Navigation Links
Evidence of host adaptation of avian-origin influenza A virus
Date:5/14/2013

A novel avian-origin reassortant influenza A (H7N9) virus emerged in China in February 2013, and is associated with severe lower respiratory tract diseases. To date, more than 100 human cases of infection, including at least 20 deaths, have been reported in China. Three early cases of infection were described in Hangzhou, Zhejiang Province, China. The general clinical features of the three patients were similar to the previously reported cases in China. Two of the three patients had a history of direct contact with live poultry markets. Interestingly, poultry cage swabs and feces from the free market visited by Patient 2 one week prior to the onset of symptoms were positive for the novel avian influenza A (H7N9) virus. This indicates a direct connection between human infection with the novel H7N9 virus and an environmental source.

Researchers analyzed the DNA sequences from the Hangzhou viruses and other human H7N9 viral sequences available from the databases, together with those from other H7 influenza viruses. This showed that the virus sequenced from Patient 2 was most closely related to the virus derived from the environmental source associated with Patient 2, while Hangzhou/1 and Hangzhou/3 were more divergent. These data suggest that several H7N9 viruses are circulating in Hangzhou. It is uncertain whether the diversity of H7N9 in Hangzhou is the result of host adaptation, or predates the transmission to humans from an avian source.

The pathogenesis of the novel avian-origin H7N9 virus in humans remains unknown, although a series of substitutions that have been confirmed as pathogenicity factors in animal models were found in viruses from Hangzhou. A glutamine to isoleucine substitution was observed at position 226 of the hemagglutinin amino acid sequence in the newly sequenced virus. Isoleucine has similar characteristics to leucine, which was previously shown to be a pivotal amino acid in the binding of avian- or human-type receptor, and might
'/>"/>

Contact: YAN Bei
yanbei@scichina.org
86-106-400-8316
Science China Press
Source:Eurekalert

Page: 1 2

Related biology news :

1. Research reveals first evidence of hunting by prehistoric Ohioans
2. Strong scientific evidence that eating berries benefits the brain
3. UNH research adds to mounting evidence against popular pavement sealcoat
4. NIST/UMass study finds evidence nanoparticles may increase plant DNA damage
5. Evidence shows that anti-depressants likely do more harm than good, researchers find
6. Evidence of familial vulnerability for epilepsy and psychosis
7. New evidence that many genes of small effect influence economic decisions and political attitudes
8. DNA evidence shows that marine reserves help to sustain fisheries
9. New evidence in fructose debate: Could it be healthy for us?
10. Study provides first evidence of coevolution between invasive, native species
11. First direct evidence that elemental fluorine occurs in nature
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... -- Winners of The Economist,s prestigious Innovation awards 2014 ... place at the JW Marriott Hong Kong on Friday, October 10 ... their experiences and the lessons those hold for others. The awards, ... the past decade, will be presented at a ceremony in ... will be the first time the ceremony has come to ...
(Date:9/29/2014)... September 29, 2014 -- Plants have a symbiotic ... the pants extract nutrients and defend against invaders ... contaminating fruits and vegetables. Now, scientist have discovered ... of seeds; thus ensuring that sprouting plants are ... University of Notre Dame, presented their findings today ...
(Date:9/29/2014)... school? According to a new Food and Brand Lab ... can increase participation in the National School Lunch Program ... vegetables by 16%! , Chefs Move to Schools (CMTS), ... chefs with schools in order to provide nutrition instruction ... service workers. , A CMTS event was held in ...
Breaking Biology News(10 mins):Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 2Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 3Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 4Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 5Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 6Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 7Plants prepackage beneficial microbes in their seeds 2Chefs move to schools can increase school meal participation and vegetable intake among students 2
... One out of three sexually active older adults infected with ... University researchers. A survey of 260 HIV-positive older adults found ... and were in a relationship. , AIDs cases among the ... for Disease Control and Prevention, they will account for half ...
... has stopped in its tracks a form of blood ... telomerase, thereby shortening the ends of chromosomes, called telomeres. ... commits suicide as a means of protecting the body," ... molecular biology and genetics at Johns Hopkins. Her study, ...
... instructions rather than drugs to treat disease - has tickled ... therapeutic method. One sizeable hurdle is getting the right ... Engineers at the University of Wisconsin-Madison are now developing a ... his colleagues have created ultrathin, nanoscale films composed of DNA ...
Cached Biology News:1/3 of sexually active older adults with HIV/AIDs has unprotected sex 2Short chromosomes put cancer cells in forced rest 2Ultrathin films deliver DNA as possible gene therapy tool 2Ultrathin films deliver DNA as possible gene therapy tool 3
(Date:9/30/2014)... Genedata, a leading provider ... and related life science research, today announced ... Selector as its host-pathogen data analysis platform ... a European consortium dedicated to improving the ... anti-fungal drug therapies. Genedata Selector supports this ...
(Date:9/30/2014)... iLab Solutions announced the results of ... which focuses on core facility operations, growth and utilization ... today. , In its 4th year running, a number ... the year-over-year decrease in the percentage of revenue that ... feeling the constraints of this trend. When asked, “What ...
(Date:9/30/2014)... September 30, 2014 Rainbow Scientific, ... research products, recently opened an online store to ... culture product lines developed and manufactured by Biological ... store include Biological Industries’ Nutristem® serum-free, xeno-free reagents ... embryonic stem cell (hESC) culture. , The ...
(Date:9/30/2014)... Cambridge MA and Pittsburgh PA (PRWEB) September 30, ... of Clinical Research Nurses ( IACRN), a ... Alliance for Clinical Research Excellence and Safety ... announced the signing of a strategic alliance agreement, ... , IACRN’s vision is to enhance clinical research ...
Breaking Biology Technology:FUNGITECT Consortium Adopts Genedata Selector as Data Analysis Platform for Anti-fungal R 2FUNGITECT Consortium Adopts Genedata Selector as Data Analysis Platform for Anti-fungal R 3iLab Solutions Announces the Results of the 2014 Core Facility Benchmarking Study 2iLab Solutions Announces the Results of the 2014 Core Facility Benchmarking Study 3Rainbow Scientific, Inc. opens online store for state-of-the-art stem cell culture and cytogenetic reagents 2IACRN and ACRES to Support Clinical Research Nurses 2IACRN and ACRES to Support Clinical Research Nurses 3
... , TAI,AN, China, Sept. ... Board: CBPO) ("China Biologic," or the "Company"),one of ... of China ("PRC"), today announced that on September ... and development agreement with the,Institute of Blood Transfusion ...
... , , ABBOTT PARK, Ill., Sept. 24 ... results on Wednesday, Oct. 14, 2009, before the market opens. , ... of the earnings conference call at 8 a.m. Central time (9 a.m. Eastern), ... An archived edition of the call will be available after 11 a.m. Central ...
... ... The increased need for pharmaceutical packaging companies to reduce waste and disposal ... led to an increased demand for specialised deblistering machines according ... Press-Outs, are used to increase production yields by recovering valuable product from ...
Cached Biology Technology:China Biologic Products Enters into a Strategic Research and Development Agreement with IBT of CAMS 2China Biologic Products Enters into a Strategic Research and Development Agreement with IBT of CAMS 3China Biologic Products Enters into a Strategic Research and Development Agreement with IBT of CAMS 4Deblistering Device Keeps Production Ahead Of Pack 2Deblistering Device Keeps Production Ahead Of Pack 3