Navigation Links
Evidence mounts for role of mutated genes in development of schizophrenia
Date:1/22/2013

Johns Hopkins researchers have identified a rare gene mutation in a single family with a high rate of schizophrenia, adding to evidence that abnormal genes play a role in the development of the disease.

The researchers, in a report published in the journal Molecular Psychiatry, say that family members with the mutation in the gene Neuronal PAS domain protein 3 (NPAS3) appear at high risk of developing schizophrenia or another debilitating mental illnesses.

Normally functioning NPAS3 regulates the development of healthy neurons, especially in a region of the brain known as the hippocampus, which appears to be affected in schizophrenia. The Johns Hopkins researchers say they have evidence that the mutation found in the family may lead to abnormal activity of NPAS3, which has implications for brain development and function.

"Understanding the molecular and biological pathways of schizophrenia is a powerful way to advance the development of treatments that have fewer side effects and work better than the treatments now available," says study leader Frederick C. Nucifora Jr., Ph.D., D.O., M.H.S., an assistant professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine. "We could definitely use better medicines."

Along with environmental factors, it is widely believed that many genes play some role in causing schizophrenia, a disease characterized by a variable combination of hallucinations, delusions, impaired cognition and a loss of drive and initiative. The disorder strikes an estimated seven in every 1,000 adults in the United States. While the Johns Hopkins experiments to date show that the NPAS3 mutation is rare, Nucifora says learning as much as possible about the biological role of NPAS3 will likely lead to a better understanding of how other genes contribute to the development of schizophrenia, even in the absence of the NPAS3 mutation.

For the study, Nucifora and his
'/>"/>

Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Best evidence yet that dinosaurs used feathers for courtship
2. Evidence contradicts idea that starvation caused saber-tooth cat extinction
3. Chinese scientists discover evidence of giant pandas population history and local adaptation
4. First evidence of fish sensing geomagnetic fields from a Czech Christmas market
5. First evidence of ocean acidification affecting live marine creatures in the Southern Ocean
6. New evidence of dinosaurs role in the evolution of bird flight
7. More evidence needed to support use of autism interventions
8. Mobile phones and wireless networks: No evidence of health risk found
9. Researchers find first evidence for a genetic cause for Barretts oesophagus
10. First photo evidence of snub-nosed monkey species in China
11. Alpine Fault study shows new evidence for regular magnitude 8 earthquakes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... and number of connections in transcription factor networks (TFNs) ... a study published in PLOS Computational Biology ... signature contributes to a network,s resilience against mutations. ... assortativity of TFN models has a greater effect on ... of assortativity," said Dov A. Pechenick, PhD, lead author ...
(Date:8/29/2014)... nucleus, chromosomal DNA is tightly bound to structural ... chromatin. Until about two decades ago, histones were ... material around which the glamorous DNA strands were ... appreciation for how DNA/histone interactions govern gene expression. ... studying the sequence of the genome from cancer ...
(Date:8/28/2014)... to announce the selection of Dr. Fred Baxendale as ... those who have served ESA for at least 20 ... Society that has reached an extraordinary level. Candidates for ... and then voted on by the ESA membership. Dr. ... Entomology 2014, ESA,s Annual Meeting in Portland, Oregon this ...
Breaking Biology News(10 mins):Assortativity signatures of transcription factor networks contribute to robustness 2'K-to-M' histone mutations: How repressing the repressors may drive tissue-specific cancers 2'K-to-M' histone mutations: How repressing the repressors may drive tissue-specific cancers 3Fred Baxendale selected as Honorary Member of the Entomological Society of America 2
... is a burden that females of many species face, and ... , In a new paper from the June issue of ... research team from the University of Leeds suggest that female ... avoid too much attention from males. Observing wild population of ...
... record abound with examples of structures so useful they've ... have debated whether examples of so-called adaptive, parallel evolution ... and proteins. , In a paper published online in ... presents evidence for one such instance in a gene ...
... European Journal of Nutrition demonstrates a strong correlation ... and the dose-dependent effect of soy germ isoflavones, ... regarding soy isoflavones for post-menopausal women. , According ... a health condition experienced by about one in ...
Cached Biology News:Parallel evolution: Proteins do it, too 2Parallel evolution: Proteins do it, too 3New research: Soy germ isoflavones reduce bone loss 2
(Date:8/28/2014)... 2014  Armetheon, Inc. ( www.armetheon.com ), a ... late-stage cardiovascular drug candidates, today announced that it ... of financing. The Series A round was co-led ... participation from investors that included Atheneos Capital and ... Larry Hsu , the founder of Impax Laboratories. ...
(Date:8/28/2014)... 27, 2014 Scientists, researchers, and technologists ... SPIE Laser Damage 2014 symposium. Marking its 46th ... lasers will run 14-17 September. The event is sponsored ... photonics . , The premier conference for basic and ... to optical materials will engage researchers and engineers from ...
(Date:8/28/2014)... Earlier this month, a report ... with the U.S. Air Force on the performance of ... that this type of fuel made from mustard seeds, ... important to America’s Eco friendly future. In fact, every ... to become independent of foreign oil over the next ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 Supplementing ... offering a promotion for Eppendorf Safe Lock ... to purchase the highest quality tubes at an ... ideal for customers doing chemical, medical, pharmaceutical, and ... who are not regularly able to afford Eppendorf ...
Breaking Biology Technology:Armetheon Completes $7.0 Million Series A Financing 2Armetheon Completes $7.0 Million Series A Financing 3Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 4Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 5Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 3
... scientists who proved it is possible to cultivate a network ... or the brain on a microchip have been involved ... activity at a resolution never achieved before. Developed ... chips are also simpler to use, which will help future ...
... confronted the stress of the Second Lebanon War suffered fewer ... by focusing on feelings. This has been shown in a ... Haifa, the Technion-Israel Institute of Technology and Carmel Medical Center. ... it is important to uncover all the factors that impact ...
... engineering school in Grenoble, France, and Virginia Tech is ... The students, work will help gene synthesis companies and ... DNA as harmful agents for bioterrorism. Synthetic biology ... production, agriculture, and other areas. For a few thousand ...
Cached Biology Technology:Neurochip technology developed by Canadian team 2Can multiple sclerosis attacks be minimized in a war zone? 2iGEM team helps prevent rogue use of synthetic biology 2
Detects activated caspases in living cells. Simple/sensitive/straight-forward procedure takes only 30 minutes. Results can be analyzed by flow cytometry/fluorescence microscopy/fluorescence plate rea...
Anti-Mouse Qa.m7, Ascites (Clone 5035-50.1) (mouse IgM)...
DAPI: 4', 6-Diamino-2-phenylindole dihydrochloride. Antifade Solution: p-Phenylenediamine and glycerol in PBS solution. 0.4g/mL DAPI suspended in Antifade....
... 13(S)-HODE-d4 contains 4 deuterium atoms at the ... intended for use as an internal standard for ... spectrometry. 13(S)-HODE is produced by incubation of linoleic ... been shown to inhibit the adhesion of tumor ...
Biology Products: