Navigation Links
Evaluating evolutionary rates could shed light into functions of uncharacterized genes
Date:2/8/2013

PITTSBURGH, Feb. 8, 2013 Genes that have roles in the same biological pathways change their rate of evolution in parallel, a finding that could be used to discover their functions, said a researcher at the University of Pittsburgh School of Medicine in the February issue of GENETICS.

Humans have nearly 21,000 genes that make as many proteins, but the functions of most of those genes have not been fully determined, said lead investigator Nathan Clark, Ph.D., assistant professor of computational and systems biology at the Pitt School of Medicine. Knowing what a particular gene does could help unravel the workings of the body, foster understanding of disease processes and identify targets for new drugs.

"For our study, we took a close look at the way genes evolved between species and we found an interesting signature," he said. "Genes that perform biological functions together have similar evolutionary histories in that the rates at which they change parallel each other. This could allow us to identify partner genes that we might never have suspected to work together in biochemical pathways."

The researchers studied the evolving genomes of 18 yeast species and 22 mammalian species, looking particularly at genes that are involved in meiosis, a cell division process, and in DNA repair. They found parallel changes, such as acceleration or deceleration, in evolutionary rates among not only genes encoding proteins that physically interact with each other, but also among those that had no direct contact but still participated in meiosis or DNA repair pathways.

All genes mutate over time, which can be beneficial, harmful or meaningless. Some yeast species evolved a different method of reproduction and meiosis stopped as it was no longer essential for survival, Dr. Clark said. Through subsequent generations, the rate of change in the genes involved in making meiosis proteins accelerated, leading to deterioration of the unnec
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. New tools for evaluating quality of life for cats, dogs with heart disease
2. Leading evolutionary scientist to discuss how genome of bacteria has evolved
3. An evolutionary surprise
4. A University of Tennessee professors hypothesis may be game changer for evolutionary theory
5. Scientists trace evolutionary history of what mammals eat
6. Battle of the sexes offers evolutionary insights
7. Revolutionary project will obtain entire genome sequences in fight against Alzheimers
8. Sandia seeks commercial partners for revolutionary SpinDx medical diagnostic tool
9. Tamarisk biocontrol efforts get evolutionary boost
10. Researchers dig through the gene bank to uncover the roots of the evolutionary tree
11. WHOI scientists/engineers partner with companies to market revolutionary new instruments
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... Dec. 10, 2014  Data Sciences International (DSI), ... released a new series of digital telemetry implants ... researchers. M series, part of the PhysioTel™ Digital ... best possible physiologic data when incorporating functional endpoints ... endpoints to toxicology studies has evolved from short ...
(Date:12/10/2014)... , Dec. 08, 2014 Research and ... the addition of the "Biometrics Market in ... http://photos.prnewswire.com/prnh/20130307/600769 ... projects such as rural banking and upgradation of ... trends witnessed in the market. Besides the aforementioned ...
(Date:12/3/2014)... Dec. 2, 2014   Marvin Test Solutions ... test solutions for military, aerospace, and manufacturing organizations, ... its successful TS-900 PXI semiconductor test platform ... of high-end systems to customers at a fraction ... to traditional ATE. "Our semiconductor ...
Breaking Biology News(10 mins):New telemetry implants expected to change how large animal toxicology studies are conducted 2Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3
... flies introduced to control red imported fire ants have ... Texas since the flies' introduction in 1999, researchers at ... new flytraps they developed. , Researchers at the Brackenridge ... parasitic flies, originally from Brazil and Argentina, to control ...
... today by World Wildlife Fund of the first assessment ... national parks reveal an alarming decline in tiger and ... accessible for visits since the ceasefire between the Maoist ... 1986, 70 rhinos were translocated to Bardia National Park, ...
... than 40 per cent of fertility clinics in the ... their child, a survey conducted by the Genetics and ... testing method, called preimplantation genetic diagnosis (PGD), was originally ... as Tay-Sachs. It is typically performed by removing a ...
Cached Biology News:Fire ant-attacking fly spreading rapidly in Texas 2Fire ant-attacking fly spreading rapidly in Texas 3Alarming decline in Nepal's rhinos and tigers in former Maoist stronghold 2Embryo tests give parents the choice 2
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... , MISSISSAUGA, ON, June 29 /PRNewswire-FirstCall/ - YM ... AIM:YMBA), a life sciences product development company that ... cancer-related products at various stages of development, today ... Oncoscience AG have resolved the issues between the ...
... 29 Palkion, Inc. announced today that it has ... therapeutic candidate that modulates the Hypoxia-Inducible Factor Prolyl Hydroxylase ... when a novel drug discovery and development firm, CrystalGenomics ... firm, ProQuest Investments, formed a new joint venture entity. ...
... led by Yale University researchers has created the first ... ultimate dream of building a quantum computer. ... run elementary algorithms, such as a simple search, demonstrating ... first time. Their findings will appear in Nature ...
Cached Biology Technology:YM BIOSCIENCES' SUBSIDIARY RESOLVES PROPOSED ARBITRATION WITH ONCOSCIENCE AG 2YM BIOSCIENCES' SUBSIDIARY RESOLVES PROPOSED ARBITRATION WITH ONCOSCIENCE AG 3YM BIOSCIENCES' SUBSIDIARY RESOLVES PROPOSED ARBITRATION WITH ONCOSCIENCE AG 4Palkion Selects Novel Oral Development Candidate for the Treatment of Anemia 2Palkion Selects Novel Oral Development Candidate for the Treatment of Anemia 3Scientists create first electronic quantum processor 2
A component of the Acridinium protein labeling kit....
... Acridinium NHS ester can ... and nucleic acids. The covalently ... produce chemiluminescence in the presence ... ester-labeled proteins can be used ...
... cytometry accessible to anyone in the lab. Novice ... to Guavas on-demand microcapillary flow cytometry systems ... surprisingly affordable, very compact, and nicely equipped with ... EasyCyte Mini has all of the functionality of ...
... real-time PCR detection system holds 48 x 0.2 ml ... LEDs independently excites fluorescence (470-500 nm) for each well, ... (523-543 nm and 540-700 nm). This item is a ... cycler. System dimensions are 18 x 32 x 33 ...
Biology Products: