Navigation Links
Fetal exposure to PVC plastic chemical linked to obesity in offspring
Date:1/14/2013

Irvine, Calif. Exposing pregnant mice to low doses of the chemical tributyltin which is used in marine hull paint and PVC plastic can lead to obesity for multiple generations without subsequent exposure, a UC Irvine study has found.

After exposing pregnant mice to TBT in concentrations similar to those found in the environment, researchers saw increased body fat, liver fat and fat-specific gene expression in their "children," "grandchildren" and "great-grandchildren" none of which had been exposed to the chemical.

These findings suggest that early-life exposure to endocrine-disrupting compounds such as TBT can have permanent effects of fat accumulation without further exposure, said study leader Bruce Blumberg, UC Irvine professor of pharmaceutical sciences and developmental & cell biology. These effects appear to be inherited without DNA mutations occurring.

The study appears online Jan. 15 in Environmental Health Perspectives, a publication of the National Institute for Environmental Health Sciences.

Human exposure to TBT can occur through PVC plastic particles in dust and via leaching of the chemical and other related organotin compounds from PVC pipes and containers.

Significant levels of TBT have been reported in house dust which is particularly relevant for young children who may spend significant time on floors and carpets. Some people are exposed by ingesting seafood contaminated with TBT, which has been used in marine hull paint and is pervasive in the environment.

Blumberg categorizes TBT as an obesogen, a class of chemicals that promote obesity by increasing the number of fat cells or the storage of fat in existing cells. He and his colleagues first identified the role of obesogens in a 2006 publication and showed in 2010 that TBT acts in part by modifying the fate of mesenchymal stem cells during development, predisposing them to become fat cells.


'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1

Related biology news :

1. Study finds Western diet detrimental to fetal hippocampal tissue transplants
2. Reproductive health providers should discuss environmental exposure risks with patients
3. Exposure to antibiotics linked to severity of allergic asthma: UBC research
4. Lower dosage CT-guided lung biopsy protocol maintains quality, minimizes exposure
5. Obese patients face higher radiation exposure from CT scans -- but new technology can help
6. Prenatal exposure to air pollution linked to childhood obesity
7. Effect of chronic exposure to chemicals used as weapons, pesticides under study
8. NOAA discovers way to detect low-level exposure to seafood toxin in marine animals
9. Socioeconomics may affect toddlers exposure to flame retardants
10. Tracking the effects of prenatal alcohol exposure through to 9 years of age
11. Chemical exposure in the womb from household items may contribute to obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... NEW YORK , Aug. 27, 2014 /PRNewswire/ ... report is available in its catalogue: ... http://www.reportlinker.com/p02316674/Law-Enforcement-Biometrics-Market-in-North-America-2014-2018.html ... to assess individuals on the basis of their ... and identification of both physiological traits such as ...
(Date:8/27/2014)... PITTSBURGHLearning a new skill is easier when it is ... a trained pianist might learn a new melody more ... , Neural engineers from the Center for the Neural ... of Pittsburgh and Carnegie Mellon Universityhave discovered a fundamental ... happens. Published as the cover story in the Aug. ...
(Date:8/27/2014)... the greatest risk to Europe based upon a proxy ... researchers using a ,big data, approach to scientific research. ... and Global Health ranked the top 100 pathogens affecting ... a system which, they believe, will help governments across ... of infectious diseases, including as a result of climate ...
Breaking Biology News(10 mins):Law Enforcement Biometrics Market in North America 2014-2018 2Law Enforcement Biometrics Market in North America 2014-2018 3Law Enforcement Biometrics Market in North America 2014-2018 4Law Enforcement Biometrics Market in North America 2014-2018 5Pitt and Carnegie Mellon engineers discover why learning can be difficult 2Pitt and Carnegie Mellon engineers discover why learning can be difficult 3Big data approach identifies Europe's most dangerous human and domestic animal pathogens 2
... as 50 percent of all human protein-coding genes are ... onset and progression of cancer, others can actually suppress ... cancer therapy. They can also serve as potential biomarkers ... Cancer Biomarkers , investigators report on non-coding miRNAs ...
... have created stunning images of the branching patterns of individual ... eLife on Dec. 18, details the arrangement of ... branching patterns define ten distinct groups that, the researchers say, ... could hold clues for pain management and other areas of ...
... inexpensive new source of a widely used chemical for plastics, ... Succinic acid, traditionally drawn from petroleum, is one focus of ... 2004, the Department of Energy named succinic acid one of ... biological means and turned into high-value materials. Several ...
Cached Biology News:MicroRNAs present exciting opportunities for cancer therapy and diagnosis 2MicroRNAs present exciting opportunities for cancer therapy and diagnosis 3Why our backs can't read braille 2Why our backs can't read braille 3Soybeans a source of valuable chemical 2
(Date:8/27/2014)... DUBLIN , Aug. 27, 2014 ... "Global Stable Isotope Ratio Mass Spectrometer Industry Report ... The Global Stable Isotope Ratio Mass Spectrometer Industry Report ... current state of the global isotope ratio mass spectrometer ... of the industry including definitions, classifications, applications and industry ...
(Date:8/27/2014)... Boca Raton, FL (PRWEB) August 27, 2014 ... that are applied through the use of a handheld ... consumers across the United States. , The brand ... care unit. BIOEQUA researchers were surprised to learn that ... to be made extremely small and delivered directly to ...
(Date:8/27/2014)... 2014 WriteResult, LLC – a premier ... again shown superiority when it comes to meeting the ... ePRO portion of their most recent study closeout on-time ... chose WriteResult’s digital writing platform to collect Patient Reported ... to complete drew data from a number of assessments ...
(Date:8/26/2014)... San Diego, CA, and Bellingham, WA (PRWEB) August ... nanoscience and optical engineering, visions for next-generation wearable ... Light 2015 among numerous highlights at this year’s ... in the San Diego, California, Convention Center. More ... suppliers last week attended conferences, courses, an exhibition, ...
Breaking Biology Technology:Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 2BIOEQUA'S EQUA ESSENTIAL Product Line Redefines Skin Care & Now Available in America 2A Perfect Record: WriteResult Maintains a 100% On-Time ePRO Record with Latest Irritable Bowel (IBS) Study Data Lock 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 3Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 4
... attract the presence of major pharmaceutical companies from out ... own environment, said a panel assembled Monday night by ... building the future today in Wisconsin has to do ... CEO Irene Hrusovsky. , ,Woody Hydrick, a senior consultant ...
... the next ten years, according to a proposal that has ... Senate for a vote this month. State Senator Joe Leibham, ... that would be regulated similarly to airports. , ,Leibhams bill, ... private space travel in the area, receive any potential federal ...
... the lineup for DEMO 2006 nears, Ive had plenty of ... launch. , ,Does a product in "beta" variously defined ... qualify as launch-ready? Must I have customers in the queue ... a shipping product that we've only talked about with our ...
Cached Biology Technology:Panel stresses drawing outside biotech firms to state 2Space port could open in Sheboygan in next 10 years 2Space port could open in Sheboygan in next 10 years 3When do you go from "beta" to "product launch"? 2When do you go from "beta" to "product launch"? 3
... in heart tissues, and is produced ... conditions. Treatment of cells with ... TIMP-4 in some cell types, but ... require concentration of cell culture media ...
Goat polyclonal to HSPC150 ( Abpromise for all tested applications). entrezGeneID: 29089...
Anti-MMP-13 Collagenase-3, amino terminal end of active enzyme; rabbit host...
...
Biology Products: