Navigation Links
Even the smallest stroke can damage brain tissue and impair cognitive function
Date:12/16/2012

Blocking a single tiny blood vessel in the brain can harm neural tissue and even alter behavior, a new study from the University of California, San Diego has shown. But these consequences can be mitigated by a drug already in use, suggesting treatment that could slow the progress of dementia associated with cumulative damage to miniscule blood vessels that feed brain cells. The team reports their results in the December 16 advance online edition of Nature Neuroscience.

"The brain is incredibly dense with vasculature. It was surprising that blocking one small vessel could have a discernable impact on the behavior of a rat," said Andy Y. Shih, lead author of the paper who completed this work as a postdoctoral fellow in physics at UC San Diego. Shih is now an assistant professor at the Medical University of South Carolina.

Working with rats, Shih and colleagues used laser light to clot blood at precise points within small blood vessels that dive from the surface of the brain to penetrate neural tissue. When they looked at the brains up to a week later, they saw tiny holes reminiscent of the widespread damage often seen when the brains of patients with dementia are examined as a part of an autopsy.

These micro-lesions are too small to be detected with conventional MRI scans, which have a resolution of about a millimeter. Nearly two dozen of these small vessels enter the brain from a square millimeter area of the surface of the brain.

"It's controversial whether that sort of damage has consequences, although the tide of evidence has been growing as human diagnostics improve," said David Kleinfeld, professor of physics and neurobiology, who leads the research group.

To see whether such minute damage could change behavior, the scientists trained thirsty rats to leap from one platform to another in the dark to get water.

The rats readily jump if they can reach the second platform with a paw or their snout,
'/>"/>

Contact: David Kleinfeld
scinews@ucsd.edu
University of California - San Diego
Source:Eurekalert  

Page: 1 2

Related biology news :

1. U-M forecasters predict second-smallest Gulf of Mexico dead zone
2. Smallest and largest fetuses at greater risk of being stillborn, research finds
3. Do the worlds smallest flies decapitate tiny ants?
4. By detecting smallest virus, researchers open possibilities for early disease detection
5. Integrated Biometrics Introduces Sherlock The Worlds Lightest, Thinnest, Smallest, Appendix F Mobile ID Fingerprint Sensors
6. Study finds soda consumption increases overall stroke risk
7. Study: In-patient, out-patient stroke rehab might benefit from yoga
8. Reorganizing brain could lead to new stroke, tinnitus treatments
9. Brain-wave-reading robot might help stroke patients
10. Double duty: Immune system regulator found to protect brain from effects of stroke
11. Stem cells can repair a damaged cornea
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Even the smallest stroke can damage brain tissue and impair cognitive function
(Date:9/1/2014)... animals, bats are perfectly adapted to a life without light. ... reflected echoes to measure distance to obstacles or prey. In ... delays. A study carried out by researchers at Technische Universitt ... map dynamically adapts to external factors. , Closer ... in too close to an object, the number of activated ...
(Date:8/31/2014)... bacteria C. diff , that causes diarrhoea, temperature ... at the University of Leicester. , Using a mass ... possible to identify the unique ,smell, of C. ... the condition., What is more, the Leicester team say ... the disease simply from their smell a chemical ...
(Date:8/31/2014)... today in Nature Climate Change , suggests that ... if not exceed, the global targets for total greenhouse gas ... we should all think carefully about the food we choose ... the world is just one of a number of actions ... and ensure there is enough food for all. , ...
Breaking Biology News(10 mins):Zooming in for a safe flight 2Scientists develop 'electronic nose' for rapid detection of C. diff infection 2Changing global diets is vital to reducing climate change 2Changing global diets is vital to reducing climate change 3Changing global diets is vital to reducing climate change 4
... they grow older, but autopsy data from a long-range study ... that the brains of a third of those who had ... the type of small, cumulative injury that can come from ... presented the study results at Experimental Biology 2008 in San ...
... what makes some people stand head and shoulders above the ... first common version of a gene influencing height has now ... can make a height difference of up to 6cm. ... today in the journal Nature Genetics, mean that scientists now ...
... or biological rhythm, controls many metabolic functions and is ... 24-hour cycle that is important in determining sleeping and ... mammals. The newly discovered rhythm, like the circadian ... brain that functions as the main control center for ...
Cached Biology News:1/3 of risk for dementia attributable to small vessel disease, autopsy study shows 2A tall story: New research adds to growing body of knowledge of genetics of height 2NYU dental professor discovers biological clock linking tooth growth to other metabolic processes 2
(Date:8/31/2014)... 2014 Available spectra is similar ... research and cultivation of a wide range of ... LEDs with proven patented and pending wide spectrum ... uniformity in critical applications in contrast to growth ... “Our customers have a large variety of differently ...
(Date:8/29/2014)... Electronic circuits are based on electrons, but one of ... photonic circuits, i.e. circuits based on light (photons) instead ... to create a stream of single photons and control ... sorts of attempts to achieve this control, but now ... creating a steady stream of photons emitted one at ...
(Date:8/29/2014)... Local veterinarian, Dr. Keith Clement, and ... candidates to participate in an investigational study of donor ... goal of this study is to determine if a ... two arthritically affected joints can help reduce pain and ... the current investigational study must be older than nine ...
(Date:8/28/2014)... SAN DIEGO, California, USA (PRWEB) August 28, 2014 ... at the Department of Physics and Optical Science and ... at the University of North Carolina at Charlotte, and ... has been elected to serve as the 2015 Vice ... photonics. , SPIE 2014 President Philip Stahl announced recent ...
Breaking Biology Technology:Breakthrough in light sources for new quantum technology 2Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2
... has been named the,Singapore Entrepreneurial Company of the ... that have pushed the boundaries of excellence in ... 2008.,Mr David Picard, CEO of Moleac, received the ... Award for Singapore Entrepreneurial Company,of the Year at ...
... April 21 GenVault, a leading provider of ... the release today of GenConnect 3.2, the newest ... Highlights of the release include a strategic ... seamlessly into third-party informatics offerings, as well as ...
... Inc. (Nasdaq: ITMN ) announced today that it ... 30, 2009 at 4:00 p.m. Eastern time. A live ... 4:30 p.m. Eastern time that same day. , ... 973-200-3372 (international), conference ID# 95970767. To access the webcast, ...
Cached Biology Technology:Moleac Named Singapore Entrepreneurial Company of the Year at the Frost & Sullivan Excellence in Healthcare Awards 2Moleac Named Singapore Entrepreneurial Company of the Year at the Frost & Sullivan Excellence in Healthcare Awards 3GenVault Corporation Launches its Latest Centralized and Standardized Software Solution for Biobanking and Biological Sample Management, GenConnect 3.2 2GenVault Corporation Launches its Latest Centralized and Standardized Software Solution for Biobanking and Biological Sample Management, GenConnect 3.2 3InterMune to Release First Quarter Financial Results on April 30 2
UltraPure DNase/RNase-Free Distilled Water is designed for use in all molecular biology applications. It is 0.1-m membrane-filtered and tested for DNase and RNase activity....
... DEPC-treated Water is suitable ... is prepared by incubating with ... autoclaved to remove the DEPC.DNase/RNase-Free ... for use in all molecular ...
The S. cerevisiae Hansen strains are the parental yeast strains from which the deletions were derived....
The Hybrid Hunter Yeast Two-Hybrid System uses the activation of reporter genes to indicate positive protein-protein interactions. Two reporters are used an auxotrophic marker and lacZ....
Biology Products: