Bethesda, MD This 2014 FASEB Science Research Conference focuses on recent advances in our understanding of lipid-regulated signal transduction cascades, lipid mediators, and lipid targets that are known to play major roles in the initiation and progression of human cancers.
This FASEB Conference brings together physician-scientists, basic scientists and scientists from industry for presentations, discussion, and collaboration to broaden our understanding of how these pathways drive cancer, and to explore these and the associated signaling network as targets for cancer therapy. There are numerous challenges in this relatively young, yet rapidly evolving field. Perhaps most critical is understanding the molecular mechanisms by which lipid effectors modulate mitogenesis, cell cycle regulation, cell death and differentiation in transformed cells, and elucidating how intracellular generation of bioactive lipids is altered in transformed cells and contributes to cancer progression.
This meeting strives to provide researchers with an update on current basic, mechanistic discoveries, and to place these discoveries in the proper translational and clinical context. Meeting topics include: The phosphoinostide pathway and its effectors including the protein kinase C (PKC) isozymes, Rho family GTPases, and Ras; modification of membrane phosphoinostides by PI3K, activation of the Akt isozymes and their downstream targets such as mTOR; new phospholipases and the characterization of novel effectors of bioactive products such as COX2 and the isoprostanes; and lipid post-translational modifications of the Ras oncogene and other GTPases that contribute to their transforming activities.
|Contact: Robin Crawford|
Federation of American Societies for Experimental Biology