Navigation Links
Exposure to low doses of BPA alters gene expression in the fetal mouse ovary
Date:8/24/2010

A study posted today (Wednesday, August 25) at the online site of the journal Biology of Reproduction reports that exposure of pregnant female mice to the endocrine-disrupting chemical bisphenol A may produce adverse reproductive consequences on gene expression in fetal ovaries as early as 12 hours after the mother has first been exposed to the chemical.

Bisphenol A (BPA) is a chemical used in plastics for making some baby and water bottles, linings of food and beverage cans, and other human consumer products.

The mice in this study were given BPA at doses thought to be equivalent to levels currently being experienced by humans.

The research, conducted in the laboratory of Dr. Patricia A. Hunt at Washington State University (WSU) in Pullman, showed that BPA exposure affects the earliest stages of egg production in the ovaries of the developing mouse fetuses, thus suggesting that the next generation (the grandchildren of the females given BPA) may suffer genetic defects in such biological processes as mitosis and DNA replication.

In addition, the WSU research team noted that their study "revealed a striking down-regulation of mitotic/cell cycle genes, raising the possibility that BPA exposure immediately before meiotic entry might act to shorten the reproductive lifespan of the female" by reducing the total pool of fetal oocytes.

Future studies in Dr. Hunt's laboratory will focus on genetic changes produced over a range of BPA exposure.


'/>"/>

Contact: Patricia A. Hunt
pathunt@wsu.edu
509-335-4954
Society for the Study of Reproduction
Source:Eurekalert

Page: 1

Related biology news :

1. Study: Bird diversity lessens human exposure to West Nile Virus
2. Birth control has long-term effect on hormone exposure
3. Major source of radon exposure overlooked at former Ohio uranium-processing plant
4. Household exposure to toxic chemicals lurks unrecognized, researchers find
5. Study reveals effects of unconscious exposure to advertisements
6. Benefits of breastfeeding outweigh risk of infant exposure to environmental chemicals in breastmilk
7. Novel technique changes lymph node biopsy, reduces radiaiton exposure
8. Novel technique changes lymph node biopsy, reduces radiation exposure
9. Swimmers at public beaches show increased risk of exposure to contagious staph bacteria
10. How increased UV exposure impacts plants
11. Exposure to insecticide may play role in obesity epidemic among some women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/15/2016)... March 15, 2016 Yissum Research Development ... technology-transfer company of the Hebrew University, announced today the ... sensing technology of various human biological indicators. Neteera Technologies ... million from private investors. ... the detection of electromagnetic emissions from sweat ducts, enables ...
(Date:3/10/2016)... , March 10, 2016 ... new market research report "Identity and Access Management Market ... Audit, Compliance, and Governance), by Organization Size, by Deployment, ... 2020", published by MarketsandMarkets, The market is estimated to ... 12.78 Billion by 2020, at a Compound Annual Growth ...
(Date:3/8/2016)... , March 8, 2016   Valencell , ... today announced it has secured $11M in Series ... Tech, a new venture fund being launched by ... participation from existing investors TDF Ventures and WSJ ... to continue its triple-digit growth and accelerate its ...
Breaking Biology News(10 mins):
(Date:5/3/2016)... ... May 03, 2016 , ... In a list published by the Boston ... 76 fastest-growing private companies; a small percentage of the state's 615,000+ small businesses. The ... percent change in revenue from 2012 to 2015. , As this award ...
(Date:5/3/2016)... May 3, 2016 - And ... and Producers of Those Competitor Biologics  - ... Activities and Prospects ,  Who are the ... And what are their sales potentials? Discover, in our ... results, trends, opportunities and revenue forecasting. ...
(Date:5/2/2016)... ... May 02, 2016 , ... Meister Media ... the fresh look and added functionality give the agricultural world a taste of ... dynamic shift in agriculture – from precision farming via satellites and Unmanned Aerial ...
(Date:4/29/2016)... ... April 29, 2016 , ... Amendia, Inc., ... surgical procedures, today announced the completion of a significant transaction and partnership that ... future customers and partners. Kohlberg & Company, L.L.C. (“Kohlberg”), a leading private ...
Breaking Biology Technology: