Navigation Links
Evidence of host adaptation of avian-origin influenza A virus
Date:5/14/2013

A novel avian-origin reassortant influenza A (H7N9) virus emerged in China in February 2013, and is associated with severe lower respiratory tract diseases. To date, more than 100 human cases of infection, including at least 20 deaths, have been reported in China. Three early cases of infection were described in Hangzhou, Zhejiang Province, China. The general clinical features of the three patients were similar to the previously reported cases in China. Two of the three patients had a history of direct contact with live poultry markets. Interestingly, poultry cage swabs and feces from the free market visited by Patient 2 one week prior to the onset of symptoms were positive for the novel avian influenza A (H7N9) virus. This indicates a direct connection between human infection with the novel H7N9 virus and an environmental source.

Researchers analyzed the DNA sequences from the Hangzhou viruses and other human H7N9 viral sequences available from the databases, together with those from other H7 influenza viruses. This showed that the virus sequenced from Patient 2 was most closely related to the virus derived from the environmental source associated with Patient 2, while Hangzhou/1 and Hangzhou/3 were more divergent. These data suggest that several H7N9 viruses are circulating in Hangzhou. It is uncertain whether the diversity of H7N9 in Hangzhou is the result of host adaptation, or predates the transmission to humans from an avian source.

The pathogenesis of the novel avian-origin H7N9 virus in humans remains unknown, although a series of substitutions that have been confirmed as pathogenicity factors in animal models were found in viruses from Hangzhou. A glutamine to isoleucine substitution was observed at position 226 of the hemagglutinin amino acid sequence in the newly sequenced virus. Isoleucine has similar characteristics to leucine, which was previously shown to be a pivotal amino acid in the binding of avian- or human-type receptor, and might
'/>"/>

Contact: YAN Bei
yanbei@scichina.org
86-106-400-8316
Science China Press
Source:Eurekalert

Page: 1 2

Related biology news :

1. Research reveals first evidence of hunting by prehistoric Ohioans
2. Strong scientific evidence that eating berries benefits the brain
3. UNH research adds to mounting evidence against popular pavement sealcoat
4. NIST/UMass study finds evidence nanoparticles may increase plant DNA damage
5. Evidence shows that anti-depressants likely do more harm than good, researchers find
6. Evidence of familial vulnerability for epilepsy and psychosis
7. New evidence that many genes of small effect influence economic decisions and political attitudes
8. DNA evidence shows that marine reserves help to sustain fisheries
9. New evidence in fructose debate: Could it be healthy for us?
10. Study provides first evidence of coevolution between invasive, native species
11. First direct evidence that elemental fluorine occurs in nature
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... IRVINE, Calif. , Jan. 27, 2015 ... trusted provider of globally deployed, innovative test ... today announced the delivery of its ... Martin Space Systems Company (LMSSC). GENASYS is ... the demands of mission-critical applications that require ...
(Date:2/5/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ... authentication company focused on the growing mobile commerce market, ... Online CEO Conference on January 29 th at ... , CEO of NXT-ID will present and host a ... smart wallet and its full suite of biometric technologies. ...
(Date:2/5/2015)... , Jan. 30, 2015  It is gratifying to ... and potential for genomic science as a means to ... prevention and treatment.  I was honored to participate in ... precision medicine program. Since the 1980s ... of genomics—from the first sequenced genome of a free ...
Breaking Biology News(10 mins):Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 2Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 3Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 4CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 3J. Craig Venter, Ph.D., Co-Founder and CEO, Human Longevity, Inc. (HLI) Participates in White House Precision Medicine Event 2
... many as 18 percent of adults who have no history ... stroke, according to results of a large national study published ... one of the JAMA/Archives journals. , Using brain imaging to ... have had an undiagnosed or silent stroke, according to background ...
... intensive care unit (ICU) previously occupied by a ... of acquiring such bacteria, according to a report ... Internal Medicine, one of the JAMA/Archives journals. , ... in hospitals: methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant ...
... approach, researchers at Children's Hospital Boston have demonstrated that ... a heart attack and protect the heart from scarring. ... a natural inhibitor of cell division with a naturally ... Together, these two agents enabled heart-muscle cells to multiply ...
Cached Biology News:Stroke symptoms common among general population 2Transmission of antibiotic-resistant bacteria linked to previous intensive care unit room occupants 2Rescuing injured hearts by enhancing regeneration 2Rescuing injured hearts by enhancing regeneration 3
(Date:2/27/2015)... , Feb. 27, 2015 Bionomics Limited ... the DisrupTOR-1 trial of BNC105 in patients with metastatic ... Orlando, Florida . The data will ... the City of Hope Comprehensive Cancer Center in ... The new data identifies Ferritin and IL-8 ...
(Date:2/27/2015)...  Steep Hill, the industry leader in cannabis testing ... open a full service medical cannabis quality assurance laboratory ... advanced scientific tools and methodology to the state, for ... currently the only laboratory licensed by the New Mexico ... in order to meet the recently adopted regulatory requirements ...
(Date:2/26/2015)... Feb. 26, 2015  23andMe, the leading personal genetics ... as Privacy Officer and Corporate Counsel. Black brings ... laws as well as health care regulations. As a ... be responsible for reviewing, updating and enhancing the company,s ... and abroad. She joined the company January 5, 2015 ...
(Date:2/26/2015)... , Feb. 26, 2015 Protiviti ( www.protiviti.com ... version of the Governance Portal , designed to ... and compliance (GRC) tasks across multiple business units and ... to help customers better align their controls with the ... Commission ) requirements. In response to client feedback, Protiviti ...
Breaking Biology Technology:New BNC105 Biomarker Data to be Presented at US Cancer Conference 2New BNC105 Biomarker Data to be Presented at US Cancer Conference 3New BNC105 Biomarker Data to be Presented at US Cancer Conference 4New BNC105 Biomarker Data to be Presented at US Cancer Conference 5Steep Hill First to Receive Provisional Approval to Establish Laboratory Services for Cannabis Testing in State of New Mexico 223andMe Appoints Kate Black as Privacy Officer and Corporate Counsel 2Protiviti Governance Portal Helps Companies Drive Governance, Risk and Compliance Productivity Across Multiple Business Units 2Protiviti Governance Portal Helps Companies Drive Governance, Risk and Compliance Productivity Across Multiple Business Units 3
... , Introduction ... used to display data from all SPEX instruments. DataMax can ... map displays multifiles or 3-D data, and looks much like a geographical ... X values are plotted on the horizontal axis, and z values are ...
... , ... The SPEX FLUOROLOG ... other accessories. The standard FLUOROLOG configuration has an R928P ... 850 nm. For near-IR fluores-cence measurements, an optional solid-state de-tector (DSS-IGA020L) ...
... , , ... Protein-containing plants are staples in the diets of all countries. The ability ... people have to have enough to eat before they can advance to higher ... the amount of rainfall, the occurrence of frost, wind erosion, etc., can be ...
Cached Biology Technology:Obtaining a contour map from multifiles or 3D data in DataMax 2Obtaining a contour map from multifiles or 3D data in DataMax 3Food science: increasing crop yields 2
Donor feline serum and plasma...
NPT1 (M-19)...
8 different frozen tissues are mounted on positively charged glass slides...
... Combining linear motor and ... offer pre-engineered Cartesian solutions that ... cable management, and motors., , ... , Pass through high-flex cabling ...
Biology Products: