Navigation Links
Fast-mutating DNA sequences shape early development; guided evolution of uniquely human traits
Date:11/10/2013

, the research team identified more than 2,600 HARs. Then, they created a program called EnhancerFinder to whittle down that list to just the HARs were likely to be enhancers.

"EnhancerFinder is a machine-learning algorithm that takes in basic genetic informationa HAR sequence, known evolutionary patterns, other functional genomics dataand returns a prediction of that HAR's function," explained Tony Capra, PhD, the study's lead author. "Using this approach, we predicted that nearly eight hundred HARs act as enhancers at a specific point during embryonic development. Confirming this prediction for several dozen HARs, our next goal was to see whether any of these HARs enhanced patterns of gene activation that were uniquely human."

Additional analyses revealed five such HARs, which were active in both human and chimpanzee genomes, but which activated genes in different embryonic regions. For example, the human versions of HARs 2xHAR.164 and 2xHAR.170 are active in a region of the brain between the midbrain and hindbrain, while the chimp versions are not. This so-called "gain of function" of these two HARs in human embryos may point to differences in the development of key brain regions such as the cerebellum, which is known to regulate not only motor control but may also regulate higher cognitive functions, such as language, fear and pleasure.

"These results, while preliminary, offer an unprecedented glimpse into how very recent changes to the human genome have modified the genetic programs that control embryonic development to potentially yield different results," said Dr. Capra. "We anticipate that if we were to look at the activity of HARs that are enhancers during later developmental stages, we would see even more differences between humans and chimpanzees."

"It's been 10 years since the Human Genome Project was declared 'complete,' but the amount of genomic knowledge we've gleaned since thenin large part due to advances in bioi
'/>"/>

Contact: Anne Holden
anne.holden@gladstone.ucsf.edu
415-734-2534
Gladstone Institutes
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Long-term research reveals causes and consequences of environmental change
2. New approach to spell checking gene sequences
3. Revolutionary project will obtain entire genome sequences in fight against Alzheimers
4. Research reveals contrasting consequences of a warmer Earth
5. DNA sequences need quality time too - guidelines for quality control published
6. Computers taught to ID regulating gene sequences
7. Global warming may have severe consequences for rare Haleakalā silverswords
8. Global warming may have severe consequences for rare Haleakalā silverswords
9. FASEB SRC announces: Molecular Mechanisms & Physiological Consequences of Protein Aggregation
10. College kids who dont drink milk could face serious consequences
11. Saving the parrots: Texas A&M team sequences genome of endangered macaw birds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Fast-mutating DNA sequences shape early development; guided evolution of uniquely human traits
(Date:10/27/2014)... in German . ... interior via electrical signals, they communicate with each other ... messenger substances, the neurotransmitters, are stored in vesicles at ... these vesicles fuse with the cell membrane and release ... lost, synapses always have some readily releasable vesicles on ...
(Date:10/27/2014)... — Recent breakthroughs may pave the way for ... parasitic helminths. These flatworms, including tapeworms that cause ... flukes (schistosomes), infect more than 300 million people ... lost due to chronic illness and death each ... of microbiology, immunology, and tropical medicine, and scientific ...
(Date:10/27/2014)... 27, 2014—New results from a safety and immunogenicity ... efficacy, indicate that a live attenuated enterotoxigenic ... combination with a novel adjuvant, provided significant protection ... for this vaccine/adjuvant combination, which was 58.5 percent ... using a highly rigorous ETEC human challenge model. ...
Breaking Biology News(10 mins):Synapses always on the starting blocks 2Synapses always on the starting blocks 3GW researcher adapting breakthrough technologies to combat parasitic worm infections 2Clinical results indicate vaccine candidate highly efficacious against bacterial diarrhea 2
... institutions led by the Georgia Institute of Technology has ... Science Foundation and the National Aeronautics and Space Administration ... understanding of how life started on Earth. Researchers will ... the spontaneous formation of functional polymers -- such as ...
... , The Virginia Tech Colleges of Engineering, Science, and ... million, five-year grant from the National Science Foundation (NSF) ... future researchers to solve emerging challenges at the intersection ... The MultiSTEPS (Multi-Scale Transport in Environmental and Physiological Systems) ...
... The 2010 Annual Meeting & OTO EXPO of the ... (AAO-HNSF), the largest meeting of ear, nose, and throat doctors ... The official abstract supplement for the annual meeting is now ... of Otolaryngology Head and Neck Surgery . (See ...
Cached Biology News:Georgia Tech awarded a $20M Center for Chemical Innovation from NSF and NASA 2Georgia Tech awarded a $20M Center for Chemical Innovation from NSF and NASA 3NSF funds Virginia Tech program to train researchers at intersection of engineering, biology 2NSF funds Virginia Tech program to train researchers at intersection of engineering, biology 3Otolaryngology -- Head and Neck Surgery Annual Meeting supplement now available 2
(Date:10/27/2014)... 2014 The report “Smart Highway ... Management, Communication, Monitoring), and by Display (Variable Message ... segments the global market into various sub-segments with ... identifies the drivers and restraints for this market ... Browse 75 market tables and 37 figures spread ...
(Date:10/27/2014)... 2014 Janssen Biotech, Inc. and the ... today the launch of Get Your ... campaign designed to provide resources for people living ... role of nutrition and appropriate therapy in managing ... associated with this release, please click: http://www.multivu.com/players/English/7261131-janssen-ccfa-get-your-full-course-for-ibd-wellness-with-sunny-anderson/ ...
(Date:10/26/2014)... The report "Data Center Networking Market [Ethernet switches, ... Appliances]: Global Advancements, Worldwide Forecasts & Analysis (2013-2018)" ... into various segments with an in-depth analysis and ... factors driving this market, various restraints and challenges, ... roadmaps. , Browse 106 market data tables and ...
(Date:10/25/2014)... The report “Adipic Acid Market by Application, by ... & Forecast to 2019” report analyzes the adipic ... and trends in different regions. , Browse 119 ... 217 slides and in-depth TOC on “Adipic Acid ... http://www.marketsandmarkets.com/Market-Reports/adipic-acid-269.html , Early buyers will receive 10% ...
Breaking Biology Technology:Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 2Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 3Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 4Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 2Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 3Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 4Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 2Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 3Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 4Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 2Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 3Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 4
... - MacoPharma increased its forecast for P-Capt(R) filters sale in 2008;, - Use of affinity prion adsorbent for ... in excess of $25 M over the next 5 years ... - $4 M in 2008;,- 10th product approved by the FDA and or the EMEA, contributing ... growth., MONTREAL, ...
... Cholesterol Test Can Help Identify Patients At Risk of Heart ... ... Atherotech, Inc., a,cardio-diagnostic company, today announced that the largest private,insurers in ... (FEHB) Program now cover the VAP (Vertical Auto Profile),Test, the most ...
... Software Platform Further Solidifies Netsmart as Leader in Behavioral Healthcare ... ... Florida, GREAT RIVER, N.Y., Feb. 6 Netsmart Technologies, Inc.,a ... organizations, today announced it has signed a contract to,provide comprehensive licensed ...
Cached Biology Technology:ProMetic provides business update - Over $35 million worth of business secured in January 2ProMetic provides business update - Over $35 million worth of business secured in January 3ProMetic provides business update - Over $35 million worth of business secured in January 4VAP Cholesterol Test From Atherotech Covers 90 Percent of Arizona Insured 2Netsmart Technologies Extends Relationship with Manatee Glens for Enterprise Behavioral Health Software Solutions 2Netsmart Technologies Extends Relationship with Manatee Glens for Enterprise Behavioral Health Software Solutions 3
Oven mesh sheets, large, 23 x 23cm, pack of 5...
Preparation Note: Prepared essentially by method of Singer, T.P., J. Biol. Chem., 174, 11 (1948). Quality Clarifier: Contains lipase Unit Definition: One unit will hydrolyze 1.0 μmole of p-ni...
... Analysis Note: Protein determined by Biuret Physical ... mM Tris-HCl, pH 7.6, 1 mM MgCl ... Preparation Unit Definition: One unit will ... minute at pH 9.8 at 37 C. ...
... The ATP Monitoring Kit measures ... high sensitivity and a dynamic ... technique, the assay measures ATP ... cells over a concentration range ...
Biology Products: