Navigation Links
Fetal exposure to PVC plastic chemical linked to obesity in offspring
Date:1/14/2013

Irvine, Calif. Exposing pregnant mice to low doses of the chemical tributyltin which is used in marine hull paint and PVC plastic can lead to obesity for multiple generations without subsequent exposure, a UC Irvine study has found.

After exposing pregnant mice to TBT in concentrations similar to those found in the environment, researchers saw increased body fat, liver fat and fat-specific gene expression in their "children," "grandchildren" and "great-grandchildren" none of which had been exposed to the chemical.

These findings suggest that early-life exposure to endocrine-disrupting compounds such as TBT can have permanent effects of fat accumulation without further exposure, said study leader Bruce Blumberg, UC Irvine professor of pharmaceutical sciences and developmental & cell biology. These effects appear to be inherited without DNA mutations occurring.

The study appears online Jan. 15 in Environmental Health Perspectives, a publication of the National Institute for Environmental Health Sciences.

Human exposure to TBT can occur through PVC plastic particles in dust and via leaching of the chemical and other related organotin compounds from PVC pipes and containers.

Significant levels of TBT have been reported in house dust which is particularly relevant for young children who may spend significant time on floors and carpets. Some people are exposed by ingesting seafood contaminated with TBT, which has been used in marine hull paint and is pervasive in the environment.

Blumberg categorizes TBT as an obesogen, a class of chemicals that promote obesity by increasing the number of fat cells or the storage of fat in existing cells. He and his colleagues first identified the role of obesogens in a 2006 publication and showed in 2010 that TBT acts in part by modifying the fate of mesenchymal stem cells during development, predisposing them to become fat cells.


'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1

Related biology news :

1. Study finds Western diet detrimental to fetal hippocampal tissue transplants
2. Reproductive health providers should discuss environmental exposure risks with patients
3. Exposure to antibiotics linked to severity of allergic asthma: UBC research
4. Lower dosage CT-guided lung biopsy protocol maintains quality, minimizes exposure
5. Obese patients face higher radiation exposure from CT scans -- but new technology can help
6. Prenatal exposure to air pollution linked to childhood obesity
7. Effect of chronic exposure to chemicals used as weapons, pesticides under study
8. NOAA discovers way to detect low-level exposure to seafood toxin in marine animals
9. Socioeconomics may affect toddlers exposure to flame retardants
10. Tracking the effects of prenatal alcohol exposure through to 9 years of age
11. Chemical exposure in the womb from household items may contribute to obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/16/2017)...  Genos, a community for personal genetic discovery ... Laboratory Accreditation from the College of American Pathologists ... that meet stringent requirements around quality, accuracy and ... "Genos is committed to maintaining the highest ... to be receiving CAP accreditation," said Jill ...
(Date:2/9/2017)... LONDON , Feb. 9, 2017 The ... in-depth analysis of the biomass boiler market globally in ... sales of biomass boilers. The market for biomass boilers ... product type, end-user, application, and country/region. The market based ... agriculture & forest residues, biogas & energy crops, urban ...
(Date:2/8/2017)... -- Report Highlights The global biosurgery market ... in 2016 at a compound annual growth rate (CAGR) ... - An overview of the global market for biosurgery. ... 2015 and 2016, and projections of compound annual growth ... on the basis of product type, source, application, and ...
Breaking Biology News(10 mins):
(Date:2/27/2017)... Fluxion Biosciences announced today that Genetracer Biotech ... appointed as a Certified Service Provider for Fluxion,s IsoFlux ... used in Genetracer Biotech,s novel liquid biopsy workflows for ... with plans to move to other cancers as additional ... System to isolate, recover, and analyze CTCs (circulating tumor ...
(Date:2/25/2017)... New York (PRWEB) , ... February 25, 2017 ... ... partnership with Verified Clinical Trials in an ongoing effort to create ... of treatment, advocacy, and pharmaceutical research with emphasis on consumers and patients’ mental ...
(Date:2/24/2017)... KNOXVILLE, Tenn. , Feb. 24, 2017 /PRNewswire/ ... ) ("Provectus" or the "Company"), a clinical-stage oncology ... information regarding the deadline to participate in its ... million units, consisting of shares of common stock ... stockholders and holders of listed warrants. ...
(Date:2/24/2017)... HONG KONG, Feb. 24, 2017 China Cord Blood ... "Company"), China,s leading provider of cord blood collection, laboratory ... services, today announced its unaudited financial results for the ... 2017 ended December 31, 2016. Third Quarter ... the third quarter of fiscal 2017 increased by 18.6% ...
Breaking Biology Technology: