Navigation Links
Exposure to low doses of BPA alters gene expression in the fetal mouse ovary
Date:8/24/2010

A study posted today (Wednesday, August 25) at the online site of the journal Biology of Reproduction reports that exposure of pregnant female mice to the endocrine-disrupting chemical bisphenol A may produce adverse reproductive consequences on gene expression in fetal ovaries as early as 12 hours after the mother has first been exposed to the chemical.

Bisphenol A (BPA) is a chemical used in plastics for making some baby and water bottles, linings of food and beverage cans, and other human consumer products.

The mice in this study were given BPA at doses thought to be equivalent to levels currently being experienced by humans.

The research, conducted in the laboratory of Dr. Patricia A. Hunt at Washington State University (WSU) in Pullman, showed that BPA exposure affects the earliest stages of egg production in the ovaries of the developing mouse fetuses, thus suggesting that the next generation (the grandchildren of the females given BPA) may suffer genetic defects in such biological processes as mitosis and DNA replication.

In addition, the WSU research team noted that their study "revealed a striking down-regulation of mitotic/cell cycle genes, raising the possibility that BPA exposure immediately before meiotic entry might act to shorten the reproductive lifespan of the female" by reducing the total pool of fetal oocytes.

Future studies in Dr. Hunt's laboratory will focus on genetic changes produced over a range of BPA exposure.


'/>"/>

Contact: Patricia A. Hunt
pathunt@wsu.edu
509-335-4954
Society for the Study of Reproduction
Source:Eurekalert

Page: 1

Related biology news :

1. Study: Bird diversity lessens human exposure to West Nile Virus
2. Birth control has long-term effect on hormone exposure
3. Major source of radon exposure overlooked at former Ohio uranium-processing plant
4. Household exposure to toxic chemicals lurks unrecognized, researchers find
5. Study reveals effects of unconscious exposure to advertisements
6. Benefits of breastfeeding outweigh risk of infant exposure to environmental chemicals in breastmilk
7. Novel technique changes lymph node biopsy, reduces radiaiton exposure
8. Novel technique changes lymph node biopsy, reduces radiation exposure
9. Swimmers at public beaches show increased risk of exposure to contagious staph bacteria
10. How increased UV exposure impacts plants
11. Exposure to insecticide may play role in obesity epidemic among some women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2016)... Dec. 14, 2016 "Increase in mobile transactions ... The mobile biometrics market is expected to grow from ... by 2022, at a CAGR of 29.3% between 2016 ... as the growing demand for smart devices, government initiatives, ... "Software component is expected to grow at a ...
(Date:12/8/2016)...  Singulex, Inc., the leader in Next Generation Immunodiagnostics ... license and supply agreement with Thermo Fisher Scientific, the ... access to Thermo Scientific BRAHMS PCT (Procalcitonin), a biomarker ... to diagnose systemic bacterial infection and sepsis and in ... in assessing the risk of critically ill patients for ...
(Date:12/7/2016)... 7, 2016   Avanade is helping Williams ... teams in history, exploit biometric data in order to ... maintain the competitive edge against their rivals after their ... Avanade has worked with Williams during the 2016 ... data (heart rate, breathing rate, temperature and peak acceleration) ...
Breaking Biology News(10 mins):
(Date:1/18/2017)... NY (PRWEB) , ... January 18, 2017 , ... Researchers from a new study ... do not fall low enough after prostate cancer treatment, this indicates there is still remaining ... risk of mortality. , “ The PSA test has always been an indicator of whether ...
(Date:1/18/2017)... , ... January 18, 2017 , ... Thirty-six startup companies ... credits by the Pennsylvania Department of Community and Economic Development in 2016 as part ... located in the University City Keystone Innovation Zone and represent the highest number of ...
(Date:1/18/2017)... , Jan. 18, 2017 /PRNewswire/ - SQI ... sciences and diagnostics company that develops and commercializes ... ("SQI" or the "Company"), today announced that ... Inc. ("Kingsdale"), has resigned from its Board of ... changes to securities regulations that have limited both ...
(Date:1/17/2017)... , Jan. 17, 2017 The Global ... a CAGR of around 7.5% over the next ... Some of the prominent trends that the market ... of diseases & graft transplant surgeries and medical ... the market is categorized into immunomodulatory biomaterials, natural, ...
Breaking Biology Technology: