Navigation Links
Evolution can select for evolvability, Penn biologists find
Date:11/14/2013

e VlsE gene is preceded by "cassettes" which are normally not expressed, or made into individual proteins, but can recombine with VlsE to alter the expressed protein and thus present a novel challenge to a host's immune defenses.

Though earlier studies had suggested that selection may directly favor the capacity to evolve, they could not definitively rule out that evolvability had arisen for other reasons. In particular, it has been difficult in empirical studies to rule out the possibility that evolvability arises and is maintained as a byproduct of selection on organismal features more directly related to fitness.

In the Lyme disease system, the researchers got around this confounding factor by looking at diversity in the unexpressed cassettes, which would not have been the object of direct selection because they have no known function on their own; they simply exist as a way of increasing the potential diversity of the VlsE protein. Thus diversity in the cassettes would offer a window into past natural selection for a more "evolvable" VlsE.

"Organisms with greater diversity among the cassettes will have a selective advantage as they will be more antigenically evolvable, or better able to repeatedly generate novel antigens, and will thus be more likely to persist within hosts," the researchers wrote.

Using long-established methods in molecular evolution, the researchers evaluated 12 strains of B. burgdorferi for signs that natural selection had acted to increase the diversity of the cassettes.

"The evidence was remarkably strong in favor of evolution for more diversity among cassettes and thus greater evolvability in the expressed protein," Brisson said.

The researchers confirmed that the more genetically diverse the cassettes, the more genetically diverse the expressed protein, VlsE. They also found that mutations in the cassettes that could affect the portion of VlsE that is recognized by the immune
'/>"/>

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Penn team elucidates evolution of bitter taste sensitivity
2. Fast-mutating DNA sequences shape early development; guided evolution of uniquely human traits
3. Targeting evolution: Could this be the next strategy to stop superbugs?
4. Alfred Russel Wallace: Co-founder of the theory of biological evolution
5. Climate change and coevolution: Weve done the math
6. Grazers and pollinators shape plant evolution
7. Evolutionary medicine of skin cancer risk among Europeans
8. Recent highlights in Molecular Biology and Evolution
9. Fear of holes may stem from evolutionary survival response
10. Penn biologists show that generosity leads to evolutionary success
11. Biometrics Can Revolutionise Mobile Payment Security, says Frost & Sullivan
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2015)... , June 26, 2015 ATL Technology, LLC, ... devices with specialties in single use solutions, headquartered in ... MedConx, Inc. (a California corporation with ... San Jose, Costa Rica ). ... Costa Rica with ATL Technology,s existing facility in ...
(Date:6/24/2015)... 2015 The biologics safety testing market is ... the market include growth of the pharmaceutical and biological ... Over the years, the number of drug approvals in ... the FDA approved 225 drug applications and Health Canada ... Europe accounted for 3,822 of the pharmaceutical ...
(Date:6/24/2015)... , June 24, 2015 Biometry ... with emerging biometric password solution one face in. ... one face in, entering the ... ground-breaking and affordable multifactor-authentication biometric answer to the ... technology, provided in partnership with KeyLemon, one face ...
Breaking Biology News(10 mins):ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 3Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 4KeyLemon Announces Partnership With Biometric Password Solution onefacein 2
... the world,s largest genomics organization, will hold its ... (ICG Americas 2013) on September 12-13, 2013 in ... California, Davis, will feature presentations from ground-breaking research ... in sequencing and bioinformatics, and offer a dynamic, ...
... research results from Uppsala University, Sweden, instil hope of efficient ... despite the prevailing scepticism based on previous research. The study, ... , changes the view on the ability of green algae ... a way of producing fuel from renewable energy sources to ...
... Montral, April 15, 2013 A team of researchers at ... discovery in breast cancer, which will published online this week ... of Sciences (PNAS). The Montral scientists identified the DOCK1 ... metastases in patients suffering from breast cancer, the most common ...
Cached Biology News:BGI hosts its '2nd International Conference on Genomics in the Americas' 2Surprising findings on hydrogen production in green algae 2An important discovery in breast cancer by IRCM researchers 2
(Date:7/29/2015)... NJ (PRWEB) , ... July 29, 2015 , ... The ... approval of combination products , in particular, drug/device combinations. The current system received ... by the Initiative for Patient Centered Innovation (iPCI) of Fairleigh Dickinson University’s ...
(Date:7/29/2015)... ... July 29, 2015 , ... Finding gooey or crusty material in the corner ... are a considerable number of terms in popular use to describe it, ophthalmologists call ... mixture of mucus, blood cells, skin cells and dust, but until now there has ...
(Date:7/29/2015)... (PRWEB) , ... July 29, 2015 , ... Costello served ... levee system to protect the Orange County, Texas area from future storm surge ... design team in determining several potential levee alignment alternatives for providing protection, Costello also ...
(Date:7/29/2015)... ... July 29, 2015 , ... Nearly everyone has heard of the potential of ... that a rich source of these cells is teeth—baby teeth that come loose during ... be pulled to make room for braces. These potent stem cells exist in ...
Breaking Biology Technology:Third Medical Innovation Impact Index Issued by Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) 2Third Medical Innovation Impact Index Issued by Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) 3What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 2What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 3What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 4Preventing Storm Surge Flooding in Houston 2Advanced Oral and Maxillofacial Surgery (AOMS) in Elmhurst, IL Partners with Provia Labs to make Store-A-Tooth™ Dental Stem Cell Banking Available to their Patients 2
... Texas The efficiency of conventional solar cells could ... mechanisms of solar energy conversion led by chemist Xiaoyang ... Zhu and his team have discovered that it,s possible ... photon of sunlight using an organic plastic semiconductor material. ...
... Tenn., Dec. 16, 2011  Quammen Health Care Consultants is ... into reality through a five-year outsourcing agreement. Under the ... of information technology, from strategic vision to vendor relations ... and at all hospitals across the country as a ...
... 2011 /PRNewswire-Asia/ -- China Sky One Medical, Inc. ("China Sky ... a leading fully integrated pharmaceutical company in the People,s Republic ... Tian Di Ren Medical Science and Technology Company ("TDR"), signed ... company, Harbin Tian Xin Biological Engineering Ltd. ...
Cached Biology Technology:Discovery of a 'dark state' could mean a brighter future for solar energy 2Quammen Health Care Consultants Takes Over Information Technology Reins at Faith Regional Health Services 2Quammen Health Care Consultants Takes Over Information Technology Reins at Faith Regional Health Services 3China Sky One Medical to Jointly Launch Adult Stem Cell Research Enterprise 2China Sky One Medical to Jointly Launch Adult Stem Cell Research Enterprise 3
... Our Smart Solutions has now entered ... Screening (HCS) by partnering up with Cellomics, ... from the integration of Beckman Coulter‘s automated ... uncovers deeper biological information at the sub-cellular ...
... in conjunction with the EasyCount System to count ... ViaSure Staining Reagent uses a mixture of ready-to-use ... Bromide to identify live and dead cells, respectively, ... 6 Multi-well Slide provides the ability to ...
... laser scanners is the starting point of ... ,Gene expression analysis, SNP (Single Nucleotide Polymorphism) ... the advancement of research in the post-genomics ... formats and sizes. These arrays call for ...
... This kit allows for rapid, convenient, and ... simple bind/wash/elute process utilizes a spin column ... beads for concentration of proteins which were ... are strong ion exchangers, offering high binding ...
Biology Products: