Navigation Links
Evolutionary medicine of skin cancer risk among Europeans
Date:9/17/2013

The proclivity of Spaniards to bask in regions like the Costa del Sol while their northern European counterparts must stay under cover to protect their paler skin or risk skin cancer is due in large part to the pigment producing qualities of the MC1R gene locus. The MC1R gene, expressed in skin and hair follicle cells, is more diverse in Eurasian populations compared to African populations.

Now, a team of researchers led by Santos Alonso, et. al., have examined the evolutionary selective pressure for MC1R among a large population of Spaniards in comparison to their Northern Europeans counterparts as well as individuals with melanoma. Using data from the 1,000 Genomes Project as well as samples from different regions of Spain, they authors show that selection for the MC1R locus is strong in South Europeans, but not the case for Northern Europeans.

Two evolutionary selective processes seem to be acting on MC1R in Southern Europeans. On the one hand, there is selective pressure to maintain at high frequencies the ancestral form of the gene, also the one most common in Africans. But simultaneously, one gene variant seems to be favored in South Europeans. This gene variant, called the V60L allele, has been associated before with red/blond hair and fair skin.

World frequency distribution of V60L is confined mostly to Europe and the Near East but mostly absent in East Asia and Africa, indicating that the first appearance of V60L mutation occurred some time after modern humans left Africa but before dispersal throughout Europe. Fair skin depigmentation could be a useful change for the adaptation of humans to this new environment. Traditionally, depigmentation had been hypothetically explained as a function of the need of humans to synthesize vitamin D in areas of reduced sun light (compared to Africa). "We have not proved that this is the underlying reason for the signature of positive selection on V60L, but our data adds support to this vie
'/>"/>

Contact: Joe Caspermeyer
MBEpress@gmail.com
480-258-8972
Molecular Biology and Evolution (Oxford University Press)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Fear of holes may stem from evolutionary survival response
2. Penn biologists show that generosity leads to evolutionary success
3. Family matters: Evolutionary relationships among species of magic mushrooms shed light on fungi
4. From obscurity to dominance: Tracking the rapid evolutionary rise of ray-finned fish
5. A revolutionary new 3-D digital brain atlas
6. Teaching complete evolutionary stories increases learning
7. Living fossils? Actually, sturgeon are evolutionary speedsters
8. Small but speedy: Short plants live in the evolutionary fast lane
9. Political motivations may have evolutionary links to physical strength
10. Revolutionary Face Recognition Media Exploitation System Now Available to Enhance Public Safety in Europe
11. Fred Hutch evolutionary geneticist Harmit Malik selected as an HHMI investigator
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... is a newly coined term for novels and films which ... University of Copenhagen shows how these fictions serve as a ... of climate change and imagine other living conditions. , ... in the atmosphere; it is also a cultural phenomenon in ... and the films we see. And there are so many ...
(Date:4/23/2014)... disease is the first cause of dementia and affects ... cure has yet been found. One of the reasons ... cellular mechanisms which cause alterations in nerve transmissions and ... the disease., Researchers from the Institute of Neuroscience at ... mechanism involved in memory consolidation and were able to ...
(Date:4/23/2014)... social mammals, ravens form different types of social relationships ... they also form strict dominance relations. From a cognitive ... key ability in daily social life ("knowing who is ... members have with each other sets the stage for ... of this study have been published in the scientific ...
Breaking Biology News(10 mins):Fiction prepares us for a world changed by global warming 2Fiction prepares us for a world changed by global warming 3Loss of memory in Alzheimer's mice models reversed through gene therapy 2Ravens understand the relations among others 2
... sleuthing system they developed to probe how cells manage ... common but hard-to-see sugar switches are partly in control. ... abundant and potential targets of manipulation by drugs, the ... for a number of diseases, including cancer, the scientists ...
... , REDWOOD CITY, Calif. , ... has selected DigitalPersona, Inc., a leader in fingerprint identity and ... Justice Information System (CJIS) mandates. Located in Central Florida , ... who serve more than 28,000 residents. The City chose DigitalPersona ® ...
... 2010 The Translational Genomics Research Institute (TGen) today ... agreement with the Van Andel Research Institute (VARI) that ... TGen expects the agreement to create a ... and treatments for patient benefit. ...
Cached Biology News:Sweet! -- sugar plays key role in cell division 2City of Winter Park Looks to DigitalPersona Software for Stronger Security and CJIS Compliance 2City of Winter Park Looks to DigitalPersona Software for Stronger Security and CJIS Compliance 3City of Winter Park Looks to DigitalPersona Software for Stronger Security and CJIS Compliance 4TGen finalizes alliance with Van Andel Research Institute 2TGen finalizes alliance with Van Andel Research Institute 3
(Date:1/15/2014)... 15, 2014 TaiGen Biotechnology Company, Limited ("TaiGen") today ... R-Pharm, a leading Russian pharmaceutical company, to develop and ... Russian Federation , Turkey ... is a novel antibiotic for the treatment of bacterial ...
(Date:1/14/2014)... Washington, DC (PRWEB) January 14, 2014 ... session for Thursday, January 23, 2014 at 2pm EST ... Actionable Knowledge.” The topic focuses on how technology can ... mission critical decisions for government agencies. The online webinar ...
(Date:1/14/2014)... 14, 2014  3D Communications, a leading provider of strategic communications services ... media events in the United States and ... Virginia Cox , JD, is returning to the firm,s ... re-joins 3D after more than two years of service as Associate ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... of Alliqua, Inc. (OTCQB: ALQA). Alliqua is an emerging ... to serve the wound care market. , Free report ... was restructured with a seasoned management team and Board, ...
Breaking Biology Technology:TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2Former FDA Associate Commissioner Returns To 3D Communications 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... Copper,s days are numbered, and a new study ... the ubiquitous metal in smart phones, tablet computers, and ... who are seeking smaller, faster devices. As ... size, so do the copper pathways that transport electricity ...
... Interleukin Genetics, Inc. (OTCQB: ILIU) today announced financial and ... Total revenue for the three months ended September ... period in the prior year. The increase was attributable to ... expenses were $325,000 for the three months ended September 30, ...
... Nov. 10, 2011 GeoVax Labs, Inc. (OTCQB/OTCBB: GOVX), ... prevent and fight Human Immunodeficiency Virus (HIV) infections, today ... September 30, 2011. GeoVax reported a net ... months ended September 30, 2011, compared to $644,666 ($0.04 ...
Cached Biology Technology:Researching graphene nanoelectronics for a post-silicon world 2Researching graphene nanoelectronics for a post-silicon world 3Interleukin Genetics Reports Third Quarter 2011 Financial Results 2Interleukin Genetics Reports Third Quarter 2011 Financial Results 3Interleukin Genetics Reports Third Quarter 2011 Financial Results 4GeoVax Labs, Inc. Announces Nine Month 2011 Financial Results 2GeoVax Labs, Inc. Announces Nine Month 2011 Financial Results 3GeoVax Labs, Inc. Announces Nine Month 2011 Financial Results 4GeoVax Labs, Inc. Announces Nine Month 2011 Financial Results 5
... a variety of motion options - roller, ... unit. Shake, rock, roll and rotate motions!,, ... hybridization and blotting procedures requiring different settings, ... chamber uses a roller action to operate ...
... Magnetic Stand-96 is designed for paramagnetic bead ... 0.2 ml PCR plates with no additional ... base in a standard SBS 96-well microplate ... permanent magnets guarantees easy and fast (as ...
... magnetic particle based purification systems provide high ... any sample. They offer increased throughput and ... systems- KingFisher, KingFisher mL and KingFisher 96, ... l. Each system consists of an instrument, ...
... no-frills, basic SpeedVac concentrator designed for the ... unit still features a standard Teflon coated ... time and heat. It is designed for ... wide variety of different rotors for maximum ...
Biology Products: