Navigation Links
Evolutionary medicine of skin cancer risk among Europeans
Date:9/17/2013

The proclivity of Spaniards to bask in regions like the Costa del Sol while their northern European counterparts must stay under cover to protect their paler skin or risk skin cancer is due in large part to the pigment producing qualities of the MC1R gene locus. The MC1R gene, expressed in skin and hair follicle cells, is more diverse in Eurasian populations compared to African populations.

Now, a team of researchers led by Santos Alonso, et. al., have examined the evolutionary selective pressure for MC1R among a large population of Spaniards in comparison to their Northern Europeans counterparts as well as individuals with melanoma. Using data from the 1,000 Genomes Project as well as samples from different regions of Spain, they authors show that selection for the MC1R locus is strong in South Europeans, but not the case for Northern Europeans.

Two evolutionary selective processes seem to be acting on MC1R in Southern Europeans. On the one hand, there is selective pressure to maintain at high frequencies the ancestral form of the gene, also the one most common in Africans. But simultaneously, one gene variant seems to be favored in South Europeans. This gene variant, called the V60L allele, has been associated before with red/blond hair and fair skin.

World frequency distribution of V60L is confined mostly to Europe and the Near East but mostly absent in East Asia and Africa, indicating that the first appearance of V60L mutation occurred some time after modern humans left Africa but before dispersal throughout Europe. Fair skin depigmentation could be a useful change for the adaptation of humans to this new environment. Traditionally, depigmentation had been hypothetically explained as a function of the need of humans to synthesize vitamin D in areas of reduced sun light (compared to Africa). "We have not proved that this is the underlying reason for the signature of positive selection on V60L, but our data adds support to this vie
'/>"/>

Contact: Joe Caspermeyer
MBEpress@gmail.com
480-258-8972
Molecular Biology and Evolution (Oxford University Press)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Fear of holes may stem from evolutionary survival response
2. Penn biologists show that generosity leads to evolutionary success
3. Family matters: Evolutionary relationships among species of magic mushrooms shed light on fungi
4. From obscurity to dominance: Tracking the rapid evolutionary rise of ray-finned fish
5. A revolutionary new 3-D digital brain atlas
6. Teaching complete evolutionary stories increases learning
7. Living fossils? Actually, sturgeon are evolutionary speedsters
8. Small but speedy: Short plants live in the evolutionary fast lane
9. Political motivations may have evolutionary links to physical strength
10. Revolutionary Face Recognition Media Exploitation System Now Available to Enhance Public Safety in Europe
11. Fred Hutch evolutionary geneticist Harmit Malik selected as an HHMI investigator
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... BOSTON, Mass , March 23, 2015 SoundView ... shipment of NXT-ID,s (NASDAQ: NXTD ) Wocket smart wallet. SoundView ... world user feedback on their experience with the Wocket in ... experience at CVS, Whole Foods and other retailers, making both ... Kris Tuttle also says, "If the company meets ...
(Date:3/20/2015)... Mar. 20, 2015 Research and Markets ... of the "India Sensors Market Forecast and ... The sensor market is projected to grow ... Consumer electronics, automotive, industrial and healthcare sectors ... the country. In addition, adoption of MEMS technology ...
(Date:3/19/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... commerce market, announces its biometric payment technology, the Wocket® smart ... week on Washington DC,s Fox 5 ... "The Next Great Thing", host Laura Evans calls ... ,a really big breakthrough in mobile payment.,  ...
Breaking Biology News(10 mins):Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3
... National Science Foundation announced this month that it is funding ... at Urbana-Champaign. The Center for the Physics of Living Cells ... and the second to explore the physics of biological systems. ... 10 percent matching grant from the university, bringing the total ...
... is available in German . , Dessau. ... molluscs more than plants. This is the finding of a ... (UFZ), TU Berlin, the German Federal Institute of Hydrology (BfG), ... observations before and after the Elbe floods of August 2002. ...
... Rebecca Sherry in the Department of Botany and Microbiology ... Verburge at the Desert Research Institute; Dale Johnson from ... the National Center for Atmospheric Research; and others to ... anomaly on grassland productivity and ecosystem carbon cycling. ...
Cached Biology News:NSF funds new 'Center for the Physics of Living Cells' at Illinois 2NSF funds new 'Center for the Physics of Living Cells' at Illinois 3Vegetation hardly affected by extreme flood events 2
(Date:4/23/2015)... April 23, 2015 Glemser ... the first EMC® Enterprise Content Division (ECD) Certified ... EMC Documentum® for Life Sciences Solution Suite ... knowledge and capabilities to provide life sciences companies ... , The EMC Documentum Solution Suite offers ...
(Date:4/23/2015)... YORK, NY , April 23, 2015 /PRNewswire/ - ... issued an Executive Informational Overview ® (EIO) on ... full 52-page report is available on Crystal Research Associates, ... as on Aeterna Zentaris, website at www.aezsinc.com . ... transitioning into a specialty biopharmaceutical company in oncology, endocrinology, ...
(Date:4/22/2015)... 22, 2015  Sangamo BioSciences, Inc. (NASDAQ: SGMO ... and accomplishments. For the first quarter ended ... of $5.3 million, or $0.08 per share, compared to ... share, for the same period in 2014. As of ... marketable securities and interest receivable of $226.1 million. ...
(Date:4/22/2015)... , April 22, 2015 Steep Hill, ... announced today that it has opened an investment ... growth and expansion.  The common stock investment round ... 506(c), a law intended to encourage funding of ... to 506(c), small businesses largely relied on friends ...
Breaking Biology Technology:Glemser Earns Accreditation for Life Sciences Solution Suite 2Crystal Research Associates, LLC Issues Executive Informational Overview (EIO) on Aeterna Zentaris Inc. 2Crystal Research Associates, LLC Issues Executive Informational Overview (EIO) on Aeterna Zentaris Inc. 3Sangamo BioSciences Reports First Quarter 2015 Financial Results 2Sangamo BioSciences Reports First Quarter 2015 Financial Results 3Sangamo BioSciences Reports First Quarter 2015 Financial Results 4Sangamo BioSciences Reports First Quarter 2015 Financial Results 5Sangamo BioSciences Reports First Quarter 2015 Financial Results 6Sangamo BioSciences Reports First Quarter 2015 Financial Results 7Sangamo BioSciences Reports First Quarter 2015 Financial Results 8Steep Hill Launches $5M Limited Stock Offering 2Steep Hill Launches $5M Limited Stock Offering 3
... one is no different. Like a creaky car on an old ... up the steep incline of recovery. After so much work, the ... ride. And to be clear in my metaphor, lets be sure ... we have not yet forgotten. , ,The next 12 months hold ...
... their grades online for the first time in December. An ... of staff members from the Universitys Division of Information ... , ,We worked out what we wanted to ... to instructors, said Connie Chatman, manager for student records in ...
... Loftus, who held the Wisconsin Legislatures top spot from ... Hyde characteristics in his book, The Art of Legislative ... individuals act collectively for the common good. A legislature ... , ,The Wisconsin Legislature over the past 10 years ...
Cached Biology Technology:Year ahead offers payoff for hard work 2Year ahead offers payoff for hard work 3UW-Madisons move to online grading goes smoothly 2In the Wisconsin Legislature, the promise of a productive session 2In the Wisconsin Legislature, the promise of a productive session 3
... The Fujifilm Life Science BAS-5000 ... all Imaging Plate equipment. The top ... scanners, it features a superior Imaging ... for versatility in target subjects. Fujifilm ...
This bispecific antibody complex has been tested for efficient depletion of CD41+ cells using the StemSep ; negative immunomagnetic cell separation system....
... solutions to meet your laboratory's requirements for data management and quality control. ... ... ... CLARA® is the standard software for Staccato Systems and custom Allegro Modules allowing for the simple ...
... microscope is described by end-users to be ... the fundamentals of light microscopy and electronic ... footprint, it does not require much space ... busy lab environment. The DM-BA300 combines Motic's ...
Biology Products: