Navigation Links
Fast-mutating DNA sequences shape early development; guided evolution of uniquely human traits
Date:11/10/2013

SAN FRANCISCO, CANovember 11, 2013What does it mean to be human? According to scientists the key lies, ultimately, in the billions of lines of genetic code that comprise the human genome. The problem, however, has been deciphering that code. But now, researchers at the Gladstone Institutes have discovered how the activation of specific stretches of DNA control the development of uniquely human characteristicsand tell an intriguing story about the evolution of our species.

In the latest issue of Philosophical Transactions of the Royal Society B, researchers in the laboratory of Gladstone Investigator Katherine Pollard, PhD, use the latest sequencing and bioinformatics tools to find genomic regions that guide the development of human-specific characteristics. These results offer new clues as to how the activation of similar stretches of DNAshared between two speciescan sometimes result in vastly different outcomes.

"Advances in DNA sequencing and supercomputing have given us the power to understand evolution at a level of detail that just a few years ago would have been impossible," said Dr. Pollard, who is also a professor of epidemiology and biostatistics at the University of California, San Francisco's (UCSF's) Institute for Human Genetics. "In this study, we found stretches of DNA that evolved much more quickly than others. We believe that these fast-evolving stretches were crucial to our human ancestors becoming distinct from our closest primate relatives."

These stretches are called human accelerated regions, or HARs, so-called because they mutate at a relatively fast rate. In addition, the majority of HARs don't appear to encode specific genes. The research team hypothesized that HARs instead acted as "enhancers," controlling when and for how long certain genes were switched on during embryonic development.

Through experiments in embryonic animal models, combined with powerful computational genomics analyses
'/>"/>

Contact: Anne Holden
anne.holden@gladstone.ucsf.edu
415-734-2534
Gladstone Institutes
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Long-term research reveals causes and consequences of environmental change
2. New approach to spell checking gene sequences
3. Revolutionary project will obtain entire genome sequences in fight against Alzheimers
4. Research reveals contrasting consequences of a warmer Earth
5. DNA sequences need quality time too - guidelines for quality control published
6. Computers taught to ID regulating gene sequences
7. Global warming may have severe consequences for rare Haleakalā silverswords
8. Global warming may have severe consequences for rare Haleakalā silverswords
9. FASEB SRC announces: Molecular Mechanisms & Physiological Consequences of Protein Aggregation
10. College kids who dont drink milk could face serious consequences
11. Saving the parrots: Texas A&M team sequences genome of endangered macaw birds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Fast-mutating DNA sequences shape early development; guided evolution of uniquely human traits
(Date:9/2/2015)... 2015 Biometric technology ... a system which uses identical human characteristic such ... DNA and finger print. Increasing number of terror ... system which provides high level of security. Traditional ... tokens are vulnerable to attacks. Furthermore, Biometric technology ...
(Date:8/28/2015)... August 28, 2015 According to ... Market by Assessment Type (Pen & Paper Based, Hosted, ... Corporate Learning, Academic Research), Vertical and Region - Global ... Training Market to grow from USD 2.4 Billion in ... Compound Annual Growth Rate (CAGR) of 25.6% from 2015 ...
(Date:8/24/2015)... 2015  Based on its recent analysis of the biometric ... African Biometrics Company of the Year Award. DERMALOG is the ... in Africa . It has particularly gained ... implemented one of the largest biometric mass applications in the ... Central Bank of Nigeria with its ...
Breaking Biology News(10 mins):Biometrics Technology Market is Expected to Reach $13.8 Billion by 2015: Hexa Research Inc. 2Biometrics Technology Market is Expected to Reach $13.8 Billion by 2015: Hexa Research Inc. 3Biometrics Technology Market is Expected to Reach $13.8 Billion by 2015: Hexa Research Inc. 4Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 2Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 3Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 4Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 2Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 3Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 4Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 5Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 6
... Institute of Standards and Technology (NIST) have demonstrated ... for studying individual proteins under conditions that mimic ... confining individual proteins in nanodroplets of water, researchers ... of these biomolecules, says physicist Lori Goldner, a ...
... from the National Institute of Standards and Technology ... Ground have developed reliable methods based on DNA ... anthrax spores after prolonged storage. The techniques and ... reference standard for anthrax detection and decontamination. ...
... (April 15, 2008) They may never win an ... (DOE) Argonne National Laboratory have developed techniques for creating ... only theorized up until now. Biological and ... the standard crystalline structures of salt or metals since ...
Cached Biology News:'Nanodrop' test tubes created with a flip of a switch 2NIST, Army researchers pave the way for anthrax spore standards 2Argonne scientists develop techniques for creating molecular movies 2
(Date:9/3/2015)... , Sept. 3, 2015  Vermillion, Inc. (NASDAQ: ... gynecologic disease, today announced that Herbert Fritsche , ... ASPiRA LABS, is the recipient of the 2015 Abbott ... Biomarkers (ISOBM) for outstanding contributions to the field of ... award on October 5 th in Zakopane, ...
(Date:9/3/2015)... 3, 2015 According to a ... (LC (HPLC, UHPLC, Flash), GC, Other Components (Autosamplers, Detectors, ... Vials) - Analysis & Global Forecasts to 2020", published ... reach around 9.223 Billion by 2020 from USD 7.062 ... Browse 141 tables and 36 figures spread through ...
(Date:9/3/2015)... ... September 03, 2015 , ... If you plan to ... Boston this October, you will also want to sign up for the tour of ... The tour includes a walk through of the (8) chemistry teaching labs that ...
(Date:9/2/2015)... ARBOR, Mich. and LIBERTYVILLE, Ill. (PRWEB) , ... ... ... NSF International, a leading provider of regulatory compliance, quality systems, analytical ... Avarent LLC, a consulting firm with expertise in medical device products/processes development, ...
Breaking Biology Technology:Vermillion Announces Dr. Herbert Fritsche as Recipient of the 2015 Abbott Award from the International Society of Oncology and Biomarkers 2Chromatography Instruments Market Worth $ 9.223 Billion by 2020 2Chromatography Instruments Market Worth $ 9.223 Billion by 2020 3Chromatography Instruments Market Worth $ 9.223 Billion by 2020 4Erlab Invites You to Tour the Largest Installation of Filtered Fume Hoods in the World 2NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 2NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 3NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 4NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 5NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 6NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 7
... innovation that can help scientists observe a reaction moving at ... spatial resolution, is a feat some would say is nearly ... scientists who developed the dynamic transmission electron microscope (DTEM). ... of scientific phenomena while it,s happening has earned it one ...
... , Aug. 2 MultiCell Technologies, Inc. (OTC ... has submitted four separate grant applications under the U.S. government,s ... Congress as part of the Patient Protection and Affordable Care ... eligible costs and expenses for tax years 2009 and 2010. ...
... August 2, 2010 INEOS Group has,today entered into a ... one of the world,s leading providers of research led,packaging to the global ... capabilities and,synergy,s of two leading global businesses. , ... INEOS Films is ...
Cached Biology Technology:Livermore's DTEM earns innovation award from Microscopy Today 2MultiCell Technologies Applies for Qualifying Therapeutic Discovery Project Grants 2MultiCell Technologies Applies for Qualifying Therapeutic Discovery Project Grants 3MultiCell Technologies Applies for Qualifying Therapeutic Discovery Project Grants 4Bilcare AG to Acquire INEOS' Global Films Business for EUR100 Million 2Bilcare AG to Acquire INEOS' Global Films Business for EUR100 Million 3
GeneRacer is an advanced RACE (rapid amplification of cDNA ends) technique that improves the efficiency of amplifying full-length 5' and 3' cDNA ends. With the GeneRacer Kit you can:...
One-step, microplate or cuvet, colorimetric, detection range 0.04% to 4%. Procedure: 30 min....
... Mouse monoclonal [APS 26] to Presenilin ... an inherited form of the disease carry ... or the amyloid precursor protein (APP). These ... the longer form of amyloid-beta (main component ...
One-step, microplate or cuvet, colorimetric, linear detection range 0.7 mg/dL to 35 mg/dL. Procedure: 5 min....
Biology Products: