Navigation Links
Fetal exposure to PVC plastic chemical linked to obesity in offspring
Date:1/14/2013

Irvine, Calif. Exposing pregnant mice to low doses of the chemical tributyltin which is used in marine hull paint and PVC plastic can lead to obesity for multiple generations without subsequent exposure, a UC Irvine study has found.

After exposing pregnant mice to TBT in concentrations similar to those found in the environment, researchers saw increased body fat, liver fat and fat-specific gene expression in their "children," "grandchildren" and "great-grandchildren" none of which had been exposed to the chemical.

These findings suggest that early-life exposure to endocrine-disrupting compounds such as TBT can have permanent effects of fat accumulation without further exposure, said study leader Bruce Blumberg, UC Irvine professor of pharmaceutical sciences and developmental & cell biology. These effects appear to be inherited without DNA mutations occurring.

The study appears online Jan. 15 in Environmental Health Perspectives, a publication of the National Institute for Environmental Health Sciences.

Human exposure to TBT can occur through PVC plastic particles in dust and via leaching of the chemical and other related organotin compounds from PVC pipes and containers.

Significant levels of TBT have been reported in house dust which is particularly relevant for young children who may spend significant time on floors and carpets. Some people are exposed by ingesting seafood contaminated with TBT, which has been used in marine hull paint and is pervasive in the environment.

Blumberg categorizes TBT as an obesogen, a class of chemicals that promote obesity by increasing the number of fat cells or the storage of fat in existing cells. He and his colleagues first identified the role of obesogens in a 2006 publication and showed in 2010 that TBT acts in part by modifying the fate of mesenchymal stem cells during development, predisposing them to become fat cells.


'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1

Related biology news :

1. Study finds Western diet detrimental to fetal hippocampal tissue transplants
2. Reproductive health providers should discuss environmental exposure risks with patients
3. Exposure to antibiotics linked to severity of allergic asthma: UBC research
4. Lower dosage CT-guided lung biopsy protocol maintains quality, minimizes exposure
5. Obese patients face higher radiation exposure from CT scans -- but new technology can help
6. Prenatal exposure to air pollution linked to childhood obesity
7. Effect of chronic exposure to chemicals used as weapons, pesticides under study
8. NOAA discovers way to detect low-level exposure to seafood toxin in marine animals
9. Socioeconomics may affect toddlers exposure to flame retardants
10. Tracking the effects of prenatal alcohol exposure through to 9 years of age
11. Chemical exposure in the womb from household items may contribute to obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... facilitates superior patient care by providing unparalleled technology to leaders of the medical imaging ... product recently added to the range of products distributed by Ampronix. Photo ... ... ... News ...
(Date:5/20/2016)... -- VoiceIt is excited to announce its new marketing ... working together, VoiceIt and VoicePass will offer an ... slightly different approaches to voice biometrics, collaboration between ... Both companies ... "This marketing and technology partnership allows VoiceIt ...
(Date:5/16/2016)...   EyeLock LLC , a market leader of ... an IoT Center of Excellence in Austin, ... of embedded iris biometric applications. EyeLock,s iris ... security with unmatched biometric accuracy, making it the most ... EyeLock,s platform uses video technology to deliver a fast ...
Breaking Biology News(10 mins):
(Date:5/27/2016)... ... May 27, 2016 , ... NeuMedics Inc. is pleased ... at Life Science Innovation Northwest on June 2, 2016. The session begins at 1:10 ... and propriety microemulsion can be successfully used as a topical agent and a treatment ...
(Date:5/27/2016)... ... ... Weeks after hosting a carpal tunnel syndrome workshop with Dr. Oz on ... of the Fitzmaurice Hand Institute, has announced the addition of MRI diagnostic imaging services ... only 1 of about 3 currently available in the United States. Developed specifically for ...
(Date:5/27/2016)... Kansas City, Missouri (PRWEB) , ... May 27, 2016 , ... ... Market Development Manager, Turf and Ornamental Products. , In his 15-year career with PBI-Gordon, ... as Herbicide Product Manager, where he was integral in the development and launch of ...
(Date:5/27/2016)... ... 27, 2016 , ... Doctors in Italy, Japan, the UK and the US ... protein (BAP1) gene and its link to malignant mesothelioma. Surviving Mesothelioma has just posted ... full article now. , The studies analyzed for the new report included more ...
Breaking Biology Technology: