Navigation Links
Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
Date:8/21/2007

When your body cranks up the heat, its a sign that somethings wrongand a fever is designed to help fight off the infection. But turning up the temperature can have a down side: in about one in 25 infants or small children, high fever can trigger fever-induced (febrile) seizures. While the seizures themselves are generally harmless, a prolonged fever resulting from infection or heatstroke of over 108˚F (42˚C) can eventually lead to respiratory distress, cognitive dysfunction, brain damage or death.

New research by scientists at the University of Toronto Mississauga and Queens University has shown that genetic variation in the foraging gene results in different tolerance for heat stress, and demonstrates how the use of specific drugs can replicate this effect in fruit flies and locusts. While the findings are at an early stage, the researchers suggest that since this genetic pathway is found in other organisms, it could lead to ways to rapidly protect the brain from extremely high fevers in mammals, including humans. The new study appears in the August 22 issue of the journal PLoS ONE, the online, open-access journal from the Public Library of Science.

Our research suggests that manipulation of a single gene or genetic pathway will be sufficient to rapidly protect the nervous system from damage due to extreme heat stress, says senior researcher, Professor Marla B. Sokolowski, who holds a Canada Research Chair in Genetics.

In their research, post-doctoral fellow Ken Dawson-Scully and Sokolowski demonstrate that the foraging gene, responsible for a protein called PKG, protects against heat-induced neural failure in fruit flies and locusts. When they increased the temperature by 5˚C per minute (starting from 22˚C and rising to 42˚C), they found that fruit flies with a lower level of PKG experienced neural failure at much higher temperatures than those with higher levels of PKG.

Using drugs that interact
'/>"/>

Contact: Nicolle Wahl
nicolle.wahl@utoronto.ca
905-569-4656
Public Library of Science
Source:Eurekalert

Page: 1 2

Related biology news :

1. Feeling old?
2. How plants avoid feeling the burn
3. Detecting cold, feeling pain: Study reveals why menthol feels fresh
4. Putting feelings into words produces therapeutic effects in the brain
5. How to lose weight and not go hungry: HU researcher develops drug that mimics feeling of fullness
6. Bioartificial kidney under study at MCG
7. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
8. W.M. Keck Foundation funds study of friendly microbes
9. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
10. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
11. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/25/2014)... 2014 A recent report, "Genetic Testing Market ... and future genetic testing market. A comprehensive introduction of ... in this report. On account of our analysis of ... strengths and challenges; forecast for genetic testing has been ... grow at a CAGR of around 9% during 2013-2018. ...
(Date:10/22/2014)... Medicine® scientists helps explain how bipolar disorder affects the ... therapies to treat the mental illness. , Scientists ... method recognized with the 2014 Nobel Prize in ... from mice with bipolar-like behaviors. In the synapses (where ... structures with concentrated levels of ANK3 -- the gene ...
(Date:10/22/2014)... 20, 2014  Leading identity analyst firm Acuity Market ... the world,s population will have a chip-based National eID ... . Asia , with its ... for more than 60% of all National eID cards ... -- "The Global National eID Industry Report: ...
Breaking Biology News(10 mins):Genetic Testing Market Outlook 2018 2Bipolar disorder discovery at the nano level 2Half the World's Population Will Have Chip-Based National Electronic Identity (eID) Cards by 2018 2
... Calif., Nov. 19, 2012 Medbox, Inc. (Ticker: MDBX) ... press release they have received many inquiries from shareholders ... during last week,s volatile trading. These inquiries were responded ... to shareholder rapport. In other news, ...
... media only" box at the end of the release ... mouse model of multiple sclerosis (MS), researchers funded by ... to selectively inhibit the part of the immune system ... fibers and facilitates electrical communication between brain cells. ...
... 16 Penguins that face the bitter cold and icy ... warmth during storms. Mathematicians at the University of California, Merced ... aims solely to minimize its own heat loss. Surprisingly, the ... sharing of heat. The results are published in the online ...
Cached Biology News:Medbox Communicates with Shareholders, Comments on Pending Transition to OTC Bulletin Board, and Announces Appearance on Fox Business News Channel 2Research breakthrough selectively represses the immune system 2Research breakthrough selectively represses the immune system 3Research breakthrough selectively represses the immune system 4New model reveals how huddling penguins share heat fairly 2New model reveals how huddling penguins share heat fairly 3
(Date:10/22/2014)... 2014 New test innovations will be the ... (IVD) test industry, especially as companies struggle with reimbursement ... more than 25 testing innovations in important disease areas ... IVD products. Kalorama details the new approaches its biennial survey ... In Vitro Diagnostic Tests , 9th Edition . ...
(Date:10/22/2014)... The North American crystal oscillator market report ... analysis and forecast of revenue. This market was valued ... reach $623.6 million by 2018, at a CAGR of ... TOC of the North American crystal oscillator market report, ... This also provides a glimpse of the segmentation of ...
(Date:10/22/2014)... 2014 Currently offering a comprehensive ... D Weighing, Rice Lake, and Ohaus, Pipette.com has ... The Sartorius CPA Semi-Micro Balance is ideal for ... and user-friendly laboratory balance. , Sartorius is a ... laboratory balances are well known for their high ...
(Date:10/22/2014)... 22, 2014   Synthetic Biologics, Inc. (NYSE ... for serious infections and diseases, announced today that the ... of Allowance for a composition of matter patent application ... program, SYN-004. This is Synthetic Biologics, first allowed ... and adds to the Company,s extensive C. difficile ...
Breaking Biology Technology:Report: Radical New IVD Test Approaches Key To Growth 2Report: Radical New IVD Test Approaches Key To Growth 3The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 2The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 3The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 4Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 2Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 4
... 11 Zimmer Holdings, Inc.,(NYSE: ZMH ; SWX: ... Blair & Company 28th Annual Growth Stock Conference in ... Time., A live webcast of the presentation can ... . The webcast will,be archived for replay following ...
... Rosetta Genomics has Signed a Binding Term Sheet to Acquire Parkway ... ... Significantly Streamline the Development and Commercialization of Rosetta Genomics, microRNA-based ... Needs to Market and Sell its microRNA-based Tests in the U.S. and ...
... DANBURY, Conn., June 11 Biodel Inc. (Nasdaq:,BIOD) today ... as,a new member of its Board of Directors, effective ... of Diabetes Technology,Consultants where he advises Fortune 500 companies ... welcome Barry to our Board of Directors at such ...
Cached Biology Technology:Rosetta Genomics Executes Binding Term Sheet to Acquire U.S. CLIA-Certified Lab to Expedite Commercialization of Diagnostic Tests 2Rosetta Genomics Executes Binding Term Sheet to Acquire U.S. CLIA-Certified Lab to Expedite Commercialization of Diagnostic Tests 3Rosetta Genomics Executes Binding Term Sheet to Acquire U.S. CLIA-Certified Lab to Expedite Commercialization of Diagnostic Tests 4Rosetta Genomics Executes Binding Term Sheet to Acquire U.S. CLIA-Certified Lab to Expedite Commercialization of Diagnostic Tests 5Rosetta Genomics Executes Binding Term Sheet to Acquire U.S. CLIA-Certified Lab to Expedite Commercialization of Diagnostic Tests 6Barry Ginsberg, M.D., Ph.D. Elected to Biodel's Board of Directors 2
BD BioCoat Collagen IV 35 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of mouse collagen type IV....
... application for DNA and protein sequence ... makes complex computational analyses of sequence ... very latest computing technology to set ... are analysed. Features include: Sequence Annotation, ...
... Cytokeratin TYPE II Reacts with most ... epidermal cell keratin of 86 and 58kD ... Broad keratin reactivity is found on human ... Immunogen: Human epidermal cells ...
... The CHEMICON XpressPack™ Colorimetric Detection System ... detection of amplified DNA generated by an ... of a selected target of interest. ... Colorimetric Detection System is a hybridization capture ...
Biology Products: