Navigation Links
Evolutionary medicine of skin cancer risk among Europeans
Date:9/17/2013

The proclivity of Spaniards to bask in regions like the Costa del Sol while their northern European counterparts must stay under cover to protect their paler skin or risk skin cancer is due in large part to the pigment producing qualities of the MC1R gene locus. The MC1R gene, expressed in skin and hair follicle cells, is more diverse in Eurasian populations compared to African populations.

Now, a team of researchers led by Santos Alonso, et. al., have examined the evolutionary selective pressure for MC1R among a large population of Spaniards in comparison to their Northern Europeans counterparts as well as individuals with melanoma. Using data from the 1,000 Genomes Project as well as samples from different regions of Spain, they authors show that selection for the MC1R locus is strong in South Europeans, but not the case for Northern Europeans.

Two evolutionary selective processes seem to be acting on MC1R in Southern Europeans. On the one hand, there is selective pressure to maintain at high frequencies the ancestral form of the gene, also the one most common in Africans. But simultaneously, one gene variant seems to be favored in South Europeans. This gene variant, called the V60L allele, has been associated before with red/blond hair and fair skin.

World frequency distribution of V60L is confined mostly to Europe and the Near East but mostly absent in East Asia and Africa, indicating that the first appearance of V60L mutation occurred some time after modern humans left Africa but before dispersal throughout Europe. Fair skin depigmentation could be a useful change for the adaptation of humans to this new environment. Traditionally, depigmentation had been hypothetically explained as a function of the need of humans to synthesize vitamin D in areas of reduced sun light (compared to Africa). "We have not proved that this is the underlying reason for the signature of positive selection on V60L, but our data adds support to this vie
'/>"/>

Contact: Joe Caspermeyer
MBEpress@gmail.com
480-258-8972
Molecular Biology and Evolution (Oxford University Press)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Fear of holes may stem from evolutionary survival response
2. Penn biologists show that generosity leads to evolutionary success
3. Family matters: Evolutionary relationships among species of magic mushrooms shed light on fungi
4. From obscurity to dominance: Tracking the rapid evolutionary rise of ray-finned fish
5. A revolutionary new 3-D digital brain atlas
6. Teaching complete evolutionary stories increases learning
7. Living fossils? Actually, sturgeon are evolutionary speedsters
8. Small but speedy: Short plants live in the evolutionary fast lane
9. Political motivations may have evolutionary links to physical strength
10. Revolutionary Face Recognition Media Exploitation System Now Available to Enhance Public Safety in Europe
11. Fred Hutch evolutionary geneticist Harmit Malik selected as an HHMI investigator
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... news release is available in German . ... are among the most expensive foods in the world. Because ... find them. But the distinctive smell of truffles is not ... French scientists under the direction of the Goethe University Frankfurt ... produced by soil bacteria which are trapped inside truffle fruiting ...
(Date:9/30/2014)... goes wrong with your muscles because of age, disease or ... is. That,s where a new research report published in the ... comes in. In the report, a team of scientists ... help scientists "see" which genes are active in an organ ... activity and that men have approximately 400 more active genes ...
(Date:9/30/2014)... suite of perilous threats in today,s ocean. From ... change, fragile coral ecosystems are disappearing at unprecedented ... species of corals surrounding the island of Moorea ... their tropical environment: coral guard-crabs. New research from ... Station scientist Seabird McKeon and the museum,s predoctoral ...
Breaking Biology News(10 mins):On the trail of the truffle flavor 2Scientists identify which genes are active in muscles of men and women 2Smithsonian scientists discover coral's best defender against an army of sea stars 2
... United States are changing and will face reduced growth ... this century, according to a study conducted by a ... of California, Santa Barbara; U.S. Geological Survey; and University ... Proceedings of the National Academy of Sciences ...
... It,s colds and flu season, and as any parent knows, ... New research using human-networking theory may give a clearer picture ... cold, influenza, whooping cough and SARS can spread through a ... With the help of 788 volunteers at a high ...
... ever, scientists have found a difference in the way males and ... that sexes likely use that difference to select their mates. ... team of researchers who found that male and female cichlid fishes ... as well. "It is difficult to say what colour ...
Cached Biology News:Drought and rising temperatures weaken southwest forests 2Human networking theory gives picture of infectious disease spread 2Human networking theory gives picture of infectious disease spread 3When it comes to selecting a mate, the eyes have it: Queen's University study 2
(Date:9/30/2014)... WASHINGTON D.C., September 30, 2014 Applying a ... of researchers at Harvard University has demonstrated the ... surface -- work that holds promise for making ... and detailing the sides of next-gen rocket ships ... When light passes through oil in water, it ...
(Date:9/30/2014)... analog of one of nature,s most efficient light-harvesting ... led by Alejandro Briseno of the University of ... developing long-sought polymer architecture to boost power-conversion efficiency ... devices. , Briseno, with colleagues and graduate ... University and Dresden University of Technology, Germany, report ...
(Date:9/30/2014)... Sept. 30, 2014 Report Details ... highest potential revenues Do you want to find ... you revenue predictions for those biological drugs from ... you find financial data, R&D trends, opportunities and ... sales forecasts to 2024 at overall world market, ...
(Date:9/30/2014)... 2014 Nematicide is a type of ... microscopic parasitic roundworms, found in massive quantities virtually ... and animals. Nematicides have tended to be broad-spectrum ... migration through the soil. A single gram of ... With more than 10,000 species classified, they are ...
Breaking Biology Technology:Taking thin films to the extreme 2Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 2Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 3Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 4Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 5Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2
... Corp ., a Madison biotechnology company, has raised $1 million ... the total raised to $3 million in the past two ... verify the efficacy of two products: adhesives that bind tissues ... and medical device coatings that block bacterial adhesion to the ...
... - Sir Ken Robinson has many ... his point about creativity than the story of a little ... a senior advisor to the J. Paul Getty Trust ... creativity and innovation, told the story during a keynote address ...
... 1995, I gave a luncheon speech to the Chicago Bar ... st Century." At that time, many who attended ... that much faith in it. My argument was that the ... maxed out. Municipalities would have to become more creative to ...
Cached Biology Technology:Sir Ken Robinson: Companies, kids "get" innovation, but K-12 doesn't nurture it 2Sir Ken Robinson: Companies, kids "get" innovation, but K-12 doesn't nurture it 3Creativity, innovation extend to municipalities 2Creativity, innovation extend to municipalities 3Creativity, innovation extend to municipalities 4