Navigation Links
European ancestry increases breast cancer risk among Latinas
Date:11/30/2008

PHILADELPHIA Latina women have a lower risk of breast cancer than European or African-American women generally, but those with higher European ancestry could be at increased risk, according to data published in the December 1 issue of Cancer Research, a journal of the American Association for Cancer Research.

"We need to study the possible factors that are placing Latina women of high European ancestry at greater risk," said Laura Fejerman, Ph.D., a post-doctoral research fellow at the University of California San Francisco. "The increased risk could be due to environmental factors, genetic factors or the interplay of the two."

Latinas are what geneticists refer to as an "admixed" population with most of their genetic ancestry from European or indigenous Americans. Fejerman said the term "indigenous Americans" usually refers to the groups that lived on the American continent prior to the arrival of the European colonizers.

For the current study, Fejerman and colleagues identified the genetic ancestry of 440 Latina women with breast cancer and 597 Latina women who did not have breast cancer.

For every 25 percent increase in European ancestry there is a 79 percent increase in the risk of breast cancer. If a woman had an estimated European ancestry of 25 percent she would be 79 percent more likely to have breast cancer than a woman of full indigenous American ancestry.

After accounting for known risk factors like number of full-term pregnancies or months of breastfeeding, the breast cancer risk for every 25 percent increase in European ancestry decreased to 39 percent, but it remained statistically significant.

Fejerman said that the overall risk of Latinas in the US is less than in European Americans but higher than indigenous Americans. She said further research would need to be conducted to determine if these differences are due to the presence of non-genetic risk factors that have not yet been described and that vary with ancestry, to the effect of genetic variants that either are protective or increase risk, or the result of the interaction between genes and non-genetic factors.


'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related biology news :

1. Overfishing threatens European bluefin tuna
2. European biodiversity and ecosystem scientists merge and gear up for long-term research
3. The MDS foundation supports vidazas recommendation for European approval
4. Vidaza receives positve opinion from European CHMP
5. European researchers harness unique properties of boron to develop new drugs and diagnostics
6. IronKey Opens New European Office
7. IOF calls on European citizens to stand tall and speak out for their bones
8. Major European program for the environment under the spotlight in Lille, France
9. Study helps pinpoint genetic variations in European Americans
10. European Science Foundation aims to strengthen regenerative medicine
11. European light research opens door for optical storage and computing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2016)... 2016 Research and Markets has ... Market 2016-2020"  report to their offering.  , ,     ... The analysts forecast the global multimodal biometrics market ... the period 2016-2020.  Multimodal biometrics is ... as the healthcare, BFSI, transportation, automotive, and government ...
(Date:4/13/2016)... physicians supporting Medicaid patients in Central Florida ... telehealth thanks to a new partnership with higi.   ... can routinely track key health measurements, such as blood ... they opt in, share them with IMPOWER clinicians through ... location at no cost. By leveraging this data, IMPOWER ...
(Date:3/22/2016)... India , March 22, 2016 /PRNewswire/ ... market research report "Electronic Sensors Market for Consumer ... Proximity, & Others), Application (Communication & IT, ... Geography - Global Forecast to 2022", published ... industry is expected to reach USD 26.76 ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... discussions on a range of subjects including policies, debt and ... Poloz. Speaking at a lecture to the Canadian ... to the country,s inflation target, which is set by both ... "In certain areas there needs to be ... why not sit down and address strategy together?" ...
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica ... in people with peritoneal or pleural mesothelioma. Their findings are the subject of a ... , Diagnostic biomarkers are signposts in the blood, lung fluid or tissue of ...
(Date:6/23/2016)... 2016   Boston Biomedical , an industry ... to target cancer stemness pathways, announced that its ... Drug Designation from the U.S. Food and Drug ... including gastroesophageal junction (GEJ) cancer. Napabucasin is an ... cancer stemness pathways by targeting STAT3, and is ...
(Date:6/23/2016)... Houston Methodist Willowbrook Hospital has signed ... to serve as their official health care provider. ... will provide sponsorship support, athletic training services, and ... volunteers, athletes and families. "We are ... and to bring Houston Methodist quality services and ...
Breaking Biology Technology: