Navigation Links
Fast-mutating DNA sequences shape early development; guided evolution of uniquely human traits
Date:11/10/2013

SAN FRANCISCO, CANovember 11, 2013What does it mean to be human? According to scientists the key lies, ultimately, in the billions of lines of genetic code that comprise the human genome. The problem, however, has been deciphering that code. But now, researchers at the Gladstone Institutes have discovered how the activation of specific stretches of DNA control the development of uniquely human characteristicsand tell an intriguing story about the evolution of our species.

In the latest issue of Philosophical Transactions of the Royal Society B, researchers in the laboratory of Gladstone Investigator Katherine Pollard, PhD, use the latest sequencing and bioinformatics tools to find genomic regions that guide the development of human-specific characteristics. These results offer new clues as to how the activation of similar stretches of DNAshared between two speciescan sometimes result in vastly different outcomes.

"Advances in DNA sequencing and supercomputing have given us the power to understand evolution at a level of detail that just a few years ago would have been impossible," said Dr. Pollard, who is also a professor of epidemiology and biostatistics at the University of California, San Francisco's (UCSF's) Institute for Human Genetics. "In this study, we found stretches of DNA that evolved much more quickly than others. We believe that these fast-evolving stretches were crucial to our human ancestors becoming distinct from our closest primate relatives."

These stretches are called human accelerated regions, or HARs, so-called because they mutate at a relatively fast rate. In addition, the majority of HARs don't appear to encode specific genes. The research team hypothesized that HARs instead acted as "enhancers," controlling when and for how long certain genes were switched on during embryonic development.

Through experiments in embryonic animal models, combined with powerful computational genomics analyses
'/>"/>

Contact: Anne Holden
anne.holden@gladstone.ucsf.edu
415-734-2534
Gladstone Institutes
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Long-term research reveals causes and consequences of environmental change
2. New approach to spell checking gene sequences
3. Revolutionary project will obtain entire genome sequences in fight against Alzheimers
4. Research reveals contrasting consequences of a warmer Earth
5. DNA sequences need quality time too - guidelines for quality control published
6. Computers taught to ID regulating gene sequences
7. Global warming may have severe consequences for rare Haleakalā silverswords
8. Global warming may have severe consequences for rare Haleakalā silverswords
9. FASEB SRC announces: Molecular Mechanisms & Physiological Consequences of Protein Aggregation
10. College kids who dont drink milk could face serious consequences
11. Saving the parrots: Texas A&M team sequences genome of endangered macaw birds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Fast-mutating DNA sequences shape early development; guided evolution of uniquely human traits
(Date:8/28/2014)... good examples of complex systems. Their infrastructure equipment ... for cooling, transport to supply fuel, and ICT ... the network chain is interconnected with a wider ... team of UK-based scientists has studied various aspects ... have been published in EPJ B by Gaihua ...
(Date:8/28/2014)... Aug. 28, 2014A new method for measuring and imaging ... doctors and researchers better understand how drug abuse affects ... and tissue engineering, and lead to better treatment options ... a team of researchers from Stony Brook University in ... Health, was published today in The Optical Society,s (OSA) ...
(Date:8/28/2014)... Dyslexia, the most commonly diagnosed learning disability ... disability that occurs when the regions of the ... , The use of non-invasive functional neuroimaging tools ... in dyslexia. However, most prior work has focused ... leaving a gap in our understanding of how ...
Breaking Biology News(10 mins):Inter-dependent networks stress test 2This is your brain's blood vessels on drugs 2This is your brain's blood vessels on drugs 3Dyslexic readers have disrupted network connections in the brain 2
... to low levels of an asbestos-like mineral from Montana ... risk for lung disease today, according to research from ... is a mineral with a flaky, fluffy-looking structure. Previous ... Mont., contained increased levels of an asbestos-like mineral fiber ...
... has on learning in ground squirrels could have an ... to a University of Chicago researcher. Jill Mateo, ... when they perform normal survival tasks, ground squirrels learn ... cortisol, a hormone produced in response to stress, than ...
... examples of creatures that try to look as big as ... to avoid being eaten alive the larvae of sand dollars ... a dollar for a couple of dimes. University of ... clones of themselves within 24 hours of being exposed to ...
Cached Biology News:Low exposure to asbestos-like mineral from Montana vermiculite may up lung disease risk 2Research with squirrels provides clues on hormone's role in human learning 2Sand dollar larvae use cloning to 'make change,' confound predators 2Sand dollar larvae use cloning to 'make change,' confound predators 3
(Date:8/28/2014)... (PRWEB) August 28, 2014 The ability ... a culture that will allow individuals to perform at ... increasingly important for employers looking to compete in this ... are embracing this trend, as the sector increasingly focuses ... a company, which will have real results on the ...
(Date:8/28/2014)... -- Next month, executives from clinical trial marketing firm BBK Worldwide ... Patient-Centered Clinical Trials 2014 , to be held at ... September 4-5. Patient recruitment experts Bonnie A. Brescia , ... share insights on the benefits of employing an effective patient ... media to mobile apps – can be used to drive ...
(Date:8/28/2014)... 2014   SunTrust Robinson Humphrey (STRH) ... to its equity research team in biotechnology and ... in equity research demonstrates our commitment to providing ... enhance their investment decision making," said Biff ... continue to make significant investments in differentiated content ...
(Date:8/28/2014)... Sterlitech is proud to announce that it is ... of products . These additional products increase the ... filters with surface charges. , “We have ... membrane process testing equipment, and correspondingly, a wider demand ... Sterlitech President Mark Spatz. “The addition of Synder ...
Breaking Biology Technology:Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3BBK Worldwide Leads Sessions at Key September Events 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 2
... , CHICAGO , May 26 ... Board: ADLS), a biopharmaceutical company engaged in the discovery, development ... infection, oncology and respiratory diseases, today announced positive results from ... assessing the efficacy of Restanza™ (cethromycin), its novel oral antibiotic, ...
... ... At the beginning of 2010, MIND360.com launched a two month ... brain training games as a creative and fun way to improve ... perception. The pilot was declared a success, showing an improvement the ...
... how they behave could help scientists to grow cells that ... Edinburgh has shown that embryonic stem cells consist of cells ... types. This may be linked to their potential to become ... help scientists catch embryonic stem cells at exactly the right ...
Cached Biology Technology:Advanced Life Sciences Announces Restanza(TM) Shows Efficacy Against Malaria 2Advanced Life Sciences Announces Restanza(TM) Shows Efficacy Against Malaria 3Advanced Life Sciences Announces Restanza(TM) Shows Efficacy Against Malaria 4Advanced Life Sciences Announces Restanza(TM) Shows Efficacy Against Malaria 5High School Brain Training - A Successful Pilot 2High School Brain Training - A Successful Pilot 3Study sheds light into the nature of embryonic stem cells 2