Navigation Links
Evidence mounts for role of mutated genes in development of schizophrenia
Date:1/22/2013

Johns Hopkins researchers have identified a rare gene mutation in a single family with a high rate of schizophrenia, adding to evidence that abnormal genes play a role in the development of the disease.

The researchers, in a report published in the journal Molecular Psychiatry, say that family members with the mutation in the gene Neuronal PAS domain protein 3 (NPAS3) appear at high risk of developing schizophrenia or another debilitating mental illnesses.

Normally functioning NPAS3 regulates the development of healthy neurons, especially in a region of the brain known as the hippocampus, which appears to be affected in schizophrenia. The Johns Hopkins researchers say they have evidence that the mutation found in the family may lead to abnormal activity of NPAS3, which has implications for brain development and function.

"Understanding the molecular and biological pathways of schizophrenia is a powerful way to advance the development of treatments that have fewer side effects and work better than the treatments now available," says study leader Frederick C. Nucifora Jr., Ph.D., D.O., M.H.S., an assistant professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine. "We could definitely use better medicines."

Along with environmental factors, it is widely believed that many genes play some role in causing schizophrenia, a disease characterized by a variable combination of hallucinations, delusions, impaired cognition and a loss of drive and initiative. The disorder strikes an estimated seven in every 1,000 adults in the United States. While the Johns Hopkins experiments to date show that the NPAS3 mutation is rare, Nucifora says learning as much as possible about the biological role of NPAS3 will likely lead to a better understanding of how other genes contribute to the development of schizophrenia, even in the absence of the NPAS3 mutation.

For the study, Nucifora and his
'/>"/>

Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Best evidence yet that dinosaurs used feathers for courtship
2. Evidence contradicts idea that starvation caused saber-tooth cat extinction
3. Chinese scientists discover evidence of giant pandas population history and local adaptation
4. First evidence of fish sensing geomagnetic fields from a Czech Christmas market
5. First evidence of ocean acidification affecting live marine creatures in the Southern Ocean
6. New evidence of dinosaurs role in the evolution of bird flight
7. More evidence needed to support use of autism interventions
8. Mobile phones and wireless networks: No evidence of health risk found
9. Researchers find first evidence for a genetic cause for Barretts oesophagus
10. First photo evidence of snub-nosed monkey species in China
11. Alpine Fault study shows new evidence for regular magnitude 8 earthquakes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... Wis. No matter how many times it,s ... social, communicating creatures. , But by using ... organisms radically alter their behavior to suit their ... of them are present, and act accordingly. , ... millions, it may change from innocuous to pathogenic, ...
(Date:9/18/2014)... turned its newborn screening program into a model other states ... the first-ever Newborn Screening Quality Award from the March of ... M.P.H., Arizona,s Department of Health Services director, with the award ... policy of full transparency for the length of time it ... lab for analysis, and set a target of having 95 ...
(Date:9/18/2014)... global cycles of carbon and nitrogen comprise all ... and environmental systems have caused imbalances and perturbations ... gases (GHGs). Increased GHGs result in climate changes ... ecosystems, oceans and the atmosphere. Understanding these feedback ... branch of environmental science during the past three ...
Breaking Biology News(10 mins):Researchers study vital 'on/off switches' that control when bacteria turn deadly 2Researchers study vital 'on/off switches' that control when bacteria turn deadly 3March of Dimes honors Arizona with first-ever newborn screening award 2March of Dimes honors Arizona with first-ever newborn screening award 3Greenhouse gas research enters a new era 2
... from the University of Southern Denmark have identified how a ... in a cell,s membrane. Such holes cause high blood pressure, ... medication for high blood pressure. High blood pressure can ... a specific mutated protein. Now the researchers at University of ...
... suffer from the consequences of maternal drug exposure during pregnancy, ... used substances. This motivated the study, published in the ... to decipher the molecular basis of how the major psychoactive ... brain development of the unborn foetus. The study ...
... have engineered an efficient and environmentally friendly catalyst for ... extensively in modern industry to manufacture fertilizer and refine ... element, it is generally not found as the pure ... (H2O) or to carbon in methane (CH4), the primary ...
Cached Biology News:Punctured cell membranes lead to high blood pressure 2Cannabis during pregnancy endangers fetal brain development 2Engineers teach old chemical new tricks to make cleaner fuels, fertilizers 2Engineers teach old chemical new tricks to make cleaner fuels, fertilizers 3Engineers teach old chemical new tricks to make cleaner fuels, fertilizers 4
(Date:9/18/2014)... About POCT POCT, ... clinical laboratory. It helps in making fast clinical ... medication. POCT is gaining popularity due to the ... as diabetes, heart disease, and obesity. It is ... to minimize errors during the diagnosis of patients. ...
(Date:9/18/2014)... Ireland , September 18, 2014 ... and Markets ( http://www.researchandmarkets.com/research/czvg3s/biocompatible ) has ... "Biocompatible Materials - Global Strategic Business ... ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ,This report analyzes ... in US$ Million by the following ...
(Date:9/18/2014)... 18, 2014 Research and Markets ... "Global N-acetylcysteine Industry Report 2014" report to ... Industry Report 2014 is a professional and in-depth ... N-acetylcysteine industry. The report provides a ... applications and industry chain structure. The N-acetylcysteine market ...
(Date:9/18/2014)...  U.S. biotech company Kultevat has strengthened ... technology developed by the Donald Danforth Plant Science ... for applications in production of natural rubber in ... developed under the direction of Roger Beachy , ... of the Danforth Plant Science Center, and is used ...
Breaking Biology Technology:POCT Market in China 2014-2018 2Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3Global N-acetylcysteine Industry Report 2014 2Kultevat obtains license of gene switch technology 2
... a provider of single-molecule DNA analysis technology, announced Thursday it ... of brain tumor, known as oligodendroglioma. OpGen, based in Madison, ... and professor of genetics and chemistry at the University of ... , ,Optical mapping, invented by Schwartz, will enable researchers to ...
... investors, and media is a leading indicator, the technology market is ... when he said DEMO 2004 felt "like a bit of the ... were repeated by dozens of attendees who talked to or emailed ... this industry unlike any we've felt in the past 36 months. ...
... to offshore outsourcing as an issue du jour. I ... (an election year at that for America) due to ... future of the U.S. Prominent voices along every point ... Democratic presidential nomination to the Bush Administration and a ...
Cached Biology Technology:OpGen joins UW, Henry Ford Heath in Improving Brain Tumor Treatment 2The Tech Market is Looking Up 2The Tech Market is Looking Up 3The Tech Market is Looking Up 4The Great Offshore Outsourcing Debate 2
... AP Conjugate Stabilizer is an aqueous ... protein and other non-toxic stabilizing chemicals ... pH 5.5 6.5. This ... methylisothiazolone and 0.02% bromonitrodioxane as a ...
... binding is a problem in your ... immobilized NeutrAvidin products as superior alternatives ... a modified avidin derivative that combines ... biotin-binding protein with exceptionally low nonspecific ...
Cells are grown to a specified density and induced, when necessary. Protein expression samples are collected at 3 growth points and analyzed by SDS-PAGE/Coomassie....
... generated hybridomas against a large variety ... you are provided with personalized project ... lines developed by Covance remain exclusive ... hybridoma development project has four phases: ...
Biology Products: