Navigation Links
Exposure to low doses of BPA alters gene expression in the fetal mouse ovary
Date:8/24/2010

A study posted today (Wednesday, August 25) at the online site of the journal Biology of Reproduction reports that exposure of pregnant female mice to the endocrine-disrupting chemical bisphenol A may produce adverse reproductive consequences on gene expression in fetal ovaries as early as 12 hours after the mother has first been exposed to the chemical.

Bisphenol A (BPA) is a chemical used in plastics for making some baby and water bottles, linings of food and beverage cans, and other human consumer products.

The mice in this study were given BPA at doses thought to be equivalent to levels currently being experienced by humans.

The research, conducted in the laboratory of Dr. Patricia A. Hunt at Washington State University (WSU) in Pullman, showed that BPA exposure affects the earliest stages of egg production in the ovaries of the developing mouse fetuses, thus suggesting that the next generation (the grandchildren of the females given BPA) may suffer genetic defects in such biological processes as mitosis and DNA replication.

In addition, the WSU research team noted that their study "revealed a striking down-regulation of mitotic/cell cycle genes, raising the possibility that BPA exposure immediately before meiotic entry might act to shorten the reproductive lifespan of the female" by reducing the total pool of fetal oocytes.

Future studies in Dr. Hunt's laboratory will focus on genetic changes produced over a range of BPA exposure.


'/>"/>

Contact: Patricia A. Hunt
pathunt@wsu.edu
509-335-4954
Society for the Study of Reproduction
Source:Eurekalert

0

GOOD

Page: 1

Related biology news :

1. Study: Bird diversity lessens human exposure to West Nile Virus
2. Birth control has long-term effect on hormone exposure
3. Major source of radon exposure overlooked at former Ohio uranium-processing plant
4. Household exposure to toxic chemicals lurks unrecognized, researchers find
5. Study reveals effects of unconscious exposure to advertisements
6. Benefits of breastfeeding outweigh risk of infant exposure to environmental chemicals in breastmilk
7. Novel technique changes lymph node biopsy, reduces radiaiton exposure
8. Novel technique changes lymph node biopsy, reduces radiation exposure
9. Swimmers at public beaches show increased risk of exposure to contagious staph bacteria
10. How increased UV exposure impacts plants
11. Exposure to insecticide may play role in obesity epidemic among some women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... Rollins School of Public Health at Emory University, ... Technology, have received a $4 million grant over ... Emory University (Health and Exposome Research Center: Understanding ... center grant awarded in the United States. ... National Institute of Environmental Health Sciences (NIEHS) of ...
(Date:5/23/2013)... the implications for the overall health, development, and ... primary role in ensuring that all students have ... per day of vigorous or moderate-intensity physical activity, ... Medicine. Recent estimates suggest that only about ... for promoting better health and development. The ...
(Date:5/23/2013)... medics have succeeded in treating cerebral palsy with autologous ... damage, a 2.5 year old boy had been in ... survival. Just two months after treatment with the cord ... the following months, the child learned to speak simple ... from a Korean study, dispel the long-held doubts about ...
Breaking Biology News(10 mins):Emory, Georgia Tech receive first human exposome center grant in US 2Emory, Georgia Tech receive first human exposome center grant in US 3Schools should provide opportunities for 60 minutes of daily physical activity to all students 2Schools should provide opportunities for 60 minutes of daily physical activity to all students 3First successful treatment of pediatric cerebral palsy with autologous cord blood 2
... is most well-known both for his book "On the Origin of ... do not think anything in my scientific life has given me ... of these plants." What could be more satisfying than ... to his studies of different forms of hermaphroditic flowers that occur ...
... , an internationally recognized expert at the University of ... been chosen by the U.S. Department of State to ... Miller is one of only ten persons selected for ... rigorous selection process, are highly accomplished in fields of ...
... gowns and bed sheets to match a patient,s skin color ... other health-related skin color changes, according to a new study ... patient, and then sees the patient again later, the doctor ... has changed color," said neurobiologist and study leader Mark Changizi, ...
Cached Biology News:'Different forms of flowers' continues to fascinate 2US Department of State names UCR entomologist a Jefferson Science Fellow 2US Department of State names UCR entomologist a Jefferson Science Fellow 3Nude-colored hospital gowns could help doctors better detect hard-to-see symptoms 2
(Date:5/24/2013)... 2013 In a sneak preview ... will present technologies with applications in multiple and ... SPIE Optics and Photonics symposium in San ... the international society for optics and photonics , ... sciences and technology meeting in North America, with ...
(Date:5/24/2013)... Canada (PRWEB) May 24, 2013 Many ... barriers, and uptake or efflux transporters at the blood-tissue ... be related to unbound fractions in the tissue rather ... of these disposition challenges is required to guide lead ... to identify any species-dependent variables that may impact the ...
(Date:5/23/2013)... day, their baby stopped breathing, his collapsed bronchus blocking ... and Bryan Gionfriddo watched helplessly, just praying that somehow ... doctors said he had a good chance of not ... now 20-month-old son, Kaiba. "At that point, we were ... and run with it." , They found hope at ...
(Date:5/23/2013)... (PRWEB) May 23, 2013 Patheon ... manufacturing services to the global pharmaceutical industry, will host ... Novel Approaches to Testing” on Tuesday, June 4, 2013 ... pharmaceutical manufacturers are required to comply with regulations for ... practices with limited scientific underpinning and little evaluation of ...
Breaking Biology Technology:See What’s in Earth’s Future ? and Out in Space Now ? at SPIE Optics and Photonics 2See What’s in Earth’s Future ? and Out in Space Now ? at SPIE Optics and Photonics 3See What’s in Earth’s Future ? and Out in Space Now ? at SPIE Optics and Photonics 4DMPK for Targeted Tissue Delivery: Solutions for the Most Challenging Part of Outsourcing, New Life Science Webinar Hosted by Xtalks 2Baby's life saved with groundbreaking 3-D printed device that restored his breathing 2Baby's life saved with groundbreaking 3-D printed device that restored his breathing 3Patheon to Present on “Cleaning Validation: Science, Risk and Novel Approaches to Testing” 2
... Calif., Aug. 30 Cepheid (Nasdaq:,CPHD) will present ... at the Four Seasons Hotel, Boston, September 5 ... and Senior Vice President, Finance and,Chief Financial Officer, ... ET on,September 7. The webcast, along with ...
... Aug. 30 Verenium,Corporation (Nasdaq: VRNM ), a ... the development of high-performance specialty,enzymes, announced today that Carlos ... be presenting at the Cowen and Company Clean,Energy Conference. ... ET,on Thursday, September 6, 2007 and will take place ...
... 30 Advanced Life Sciences,Holdings, Inc. (Nasdaq: ... and CEO will present at the 2007 UBS ... the Grand Hyatt New York on Wednesday,September 26 ... ) A live webcast of the presentation ...
Cached Biology Technology:Cepheid to Present at Thomas Weisel Partners Healthcare Conference 2Verenium Corporation to Present at the Upcoming Cowen and Company Clean Energy Conference 2Verenium Corporation to Present at the Upcoming Cowen and Company Clean Energy Conference 3Advanced Life Sciences to Present at 2007 UBS Global Life Sciences Conference 2
... ZMD.368. Immunogen: Synthetic peptide derived ... human WNT2B/WNT13 protein. Specificity: Specific ... and rat WNT2B/WNT13 proteins. Recognizes both ... Reactivity: Mouse Human Rat (positive controls: ...
Immunogen: Heat inactivated bacterial cells of Salmonella enteriditis,paratyphi and typhimurium Storage: 4 C...
Immunogen: Secretory component isolated from human colostrum. Storage: 4 C...
... I-96 Plate can be used either in ... large-scale (i.e., 96-well) purification of DNA and/or ... unique silica-based matrix make it perfect for ... RNA in = 10 l eluate per ...
Biology Products: