Navigation Links
Faster DNA analysis at room temperature
Date:8/3/2010

This release is also available in Chinese.

College Park, MD (August 3, 2010) -- DNA microarrays are one of the most powerful tools in molecular biology today. The devices, which can be used to probe biological samples and detect particular genes or genetic sequences, are employed in everything from forensic analysis to disease detection to drug development.

Now Paul Li and colleagues at Simon Fraser University in Burnaby, Canada have combined DNA microarrays with microfluidic devices, which are used for the precise control of liquids at the nanoscale. In an upcoming issue of the journal Biomicrofluidics, which is published by the American Institute of Physics (AIP), Li and his colleagues describe how the first combined device can be used for probing and detecting DNA.

The key to Li's result: gold nanoparticles. Suspended in liquid and mixed with DNA, the nanometer-scale spheres of gold act as mini magnets that adhere to each of the DNA's twin strands. When the DNA is heated, the two strands separate, and the gold nanoparticles keep them apart, which allows the single strands to be probed with other pieces of DNA that are engineered to recognize particular sequences.

Li, whose work is funded by the Natural Sciences and Engineering Research Council of Canada, is applying for a patent for his technique. He sees a host of benefits from the combination of DNA microarrays and microfluidics.

"It's faster and requires a relatively small sample," he says, adding in his paper that "the whole procedure is accomplished at room temperature in an hour and apparatus for high temperature is not required"


'/>"/>

Contact: Jason Socrates Bardi
jbardi@aip.org
301-209-3091
American Institute of Physics
Source:Eurekalert  

Page: 1

Related biology news :

1. Synthetic bone graft recruits stem cells for faster bone healing
2. Faster Salmonella detection now possible with new technique
3. UCLA engineers develop faster method to detect bacterial contamination in coastal waters
4. Chubby birds get there faster
5. ASU scientists develop universal DNA reader to advance faster, cheaper sequencing efforts
6. Ecologists discover forests are growing faster
7. Boston University reseachers develop faster, cheaper DNA sequencing method
8. Faster, cheaper way to find disease genes in human genome passes initial test
9. Faster, more cost-effective DNA test for crime scenes, disease diagnosis
10. Mice run faster on high-grade oil
11. The faster they come
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Faster DNA analysis at room temperature
(Date:7/28/2014)... Roald Amundsen reached the South Pole in 1911, but ... before any human. , Using data from 16 ice ... continent, including the South Pole, a group led by ... Reno, Nevada, created the most accurate and precise reconstruction ... The new record, described in an article published today ...
(Date:7/28/2014)... among minerals and organic compounds in hydrothermal environments are ... provide energy for the deep biosphere, and may have ... is known about how minerals influence organic reactions. ... demonstrated how a common mineral acts as a catalysts ... for toxic solvents or expensive reagents. , At the ...
(Date:7/28/2014)... of juvenile rat brain cells suggests that the effects ... between brain cells are temporary. , The study, published ... ONE , was conducted by biologists at the University ... in New York in response to concerns, arising from ... exposing children to general anesthetics may increase their susceptibility ...
Breaking Biology News(10 mins):Lead pollution beat explorers to South Pole, persists today 2Lead pollution beat explorers to South Pole, persists today 3Mineral magic? Common mineral capable of making and breaking bonds 2Mineral magic? Common mineral capable of making and breaking bonds 3Study suggests disruptive effects of anesthesia on brain cell connections are temporary 2Study suggests disruptive effects of anesthesia on brain cell connections are temporary 3
... UT Southwestern Medical Center have discovered a basic mechanism ... vessels can grow ?sometimes abnormally ?suggesting methods of treatment ... blood vessels is involved in hypertension, coronary artery disease, ... this detailed mechanism, it is now possible to begin ...
... line that produced humans seems to be among the slowest. ... the European Molecular Biology Laboratory (EMBL), is that our species ... been lost in more quickly-evolving animals. This overturns a commonly-held ... The work appears in the current issue of the journal ...
... willow warblers and beaver dams once were bountiful in an ... wolves left this area, elk grew more plentiful, browsing heavily ... and sparrows have replaced the warblers in what is now ... absence of the wolf, a top predator. That's the compelling ...
Cached Biology News:UT Southwestern researchers unravel control of growing blood vessels 2The earliest animals had human-like genes 2The earliest animals had human-like genes 3Wolves' top-down effect 2
(Date:7/29/2014)... foam of atom-thick sheets can be made to any ... Rice University. , In microscopic images, the foam ... and walls that reinforce each other. The structure consists ... of graphene oxide that self-assemble with the assistance of ... the foam could find use in structural components, as ...
(Date:7/29/2014)... According to the new research ... (Image Analysis Software), Delivery Modes (Web Based/Cloud Based) & ... to 2018", published by MarketsandMarkets, analyzes and studies the ... North America , Europe ... Rest of the World (RoW). Browse 78 ...
(Date:7/29/2014)... , July 29, 2014  ImmunoClin Corporation (IMCL) ... medicine, treatment of infectious diseases as well as ... and prevention of pathologies like cardiovascular disease, Alzheimer,s ... 2014, ImmunoClin Corporation will complete the strategic relocation ... D.C. , a key center of North ...
(Date:7/29/2014)... , July 29, 2014  Sigma-Aldrich Corporation (NASDAQ: ... and energy use, increased its investment in Green Chemistry ... around the world last year, the Company announced Monday ... if Science Changed the World? The ... several honors for being a responsible corporate citizen, including ...
Breaking Biology Technology:Tough foam from tiny sheets 2Digital Pathology Market worth $437 Million by 2018 2Digital Pathology Market worth $437 Million by 2018 3ImmunoClin Corporation (IMCL) Relocates Corporate Headquarters to Washington, DC 2ImmunoClin Corporation (IMCL) Relocates Corporate Headquarters to Washington, DC 3Sigma-Aldrich Achieves Record Success in Environmental, Community Initiatives 2Sigma-Aldrich Achieves Record Success in Environmental, Community Initiatives 3
... 2011 BioStorage Technologies, Inc. a global provider ... cold chain logistics for the bioscience industry, will ... the International Contract Services Expo (ICSE), on Wednesday, ... The symposium will include two 1-hour presentations ...
... International, Inc. (OTC Pink: DYAI), a global biotechnology ... financial results for the third quarter ended September ... to discuss those financial results as follows: ...  After market close, Thursday, November 3, 2011. ...
... 2011 Verenium Corporation (Nasdaq: VRNM ), ... enzymes, today announced that it has entered into an ... the United States ("Ex-Im Bank") for two 18-month, secured ... These new credit facilities will allow the ...
Cached Biology Technology:BioStorage Technologies to Host Global Sample Management Benchmarking Symposium at International Contract Services Expo 2Verenium Announces Up to $16 Million in New Secured Financings 2Verenium Announces Up to $16 Million in New Secured Financings 3
... hydrolytic enzyme that catalyzes the conversion,of ... maltose, maltotriose and,dextrins. The level of ... human,body are of clinical importance,1-3 while ... for industry.4, The EnzChek Amylase Assay ...
Rat monoclonal [20d5] to NKG2A + C+ E ( Abpromise for all tested applications). Antigen: Tissue / cell preparation (Mouse): CHO transfected cells expressing the B6 allele of NKG2A. Entrez Gen...
... FL is equipped with ... measurement technologies that complement ... advanced features of Fluoroskan ... Fluoroskan Ascent FL provides ...
... Forma's stainless steel rack ... adjustable mechanism that permits ... shaking angles, and "snap-in" ... universal rack holder will ...
Biology Products: