Navigation Links
Evolution can select for evolvability, Penn biologists find
Date:11/14/2013

e VlsE gene is preceded by "cassettes" which are normally not expressed, or made into individual proteins, but can recombine with VlsE to alter the expressed protein and thus present a novel challenge to a host's immune defenses.

Though earlier studies had suggested that selection may directly favor the capacity to evolve, they could not definitively rule out that evolvability had arisen for other reasons. In particular, it has been difficult in empirical studies to rule out the possibility that evolvability arises and is maintained as a byproduct of selection on organismal features more directly related to fitness.

In the Lyme disease system, the researchers got around this confounding factor by looking at diversity in the unexpressed cassettes, which would not have been the object of direct selection because they have no known function on their own; they simply exist as a way of increasing the potential diversity of the VlsE protein. Thus diversity in the cassettes would offer a window into past natural selection for a more "evolvable" VlsE.

"Organisms with greater diversity among the cassettes will have a selective advantage as they will be more antigenically evolvable, or better able to repeatedly generate novel antigens, and will thus be more likely to persist within hosts," the researchers wrote.

Using long-established methods in molecular evolution, the researchers evaluated 12 strains of B. burgdorferi for signs that natural selection had acted to increase the diversity of the cassettes.

"The evidence was remarkably strong in favor of evolution for more diversity among cassettes and thus greater evolvability in the expressed protein," Brisson said.

The researchers confirmed that the more genetically diverse the cassettes, the more genetically diverse the expressed protein, VlsE. They also found that mutations in the cassettes that could affect the portion of VlsE that is recognized by the immune
'/>"/>

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Penn team elucidates evolution of bitter taste sensitivity
2. Fast-mutating DNA sequences shape early development; guided evolution of uniquely human traits
3. Targeting evolution: Could this be the next strategy to stop superbugs?
4. Alfred Russel Wallace: Co-founder of the theory of biological evolution
5. Climate change and coevolution: Weve done the math
6. Grazers and pollinators shape plant evolution
7. Evolutionary medicine of skin cancer risk among Europeans
8. Recent highlights in Molecular Biology and Evolution
9. Fear of holes may stem from evolutionary survival response
10. Penn biologists show that generosity leads to evolutionary success
11. Biometrics Can Revolutionise Mobile Payment Security, says Frost & Sullivan
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) ... Recognition Market 2015-2019" report to their offering. ... to grow at a CAGR of 23.5 percent over ... present scenario and the growth prospects of the Global ... the market size, the report considers the revenue generated ...
(Date:3/24/2015)... Fla. , March 24, 2015   ... management solutions, today announced that its U.are.U ® ... accessory retailer Goorin Bros . to achieve ... biometrics-based solution secures access to the POS terminal, ... increased risk of data breaches. ...
(Date:3/23/2015)... March 23, 2015  In the 2014 fiscal year, ... conviction losses. This figure accounts for a fraction of ... The Nilson Report, exceeds $11 billion globally. The polygraph ... a crime has occurred. Investor Mark Saint Juste ... Joe Paolella partnered to administer the test ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3
... 2012 Genomic sequencing has revealed therapeutic drug targets ... an unprecedented study by the Translational Genomic Research Institute ... published by the journal Molecular Cancer Therapeutics ... spelling out, the billions of letters contained in the ...
... joined international delegates in Doha, Qatar, to discuss how satellite ... change and how this information is useful to the ... and negotiations, the UN Climate Change Conference has entered its ... of Environment. ,During the first week of the ,COP 18, ...
... Entomologist Marshall Johnson , an extension specialist and ... the Distinguished Scientist of the Year Award from the ... (IOBC-NRS). Only one individual is recognized annually for ... career in the nearctic region , which encompasses ...
Cached Biology News:TGen-US Oncology data guides treatment of metastatic triple-negative breast cancer patients 2TGen-US Oncology data guides treatment of metastatic triple-negative breast cancer patients 3Climate - the hot topic in Doha 2UC Riverside entomologist named Distinguished Scientist of the Year 2
(Date:5/5/2015)...  23andMe, Inc., the leading personal genetics company, today ... in collaboration with Pfizer Inc. The companies aim ... commonly known as lupus, into the study to help ... also in collaboration with the Lupus Research Institute, and ... Approximately 1.5 million people in the U.S. suffer ...
(Date:5/5/2015)... 05, 2015 Hayden-McNeil is ... develop custom course materials for smaller courses. This program ... low as 200 students. , “I’m very excited ... of higher education instructors,” said Jeff McCarthy, Hayden-McNeil president. ... can do our part to make education both more ...
(Date:5/5/2015)... MILFORD, Mass. , May 5, 2015 ... a strategic alliance which offers a first-of-its-kind platform that ... patient access to lab results, transforms the way patients ... Luminate Health provides a HIPAA-compliant ... patients to access, manage, and understand their lab results, ...
(Date:5/5/2015)... The Academy of Model Aeronautics is pleased ... Indiana Gov. Mike Pence, has declared August 15, 2015, ... a Family Fest and aviation themed Motorcycle Rally in ... Wounded Warrior Project. , National Model Aviation Day has ... foremost organization for model aviation—to celebrate the history of ...
Breaking Biology Technology:23andMe Launches the Lupus Research Study in Collaboration with Pfizer Inc. 223andMe Launches the Lupus Research Study in Collaboration with Pfizer Inc. 3Hayden-McNeil Expands Publishing Program to Service Lower Enrollment Courses 2Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 2Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 3State of Indiana proclaims August 15 as Model Aviation Day 2
... October 19, 2011 Stakeholder representative to ... Stevenage Bioscience Catalyst (SBC), the UK,s first ... Ian Tomlinson, Senior Vice President, Head of Biopharmaceuticals R&D ... to its Board. In his role as ...
... demonstrated that they can build some of the basic ... which could pave the way for a new generation ... the journal Nature Communications . The ... can build logic gates, which are used for processing ...
... Minimally Invasive Devices, Inc . (MID) announced today the early ... utilizing the novel Flo-X laparoscopic cleaning agent, which allows for ... without removal from the abdominal cavity. Flo-X is ... the first 19 FloShield PLUS cases utilizing the Flo-X, any ...
Cached Biology Technology:Ian Tomlinson Joins SBC Board as GlaxoSmithKline Representative Director 2Ian Tomlinson Joins SBC Board as GlaxoSmithKline Representative Director 3Ian Tomlinson Joins SBC Board as GlaxoSmithKline Representative Director 4Ian Tomlinson Joins SBC Board as GlaxoSmithKline Representative Director 5Scientists create computing building blocks from bacteria and DNA 2
Recombinant DNA polymerase from Thermus aquaticus expressed in E. coli; 5 units/uL; 25 tubes of 1, 000 units enzyme/tube w/ Buffer I...
Aspergillus (IgG) Ab EIA Sample Size: 100 l...
Ps-Aeruginosa (IgG) -Ab EIA Sample Size: 100 l...
APO(a) EIA Sample Size: 25 l...
Biology Products: