of the Company, commented, "Our ...
(Date:11/24/2014)... , Nov. 24, 2014 VolitionRx Limited ... tests for cancer and other conditions, today announced that data ... the Science for Business BioWin Day 2014, being held November ... data come from VolitionRx,s lung cancer pilot study, the samples ... Centre Hospitalier Universitaire (CHU) de Liege in Belgium ...
Breaking Biology Technology:CURE Magazine and Incyte to Honor MPN Heroes 2CURE Magazine and Incyte to Honor MPN Heroes 3CURE Magazine and Incyte to Honor MPN Heroes 4Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 2Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 3IGI Laboratories, Inc. Announces ANDA Submission 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 4VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 5VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 6
... another step towards realizing a new class of ... door for the development of highly sensitive chemical ... The blueprint for building synthetic structures to ... as small molecule medical analytes (signalers of disease ...
... Oct. 15 UBM Medica today announces that it ... MediSpecialty.com, Inc.   OBGYN.net is a women,s ...  The site provides article-based and multimedia content generated by ... – some of which have been running for over ...
... Calif., Oct. 15 Connected ... listening to the music you love, comes to Fresno, ... 2010, the weekend before Veterans Day. ... those with combat-related post- traumatic stress. (Photo: ...
Cached Biology Technology:Catalyst sandwich 2UBM Medica Acquires Leading Online Community OBGYN.net 2UBM Medica Acquires Leading Online Community OBGYN.net 3Connected! at The Fresno Revue 2Connected! at The Fresno Revue 3
Invitrogen's Calcium Phosphate Transfection Kit provides high-quality reagents to enable the introduction of DNA into tissue culture cells via calcium phosphate co-precipitation....
Request Info...
...
...
Biology Products: