Navigation Links
Fetal stem cell transplantation favorably impacts radiation-induced cognitive dysfunction
Date:8/22/2013

Putnam Valley, NY. (Aug. 22, 2013) Patients receiving cranial irradiation treatment for brain cancer may find the treatment life-saving, but often suffer progressive and debilitating cognitive detriments, including spatial learning and memory deficits. The cognitive deficits are a contributing factor to the often significant adverse impacts on the surviving patients' quality of life after radiation therapy. In an effort to improve post-irradiation cognitive impairment, scientists at the University of California, Irvine, and colleagues at Neuralstem, Inc. (Rockville, MD), have transplanted fetal stem cells into laboratory animals with radiation-induced cognitive impairments and found that this led to a number of cognitive improvements. The study appears as an early e-publication for the journal Cell Transplantation, and is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/pre-prints/ct1048acharya.

"Multiple mechanisms contribute to disrupted cognition following irradiation for patients with central nervous system malignancies. These include the depletion of radiosensitive populations of stem and progenitor cells in the hippocampus," said study co-author Dr. Charles L. Limoli of the Department of Radiation Oncology at the University of California, Irvine. "Interventions to combat long-term brain damage resulting from toxic radiation and chemotherapies therapies have yet to be developed. However, stem cell replacement strategies may provide a much needed intervention."

The researchers explored the potential beneficial impact of intra-hippocampal transplantation of fetal-derived human neural stem cells by transplanting the cells into laboratory rats a month after the animals were subjected to cranial irradiation with resulting cognitive deficits. The stem cells were FDA-approved human, fetal-derived neural stem cells provided by Neuralstem, Inc.

"Engrafted stem cells underwent extensive neuronal differentiation, formed new synaptic contacts, released neurotrophic factors, and showed an advanced degree of structural integration into the motor circuitry," reported the research team.

They found that the test animals showed improved hippocampal spatial memory and hippocampal-related "fear conditioning performance" when compared to a control group of irradiated animals that did not receive stem cell transplantation. The engrafted cells also migrated and differentiated into neural and glial subtypes in areas of the hippocampus.

"The engrafted stem cells survived and differentiated throughout an area of the hippocampus and significantly ameliorated cognitive dysfunction as shown at a one-month follow-up on the irradiated animals," said Dr. Limoli. "While it is premature to presume efficacy in the absence of human data, our efforts to thwart cognitive dysfunction by cell replacement therapy with fetal stem cell transplantation may provide an experimental backdrop for a potential treatment for cranially irradiated patients who developed cognitive dysfunctions."

"Cognitive dysfunction is an unfortunate side effect of the therapeutic use of radiation therapy for brain cancer and the identification of ways to ameliorate the dysfunction, such as the application of stem cell transplantation, is a significant area of research" said Dr. Paul R. Sanberg, distinguished professor at the Center of Excellence for Aging and Brain Repair, Morsani College of Medicine, University of South Florida, Tampa, FL.

"This study is an important step towards the development of a clinical therapy, though further research is still required."


'/>"/>

Contact: Bob Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related biology news :

1. Study finds Western diet detrimental to fetal hippocampal tissue transplants
2. Fetal exposure to PVC plastic chemical linked to obesity in offspring
3. Pandemic vaccination did not increase risk of fetal death
4. Signaling pathway linked to fetal alcohol risk
5. New genetic link found between normal fetal growth and cancer
6. Fetal neuromaturation associated with mothers exposure to ddt and other environmental contaminants
7. CWRU dental researchers NIDCR grant targets oral bacteria and fetal death link
8. New protocol developed to decontaminate human fetal tissues used for cell transplantation
9. Fetal programming of sweet tastes elicited pleasure
10. Fetal stress disrupts the way genes are transmitted
11. Gut microbiota transplantation may prevent development of diabetes and fatty liver disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/16/2017)... 2017 - Against identity fraud with DERMALOG solutions "Made in Germany "  ... ... project, multi-biometric solutions provide a crucial contribution against identity fraud. (PRNewsFoto/Dermalog Identification Systems) ... Used combined in one project, multi-biometric solutions provide a crucial contribution against ... ...
(Date:3/7/2017)... March 7, 2017 Brandwatch , the leading social ... The Prince,s Trust to uncover insights to support its reporting, ... The UK,s leading youth charity will be using Brandwatch ... and get a better understanding of the topics and issues that ... ...
(Date:3/2/2017)... 2017 Summary This report provides ... KGaA and its partnering interests and activities since 2010. ... Description The Partnering Deals and Alliance since 2010 report ... one of the world,s leading life sciences companies. ... to ensure inclusion of the most up to date ...
Breaking Biology News(10 mins):
(Date:3/24/2017)... 24, 2017 On Thursday, March ... at 5,817.69, down 0.07%; the Dow Jones Industrial Average ... S&P 500 closed at 2,345.96, marginally dropping 0.11%. US ... in green, 4 sectors finished in red, and 1 ... has initiated reports coverage on the following Biotechnology equities: ...
(Date:3/23/2017)... ... ... is proud to announce it has become the premiere team-building cooking event company in San ... world, such as Illumina, HP and Qualcomm, and is ranked #1 in its category on ... to its new team building format, a way for teams to not only interact with ...
(Date:3/23/2017)...  GlobeImmune, Inc. today announced it has entered into ... shares of its common stock to NantCell, Inc., a ... the sale of its common stock, NantCell has agreed ... GlobeImmune 200,000 shares, an estimated $2.0 million in value, ... pleased to enter into this strategic agreement with NantCell," ...
(Date:3/23/2017)... 2017 NetworkNewsWire Editorial Coverage  ... Cancer remains one ... on health care systems, in terms of costs and resources. ... does the development of innovative and efficient therapies that demonstrate ... many types of cancer treatments, a growing number of patients ...
Breaking Biology Technology: