Navigation Links
Family history of liver cancer increases risk of developing the disease
Date:4/24/2012

A family history of liver cancer is reported to increase risk of developing hepatocellular carcinomas (HCC), independent of hepatitis according to findings published in the May issue of Hepatology, a journal of the American Association for the Study of Liver Diseases. The study also shows 70-fold elevated risk of HCC in those with liver cancer in the family and markers for hepatitis B (HBV) or hepatitis C (HCV).

Liver cancer ranks sixth in incidence and the third cause of mortality worldwide. According to the World Health Organization (WHO) liver cancer was responsible for 700,000 deaths in 2008, with HBV and HCV accounting for 78% of all cases of HCC. A vaccine for HBV has been available since 1982; however prior studies have shown familial clustering of HCC in East Asia where HBV is common. While medical evidence reports family history to be related to HCC risk, little is known of this relationship in non-Asian populations.

"There is a high incidence of liver cancer in southern Italy which is likely a result of a higher frequency of HCV in this area," explains Professor Carlo La Vecchia from the Istituto di Ricerche Farmacologiche ''Mario Negri" and the University of Milan in Italy. "Our study investigated the relationship between family history and liver cancer in a Western population."

The case-control study was carried out between January 1999 and July 2002, and included 229 cases of HCC and 431 hospital controls. HCC patients ranged in age from 43 to 84 years, providing survey information and blood samples. The control group included patients admitted to hospital for conditions not related to tumors. Analysis of data on family history and liver cancer updated to April 2011 was also performed.

Results show that 75% of the cases and 11% of controls showed evidence of HBV and HCV infection. Family history of liver cancer was associated to HCC risk after adjusting for chronic HBV and HCV. Compared to subjects wit
'/>"/>

Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Page: 1 2

Related biology news :

1. Merkin Family Foundation to fund next generation of Broad Institute scientists
2. New miniature grasshopper-like insect is first member of its family from Belize
3. Close family ties keep microbial cheaters in check, study finds
4. Do plants perform best with family or strangers? Researchers consider social interactions
5. Scientists determine family tree for most-endangered bird family in the world
6. Long bone shape: A family affair
7. Researchers at Cruces Hospital describe new syndrome of slight family intellectual disability
8. The risk of suffering from insomnia is 67 percent higher if a family member is insomniac
9. Highlights of upcoming conference on aldosterone & the ENaC/Degenerin family of ion channels
10. BUSM professor authors book on how knowledge about genes and family history can save lives
11. Methyl magnet genes can cause family cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... fragmentation of forests in the Amazon help create ... to rapid and widespread forest loss during drought ... findings show that forests in the Amazon could ... with forest fires lead to large-scale loss of ... assistant professor of geography, Penn State. , "We ...
(Date:4/17/2014)... in the Cell Press journal Current Biology ... rather novel sex lives. The Brazilian insects, which represent ... Neotrogla , are the first example of an animal ... been identified in several different animals, Neotrogla ... is also reversed," says Kazunori Yoshizawa from Hokkaido University ...
(Date:4/17/2014)... animals and plant life, but there,s an invisible machine ... the soil, decomposing organic matter and releasing carbon into ... play in ecological systems, their identities have only now ... a genetic map of more than 10,000 species of ... week in the Proceedings of the National Academy ...
Breaking Biology News(10 mins):Drought and fire in the Amazon lead to sharp increases in forest tree mortality 2Drought and fire in the Amazon lead to sharp increases in forest tree mortality 3In sex-reversed cave insects, females have the penises 2Stanford biologists help solve fungal mysteries 2Stanford biologists help solve fungal mysteries 3
... found that the allergenicity of peanut products could be ... North Carolina A&T University report their findings today at ... Microbiology. , "Due to the wide use of peanuts ... soups there is a need to inactivate peanut allergens ...
... Researchers from the University of Pittsburgh report the first ... treatment of congenital muscular dystrophy (CMD) in mice, demonstrating ... on gene therapy ever being feasible for children with ... in this week's online edition of the Proceedings of ...
... analyze DNA from giant, extinct lemurs, according to a Yale ... the National Academy of Sciences. , Radiocarbon dating of the ... that each of the individuals analyzed died well over 1,000 ... professor in the Department of Ecology and Evolutionary Biology. , ...
Cached Biology News:No small feat: First ever gene therapy success for muscular dystrophy achieved 2No small feat: First ever gene therapy success for muscular dystrophy achieved 3Ancient DNA confirms single origin of Malagasy primates 2
(Date:1/15/2014)... AudioNotch is the internet's leading provider ... treatment of tinnitus. Patients listen to sound therapy that ... period of weeks to months, their tinnitus volume decreases. , ... Notched Music and Notched White Noise. Now, AudioNotch is pleased ...
(Date:1/14/2014)... January 14, 2014 Date: Friday, April 11, ... Warrington Country Club, 1360 Almshouse Road, Warrington, Pa. ... organization solely dedicated to finding a cure for hepatitis B ... will host its annual Crystal Ball on Friday, April 11 ...
(Date:1/14/2014)... San Diego, CA (PRWEB) January 14, 2014 ... based on the products of cells grown under simulated ... an international license agreement with Suneva Medical, Inc. for ... media (CCM). , This agreement is an ...
(Date:1/14/2014)... Calif. , Jan. 14, 2014 As pet owners drew ... doubt many of them wrote: "Take better care of my furry ... even designer clothes and top-brand carrying cases to take the little ... parents might also feel compelled to buy some pricey toys at ...
Breaking Biology Technology:Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2
... 10% of all sales ... to be donated to ALSF, ... Tastykake snack line, today announced the re-issue,of Alex,s Lemon Krimpets(R) and ... nation,s leading organizations in the,fight against childhood cancer. Named for Alexandra ...
... 4, 2008 Scientists in fields,as diverse as ... the Olympus FluoroPoint(TM) single molecule fluorescence,detection system for ... laboratories around the world, the system, with its ... use, is now,available for the first time to ...
... Professionals and Addressing the ... Issues Facing Clinical Labs Worldwide, ABBOTT PARK, Ill., April ... support of an initiative to,raise international awareness of the role ... contribution to improve,patient outcomes. Through a program called Labs Are ...
Cached Biology Technology:Tasty Baking Company Continues Partnership With Alex's Lemonade Stand Foundation To Fight Childhood Cancer 2Olympus FluoroPoint(TM) System Provides High-Sensitivity Single Molecule and Protein Interaction Analysis for Screening and Research 2Olympus FluoroPoint(TM) System Provides High-Sensitivity Single Molecule and Protein Interaction Analysis for Screening and Research 3International Federation of Clinical Chemistry Forms Partnership With the Labs Are Vital(TM) Initiative 2International Federation of Clinical Chemistry Forms Partnership With the Labs Are Vital(TM) Initiative 3
MarrowMAX Bone Marrow Medium...
... recognizes murine IRF7 protein, and ... related IRF proteins. Reactivity of ... protein was confirmed by western ... cells transfected with IRF7. Reactivity ...
Rabbit anti-phospho-EGFr (Tyr992) - Concentrate...
Contains L-glutamine...
Biology Products: