Navigation Links
Evidence of host adaptation of avian-origin influenza A virus
Date:5/14/2013

A novel avian-origin reassortant influenza A (H7N9) virus emerged in China in February 2013, and is associated with severe lower respiratory tract diseases. To date, more than 100 human cases of infection, including at least 20 deaths, have been reported in China. Three early cases of infection were described in Hangzhou, Zhejiang Province, China. The general clinical features of the three patients were similar to the previously reported cases in China. Two of the three patients had a history of direct contact with live poultry markets. Interestingly, poultry cage swabs and feces from the free market visited by Patient 2 one week prior to the onset of symptoms were positive for the novel avian influenza A (H7N9) virus. This indicates a direct connection between human infection with the novel H7N9 virus and an environmental source.

Researchers analyzed the DNA sequences from the Hangzhou viruses and other human H7N9 viral sequences available from the databases, together with those from other H7 influenza viruses. This showed that the virus sequenced from Patient 2 was most closely related to the virus derived from the environmental source associated with Patient 2, while Hangzhou/1 and Hangzhou/3 were more divergent. These data suggest that several H7N9 viruses are circulating in Hangzhou. It is uncertain whether the diversity of H7N9 in Hangzhou is the result of host adaptation, or predates the transmission to humans from an avian source.

The pathogenesis of the novel avian-origin H7N9 virus in humans remains unknown, although a series of substitutions that have been confirmed as pathogenicity factors in animal models were found in viruses from Hangzhou. A glutamine to isoleucine substitution was observed at position 226 of the hemagglutinin amino acid sequence in the newly sequenced virus. Isoleucine has similar characteristics to leucine, which was previously shown to be a pivotal amino acid in the binding of avian- or human-type receptor, and might
'/>"/>

Contact: YAN Bei
yanbei@scichina.org
86-106-400-8316
Science China Press
Source:Eurekalert

Page: 1 2

Related biology news :

1. Research reveals first evidence of hunting by prehistoric Ohioans
2. Strong scientific evidence that eating berries benefits the brain
3. UNH research adds to mounting evidence against popular pavement sealcoat
4. NIST/UMass study finds evidence nanoparticles may increase plant DNA damage
5. Evidence shows that anti-depressants likely do more harm than good, researchers find
6. Evidence of familial vulnerability for epilepsy and psychosis
7. New evidence that many genes of small effect influence economic decisions and political attitudes
8. DNA evidence shows that marine reserves help to sustain fisheries
9. New evidence in fructose debate: Could it be healthy for us?
10. Study provides first evidence of coevolution between invasive, native species
11. First direct evidence that elemental fluorine occurs in nature
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... of Life, is a non-traditional biophysics textbook and it ... is a journey of discovery into biological systems and ... biological regulation. It is about how our genes make ... the billions of cells in an organism. It quantifies ... principles, which can be found on both large and ...
(Date:10/15/2014)... Alt will be awarded the 44th Rosenstiel Award for ... his pioneering research exploring the mechanisms of genomic instability ... cells. Alt is the second alumnus to win the ... Prize in 2003. , Alt is the Charles A. ... Harvard Medical School and an investigator at the Howard ...
(Date:10/14/2014)... house fly genome for the first time, revealing robust ... that thrives in pathogen-rich dung piles and garbage heaps. ... Genome Biology , will increase understanding of house ... adapt to resist insecticides, which could lead to novel ... and transmit more than 100 human and animal diseases, ...
Breaking Biology News(10 mins):New book about life as seen from physics 2Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2House fly genome reveals expanded immune system 2
... SANTA CRUZ, CA--Researchers at the University of California, Santa Cruz, ... migrations of elephant seals have compiled one of the largest ... and diving behavior at sea in unprecedented detail. ... PLoS ONE focuses on the annual migrations of adult ...
... saliva of the Gila monster lizard is effective in ... Academy, University of Gothenburg, have tested the drug on ... food and chocolate. An increasing number of patients ... preparation called Exenatide, which helps them to control their ...
... have now been found in shipwrecks both in the Baltic ... the results, presented in the Journal of Archaeological Science, ... University. A few years ago scientists reported large quantities ... warship Vasa, resulting in the development of sulphuric acid ...
Cached Biology News:Elephant seal tracking reveals hidden lives of deep-diving animals 2Elephant seal tracking reveals hidden lives of deep-diving animals 3Drugs from lizard saliva reduces the cravings for food 2Sulphur and iron compounds common in old shipwrecks 2
(Date:10/18/2014)... October 18, 2014 The Asian Electronic Medical ... in Asian with analysis and forecast of revenue. The electronic ... grow to $2,328.0 million by 2018, at a CAGR of ... of the Asian Electronic Medical Record (EMR) market, to get ... a glimpse of the segmentation of the market in the ...
(Date:10/18/2014)... The report " Cloud Analytics ... Web; Speech; Machine; Video; Predictive Analytics: Global Advancements, ... & Analysis (2013 - 2018) ", defines and ... sub segments with an in-depth analysis and forecasting ... factors driving this market, various restraints, and opportunities ...
(Date:10/17/2014)... journey through the looking-glass to Wonderland, mirrors in the ... ways, including a new class of mirror that works ... The Optical Society,s (OSA) new high-impact journal ... time, a new type of mirror that forgoes a ... by using an unusual magnetic property of a non-metallic ...
(Date:10/17/2014)... Horsham, PA (PRWEB) October 17, 2014 ... is being called upon by health facilities around ... exposed patients are being treated. Among the many ... used includes Texas Health Presbyterian Hospital Dallas and ... Center. The state-of-the-art vapor-producing robots have been utilized ...
Breaking Biology Technology:The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 2The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 3The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 4The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 5Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 2Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 3Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 4Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 5Magnetic mirrors enable new technologies by reflecting light in uncanny ways 2Magnetic mirrors enable new technologies by reflecting light in uncanny ways 3Magnetic mirrors enable new technologies by reflecting light in uncanny ways 4Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 2Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 3Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 4Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 5Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 6
...   Reportlinker.com announces that a new market ... , Strategic Analysis of the Collagen ... http://www.reportlinker.com/p0760990/Strategic-Analysis-of-the-Collagen-Peptide-Market-in-the-United-States.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Biomaterial This ... peptides. The historical period is from 2007, ...
... Jan. 17, 2012  Synthetic Genomics Inc. (SGI), a privately ... a wide range of global challenges, today announced they ... Nutritional Products. Stagnitti is a proven leader with experience ... high value food and nutritional products for humans and ...
... Using growth factors derived from a woman,s own blood, ... developed a simple, office-based procedure that appears to markedly ... preliminary results of this procedure, which involves the injection ... on the upper wall of the vagina and the ...
Cached Biology Technology:Strategic Analysis of the Collagen Peptide Market in the United States 2Synthetic Genomics Inc. Hires Industry Leader George E. Stagnitti to Head Food and Nutritional Products Development Program 2"O-Shot™" May Improve Female Sexual Response 2"O-Shot™" May Improve Female Sexual Response 3
Sf21 Insect Cells (Live) in Max-XP Medium...
... Super Sensitive Polymer-HRP IHC ... novel product based on ... technology. This system yields ... noise ratio and minimizes ...
Artisan™ Wash Solution (x 50) Additional Information: EU regulatory status: CE US regulatory status: IVD ...
MiniCycler thermal cycler with Hot Bonnet heated lid, holds 25x0.2ml tubes...
Biology Products: