Navigation Links
Finding keys to glioblastoma therapeutic resistance
Date:8/25/2014

Researchers at the University of California, San Diego School of Medicine have found one of the keys to why certain glioblastomas the primary form of a deadly brain cancer are resistant to drug therapy. The answer lies not in the DNA sequence of the tumor, but in its epigenetic signature. These findings have been published online as a priority report in the journal Oncotarget.

"There is a growing interest to guide cancer therapy by sequencing the DNA of the cancer cell," said Clark Chen, MD, PhD, vice-chairman of Research and Academic Development, UC San Diego Division of Neurosurgery and the principal investigator of the study. "Our study demonstrates that the sensitivity of glioblastoma to a drug is influenced not only by the content of its DNA sequences, but also by how the DNA sequences are organized and interpreted by the cell."

The team of scientists, led by Chen, used a method called comparative gene signature analysis to study the genetic profiles of tumor specimens collected from approximately 900 glioblastoma patients. The method allows investigators to discriminate whether specific cellular processes are "turned on" or "turned off" in glioblastomas. "Our study showed that not all glioblastomas are the same. We were able to classify glioblastomas based on the type of cellular processes that the cancer cells used to drive tumor growth," said Jie Li, PhD, senior postdoctoral researcher in the Center for Theoretical and Applied Neuro-Oncology at UC San Diego and co-first author of the paper.

One of these cellular processes involves Epidermal Growth Factor Receptor (EGFR). The study revealed that EGFR signaling is suppressed in a subset of glioblastomas. Importantly, this suppression is not the result of altered DNA sequences or mutations. Instead, EGFR is turned off as a result of how the DNA encoding the EGFR gene is organized in the cancer cell. This form of regulation is termed "epigenetic." Because EGFR is turned
'/>"/>

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related biology news :

1. UMD finding may hold key to Gaia hypothesis
2. ACRG and BGI report findings from genomics research on recurrent hepatitis B virus integration
3. Blue Ribbon Panel unveils findings on logistical improvements to support Antarctic science
4. BGI reports the latest finding on NMNAT1 mutations linked to Leber congenital amaurosis
5. Team discovers reason that male moths can keep finding females
6. Finding new research frontiers in a single cell
7. New findings on protein misfolding
8. One click away: Finding data on Floridas endangered species just got easier
9. Finding triggers of birth defects in an embryo heart
10. New findings on gene regulation and bone development
11. Verinata Health Announces New Findings At The American Society Of Human Genetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/19/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/kx9zp8/military ) ... Electro-Optical / Infrared Systems Market by Type, by ... to 2020" report to their offering. ... expected to reach $16.35 billion by 2020, to ... report segments the military electro-optical/infrared systems market on ...
(Date:2/12/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ... authentication company focused on the growing mobile commerce market, ... for DISTRIBUTED METHOD AND SYSTEM TO IMPROVE ... further establishes NXT-ID,s position in the emerging "Internet of ... ability for multiple devices to collaborate with one another ...
(Date:2/5/2015)... , 5. Februar 2015 ... spezialisiertes Logistikunternehmen und hat eine neue Marketingkampagne ... Logistikfirma (Clinical Logistics Organization – CLO) der ... Kampagne lautet First , mit Schwerpunkt ... Foto: http://photos.prnewswire.com/prnh/20150205/173753 Logo ...
Breaking Biology News(10 mins):Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 2Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 3NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 2NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 3Marken startet Kampagne mit Patienten im Mittelpunkt 2Marken startet Kampagne mit Patienten im Mittelpunkt 3
... may do more than keep the body cool. It also ... respiratory condition among trained athletes. New research appearing in the ... the American College of Chest Physicians (ACCP), shows that athletes ... who do not have breathing problems. Warren Lockette, ...
... a living sensor that can spot contamination. They have ... spills even in previously untreatable cold areas, microbiologists heard ... General Microbiology,s Autumn meeting being held this week at ... is in the sub-arctic. It contains over 230,000 tonnes ...
... Switzerland have developed a new method to ... systems, these "Pyrex"-like nanoparticles are more stable ... chemical environments than currently used nanoparticles made ... could extend the range of potential nanoparticle ...
Cached Biology News:Athletes' 'sweat and tears' linked to asthma 2Athletes' 'sweat and tears' linked to asthma 3Living sensor can warn of arsenic pollution 2
(Date:3/2/2015)... 2015 VLP Therapeutics, LLC. ("VLP"), a ... on the research and development of therapeutic and ... upon a novel and proprietary vaccine technology, today ... Grant Award from the Montgomery County Department of ... is awarded to life sciences companies in ...
(Date:3/2/2015)... , March 2, 2015  Asterias Biotherapeutics, Inc. ... emerging field of regenerative medicine, today announced that it ... and operating results on Tuesday, March 10, 2015 after ... will host a conference call and webcast on Tuesday, ... p.m. Pacific to discuss the results and recent corporate ...
(Date:3/1/2015)... London, UK (PRWEB) March 01, 2015 ... a partnership agreement for quality market research promotion ... and sell research reports worked out by DataGroup ... Department at Market Publishers Ltd, commented on the ... to have DataGroup Booksellers in our team of ...
(Date:2/27/2015)... , Feb. 27, 2015 A ... the NCATS rare-diseases portfolio " in Science ... new financing technique to reduce the risk associated ... and potentially unlock new levels of funding for ... product of a unique collaboration between scientists at ...
Breaking Biology Technology:VLP Therapeutics Wins the 2015 Life Sciences Impact Grant Award from the Montgomery County Department of Economic Development 2Asterias Biotherapeutics to Report Fourth Quarter and Full Year 2014 Results on March 10, 2015 2Market Publishers Ltd and DataGroup Booksellers Sign Partnership Agreement 2Market Publishers Ltd and DataGroup Booksellers Sign Partnership Agreement 3New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 2New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 3New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 4
... (OSL:DIAG),today announced that it has signed a ... provider of gene expression-based,diagnostic testing and services ... scheduled in early2009, DiaGenic will be able ... its innovative blood-based,gene-expression diagnostic test for early ...
... Northern Antibiotics Ltd., the,developer of novel ... by multidrug-resistant Gram-negative bacteria, revealed today animal,efficacy ... at the 48th,Annual ICAAC/IDSA 46th Annual Meeting ... developed two series of novel polymyxin (NAB),compounds ...
... 28 Volcano Corporation,(Nasdaq: VOLC ), a leader ... diagnosis and treatment of coronary and peripheral artery,disease, today ... the,third quarter and first nine months of fiscal 2008 ... conference call to discuss its financial,results and operating activities ...
Cached Biology Technology:Diagenic Partners With DNAVision to Offer First Breast Cancer and Alzheimers Gene-Expression Blood Tests 2Northern Antibiotics Presents New Data on Novel Polymyxin Compounds at the Joint ICAAC/IDSA 2008 2Northern Antibiotics Presents New Data on Novel Polymyxin Compounds at the Joint ICAAC/IDSA 2008 3Volcano Corporation Schedules Third Quarter Conference Call, Webcast 2
MOUSE ANTI SIMIAN VIRUS 5 Immunogen: Simian virus 5...
MOUSE ANTI SIMIAN VIRUS 5:FITC Immunogen: Simian virus 5...
MOUSE ANTI HUMAN MBP (67-74) Immunogen: Human myelin basic protein...
... DNAclear cDNA Purification Kit is designed to purify ... as cDNA synthesis and PCR. The process is ... ng to 3 g can be efficiently purified ... steps: 1) DNA is bound to the Microfilter ...
Biology Products: